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Assessment of the results of a 3-Year Program for National Standardization and Quality Improvement of Medical Laboratories on Drug of Abuse Testing by the Ministry of Health in Turkey.

Küme T, Mercan F, Topsakal H, Karakükcü Ç, Şeneş M, Pınar A, Gürler M, Kalafat H, Ünal B, Verstraete AG, Hamurtekin Y, Aydınlı A, Şenol Y, Eğin ME, Cihan A, Kazancı EG, Gümüş E.

Drug Test Anal. 2018 Aug 14. doi: 10.1002/dta.2479. [Epub ahead of print]


Comparison of levetiracetam with phenytoin for the prevention of intravenous busulfan-induced seizures in hematopoietic cell transplantation recipients.

Akiyama K, Kume T, Fukaya M, Shiki I, Enami T, Tatara R, Shino M, Ikeda T.

Cancer Chemother Pharmacol. 2018 Aug 6. doi: 10.1007/s00280-018-3659-8. [Epub ahead of print]


A Randomized Study of Distal Filter Protection Versus Conventional Treatment During Percutaneous Coronary Intervention in Patients With Attenuated Plaque Identified by Intravascular Ultrasound.

Hibi K, Kozuma K, Sonoda S, Endo T, Tanaka H, Kyono H, Koshida R, Ishihara T, Awata M, Kume T, Tanabe K, Morino Y, Tsukahara K, Ikari Y, Fujii K, Yamasaki M, Yamanaka T, Kimura K, Isshiki T; VAMPIRE 3 Investigators.

JACC Cardiovasc Interv. 2018 Jul 26. pii: S1936-8798(18)30746-5. doi: 10.1016/j.jcin.2018.03.021. [Epub ahead of print]


Positive correlation of galanin with insulin resistance and triglyceride levels in obese children

Acar S, Paketçi A, Küme T, Demir K, Gürsoy Çalan Ö, Böber E, Abacı A.

Turk J Med Sci. 2018 Jun 14;48(3):560-568. doi: 10.3906/sag-1710-68.


A case of ventricular septal defect detected after myomectomy by intra-operative transesophageal echocardiography in patient with situs inversus and double-chambered right ventricle.

Kawamura A, Imai K, Kume T, Tanemoto K, Tamada T, Okamoto H, Uemura S.

J Echocardiogr. 2018 May 8. doi: 10.1007/s12574-018-0376-6. [Epub ahead of print] No abstract available.


Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Acar S, Çatlı G, Küme T, Tuhan H, Gürsoy Çalan Ö, Demir K, Böber E, Abacı A.

Turk J Med Sci. 2018 Apr 30;48(2):378-385. doi: 10.3906/sag-1705-20.


Vascular Healing Response after Everolimus-Eluting Stent Implantation in Acute Coronary Syndrome Culprit Lesions: Comparison with Implantation in Stable Angina Pectoris.

Goryo Y, Kume T, Ueda T, Watanabe M, Yamada R, Neishi Y, Saito Y, Uemura S.

Acta Cardiol Sin. 2018 Mar;34(2):124-129. doi: 10.6515/ACS.201803_34(2).20171115A.


Acute Traumatic Coagulopathy: The Value of Histone in Pediatric Trauma Patients.

Ulusoy E, Duman M, Çağlar A, Küme T, Er A, Akgül F, Çitlenbik H, Yılmaz D, Ören H.

Turk J Haematol. 2018 May 25;35(2):122-128. doi: 10.4274/tjh.2017.0444. Epub 2018 Mar 28.


Elevated serum neopterin levels in children with functional constipation: association with systemic proinflammatory cytokines.

Cıralı C, Ulusoy E, Kume T, Arslan N.

World J Pediatr. 2018 Mar 16. doi: 10.1007/s12519-018-0144-8. [Epub ahead of print]


Brain injury markers: S100 calcium-binding protein B, neuron-specific enolase and glial fibrillary acidic protein in children with diabetic ketoacidosis.

Çatlı G, Anık A, Acar S, Küme T, Karabulut M, Çalan ÖG, Dündar BN, Abacı A.

Pediatr Diabetes. 2018 Aug;19(5):1000-1006. doi: 10.1111/pedi.12667. Epub 2018 Mar 13.


Predictors of cardiac benefits of renal artery stenting from a multicentre retrospective registry.

Nakajima Y, Kawarada O, Higashimori A, Yokoi Y, Zen K, Anzai H, Doi H, Hokimoto S, Ito S, Kato T, Kume T, Shintani Y, Tanimoto S, Tsubakimoto Y, Utsunomiya M, Nishimura K, Yasuda S.

Heart Asia. 2017 Sep 14;9(2):e010934. doi: 10.1136/heartasia-2017-010934. eCollection 2017.


Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling.

Xia S, Menden HL, Korfhagen TR, Kume T, Sampath V.

J Physiol. 2018 Apr 15;596(8):1397-1417. doi: 10.1113/JP275453. Epub 2018 Mar 2.


Are cytokines and cortisol important predictors for the severity of pediatric croup: A case control study.

Üzüm Ö, Çağlar A, Küme T, Sayıner A, Er A, Akgül F, Ulusoy E, Yılmaz D, Duman M.

Turk J Pediatr. 2017;59(3):281-287. doi: 10.24953/turkjped.2017.03.008.


Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model.

Nakada T, Kudo T, Kume T, Kusuhara H, Ito K.

Drug Metab Pharmacokinet. 2018 Feb;33(1):103-110. doi: 10.1016/j.dmpk.2017.11.314. Epub 2017 Dec 5.


Transcription factor Foxc1 is involved in anterior part of cranial base formation.

Mya N, Furutera T, Okuhara S, Kume T, Takechi M, Iseki S.

Congenit Anom (Kyoto). 2018 Jan 11. doi: 10.1111/cga.12268. [Epub ahead of print]


Red-Light-Driven Water Splitting by Au(Core)-CdS(Shell) Half-Cut Nanoegg with Heteroepitaxial Junction.

Naya SI, Kume T, Akashi R, Fujishima M, Tada H.

J Am Chem Soc. 2018 Jan 31;140(4):1251-1254. doi: 10.1021/jacs.7b12972. Epub 2018 Jan 19.


Correction to: Soil respiration patterns and rates at three Taiwanese forest plantations: dependence on elevation, temperature, precipitation, and litterfall.

Huang YH, Hung CY, Lin IR, Kume T, Menyailo OV, Cheng CH.

Bot Stud. 2017 Dec 12;58(1):60. doi: 10.1186/s40529-017-0215-5.


Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons.

Izumi Y, Kataoka H, Inose Y, Akaike A, Koyama Y, Kume T.

Eur J Pharmacol. 2018 Jan 5;818:470-479. doi: 10.1016/j.ejphar.2017.11.023. Epub 2017 Nov 14.


Soil respiration patterns and rates at three Taiwanese forest plantations: dependence on elevation, temperature, precipitation, and litterfall.

Huang YH, Hung CY, Lin IR, Kume T, Menyailo OV, Cheng CH.

Bot Stud. 2017 Nov 15;58(1):49. doi: 10.1186/s40529-017-0205-7. Erratum in: Bot Stud. 2017 Dec 12;58(1):60.


[The Scope, Quality and Safety Requirements of Drug Abuse Testing].

Küme T, Karakükcü Ç, Pınar A, Coşkunol H.

Turk Psikiyatri Derg. 2017 Fall;28(3):198-207. Turkish.


Neointimal coverage of jailed side branches in coronary bifurcation lesions: an optical coherence tomography analysis.

Kume T, Yamada R, Terumasa K, Tamada T, Imai K, Fukuhara K, Goryo Y, Kawamura A, Hiroshi O, Neishi Y, Uemura S.

Coron Artery Dis. 2018 Mar;29(2):114-118. doi: 10.1097/MCA.0000000000000563.


A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease.

Izuo N, Kasahara C, Murakami K, Kume T, Maeda M, Irie K, Yokote K, Shimizu T.

Sci Rep. 2017 Sep 18;7(1):11811. doi: 10.1038/s41598-017-11671-6.


Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.

Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H.

Sci Rep. 2017 Jul 28;7(1):6771. doi: 10.1038/s41598-017-06964-9.


Endovascular Therapy Outcomes and Intravascular Ultrasound Findings in Thromboangiitis Obliterans (Buerger's Disease).

Kawarada O, Kume T, Ayabe S, Nakaya T, Nakai M, Nishimura K, Noguchi T, Yokoi Y, Ogawa H, Yasuda S.

J Endovasc Ther. 2017 Aug;24(4):504-515. doi: 10.1177/1526602817710917.


Serum galectin-1 levels are positively correlated with body fat and negatively with fasting glucose in obese children.

Acar S, Paketçi A, Küme T, Tuhan H, Gürsoy Çalan Ö, Demir K, Böber E, Abacı A.

Peptides. 2017 Sep;95:51-56. doi: 10.1016/j.peptides.2017.07.009. Epub 2017 Jul 17.


Human venous valve disease caused by mutations in FOXC2 and GJC2.

Lyons O, Saha P, Seet C, Kuchta A, Arnold A, Grover S, Rashbrook V, Sabine A, Vizcay-Barrena G, Patel A, Ludwinski F, Padayachee S, Kume T, Kwak BR, Brice G, Mansour S, Ostergaard P, Mortimer P, Jeffery S, Brown N, Makinen T, Petrova TV, Modarai B, Smith A.

J Exp Med. 2017 Jul 19. pii: jem.20160875. doi: 10.1084/jem.20160875. [Epub ahead of print]


Current clinical applications of coronary optical coherence tomography.

Kume T, Uemura S.

Cardiovasc Interv Ther. 2018 Jan;33(1):1-10. doi: 10.1007/s12928-017-0483-8. Epub 2017 Jul 14. Review.


Evaluation of expression and glycosylation status of UGT1A10 in Supersomes and intestinal epithelial cells with a novel specific UGT1A10 monoclonal antibody.

Oda S, Kato Y, Hatakeyama M, Iwamura A, Fukami T, Kume T, Yokoi T, Nakajima M.

Drug Metab Dispos. 2017 Sep;45(9):1027-1034. doi: 10.1124/dmd.117.075291. Epub 2017 Jul 11.


PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8.

Okuda M, Fujita Y, Hijikuro I, Wada M, Uemura T, Kobayashi Y, Waku T, Tanaka N, Nishimoto T, Izumi Y, Kume T, Akaike A, Takahashi T, Sugimoto H.

J Alzheimers Dis. 2017;59(1):313-328. doi: 10.3233/JAD-161017.


Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes.

Makitani K, Nakagawa S, Izumi Y, Akaike A, Kume T.

J Pharmacol Sci. 2017 May;134(1):37-44. doi: 10.1016/j.jphs.2017.03.008. Epub 2017 Apr 24.


Precise prediction of activators for the human constitutive androstane receptor using structure-based three-dimensional quantitative structure-activity relationship methods.

Kato H, Yamaotsu N, Iwazaki N, Okamura S, Kume T, Hirono S.

Drug Metab Pharmacokinet. 2017 Jun;32(3):179-188. doi: 10.1016/j.dmpk.2017.02.001. Epub 2017 Feb 9.


Perilipin polymorphisms are risk factors for the development of obesity in adolescents? A case-control study.

Tokgöz Y, Işık IA, Akbari S, Kume T, Sayın O, Erdal E, Arslan N.

Lipids Health Dis. 2017 Mar 9;16(1):52. doi: 10.1186/s12944-017-0440-7.


The relationship between lipocalin-2 and free testosterone levels in polycystic ovary syndrome.

Yilmaz Ö, Temur M, Calan M, Kume T, Özbay PÖ, Karakulak M, Yapucu S.

Endokrynol Pol. 2017;68(1):7-12. doi: 10.5603/EP.2017.0002.


Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development.

Seo S, Chen L, Liu W, Zhao D, Schultz KM, Sasman A, Liu T, Zhang HF, Gage PJ, Kume T.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1368-1377. doi: 10.1167/iovs.16-21217.


Effect of dexmedetomidine on acute lung injury in experimental ischemia-reperfusion model.

Küçükebe ÖB, Özzeybek D, Abdullayev R, Ustaoğlu A, Tekmen I, Küme T.

Braz J Anesthesiol. 2017 Mar - Apr;67(2):139-146. doi: 10.1016/j.bjane.2015.08.002. Epub 2016 Mar 21.


Foxc1 and Foxc2 are necessary to maintain glomerular podocytes.

Motojima M, Kume T, Matsusaka T.

Exp Cell Res. 2017 Mar 15;352(2):265-272. doi: 10.1016/j.yexcr.2017.02.016. Epub 2017 Feb 20.


Evaluation and comparison of Abbott Jaffe and enzymatic creatinine methods: Could the old method meet the new requirements?

Küme T, Sağlam B, Ergon C, Sisman AR.

J Clin Lab Anal. 2018 Jan;32(1). doi: 10.1002/jcla.22168. Epub 2017 Feb 15.


Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons.

Izumi Y, Wakita S, Kanbara C, Nakai T, Akaike A, Kume T.

Sci Rep. 2017 Feb 8;7:42111. doi: 10.1038/srep42111.


Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model.

Masaki Y, Izumi Y, Matsumura A, Akaike A, Kume T.

Eur J Pharmacol. 2017 Mar 5;798:26-34. doi: 10.1016/j.ejphar.2017.02.005. Epub 2017 Feb 4.


Acute Coronary Syndrome Demonstrating Plaque Rupture in Calcified Lesions Visualized by Optical Frequency Domain Imaging.

Goryo Y, Kume T, Kobayashi Y, Okamoto H, Kawamura A, Fukuhara K, Koyama T, Yamada R, Imai K, Neishi Y, Uemura S.

Int Heart J. 2017 Feb 7;58(1):131-133. doi: 10.1536/ihj.16-136. Epub 2017 Jan 11.


The Relationship between Serum Zonulin Level and Clinical and Laboratory Parameters of Childhood Obesity.

Küme T, Acar S, Tuhan H, Çatlı G, Anık A, Gürsoy Çalan Ö, Böber E, Abacı A.

J Clin Res Pediatr Endocrinol. 2017 Mar 1;9(1):31-38. doi: 10.4274/jcrpe.3682. Epub 2016 Dec 23.


Effects of a sweetpotato protein digest on lipid metabolism in mice administered a high-fat diet.

Ishiguro K, Kurata R, Shimada Y, Sameshima Y, Kume T.

Heliyon. 2016 Dec 7;2(12):e00201. eCollection 2016 Dec.


Electron Filtering by an Intervening ZnS Thin Film in the Gold Nanoparticle-Loaded CdS Plasmonic Photocatalyst.

Takayama K, Fujiwara K, Kume T, Naya SI, Tada H.

J Phys Chem Lett. 2017 Jan 5;8(1):86-90. doi: 10.1021/acs.jpclett.6b02642. Epub 2016 Dec 13.


Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women.

Ozay AC, Emekci Ozay O, Okyay RE, Cagliyan E, Kume T, Gulekli B.

Int J Endocrinol. 2016;2016:3206872. Epub 2016 Nov 2.


Optical Coherence Tomography Findings in Early Stent Thrombosis by Heparin-Induced Thrombocytopenia.

Okamoto H, Kume T, Fukuhara K, Kobayashi Y, Kawamura A, Goryo Y, Koyama T, Tamada T, Yamada R, Imai K, Neishi Y, Uemura S.

Int Heart J. 2016 Dec 2;57(6):763-765. Epub 2016 Nov 4.


Impact of branching angle on neointimal coverage of drug-eluting stents implanted in bifurcation lesions.

Watanabe M, Uemura S, Kita Y, Sugawara Y, Goryo Y, Ueda T, Soeda T, Okayama S, Okura H, Kume T, Saito Y.

Coron Artery Dis. 2016 Dec;27(8):682-689.


In vivo assessment of vasa vasorum neovascularization using intravascular ultrasound: A comparison between acute coronary syndrome and stable angina pectoris.

Kume T, Okura H, Yamada R, Koyama T, Fukuhara K, Goryo Y, Kamata Y, Okamoto H, Tamada T, Imai K, Neishi Y, Uemura S.

J Cardiol. 2017 Apr;69(4):601-605. doi: 10.1016/j.jjcc.2016.09.013. Epub 2016 Oct 25.


Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

Takahashi T, Ohtsuka T, Uno Y, Utoh M, Yamazaki H, Kume T.

Biopharm Drug Dispos. 2016 Nov;37(8):479-490. doi: 10.1002/bdd.2039. Epub 2016 Oct 14.


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