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Items: 1 to 50 of 53

1.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Jun 28. doi: 10.1021/acschembio.8b00466. [Epub ahead of print]

PMID:
29953201
2.

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR.

Cell Rep. 2018 Jun 19;23(12):3492-3500. doi: 10.1016/j.celrep.2018.05.074.

3.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
4.

Clusterin protects neurons against intracellular proteotoxicity.

Gregory JM, Whiten DR, Brown RA, Barros TP, Kumita JR, Yerbury JJ, Satapathy S, McDade K, Smith C, Luheshi LM, Dobson CM, Wilson MR.

Acta Neuropathol Commun. 2017 Nov 7;5(1):81. doi: 10.1186/s40478-017-0481-1.

5.

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.

Ahn M, Waudby CA, Bernardo-Gancedo A, De Genst E, Dhulesia A, Salvatella X, Christodoulou J, Dobson CM, Kumita JR.

Sci Rep. 2017 Nov 3;7(1):15018. doi: 10.1038/s41598-017-14739-5.

6.

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.

Hanspal MA, Dobson CM, Yerbury JJ, Kumita JR.

Biochim Biophys Acta. 2017 Nov;1863(11):2762-2771. doi: 10.1016/j.bbadis.2017.07.007. Epub 2017 Jul 13. Review.

7.

Amyloid-like Fibrils from an α-Helical Transmembrane Protein.

Stroobants K, Kumita JR, Harris NJ, Chirgadze DY, Dobson CM, Booth PJ, Vendruscolo M.

Biochemistry. 2017 Jun 27;56(25):3225-3233. doi: 10.1021/acs.biochem.7b00157. Epub 2017 Jun 12.

8.

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.

Zeineddine R, Whiten DR, Farrawell NE, McAlary L, Hanspal MA, Kumita JR, Wilson MR, Yerbury JJ.

Prion. 2017 May 4;11(3):195-204. doi: 10.1080/19336896.2017.1314426. Epub 2017 May 9.

9.

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N.

Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23.

PMID:
28230968
10.

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.

Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208. doi: 10.1073/pnas.1615613114. Epub 2016 Dec 23.

11.

The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.

Ahn M, Hagan CL, Bernardo-Gancedo A, De Genst E, Newby FN, Christodoulou J, Dhulesia A, Dumoulin M, Robinson CV, Dobson CM, Kumita JR.

Biophys J. 2016 Dec 6;111(11):2358-2367. doi: 10.1016/j.bpj.2016.10.028.

12.

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide.

Aran Terol P, Kumita JR, Hook SC, Dobson CM, Esbjörner EK.

Biochem Biophys Res Commun. 2015 Dec 25;468(4):696-701. doi: 10.1016/j.bbrc.2015.11.018. Epub 2015 Nov 10.

13.

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies.

Wyatt AR, Kumita JR, Farrawell NE, Dobson CM, Wilson MR.

PLoS One. 2015 Jun 23;10(6):e0130036. doi: 10.1371/journal.pone.0130036. eCollection 2015.

14.

The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution.

Pietralik Z, Kumita JR, Dobson CM, Kozak M.

Colloids Surf B Biointerfaces. 2015 Jul 1;131:83-92. doi: 10.1016/j.colsurfb.2015.04.042. Epub 2015 Apr 27.

PMID:
25969417
15.

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms.

Kukic P, Alvin Leung HT, Bemporad F, Aprile FA, Kumita JR, De Simone A, Camilloni C, Vendruscolo M.

Structure. 2015 Apr 7;23(4):745-53. doi: 10.1016/j.str.2014.12.020. Epub 2015 Mar 12.

16.

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain.

Leung HT, Kukic P, Camilloni C, Bemporad F, De Simone A, Aprile FA, Kumita JR, Vendruscolo M.

Protein Sci. 2014 Nov;23(11):1596-606. doi: 10.1002/pro.2538. Epub 2014 Sep 5.

17.

Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin.

Wyatt AR, Kumita JR, Mifsud RW, Gooden CA, Wilson MR, Dobson CM.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2081-90. doi: 10.1073/pnas.1403379111. Epub 2014 May 5.

18.

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.

Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi LM, Yousefi M, Coleman BM, Hill AF, Plotkin SS, Mackenzie IR, Cashman NR.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3620-5. doi: 10.1073/pnas.1312245111. Epub 2014 Feb 18.

19.

A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.

De Genst E, Chan PH, Pardon E, Hsu SD, Kumita JR, Christodoulou J, Menzer L, Chirgadze DY, Robinson CV, Muyldermans S, Matagne A, Wyns L, Dobson CM, Dumoulin M.

J Phys Chem B. 2013 Oct 24;117(42):13245-13258. doi: 10.1021/jp403425z. Epub 2013 Sep 24.

20.

Protein amyloids develop an intrinsic fluorescence signature during aggregation.

Chan FT, Kaminski Schierle GS, Kumita JR, Bertoncini CW, Dobson CM, Kaminski CF.

Analyst. 2013 Apr 7;138(7):2156-62. doi: 10.1039/c3an36798c. Epub 2013 Feb 18.

21.

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms.

Wyatt AR, Constantinescu P, Ecroyd H, Dobson CM, Wilson MR, Kumita JR, Yerbury JJ.

FEBS Lett. 2013 Mar 1;587(5):398-403. doi: 10.1016/j.febslet.2013.01.020. Epub 2013 Jan 23.

22.

Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.

Ahn M, De Genst E, Kaminski Schierle GS, Erdelyi M, Kaminski CF, Dobson CM, Kumita JR.

PLoS One. 2012;7(11):e50192. doi: 10.1371/journal.pone.0050192. Epub 2012 Nov 16.

23.

Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster.

Kumita JR, Helmfors L, Williams J, Luheshi LM, Menzer L, Dumoulin M, Lomas DA, Crowther DC, Dobson CM, Brorsson AC.

FASEB J. 2012 Jan;26(1):192-202. doi: 10.1096/fj.11-185983. Epub 2011 Sep 29.

24.

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Whyteside G, Alcocer MJ, Kumita JR, Dobson CM, Lazarou M, Pleass RJ, Archer DB.

PLoS One. 2011;6(7):e22692. doi: 10.1371/journal.pone.0022692. Epub 2011 Jul 27.

25.

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein.

Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM, Salvatella X.

Angew Chem Int Ed Engl. 2011 Jul 25;50(31):7048-51. doi: 10.1002/anie.201100986. Epub 2011 Jun 10. No abstract available.

26.

Population of nonnative states of lysozyme variants drives amyloid fibril formation.

Buell AK, Dhulesia A, Mossuto MF, Cremades N, Kumita JR, Dumoulin M, Welland ME, Knowles TPJ, Salvatella X, Dobson CM.

J Am Chem Soc. 2011 May 25;133(20):7737-7743. doi: 10.1021/ja109620d. Epub 2011 Apr 29.

27.

A FRET sensor for non-invasive imaging of amyloid formation in vivo.

Kaminski Schierle GS, Bertoncini CW, Chan FTS, van der Goot AT, Schwedler S, Skepper J, Schlachter S, van Ham T, Esposito A, Kumita JR, Nollen EAA, Dobson CM, Kaminski CF.

Chemphyschem. 2011 Feb 25;12(3):673-680. doi: 10.1002/cphc.201000996. Epub 2011 Feb 9.

28.

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution.

Dhulesia A, Cremades N, Kumita JR, Hsu ST, Mossuto MF, Dumoulin M, Nietlispach D, Akke M, Salvatella X, Dobson CM.

J Am Chem Soc. 2010 Nov 10;132(44):15580-8. doi: 10.1021/ja103524m.

29.

The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity.

Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM, Salvatella X.

J Mol Biol. 2010 Oct 8;402(5):783-96. doi: 10.1016/j.jmb.2010.07.005. Epub 2010 Jul 17.

30.

ANS binding reveals common features of cytotoxic amyloid species.

Bolognesi B, Kumita JR, Barros TP, Esbjorner EK, Luheshi LM, Crowther DC, Wilson MR, Dobson CM, Favrin G, Yerbury JJ.

ACS Chem Biol. 2010 Aug 20;5(8):735-40. doi: 10.1021/cb1001203.

PMID:
20550130
31.

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.

Hagan CL, Johnson RJ, Dhulesia A, Dumoulin M, Dumont J, De Genst E, Christodoulou J, Robinson CV, Dobson CM, Kumita JR.

Protein Eng Des Sel. 2010 Jul;23(7):499-506. doi: 10.1093/protein/gzq023. Epub 2010 Apr 9.

32.

Methods and models in neurodegenerative and systemic protein aggregation diseases.

Brorsson AC, Kumita JR, MacLeod I, Bolognesi B, Speretta E, Luheshi LM, Knowles TP, Dobson CM, Crowther DC.

Front Biosci (Landmark Ed). 2010 Jan 1;15:373-96. Review.

PMID:
20036826
33.

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation.

van Ham TJ, Esposito A, Kumita JR, Hsu ST, Kaminski Schierle GS, Kaminski CF, Dobson CM, Nollen EA, Bertoncini CW.

J Mol Biol. 2010 Jan 22;395(3):627-42. doi: 10.1016/j.jmb.2009.10.066. Epub 2009 Nov 3.

PMID:
19891973
34.

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species.

Yerbury JJ, Kumita JR, Meehan S, Dobson CM, Wilson MR.

J Biol Chem. 2009 Feb 13;284(7):4246-54. doi: 10.1074/jbc.M807242200. Epub 2008 Dec 11.

35.

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.

Chan PH, Pardon E, Menzer L, De Genst E, Kumita JR, Christodoulou J, Saerens D, Brans A, Bouillenne F, Archer DB, Robinson CV, Muyldermans S, Matagne A, Redfield C, Wyns L, Dobson CM, Dumoulin M.

Biochemistry. 2008 Oct 21;47(42):11041-54. doi: 10.1021/bi8005797. Epub 2008 Sep 25.

PMID:
18816062
36.

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.

Rivers RC, Kumita JR, Tartaglia GG, Dedmon MM, Pawar A, Vendruscolo M, Dobson CM, Christodoulou J.

Protein Sci. 2008 May;17(5):887-98. doi: 10.1110/ps.073181508.

37.

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.

Yerbury JJ, Poon S, Meehan S, Thompson B, Kumita JR, Dobson CM, Wilson MR.

FASEB J. 2007 Aug;21(10):2312-22. Epub 2007 Apr 5.

PMID:
17412999
38.

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

Kumita JR, Poon S, Caddy GL, Hagan CL, Dumoulin M, Yerbury JJ, Stewart EM, Robinson CV, Wilson MR, Dobson CM.

J Mol Biol. 2007 May 25;369(1):157-67. Epub 2007 Mar 7.

PMID:
17407782
39.

Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes.

Calamai M, Kumita JR, Mifsud J, Parrini C, Ramazzotti M, Ramponi G, Taddei N, Chiti F, Dobson CM.

Biochemistry. 2006 Oct 24;45(42):12806-15.

PMID:
17042499
40.
41.

Reversible photocontrol of DNA binding by a designed GCN4-bZIP protein.

Woolley GA, Jaikaran AS, Berezovski M, Calarco JP, Krylov SN, Smart OS, Kumita JR.

Biochemistry. 2006 May 16;45(19):6075-84.

PMID:
16681380
42.

Impact of the native-state stability of human lysozyme variants on protein secretion by Pichia pastoris.

Kumita JR, Johnson RJ, Alcocer MJ, Dumoulin M, Holmqvist F, McCammon MG, Robinson CV, Archer DB, Dobson CM.

FEBS J. 2006 Feb;273(4):711-20.

43.

Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme.

Johnson RJ, Christodoulou J, Dumoulin M, Caddy GL, Alcocer MJ, Murtagh GJ, Kumita JR, Larsson G, Robinson CV, Archer DB, Luisi B, Dobson CM.

J Mol Biol. 2005 Sep 30;352(4):823-36.

PMID:
16126226
44.

Alpha-helix formation in a photoswitchable peptide tracked from picoseconds to microseconds by time-resolved IR spectroscopy.

Bredenbeck J, Helbing J, Kumita JR, Woolley GA, Hamm P.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2379-84. Epub 2005 Feb 7.

45.

Origins of helix-coil switching in a light-sensitive peptide.

Burns DC, Flint DG, Kumita JR, Feldman HJ, Serrano L, Zhang Z, Smart OS, Woolley GA.

Biochemistry. 2004 Dec 14;43(49):15329-38.

PMID:
15581345
46.

The kinetics of helix unfolding of an azobenzene cross-linked peptide probed by nanosecond time-resolved optical rotatory dispersion.

Chen E, Kumita JR, Woolley GA, Kliger DS.

J Am Chem Soc. 2003 Oct 15;125(41):12443-9.

PMID:
14531687
47.

A water-soluble azobenzene cross-linker for photocontrol of peptide conformation.

Zhang Z, Burns DC, Kumita JR, Smart OS, Woolley GA.

Bioconjug Chem. 2003 Jul-Aug;14(4):824-9.

PMID:
12862437
48.

Prevention of peptide fibril formation in an aqueous environment by mutation of a single residue to Aib.

Kumita JR, Weston CJ, Choo-Smith LP, Woolley GA, Smart OS.

Biochemistry. 2003 Apr 22;42(15):4492-8.

PMID:
12693945
49.

Achieving photo-control of protein conformation and activity: producing a photo-controlled leucine zipper.

Kumita JR, Flint DG, Woolley GA, Smart OS.

Faraday Discuss. 2003;122:89-103; discussion 171-90.

PMID:
12555851
50.

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