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Items: 39


Discovery of CDK5 Inhibitors through Structure-Guided Approach.

Khair NZ, Lenjisa JL, Tadesse S, Kumarasiri M, Basnet SKC, Mekonnen LB, Li M, Diab S, Sykes MJ, Albrecht H, Milne R, Wang S.

ACS Med Chem Lett. 2019 Mar 20;10(5):786-791. doi: 10.1021/acsmedchemlett.9b00029. eCollection 2019 May 9.


Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.

Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S.

Sci Rep. 2018 Mar 7;8(1):4110. doi: 10.1038/s41598-018-22527-y.


Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

Philip S, Kumarasiri M, Teo T, Yu M, Wang S.

J Med Chem. 2018 Jun 28;61(12):5073-5092. doi: 10.1021/acs.jmedchem.7b00901. Epub 2018 Jan 9. Review.


CDK5 in oncology: recent advances and future prospects.

Lenjisa JL, Tadesse S, Khair NZ, Kumarasiri M, Yu M, Albrecht H, Milne R, Wang S.

Future Med Chem. 2017 Oct;9(16):1939-1962. doi: 10.4155/fmc-2017-0097. Epub 2017 Oct 27. Review.


Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents.

Tadesse S, Bantie L, Tomusange K, Yu M, Islam S, Bykovska N, Noll B, Zhu G, Li P, Lam F, Kumarasiri M, Milne R, Wang S.

Br J Pharmacol. 2018 Jun;175(12):2399-2413. doi: 10.1111/bph.13974. Epub 2018 May 8.


In Search of Novel CDK8 Inhibitors by Virtual Screening.

Kumarasiri M, Teo T, Yu M, Philip S, Basnet SK, Albrecht H, Sykes MJ, Wang P, Wang S.

J Chem Inf Model. 2017 Mar 27;57(3):413-416. doi: 10.1021/acs.jcim.6b00711. Epub 2017 Feb 16.


Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents.

Long Y, Yu M, Li P, Islam S, Goh AW, Kumarasiri M, Wang S.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5674-5678. doi: 10.1016/j.bmcl.2016.10.062. Epub 2016 Oct 24.


Targeting CDK9: a promising therapeutic opportunity in prostate cancer.

Rahaman MH, Kumarasiri M, Mekonnen LB, Yu M, Diab S, Albrecht H, Milne RW, Wang S.

Endocr Relat Cancer. 2016 Dec;23(12):T211-T226. Epub 2016 Aug 31. Review.


Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.

Leemans E, Mahasenan KV, Kumarasiri M, Spink E, Ding D, O'Daniel PI, Boudreau MA, Lastochkin E, Testero SA, Yamaguchi T, Lee M, Hesek D, Fisher JF, Chang M, Mobashery S.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):1011-1015. doi: 10.1016/j.bmcl.2015.12.041. Epub 2015 Dec 12.


An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis.

Teo T, Yang Y, Yu M, Basnet SK, Gillam T, Hou J, Schmid RM, Kumarasiri M, Diab S, Albrecht H, Sykes MJ, Wang S.

Eur J Med Chem. 2015 Oct 20;103:539-50. doi: 10.1016/j.ejmech.2015.09.008. Epub 2015 Sep 9.


Targeting CDK6 in cancer: State of the art and new insights.

Tadesse S, Yu M, Kumarasiri M, Le BT, Wang S.

Cell Cycle. 2015;14(20):3220-30. doi: 10.1080/15384101.2015.1084445. Review.


Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium.

Wang H, Lee M, Peng Z, Blázquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S.

J Med Chem. 2015 May 28;58(10):4194-203. doi: 10.1021/jm501831g. Epub 2015 May 12.


Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation.

Yu M, Li P, Basnet SK, Kumarasiri M, Diab S, Teo T, Albrecht H, Wang S.

Eur J Med Chem. 2015 May 5;95:116-26. doi: 10.1016/j.ejmech.2015.03.032. Epub 2015 Mar 17.


Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery.

Kumarasiri M, Teo T, Wang S.

Future Med Chem. 2015;7(2):91-102. doi: 10.4155/fmc.14.153.


Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2015 Feb 11;137(5):1738-41. doi: 10.1021/jacs.5b00056. Epub 2015 Feb 2.


Targeting Pim kinases for cancer treatment: opportunities and challenges.

Le BT, Kumarasiri M, Adams JR, Yu M, Milne R, Sykes MJ, Wang S.

Future Med Chem. 2015;7(1):35-53. doi: 10.4155/fmc.14.145. Review.


Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.

Diab S, Teo T, Kumarasiri M, Li P, Yu M, Lam F, Basnet SK, Sykes MJ, Albrecht H, Milne R, Wang S.

ChemMedChem. 2014 May;9(5):962-72. doi: 10.1002/cmdc.201300552. Epub 2014 Feb 12.


MAP kinase-interacting kinases--emerging targets against cancer.

Diab S, Kumarasiri M, Yu M, Teo T, Proud C, Milne R, Wang S.

Chem Biol. 2014 Apr 24;21(4):441-452. doi: 10.1016/j.chembiol.2014.01.011. Epub 2014 Mar 6. Review.


Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

O'Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull LI, Song W, Lastochkin E, Kumarasiri M, Antunes NT, Espahbodi M, Lichtenwalter K, Suckow MA, Vakulenko S, Mobashery S, Chang M.

J Am Chem Soc. 2014 Mar 5;136(9):3664-72. doi: 10.1021/ja500053x. Epub 2014 Feb 21.


Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).

Fu HL, Valiathan RR, Payne L, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Fridman R.

J Biol Chem. 2014 Mar 28;289(13):9275-87. doi: 10.1074/jbc.M113.541102. Epub 2014 Feb 7.


Protonation states of active-site lysines of penicillin-binding protein 6 from Escherichia coli and the mechanistic implications.

Kumarasiri M, Zhang W, Shi Q, Fisher JF, Mobashery S.

Proteins. 2014 Jul;82(7):1348-58. doi: 10.1002/prot.24501. Epub 2014 Feb 6.


How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.

Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16808-13. doi: 10.1073/pnas.1300118110. Epub 2013 Oct 1.


Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii.

Smith CA, Antunes NT, Stewart NK, Toth M, Kumarasiri M, Chang M, Mobashery S, Vakulenko SB.

Chem Biol. 2013 Sep 19;20(9):1107-15. doi: 10.1016/j.chembiol.2013.07.015. Epub 2013 Sep 5.


Structural analysis of the role of Pseudomonas aeruginosa penicillin-binding protein 5 in β-lactam resistance.

Smith JD, Kumarasiri M, Zhang W, Hesek D, Lee M, Toth M, Vakulenko S, Fisher JF, Mobashery S, Chen Y.

Antimicrob Agents Chemother. 2013 Jul;57(7):3137-46. doi: 10.1128/AAC.00505-13. Epub 2013 Apr 29.


Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases.

Fu HL, Sohail A, Valiathan RR, Wasinski BD, Kumarasiri M, Mahasenan KV, Bernardo MM, Tokmina-Roszyk D, Fields GB, Mobashery S, Fridman R.

J Biol Chem. 2013 Apr 26;288(17):12114-29. doi: 10.1074/jbc.M112.409599. Epub 2013 Mar 21.


Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.

Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R.

J Biol Chem. 2013 Mar 15;288(11):7430-7. doi: 10.1074/jbc.R112.444158. Epub 2013 Jan 18. Review.


Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases.

Smith CA, Frase H, Toth M, Kumarasiri M, Wiafe K, Munoz J, Mobashery S, Vakulenko SB.

J Am Chem Soc. 2012 Dec 5;134(48):19512-5. doi: 10.1021/ja308197j. Epub 2012 Nov 16.


Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.

Lee M, Ikejiri M, Klimpel D, Toth M, Espahbodi M, Hesek D, Forbes C, Kumarasiri M, Noll BC, Chang M, Mobashery S.

ACS Med Chem Lett. 2012 Jun 14;3(6):490-495. Epub 2012 May 2.


An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D β-lactamases.

Kumarasiri M, Llarrull LI, Borbulevych O, Fishovitz J, Lastochkin E, Baker BM, Mobashery S.

J Biol Chem. 2012 Mar 9;287(11):8232-41. doi: 10.1074/jbc.M111.333179. Epub 2012 Jan 18.


Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane.

Park JS, Lee WC, Yeo KJ, Ryu KS, Kumarasiri M, Hesek D, Lee M, Mobashery S, Song JH, Kim SI, Lee JC, Cheong C, Jeon YH, Kim HY.

FASEB J. 2012 Jan;26(1):219-28. doi: 10.1096/fj.11-188425. Epub 2011 Sep 30.


Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus.

Borbulevych O, Kumarasiri M, Wilson B, Llarrull LI, Lee M, Hesek D, Shi Q, Peng J, Baker BM, Mobashery S.

J Biol Chem. 2011 Sep 9;286(36):31466-72. doi: 10.1074/jbc.M111.252189. Epub 2011 Jul 20.


High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli.

Artola-Recolons C, Carrasco-López C, Llarrull LI, Kumarasiri M, Lastochkin E, Martínez de Ilarduya I, Meindl K, Usón I, Mobashery S, Hermoso JA.

Biochemistry. 2011 Apr 5;50(13):2384-6. doi: 10.1021/bi200085y. Epub 2011 Mar 8.


Computational approach for ranking mutant enzymes according to catalytic reaction rates.

Kumarasiri M, Baker GA, Soudackov AV, Hammes-Schiffer S.

J Phys Chem B. 2009 Mar 19;113(11):3579-83. doi: 10.1021/jp810363k.


Implementation of umbrella integration within the framework of the empirical valence bond approach.

Chakravorty DK, Kumarasiri M, Soudackov AV, Hammes-Schiffer S.

J Chem Theory Comput. 2008;4(11):1974-1980.


Anharmonic effects in ammonium nitrate and hydroxylammonium nitrate clusters.

Kumarasiri M, Swalina C, Hammes-Schiffer S.

J Phys Chem B. 2007 May 10;111(18):4653-8.


Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter.

Ballabh P, Hu F, Kumarasiri M, Braun A, Nedergaard M.

Pediatr Res. 2005 Oct;58(4):791-8.


Cell cycle dependence of thyroid hormone nuclear receptors in cultured GC cells: relationship to nuclear matrix.

Kumarasiri MH, Shapiro LE, Surks MI.

Endocrinology. 1988 May;122(5):1897-904.


Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis.

Wheatley VR, Hodgins LT, Coon WM, Kumarasiri M, Berenzweig H, Feinstein JM.

J Lipid Res. 1971 May;12(3):347-60.

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