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Items: 1 to 50 of 54

1.

Profound but transient changes in the inflammatory milieu of the blood during autologous hematopoietic stem cell transplantation.

Wiberg A, Olsson-Strömberg U, Herman S, Kultima K, Burman J.

Biol Blood Marrow Transplant. 2019 Sep 13. pii: S1083-8791(19)30596-8. doi: 10.1016/j.bbmt.2019.09.010. [Epub ahead of print]

PMID:
31525494
2.

CSF biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression.

Ericson H, Hamdeh SA, Freyhult E, Stiger F, Bäckryd E, Svenningsson A, Gordh T, Kultima K.

Pain. 2019 Aug 1. doi: 10.1097/j.pain.0000000000001649. [Epub ahead of print]

PMID:
31373951
3.

Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes.

Saul MJ, Hegewald AB, Emmerich AC, Ossipova E, Vogel M, Baumann I, Kultima K, Lengqivst J, Steinhilber D, Jakobsson PJ.

Front Pharmacol. 2019 Jun 5;10:640. doi: 10.3389/fphar.2019.00640. eCollection 2019.

4.

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.

Bergqvist F, Ossipova E, Idborg H, Raouf J, Checa A, Englund K, Englund P, Khoonsari PE, Kultima K, Wheelock CE, Larsson K, Korotkova M, Jakobsson PJ.

Front Pharmacol. 2019 Jun 7;10:636. doi: 10.3389/fphar.2019.00636. eCollection 2019.

5.

A sensitive method detecting trace levels of levonorgestrel using LC-HRMS.

Abujrais S, Olovsson M, Ahnoff M, Rasmusson AJ, Larsson A, Åkerfeldt T, Kultima K.

Contraception. 2019 Sep;100(3):247-249. doi: 10.1016/j.contraception.2019.06.001. Epub 2019 Jun 16.

PMID:
31216423
6.

Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.

Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas DB, Morado Urbina C, Nandakumar KS, Sandor K, Xu B, Abdelmoaty S, Hunt MA, Ängeby Möller K, Baharpoor A, Sinclair J, Jardemark K, Lanner JT, Khmaladze I, Borm LE, Zhang L, Wermeling F, Cragg MS, Lengqvist J, Chabot-Doré AJ, Diatchenko L, Belfer I, Collin M, Kultima K, Heyman B, Jimenez-Andrade JM, Codeluppi S, Holmdahl R, Svensson CI.

J Exp Med. 2019 Aug 5;216(8):1904-1924. doi: 10.1084/jem.20181657. Epub 2019 Jun 13.

PMID:
31196979
7.

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.

Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, Checa A, Sohrabian A, Pucholt P, Sandling JK, Fernandes-Cerqueira C, Rönnelid J, Oke V, Grosso G, Kvarnström M, Larsson A, Wheelock CE, Syvänen AC, Rönnblom L, Kultima K, Persson H, Gräslund S, Gunnarsson I, Nilsson P, Svenungsson E, Jakobsson PJ.

Front Immunol. 2019 May 17;10:1029. doi: 10.3389/fimmu.2019.01029. eCollection 2019.

8.

Measurement of sCD27 in the cerebrospinal fluid identifies patients with neuroinflammatory disease.

Feresiadou A, Nilsson K, Ingelsson M, Press R, Kmezic I, Nygren I, Svenningsson A, Niemelä V, Gordh T, Cunningham J, Kultima K, Larsson A, Burman J.

J Neuroimmunol. 2019 Jul 15;332:31-36. doi: 10.1016/j.jneuroim.2019.03.015. Epub 2019 Mar 25.

PMID:
30928869
9.

Alterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington's disease subjects.

Herman S, Niemelä V, Emami Khoonsari P, Sundblom J, Burman J, Landtblom AM, Spjuth O, Nyholm D, Kultima K.

Sci Rep. 2019 Mar 11;9(1):4129. doi: 10.1038/s41598-019-40186-5.

10.

Interoperable and scalable data analysis with microservices: Applications in Metabolomics.

Emami Khoonsari P, Moreno P, Bergmann S, Burman J, Capuccini M, Carone M, Cascante M, de Atauri P, Foguet C, Gonzalez-Beltran A, Hankemeier T, Haug K, He S, Herman S, Johnson D, Kale N, Larsson A, Neumann S, Peters K, Pireddu L, Rocca-Serra P, Roger P, Rueedi R, Ruttkies C, Sadawi N, Salek RM, Sansone SA, Schober D, Selivanov V, Thévenot EA, van Vliet M, Zanetti G, Steinbeck C, Kultima K, Spjuth O.

Bioinformatics. 2019 Mar 9. pii: btz160. doi: 10.1093/bioinformatics/btz160. [Epub ahead of print]

PMID:
30851093
11.

Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing⁻Remitting Multiple Sclerosis.

Herman S, Åkerfeldt T, Spjuth O, Burman J, Kultima K.

Cells. 2019 Jan 24;8(2). pii: E84. doi: 10.3390/cells8020084.

12.

Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers.

Khoonsari PE, Shevchenko G, Herman S, Remnestål J, Giedraitis V, Brundin R, Degerman Gunnarsson M, Kilander L, Zetterberg H, Nilsson P, Lannfelt L, Ingelsson M, Kultima K.

J Alzheimers Dis. 2019;67(2):639-651. doi: 10.3233/JAD-180855.

13.

PhenoMeNal: processing and analysis of metabolomics data in the cloud.

Peters K, Bradbury J, Bergmann S, Capuccini M, Cascante M, de Atauri P, Ebbels TMD, Foguet C, Glen R, Gonzalez-Beltran A, Günther UL, Handakas E, Hankemeier T, Haug K, Herman S, Holub P, Izzo M, Jacob D, Johnson D, Jourdan F, Kale N, Karaman I, Khalili B, Emami Khonsari P, Kultima K, Lampa S, Larsson A, Ludwig C, Moreno P, Neumann S, Novella JA, O'Donovan C, Pearce JTM, Peluso A, Piras ME, Pireddu L, Reed MAC, Rocca-Serra P, Roger P, Rosato A, Rueedi R, Ruttkies C, Sadawi N, Salek RM, Sansone SA, Selivanov V, Spjuth O, Schober D, Thévenot EA, Tomasoni M, van Rijswijk M, van Vliet M, Viant MR, Weber RJM, Zanetti G, Steinbeck C.

Gigascience. 2019 Feb 1;8(2). pii: giy149. doi: 10.1093/gigascience/giy149.

14.

Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis.

Herman S, Khoonsari PE, Tolf A, Steinmetz J, Zetterberg H, Åkerfeldt T, Jakobsson PJ, Larsson A, Spjuth O, Burman J, Kultima K.

Theranostics. 2018 Aug 7;8(16):4477-4490. doi: 10.7150/thno.26249. eCollection 2018.

15.

Container-based bioinformatics with Pachyderm.

Novella JA, Emami Khoonsari P, Herman S, Whitenack D, Capuccini M, Burman J, Kultima K, Spjuth O.

Bioinformatics. 2019 Mar 1;35(5):839-846. doi: 10.1093/bioinformatics/bty699.

16.

The human CSF pain proteome.

Khoonsari PE, Ossipova E, Lengqvist J, Svensson CI, Kosek E, Kadetoff D, Jakobsson PJ, Kultima K, Lampa J.

J Proteomics. 2019 Jan 6;190:67-76. doi: 10.1016/j.jprot.2018.05.012. Epub 2018 May 28.

PMID:
29852297
17.

Spinal injection of newly identified cerebellin-1 and cerebellin-2 peptides induce mechanical hypersensitivity in mice.

Sandor K, Krishnan S, Agalave NM, Krock E, Salcido JV, Fernandez-Zafra T, Khoonsari PE, Svensson CI, Kultima K.

Neuropeptides. 2018 Jun;69:53-59. doi: 10.1016/j.npep.2018.04.004. Epub 2018 Apr 14.

PMID:
29705514
18.

Systematic analysis of the cerebrospinal fluid proteome of fibromyalgia patients.

Khoonsari PE, Musunri S, Herman S, Svensson CI, Tanum L, Gordh T, Kultima K.

J Proteomics. 2019 Jan 6;190:35-43. doi: 10.1016/j.jprot.2018.04.014. Epub 2018 Apr 12.

PMID:
29656018
19.

Corrigendum to "Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways" [Free Rad. Biol. Med. (2017) 421-431].

Almandoz-Gil L, Welander H, Ihse E, Khoonsari PE, Musunuri S, Lendel C, Sigvardson J, Karlsson M, Ingelsson M, Kultima K, Bergström J.

Free Radic Biol Med. 2018 Mar;117:258. doi: 10.1016/j.freeradbiomed.2018.02.007. Epub 2018 Feb 16. No abstract available.

20.

The future of metabolomics in ELIXIR.

van Rijswijk M, Beirnaert C, Caron C, Cascante M, Dominguez V, Dunn WB, Ebbels TMD, Giacomoni F, Gonzalez-Beltran A, Hankemeier T, Haug K, Izquierdo-Garcia JL, Jimenez RC, Jourdan F, Kale N, Klapa MI, Kohlbacher O, Koort K, Kultima K, Le Corguillé G, Moreno P, Moschonas NK, Neumann S, O'Donovan C, Reczko M, Rocca-Serra P, Rosato A, Salek RM, Sansone SA, Satagopam V, Schober D, Shimmo R, Spicer RA, Spjuth O, Thévenot EA, Viant MR, Weber RJM, Willighagen EL, Zanetti G, Steinbeck C.

Version 2. F1000Res. 2017 Sep 6 [revised 2017 Jan 1];6. pii: ELIXIR-1649. doi: 10.12688/f1000research.12342.2. eCollection 2017.

21.

Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-β Protofibril Exposure of Neuroglial Co-Cultures.

Nikitidou E, Khoonsari PE, Shevchenko G, Ingelsson M, Kultima K, Erlandsson A.

J Alzheimers Dis. 2017;60(1):305-321. doi: 10.3233/JAD-170278.

22.

Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways.

Almandoz-Gil L, Welander H, Ihse E, Khoonsari PE, Musunuri S, Lendel C, Sigvardson J, Karlsson M, Ingelsson M, Kultima K, Bergström J.

Free Radic Biol Med. 2017 Sep;110:421-431. doi: 10.1016/j.freeradbiomed.2017.07.004. Epub 2017 Jul 6. Erratum in: Free Radic Biol Med. 2018 Feb 15;:.

23.

Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions.

Herman S, Emami Khoonsari P, Aftab O, Krishnan S, Strömbom E, Larsson R, Hammerling U, Spjuth O, Kultima K, Gustafsson M.

Metabolomics. 2017;13(7):79. doi: 10.1007/s11306-017-1213-z. Epub 2017 May 19.

24.

Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids.

Senkowski W, Jarvius M, Rubin J, Lengqvist J, Gustafsson MG, Nygren P, Kultima K, Larsson R, Fryknäs M.

Cell Chem Biol. 2016 Nov 17;23(11):1428-1438. doi: 10.1016/j.chembiol.2016.09.013. Epub 2016 Oct 27.

25.

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.

Remnestål J, Just D, Mitsios N, Fredolini C, Mulder J, Schwenk JM, Uhlén M, Kultima K, Ingelsson M, Kilander L, Lannfelt L, Svenningsson P, Nellgård B, Zetterberg H, Blennow K, Nilsson P, Häggmark-Månberg A.

Proteomics Clin Appl. 2016 Dec;10(12):1242-1253. doi: 10.1002/prca.201500150. Epub 2016 Oct 10.

26.

Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.

Musunuri S, Khoonsari PE, Mikus M, Wetterhall M, Häggmark-Mänberg A, Lannfelt L, Erlandsson A, Bergquist J, Ingelsson M, Shevchenko G, Nilsson P, Kultima K.

J Alzheimers Dis. 2016 Oct 18;54(4):1671-1686.

PMID:
27636840
27.

Spinal Cord Stimulation Alters Protein Levels in the Cerebrospinal Fluid of Neuropathic Pain Patients: A Proteomic Mass Spectrometric Analysis.

Lind AL, Emami Khoonsari P, Sjödin M, Katila L, Wetterhall M, Gordh T, Kultima K.

Neuromodulation. 2016 Aug;19(6):549-62. doi: 10.1111/ner.12473.

PMID:
27513633
28.

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.

Khoonsari PE, Häggmark A, Lönnberg M, Mikus M, Kilander L, Lannfelt L, Bergquist J, Ingelsson M, Nilsson P, Kultima K, Shevchenko G.

PLoS One. 2016 Mar 7;11(3):e0150672. doi: 10.1371/journal.pone.0150672. eCollection 2016.

29.

Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study.

Adori C, Barde S, Vas S, Ebner K, Su J, Svensson C, Mathé AA, Singewald N, Reinscheid RR, Uhlén M, Kultima K, Bagdy G, Hökfelt T.

Brain Struct Funct. 2016 Sep;221(7):3521-46. doi: 10.1007/s00429-015-1117-5. Epub 2015 Oct 13.

PMID:
26462664
30.

Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome.

Musunuri S, Kultima K, Richard BC, Ingelsson M, Lannfelt L, Bergquist J, Shevchenko G.

Anal Bioanal Chem. 2015 Feb;407(4):1041-57. doi: 10.1007/s00216-014-8320-8. Epub 2014 Nov 22.

PMID:
25416231
31.

Identification and quantification of neuropeptides in naïve mouse spinal cord using mass spectrometry reveals [des-Ser1]-cerebellin as a novel modulator of nociception.

Su J, Sandor K, Sköld K, Hökfelt T, Svensson CI, Kultima K.

J Neurochem. 2014 Jul;130(2):199-214. doi: 10.1111/jnc.12730. Epub 2014 May 7.

32.

Quantification of the brain proteome in Alzheimer's disease using multiplexed mass spectrometry.

Musunuri S, Wetterhall M, Ingelsson M, Lannfelt L, Artemenko K, Bergquist J, Kultima K, Shevchenko G.

J Proteome Res. 2014 Apr 4;13(4):2056-68. doi: 10.1021/pr401202d. Epub 2014 Mar 19.

PMID:
24606058
33.

Comparative study of label and label-free techniques using shotgun proteomics for relative protein quantification.

Sjödin MO, Wetterhall M, Kultima K, Artemenko K.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jun 1;928:83-92. doi: 10.1016/j.jchromb.2013.03.027. Epub 2013 Mar 31.

PMID:
23608324
34.

Neurotoxin-induced neuropeptide perturbations in striatum of neonatal rats.

Karlsson O, Kultima K, Wadensten H, Nilsson A, Roman E, Andrén PE, Brittebo EB.

J Proteome Res. 2013 Apr 5;12(4):1678-90. doi: 10.1021/pr3010265. Epub 2013 Mar 5.

PMID:
23410195
35.

Longitudinal characterization of the brain proteomes for the tg2576 amyloid mouse model using shotgun based mass spectrometry.

Shevchenko G, Wetterhall M, Bergquist J, Höglund K, Andersson LI, Kultima K.

J Proteome Res. 2012 Dec 7;11(12):6159-74. doi: 10.1021/pr300808h. Epub 2012 Oct 30.

PMID:
23050487
36.

Biomarkers of disease and post-mortem changes - Heat stabilization, a necessary tool for measurement of protein regulation.

Kultima K, Sköld K, Borén M.

J Proteomics. 2011 Dec 10;75(1):145-59. doi: 10.1016/j.jprot.2011.06.009. Epub 2011 Jun 17. Review.

PMID:
21708298
37.

Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity.

Kultima K, Jergil M, Salter H, Gustafson AL, Dencker L, Stigson M.

Reprod Toxicol. 2010 Nov;30(3):457-68. doi: 10.1016/j.reprotox.2010.05.014. Epub 2010 May 28.

PMID:
20546886
38.

Neuropeptidomic analysis of the embryonic Japanese quail diencephalon.

Scholz B, Alm H, Mattsson A, Nilsson A, Kultima K, Savitski MM, Fälth M, Sköld K, Brunström B, Andren PE, Dencker L.

BMC Dev Biol. 2010 Mar 18;10:30. doi: 10.1186/1471-213X-10-30.

39.

Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.

Nilsson MF, Danielsson C, Sköld AC, Johansson A, Blomgren B, Wilson J, Khan KM, Bengtsson E, Kultima K, Webster WS, Danielsson BR.

Reprod Toxicol. 2010 Apr;29(2):156-63. doi: 10.1016/j.reprotox.2010.01.014. Epub 2010 Feb 6.

PMID:
20144703
40.

Impact of temperature dependent sampling procedures in proteomics and peptidomics--a characterization of the liver and pancreas post mortem degradome.

Scholz B, Sköld K, Kultima K, Fernandez C, Waldemarson S, Savitski MM, Söderquist M, Borén M, Stella R, Andrén P, Zubarev R, James P.

Mol Cell Proteomics. 2011 Mar;10(3):M900229MCP200. doi: 10.1074/mcp.M900229-MCP200. Epub 2010 Jan 28.

41.

In vitro neurotoxicity of PBDE-99: immediate and concentration-dependent effects on protein expression in cerebral cortex cells.

Alm H, Scholz B, Kultima K, Nilsson A, Andrén PE, Savitski MM, Bergman A, Stigson M, Fex-Svenningsen A, Dencker L.

J Proteome Res. 2010 Mar 5;9(3):1226-35. doi: 10.1021/pr900723c.

PMID:
19954255
42.

Development and evaluation of normalization methods for label-free relative quantification of endogenous peptides.

Kultima K, Nilsson A, Scholz B, Rossbach UL, Fälth M, Andrén PE.

Mol Cell Proteomics. 2009 Oct;8(10):2285-95. doi: 10.1074/mcp.M800514-MCP200. Epub 2009 Jul 12.

43.

A quantitative peptidomic analysis of peptides related to the endogenous opioid and tachykinin systems in nucleus accumbens of rats following naloxone-precipitated morphine withdrawal.

Rossbach U, Nilsson A, Fälth M, Kultima K, Zhou Q, Hallberg M, Gordh T, Andren PE, Nyberg F.

J Proteome Res. 2009 Feb;8(2):1091-8. doi: 10.1021/pr800669g.

PMID:
19159213
44.

Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects.

Jergil M, Kultima K, Gustafson AL, Dencker L, Stigson M.

Toxicol Sci. 2009 Mar;108(1):132-48. doi: 10.1093/toxsci/kfp002. Epub 2009 Jan 8.

PMID:
19136453
45.

Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease.

Nilsson A, Fälth M, Zhang X, Kultima K, Sköld K, Svenningsson P, Andrén PE.

Mol Cell Proteomics. 2009 May;8(5):1094-104. doi: 10.1074/mcp.M800454-MCP200. Epub 2009 Jan 8.

46.

Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex.

Alm H, Kultima K, Scholz B, Nilsson A, Andrén PE, Fex-Svenningsen A, Dencker L, Stigson M.

Neurotoxicology. 2008 Jul;29(4):628-37. doi: 10.1016/j.neuro.2008.04.021. Epub 2008 May 8.

PMID:
18550172
47.

Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure.

Scholz B, Svensson M, Alm H, Sköld K, Fälth M, Kultima K, Guigoni C, Doudnikoff E, Li Q, Crossman AR, Bezard E, Andrén PE.

PLoS One. 2008 Feb 13;3(2):e1589. doi: 10.1371/journal.pone.0001589.

48.

Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes.

Ellegren H, Hultin-Rosenberg L, Brunström B, Dencker L, Kultima K, Scholz B.

BMC Biol. 2007 Sep 20;5:40.

49.

Molecular targets and early response biomarkers for the prediction of developmental toxicity in vitro.

Stigson M, Kultima K, Jergil M, Scholz B, Alm H, Gustafson AL, Dencker L.

Altern Lab Anim. 2007 Jun;35(3):335-42.

PMID:
17650952
50.

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