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Items: 1 to 50 of 240

1.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.

Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Tröder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW.

Nat Commun. 2020 Jan 31;11(1):644. doi: 10.1038/s41467-020-14323-y.

2.

Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention.

Nakayasu ES, Syed F, Tersey SA, Gritsenko MA, Mitchell HD, Chan CY, Dirice E, Turatsinze JV, Cui Y, Kulkarni RN, Eizirik DL, Qian WJ, Webb-Robertson BM, Evans-Molina C, Mirmira RG, Metz TO.

Cell Metab. 2020 Feb 4;31(2):363-374.e6. doi: 10.1016/j.cmet.2019.12.005. Epub 2020 Jan 9.

PMID:
31928885
3.

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.

Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y.

Diabetologia. 2020 Mar;63(3):577-587. doi: 10.1007/s00125-019-05071-w. Epub 2020 Jan 3.

PMID:
31897526
4.

RADAR: differential analysis of MeRIP-seq data with a random effect model.

Zhang Z, Zhan Q, Eckert M, Zhu A, Chryplewicz A, De Jesus DF, Ren D, Kulkarni RN, Lengyel E, He C, Chen M.

Genome Biol. 2019 Dec 23;20(1):294. doi: 10.1186/s13059-019-1915-9.

5.

m6A mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes.

De Jesus DF, Zhang Z, Kahraman S, Brown NK, Chen M, Hu J, Gupta MK, He C, Kulkarni RN.

Nat Metab. 2019 Aug;1(8):765-774. doi: 10.1038/s42255-019-0089-9. Epub 2019 Jul 29.

6.

Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors.

Loo LSW, Vethe H, Soetedjo AAP, Paulo JA, Jasmen J, Jackson N, Bjørlykke Y, Valdez IA, Vaudel M, Barsnes H, Gygi SP, Raeder H, Teo AKK, Kulkarni RN.

Stem Cells. 2019 Dec 11. doi: 10.1002/stem.3135. [Epub ahead of print]

PMID:
31828876
7.

"Omics" and "epi-omics" underlying the β-cell adaptation to insulin resistance.

De Jesus DF, Kulkarni RN.

Mol Metab. 2019 Sep;27S:S42-S48. doi: 10.1016/j.molmet.2019.06.003. Review.

8.

Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes.

Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN.

Nat Metab. 2019 May;1(5):509-518. doi: 10.1038/s42255-019-0061-8. Epub 2019 May 6.

9.

How, When, and Where Do Human β-Cells Regenerate?

Basile G, Kulkarni RN, Morgan NG.

Curr Diab Rep. 2019 Jun 27;19(8):48. doi: 10.1007/s11892-019-1176-8. Review.

10.

Lemierre's Syndrome: An Atypical Presentation.

Chapman SC, Andraska E, Kulkarni RN, Haga LM, Phillips A, Redlinger RE, Hager ES, Madigan MC.

Ann Vasc Surg. 2019 Oct;60:479.e1-479.e4. doi: 10.1016/j.avsg.2019.03.011. Epub 2019 Jun 13.

PMID:
31201970
11.

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.

Ng NHJ, Jasmen JB, Lim CS, Lau HH, Krishnan VG, Kadiwala J, Kulkarni RN, Ræder H, Vallier L, Hoon S, Teo AKK.

iScience. 2019 Jun 28;16:192-205. doi: 10.1016/j.isci.2019.05.032. Epub 2019 May 27.

12.

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity.

Ji Y, Sun S, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, Ma M, Oberholzer J, Soleimanpour SA, Gannon M, Liu C, Naji A, Kulkarni RN, Wang Y, Kersten S, Qi L.

Nat Immunol. 2019 Jun;20(6):677-686. doi: 10.1038/s41590-019-0396-z. Epub 2019 May 20.

13.

β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity.

Mezza T, Cinti F, Cefalo CMA, Pontecorvi A, Kulkarni RN, Giaccari A.

Diabetes. 2019 Jun;68(6):1121-1129. doi: 10.2337/db18-0856. Review.

14.

Human duct cells contribute to β cell compensation in insulin resistance.

Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN.

JCI Insight. 2019 Apr 18;4(8). pii: 99576. doi: 10.1172/jci.insight.99576. eCollection 2019 Apr 18.

15.

Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.

Yi L, Tsai CF, Dirice E, Swensen AC, Chen J, Shi T, Gritsenko MA, Chu RK, Piehowski PD, Smith RD, Rodland KD, Atkinson MA, Mathews CE, Kulkarni RN, Liu T, Qian WJ.

Anal Chem. 2019 May 7;91(9):5794-5801. doi: 10.1021/acs.analchem.9b00024. Epub 2019 Mar 15.

16.

Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes.

Jungtrakoon P, Shirakawa J, Buranasupkajorn P, Gupta MK, De Jesus DF, Pezzolesi MG, Panya A, Hastings T, Chanprasert C, Mendonca C, Kulkarni RN, Doria A.

Diabetes. 2019 May;68(5):1084-1093. doi: 10.2337/db17-0821. Epub 2019 Mar 4.

17.

Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion.

El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG.

J Biol Chem. 2019 Jan 18;294(3):1059-1069. doi: 10.1074/jbc.RA118.006031. Epub 2018 Nov 20.

18.

Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.

Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ.

EMBO J. 2018 Dec 14;37(24). pii: e100409. doi: 10.15252/embj.2018100409. Epub 2018 Nov 16.

19.

Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation.

Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F, Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN.

Mol Metab. 2018 Dec;18:153-163. doi: 10.1016/j.molmet.2018.09.003. Epub 2018 Sep 19.

20.

Fluorescent probes for G-protein-coupled receptor drug discovery.

Iliopoulos-Tsoutsouvas C, Kulkarni RN, Makriyannis A, Nikas SP.

Expert Opin Drug Discov. 2018 Oct;13(10):933-947. doi: 10.1080/17460441.2018.1518975. Epub 2018 Sep 24. Review.

PMID:
30249143
21.

Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells.

Jeong DE, Heo S, Han JH, Lee EY, Kulkarni RN, Kim W.

Mol Cells. 2018 Oct 31;41(10):909-916. doi: 10.14348/molcells.2018.0147. Epub 2018 Aug 31.

22.

Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis.

Kim C, Jeong DE, Heo S, Ji E, Rho JG, Jung M, Ahn S, Kim YJ, Kim YS, Nam SW, Kulkarni RN, Lee KB, Lee EK, Kim W.

J Pathol. 2018 Oct;246(2):231-243. doi: 10.1002/path.5135. Epub 2018 Aug 28.

23.

Sex differences underlying pancreatic islet biology and its dysfunction.

Gannon M, Kulkarni RN, Tse HM, Mauvais-Jarvis F.

Mol Metab. 2018 Sep;15:82-91. doi: 10.1016/j.molmet.2018.05.017. Epub 2018 May 30. Review.

24.

Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation.

Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Orime K, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y.

J Biol Chem. 2018 Apr 20;293(16):5934-5946. doi: 10.1074/jbc.M117.809228. Epub 2018 Mar 1.

25.

Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells.

Shin H, Han JH, Yoon J, Sim HJ, Park TJ, Yang S, Lee EK, Kulkarni RN, Egan JM, Kim W.

J Cell Mol Med. 2018 Apr;22(4):2337-2345. doi: 10.1111/jcmm.13523. Epub 2018 Feb 12.

26.

The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.

Johansson BB, Fjeld K, El Jellas K, Gravdal A, Dalva M, Tjora E, Ræder H, Kulkarni RN, Johansson S, Njølstad PR, Molven A.

Pancreatology. 2018 Jan;18(1):12-19. doi: 10.1016/j.pan.2017.12.001. Epub 2017 Dec 5. Review.

PMID:
29233499
27.

Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.

Dirice E, Ng RWS, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN.

J Biol Chem. 2017 Oct 27;292(43):17598-17608. doi: 10.1074/jbc.M117.804328. Epub 2017 Aug 31.

28.

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.

Johansson BB, Fjeld K, Solheim MH, Shirakawa J, Zhang E, Keindl M, Hu J, Lindqvist A, Døskeland A, Mellgren G, Flatmark T, Njølstad PR, Kulkarni RN, Wierup N, Aukrust I, Bjørkhaug L.

Mol Cell Endocrinol. 2017 Oct 15;454:146-157. doi: 10.1016/j.mce.2017.06.020. Epub 2017 Jun 22.

PMID:
28648619
29.

Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene.

Ghanem SS, Muturi HT, DeAngelis AM, Hu J, Kulkarni RN, Heinrich G, Najjar SM.

Diabetologia. 2017 Sep;60(9):1751-1760. doi: 10.1007/s00125-017-4307-2. Epub 2017 May 31.

30.

GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.

Kawamori D, Shirakawa J, Liew CW, Hu J, Morioka T, Duttaroy A, Burkey B, Kulkarni RN.

Diabetologia. 2017 Aug;60(8):1442-1453. doi: 10.1007/s00125-017-4303-6. Epub 2017 May 20.

31.

Heterogeneity of proliferative markers in pancreatic β-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass.

Patti ME, Goldfine AB, Hu J, Hoem D, Molven A, Goldsmith J, Schwesinger WH, La Rosa S, Folli F, Kulkarni RN.

Acta Diabetol. 2017 Aug;54(8):737-747. doi: 10.1007/s00592-017-1001-2. Epub 2017 May 17.

32.

Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass.

Shirakawa J, De Jesus DF, Kulkarni RN.

Eur J Clin Nutr. 2017 Jul;71(7):896-903. doi: 10.1038/ejcn.2017.13. Epub 2017 Mar 15. Review.

PMID:
28294170
33.

Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.

Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A, Kulkarni RN.

Cell Metab. 2017 Apr 4;25(4):868-882.e5. doi: 10.1016/j.cmet.2017.02.004. Epub 2017 Mar 9.

34.

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR.

Cell Metab. 2017 Feb 7;25(2):448-462. doi: 10.1016/j.cmet.2016.12.008. Epub 2017 Jan 5.

35.

Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Oct 10;6:34969. doi: 10.1038/srep34969. No abstract available.

36.

Novel factors modulating human β-cell proliferation.

Shirakawa J, Kulkarni RN.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:71-7. doi: 10.1111/dom.12731. Review.

37.

Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors.

Mezza T, Shirakawa J, Martinez R, Hu J, Giaccari A, Kulkarni RN.

J Biol Chem. 2016 Oct 7;291(41):21485-21495. Epub 2016 Aug 17.

38.

IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Jul 5;6:28177. doi: 10.1038/srep28177. Erratum in: Sci Rep. 2016 Oct 10;6:34969.

39.

Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?

Kahraman S, Okawa ER, Kulkarni RN.

Curr Diab Rep. 2016 Aug;16(8):70. doi: 10.1007/s11892-016-0764-0. Review.

40.

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.

Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O'Neill BT, Kahn CR.

Diabetes. 2016 Aug;65(8):2201-13. doi: 10.2337/db16-0212. Epub 2016 May 13.

41.

ERRγ-A New Player in β Cell Maturation.

Shirakawa J, Kulkarni RN.

Cell Metab. 2016 May 10;23(5):765-7. doi: 10.1016/j.cmet.2016.04.026.

42.

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation.

Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AKK, Kulkarni RN.

Cell Rep. 2016 Apr 19;15(3):460-470. doi: 10.1016/j.celrep.2016.03.036. Epub 2016 Apr 7.

43.

The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice.

Molven A, Hollister-Lock J, Hu J, Martinez R, Njølstad PR, Liew CW, Weir G, Kulkarni RN.

Diabetes. 2016 Jun;65(6):1672-8. doi: 10.2337/db15-1475. Epub 2016 Mar 7.

44.

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.

Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK.

Diabetes. 2016 Jun;65(6):1660-71. doi: 10.2337/db15-1127. Epub 2016 Mar 7.

45.

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication.

Dhawan S, Dirice E, Kulkarni RN, Bhushan A.

Diabetes. 2016 May;65(5):1208-18. doi: 10.2337/db15-1331. Epub 2016 Mar 2.

46.

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.

Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN.

Stem Cell Reports. 2016 Mar 8;6(3):357-67. doi: 10.1016/j.stemcr.2016.01.007. Epub 2016 Feb 11.

47.

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas.

Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E.

PLoS One. 2016 Feb 12;11(2):e0148252. doi: 10.1371/journal.pone.0148252. eCollection 2016.

48.

Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome.

Khor EC, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni RN, Enriquez RF, Purtell L, Lee NJ, Wee NK, Croucher PI, Campbell L, Herzog H, Baldock PA.

PLoS One. 2016 Jan 29;11(1):e0148155. doi: 10.1371/journal.pone.0148155. eCollection 2016.

49.

Harnessing immune cells to enhance β-cell mass in type 1 diabetes.

Dirice E, Kulkarni RN.

J Investig Med. 2016 Jan;64(1):14-20. doi: 10.1136/jim-d-15-00196.

PMID:
26755809
50.

The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay.

Khor EC, Yulyaningsih E, Driessler F, Kovaĉić N, Wee NKY, Kulkarni RN, Lee NJ, Enriquez RF, Xu J, Zhang L, Herzog H, Baldock PA.

Bone. 2016 Mar;84:139-147. doi: 10.1016/j.bone.2015.12.011. Epub 2015 Dec 22.

PMID:
26721736

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