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Items: 1 to 50 of 213

1.

Plasma membrane cholesterol regulates the allosteric binding of 1-methyl-4-phenylpyridinium (MPP+) to organic cation transporter 2 (OCT2, SLC22A2).

Hoermann S, Gai Z, Kullak-Ublick GA, Visentin M.

J Pharmacol Exp Ther. 2019 Oct 17. pii: jpet.119.260877. doi: 10.1124/jpet.119.260877. [Epub ahead of print]

2.

Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.

Liberale L, Gaul DS, Akhmedov A, Bonetti NR, Nageswaran V, Costantino S, Pahla J, Weber J, Fehr V, Vdovenko D, Semerano A, Giacalone G, Kullak-Ublick GA, Sessa M, Eriksson U, Paneni F, Ruschitzka F, Montecucco F, Beer JH, Lüscher TF, Matter CM, Camici GG.

Eur Heart J. 2019 Oct 11. pii: ehz712. doi: 10.1093/eurheartj/ehz712. [Epub ahead of print]

PMID:
31603194
3.

Renal glycosuria as a novel early sign of colistin-induced kidney damage in mice.

Samodelov SL, Visentin M, Gai Z, Häusler S, Kullak-Ublick GA.

Antimicrob Agents Chemother. 2019 Oct 7. pii: AAC.01650-19. doi: 10.1128/AAC.01650-19. [Epub ahead of print]

4.

Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots.

Samodelov SL, Gai Z, Kullak-Ublick GA, Visentin M.

Nutrients. 2019 Oct 2;11(10). pii: E2353. doi: 10.3390/nu11102353. Review.

5.

Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling: A DNA methylation analysis of miRNA genes.

Boström AE, Chatzittofis A, Ciuculete DM, Flanagan JN, Krattinger R, Bandstein M, Mwinyi J, Kullak-Ublick GA, Öberg KG, Arver S, Schiöth HB, Jokinen J.

Epigenetics. 2019 Sep 22:1-16. doi: 10.1080/15592294.2019.1656157. [Epub ahead of print]

PMID:
31542994
6.

Drug-induced liver injury.

Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP.

Nat Rev Dis Primers. 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. Review.

PMID:
31439850
7.

microRNA-206 modulates the hepatic expression of the organic anion-transporting polypeptide 1B1.

El Saadany T, van Rosmalen B, Gai Z, Hiller C, Verheij J, Stieger B, van Gulik T, Visentin M, Kullak-Ublick GA.

Liver Int. 2019 Aug 13. doi: 10.1111/liv.14212. [Epub ahead of print]

PMID:
31408569
8.

Pharmacovigilance in ophthalmology in Switzerland: an analysis of the most frequently reported ocular adverse drug reactions within the last 25 years.

Karrer JE, Giovannoni L, Kullak-Ublick GA, Weiler S.

Swiss Med Wkly. 2019 Jun 30;149:w20085. doi: 10.4414/smw.2019.20085. eCollection 2019 Jun 17.

9.

Drugs and hepatic transporters: A review.

Jetter A, Kullak-Ublick GA.

Pharmacol Res. 2019 Apr 17:104234. doi: 10.1016/j.phrs.2019.04.018. [Epub ahead of print] Review.

PMID:
31004787
10.

Lipid Accumulation and Chronic Kidney Disease.

Gai Z, Wang T, Visentin M, Kullak-Ublick GA, Fu X, Wang Z.

Nutrients. 2019 Mar 28;11(4). pii: E722. doi: 10.3390/nu11040722. Review.

11.

Kounis syndrome: A retrospective analysis of individual case safety reports from the international WHO database in pharmacovigilance
.

Orion K, Mack J, Kullak-Ublick GA, Weiler S.

Int J Clin Pharmacol Ther. 2019 May;57(5):240-248. doi: 10.5414/CP203344.

PMID:
30900982
12.

Molecular Mechanisms of Colistin-Induced Nephrotoxicity.

Gai Z, Samodelov SL, Kullak-Ublick GA, Visentin M.

Molecules. 2019 Feb 12;24(3). pii: E653. doi: 10.3390/molecules24030653. Review.

13.

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.

Tcymbarevich IV, Eloranta JJ, Rossel JB, Obialo N, Spalinger M, Cosin-Roger J, Lang S, Kullak-Ublick GA, Wagner CA, Scharl M, Seuwen K, Ruiz PA, Rogler G, de Vallière C, Misselwitz B; Swiss IBD Cohort Study Group.

BMC Gastroenterol. 2019 Jan 7;19(1):2. doi: 10.1186/s12876-018-0922-8.

14.

Do clinical and laboratory parameters predict thiopurine metabolism and clinical outcome in patients with inflammatory bowel diseases?

Frick S, Müller D, Kullak-Ublick GA, Jetter A.

Eur J Clin Pharmacol. 2019 Mar;75(3):335-342. doi: 10.1007/s00228-018-02616-7. Epub 2019 Jan 4.

PMID:
30610277
15.

Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase.

Essers D, Schäublin M, Kullak-Ublick GA, Weiler S.

Eur J Clin Pharmacol. 2019 Mar;75(3):409-416. doi: 10.1007/s00228-018-2589-z. Epub 2018 Nov 15.

PMID:
30430215
16.

Safety differentiation: emerging competitive edge in drug development.

Uteng M, Urban L, Brees D, Muller PY, Kullak-Ublick GA, Bouchard P, Tougas G, Chibout SD.

Drug Discov Today. 2019 Jan;24(1):285-292. doi: 10.1016/j.drudis.2018.09.009. Epub 2018 Sep 19. Review.

PMID:
30244081
17.

Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury.

Akhmedov A, Bonetti NR, Reiner MF, Spescha RD, Amstalden H, Merlini M, Gaul DS, Diaz-Cañestro C, Briand-Schumacher S, Spescha RS, Semerano A, Giacalone G, Savarese G, Montecucco F, Kulic L, Nitsch RM, Matter CM, Kullak-Ublick GA, Sessa M, Lüscher TF, Beer JH, Liberale L, Camici GG.

J Cereb Blood Flow Metab. 2019 Nov;39(11):2233-2245. doi: 10.1177/0271678X18793266. Epub 2018 Aug 3. Erratum in: J Cereb Blood Flow Metab. 2019 Nov;39(11):NP1.

PMID:
30073881
18.

Corrigendum to 'Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury' [Int. J. Cardiol. 260 (2018) 148-155].

Diaz-Cañestro C, Merlini M, Bonetti NR, Liberale L, Wüst P, Briand-Schumacher S, Klohs J, Costantino S, Miranda M, Schoedon-Geiser G, Kullak-Ublick GA, Akhmedov A, Paneni F, Beer JH, Lüscher TF, Camici GG.

Int J Cardiol. 2018 Nov 15;271:405. doi: 10.1016/j.ijcard.2018.07.004. Epub 2018 Jul 13. No abstract available.

PMID:
30007483
19.

Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors.

Visentin M, Torozi A, Gai Z, Häusler S, Li C, Hiller C, Schraml PH, Moch H, Kullak-Ublick GA.

Drug Metab Dispos. 2018 Aug;46(8):1129-1136. doi: 10.1124/dmd.118.081091. Epub 2018 May 24.

PMID:
29794161
20.

Analysis of Drug-Drug Interactions in Swiss Claims Data Using Tizanidine and Ciprofloxacin as a Prototypical Contraindicated Combination.

Jödicke AM, Curkovic I, Zellweger U, Tomka IT, Neuer T, Kullak-Ublick GA, Roos M, Egbring M.

Ann Pharmacother. 2018 Oct;52(10):983-991. doi: 10.1177/1060028018775914. Epub 2018 May 11.

21.

Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation.

Gai Z, Visentin M, Gui T, Zhao L, Thasler WE, Häusler S, Hartling I, Cremonesi A, Hiller C, Kullak-Ublick GA.

Mol Pharmacol. 2018 Aug;94(2):802-811. doi: 10.1124/mol.117.111047. Epub 2018 May 9.

PMID:
29743187
22.

Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury.

Diaz-Cañestro C, Merlini M, Bonetti NR, Liberale L, Wüst P, Briand-Schumacher S, Klohs J, Costantino S, Miranda M, Schoedon-Geiser G, Kullak-Ublick GA, Akhmedov A, Paneni F, Beer JH, Lüscher TF, Camici GG.

Int J Cardiol. 2018 Jun 1;260:148-155. doi: 10.1016/j.ijcard.2017.12.060. Erratum in: Int J Cardiol. 2018 Nov 15;271:405.

PMID:
29622432
23.

Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation.

Schadt HS, Wolf A, Mahl JA, Wuersch K, Couttet P, Schwald M, Fischer A, Lienard M, Emotte C, Teng CH, Skuba E, Richardson TA, Manenti L, Weiss A, Graus Porta D, Fairhurst RA, Kullak-Ublick GA, Chibout SD, Pognan F, Kluwe W, Kinyamu-Akunda J.

Toxicol Sci. 2018 May 1;163(1):265-278. doi: 10.1093/toxsci/kfy031.

PMID:
29432567
24.

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort.

Church RJ, Kullak-Ublick GA, Aubrecht J, Bonkovsky HL, Chalasani N, Fontana RJ, Goepfert JC, Hackman F, King NMP, Kirby S, Kirby P, Marcinak J, Ormarsdottir S, Schomaker SJ, Schuppe-Koistinen I, Wolenski F, Arber N, Merz M, Sauer JM, Andrade RJ, van Bömmel F, Poynard T, Watkins PB.

Hepatology. 2019 Feb;69(2):760-773. doi: 10.1002/hep.29802. Epub 2018 Jun 27.

PMID:
29357190
25.

Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5).

Visentin M, Gai Z, Torozi A, Hiller C, Kullak-Ublick GA.

Drug Metab Dispos. 2017 Dec;45(12):1240-1244. doi: 10.1124/dmd.117.077248. Epub 2017 Oct 6.

PMID:
28986476
26.

Drug-induced bile duct injury.

Visentin M, Lenggenhager D, Gai Z, Kullak-Ublick GA.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1498-1506. doi: 10.1016/j.bbadis.2017.08.033. Epub 2017 Sep 4. Review.

27.

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage.

Gai Z, Chu L, Xu Z, Song X, Sun D, Kullak-Ublick GA.

Sci Rep. 2017 Aug 29;7(1):9815. doi: 10.1038/s41598-017-10168-6.

28.

TNF-α Deficiency Prevents Renal Inflammation and Oxidative Stress in Obese Mice.

Wang H, Li J, Gai Z, Kullak-Ublick GA, Liu Z.

Kidney Blood Press Res. 2017;42(3):416-427. doi: 10.1159/000478869. Epub 2017 Jul 7.

29.

Severe injection site reactions after subcutaneous administration of Sayana©.

Jödicke AM, Dahmke H, Damke B, Schäublin M, Kullak-Ublick GA, Weiler S.

Swiss Med Wkly. 2017 May 10;147:w14432. doi: 10.4414/smw.2017.14432. eCollection 2017.

30.

A MIR4646 associated methylation locus is hypomethylated in adolescent depression.

Boström AE, Ciuculete DM, Attwood M, Krattinger R, Nikontovic L, Titova OE, Kullak-Ublick GA, Mwinyi J, Schiöth HB.

J Affect Disord. 2017 Oct 1;220:117-128. doi: 10.1016/j.jad.2017.05.017. Epub 2017 May 17.

31.

Drug-induced liver injury: recent advances in diagnosis and risk assessment.

Kullak-Ublick GA, Andrade RJ, Merz M, End P, Benesic A, Gerbes AL, Aithal GP.

Gut. 2017 Jun;66(6):1154-1164. doi: 10.1136/gutjnl-2016-313369. Epub 2017 Mar 23. Review.

32.

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68).

de Vallière C, Cosin-Roger J, Simmen S, Atrott K, Melhem H, Zeitz J, Madanchi M, Tcymbarevich I, Fried M, Kullak-Ublick GA, Vavricka SR, Misselwitz B, Seuwen K, Wagner CA, Eloranta JJ, Rogler G, Ruiz PA.

Cell Mol Gastroenterol Hepatol. 2016 Jun 25;2(6):796-810. doi: 10.1016/j.jcmgh.2016.06.003. eCollection 2016 Nov.

33.

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

Nicoletti P, Aithal GP, Bjornsson ES, Andrade RJ, Sawle A, Arrese M, Barnhart HX, Bondon-Guitton E, Hayashi PH, Bessone F, Carvajal A, Cascorbi I, Cirulli ET, Chalasani N, Conforti A, Coulthard SA, Daly MJ, Day CP, Dillon JF, Fontana RJ, Grove JI, Hallberg P, Hernández N, Ibáñez L, Kullak-Ublick GA, Laitinen T, Larrey D, Lucena MI, Maitland-van der Zee AH, Martin JH, Molokhia M, Pirmohamed M, Powell EE, Qin S, Serrano J, Stephens C, Stolz A, Wadelius M, Watkins PB, Floratos A, Shen Y, Nelson MR, Urban TJ, Daly AK; International Drug-Induced Liver Injury Consortium, Drug-Induced Liver Injury Network Investigators, and International Serious Adverse Events Consortium.

Gastroenterology. 2017 Apr;152(5):1078-1089. doi: 10.1053/j.gastro.2016.12.016. Epub 2016 Dec 30.

34.

Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.

Visentin M, van Rosmalen BV, Hiller C, Bieze M, Hofstetter L, Verheij J, Kullak-Ublick GA, Koepsell H, Phoa SS, Tamai I, Bennink RJ, van Gulik TM, Stieger B.

Drug Metab Dispos. 2017 Feb;45(2):166-173. doi: 10.1124/dmd.116.072371. Epub 2016 Nov 30.

PMID:
27903597
35.

A Mobile App to Stabilize Daily Functional Activity of Breast Cancer Patients in Collaboration With the Physician: A Randomized Controlled Clinical Trial.

Egbring M, Far E, Roos M, Dietrich M, Brauchbar M, Kullak-Ublick GA, Trojan A.

J Med Internet Res. 2016 Sep 6;18(9):e238. doi: 10.2196/jmir.6414.

36.

HER2/CEP17 Ratios and Clinical Outcome in HER2-Positive Early Breast Cancer Undergoing Trastuzumab-Containing Therapy.

Stocker A, Hilbers ML, Gauthier C, Grogg J, Kullak-Ublick GA, Seifert B, Varga Z, Trojan A.

PLoS One. 2016 Jul 27;11(7):e0159176. doi: 10.1371/journal.pone.0159176. eCollection 2016.

37.

Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.

Gai Z, Visentin M, Hiller C, Krajnc E, Li T, Zhen J, Kullak-Ublick GA.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5573-80. doi: 10.1128/AAC.00907-16. Print 2016 Sep.

38.

Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes.

Krattinger R, Boström A, Lee SML, Thasler WE, Schiöth HB, Kullak-Ublick GA, Mwinyi J.

Life Sci. 2016 Jul 1;156:47-56. doi: 10.1016/j.lfs.2016.04.037. Epub 2016 May 10.

39.

Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor.

Claro da Silva T, Hiller C, Gai Z, Kullak-Ublick GA.

J Steroid Biochem Mol Biol. 2016 Oct;163:77-87. doi: 10.1016/j.jsbmb.2016.04.006. Epub 2016 Apr 20.

40.

microRNA-192 suppresses the expression of the farnesoid X receptor.

Krattinger R, Boström A, Schiöth HB, Thasler WE, Mwinyi J, Kullak-Ublick GA.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1044-51. doi: 10.1152/ajpgi.00297.2015. Epub 2016 Apr 14.

41.

No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers.

Kullak-Ublick GA, Gubler C, Spanaus K, Ismair MG, Claro da Silva T, Jetter A.

Eur J Clin Pharmacol. 2016 Jul;72(7):797-805. doi: 10.1007/s00228-016-2050-0. Epub 2016 Mar 29.

42.

Bile acids in drug induced liver injury: Key players and surrogate markers.

Schadt HS, Wolf A, Pognan F, Chibout SD, Merz M, Kullak-Ublick GA.

Clin Res Hepatol Gastroenterol. 2016 Jun;40(3):257-266. doi: 10.1016/j.clinre.2015.12.017. Epub 2016 Feb 10. Review.

43.

Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice.

Gai Z, Gui T, Hiller C, Kullak-Ublick GA.

J Biol Chem. 2016 Jan 29;291(5):2397-411. doi: 10.1074/jbc.M115.694323. Epub 2015 Dec 11.

44.

[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis].

Weiler S, Bellmann R, Kullak-Ublick GA.

Ther Umsch. 2015 Dec;72(11-12):737-41. doi: 10.1024/0040-5930/a000745. Review. German.

45.

Concomitant administration of rifampicin and oxcarbazepine results in a significant decrease of the active MHD metabolite of oxcarbazepine.

Sigaroudi A, Kullak-Ublick GA, Weiler S.

Eur J Clin Pharmacol. 2016 Mar;72(3):377-8. doi: 10.1007/s00228-015-1991-z. Epub 2015 Dec 3. No abstract available.

46.

Too frequent low-dose methotrexate prescriptions: multicentre quality control and quality assurance with pre- and post-analysis.

Karlen S, Oertle M, Weiler S, Schneemann M, Eschmann E, Kullak-Ublick GA, Blaser J.

Swiss Med Wkly. 2015 Nov 24;145:w14218. doi: 10.4414/smw.2015.14218. eCollection 2015.

47.

[Nalmefene and Opioid Withdrawal Syndrome: Analysis of the Global Pharmacovigilance Database for Adverse Drug Reactions].

Dahmke H, Kupferschmidt H, Kullak-Ublick GA, Weiler S.

Praxis (Bern 1994). 2015 Oct 14;104(21):1129-34. doi: 10.1024/1661-8157/a002160. German.

48.

Therapeutic Drug Monitoring of Daptomycin: A Retrospective Monocentric Analysis.

Reiber C, Senn O, Müller D, Kullak-Ublick GA, Corti N.

Ther Drug Monit. 2015 Oct;37(5):634-40. doi: 10.1097/FTD.0000000000000196.

49.

Octreotide inhibits the bilirubin carriers organic anion transporting polypeptides 1B1 and 1B3 and the multidrug resistance-associated protein 2.

Visentin M, Stieger B, Merz M, Kullak-Ublick GA.

J Pharmacol Exp Ther. 2015 Nov;355(2):145-51. doi: 10.1124/jpet.115.227546. Epub 2015 Sep 1.

PMID:
26330539
50.

The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment.

de Vallière C, Vidal S, Clay I, Jurisic G, Tcymbarevich I, Lang S, Ludwig MG, Okoniewski M, Eloranta JJ, Kullak-Ublick GA, Wagner CA, Rogler G, Seuwen K.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G475-90. doi: 10.1152/ajpgi.00408.2014. Epub 2015 Jul 23.

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