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Items: 37


Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2.

Mihaila R, Ruhela D, Galinski B, Card A, Cancilla M, Shadel T, Kang J, Tep S, Wei J, Haas RM, Caldwell J, Flanagan WM, Kuklin N, Cherkaev E, Ason B.

Mol Ther Nucleic Acids. 2019 Jun 7;16:367-377. doi: 10.1016/j.omtn.2019.03.004. Epub 2019 Mar 23.


The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator.

Brandish PE, Anderson K, Baltus GA, Bai C, Bungard CJ, Bunting P, Byford A, Chiu CS, Cicmil M, Corcoran H, Euler D, Fisher JE, Gambone C, Hasbun-Manning M, Kuklin N, Landis E, Lifsted TQ, McElwee-Witmer S, McIntosh IS, Meissner RS, Miao J, Mitchell HJ, Musselman A, Schmidt A, Shin J, Szczerba P, Thompson CD, Tribouley C, Vogel RL, Warrier S, Hershey JC.

Eur J Pharmacol. 2014 Feb 5;724:102-11. doi: 10.1016/j.ejphar.2013.12.031. Epub 2013 Dec 27.


Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.

Tep S, Mihaila R, Freeman A, Pickering V, Huynh F, Tadin-Strapps M, Stracks A, Hubbard B, Caldwell J, Flanagan WM, Kuklin NA, Ason B.

J Lipid Res. 2012 May;53(5):859-67. doi: 10.1194/jlr.M021063. Epub 2012 Feb 21. Erratum in: J Lipid Res. 2012 Nov;53(11):2484. Huyhn, Felicia [corrected to Huynh, Felicia].


Lipid nanoparticle purification by spin centrifugation-dialysis (SCD): a facile and high-throughput approach for small scale preparation of siRNA-lipid complexes.

Mihaila R, Chang S, Wei AT, Hu ZY, Ruhela D, Shadel TR, Duenwald S, Payson E, Cunningham JJ, Kuklin N, Mathre DJ.

Int J Pharm. 2011 Nov 25;420(1):118-21. doi: 10.1016/j.ijpharm.2011.08.017. Epub 2011 Aug 27.


ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).

Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, Hankemeier T, Hubbard B, Sachs AB, Michael Flanagan W, Kuklin NA, Mitnaul LJ.

Lipids. 2011 Nov;46(11):991-1003. doi: 10.1007/s11745-011-3596-3. Epub 2011 Aug 9.


RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice.

Wei J, Jones J, Kang J, Card A, Krimm M, Hancock P, Pei Y, Ason B, Payson E, Dubinina N, Cancilla M, Stroh M, Burchard J, Sachs AB, Hochman JH, Flanagan WM, Kuklin NA.

Mol Pharmacol. 2011 Jun;79(6):953-63. doi: 10.1124/mol.110.070409. Epub 2011 Mar 22.


Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9.

Ason B, Tep S, Davis HR Jr, Xu Y, Tetzloff G, Galinski B, Soriano F, Dubinina N, Zhu L, Stefanni A, Wong KK, Tadin-Strapps M, Bartz SR, Hubbard B, Ranalletta M, Sachs AB, Flanagan WM, Strack A, Kuklin NA.

J Lipid Res. 2011 Apr;52(4):679-87. doi: 10.1194/jlr.M013664. Epub 2011 Jan 24.


Quantitative evaluation of siRNA delivery in vivo.

Pei Y, Hancock PJ, Zhang H, Bartz R, Cherrin C, Innocent N, Pomerantz CJ, Seitzer J, Koser ML, Abrams MT, Xu Y, Kuklin NA, Burke PA, Sachs AB, Sepp-Lorenzino L, Barnett SF.

RNA. 2010 Dec;16(12):2553-63. doi: 10.1261/rna.2255810. Epub 2010 Oct 12.


Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

Kenski DM, Cooper AJ, Li JJ, Willingham AT, Haringsma HJ, Young TA, Kuklin NA, Jones JJ, Cancilla MT, McMasters DR, Mathur M, Sachs AB, Flanagan WM.

Nucleic Acids Res. 2010 Jan;38(2):660-71. doi: 10.1093/nar/gkp913. Epub 2009 Nov 16.


Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues.

Burns JA, Li Y, Cheney CA, Ou Y, Franlin-Pfeifer LL, Kuklin N, Zhang ZQ.

J Histochem Cytochem. 2009 Mar;57(3):257-64. doi: 10.1369/jhc.2008.952911. Epub 2008 Nov 11.


Staphylococcus aureus capsule type 8 antibodies provide inconsistent efficacy in murine models of staphylococcal infection.

Cook J, Hepler R, Pancari G, Kuklin N, Fan H, Wang XM, Cope L, Tan C, Joyce J, Onishi J, Montgomery D, Anderson A, McNeely T.

Hum Vaccin. 2009 Apr;5(4):254-63. Epub 2009 Apr 10.


A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model.

Kuklin NA, Clark DJ, Secore S, Cook J, Cope LD, McNeely T, Noble L, Brown MJ, Zorman JK, Wang XM, Pancari G, Fan H, Isett K, Burgess B, Bryan J, Brownlow M, George H, Meinz M, Liddell ME, Kelly R, Schultz L, Montgomery D, Onishi J, Losada M, Martin M, Ebert T, Tan CY, Schofield TL, Nagy E, Meineke A, Joyce JG, Kurtz MB, Caulfield MJ, Jansen KU, McClements W, Anderson AS.

Infect Immun. 2006 Apr;74(4):2215-23.


Real-time monitoring of bacterial infection in vivo: development of bioluminescent staphylococcal foreign-body and deep-thigh-wound mouse infection models.

Kuklin NA, Pancari GD, Tobery TW, Cope L, Jackson J, Gill C, Overbye K, Francis KP, Yu J, Montgomery D, Anderson AS, McClements W, Jansen KU.

Antimicrob Agents Chemother. 2003 Sep;47(9):2740-8.


Influence of DNA encoding cytokines on systemic and mucosal immunity following genetic vaccination against herpes simplex virus.

Lee S, Gierynska M, Eo SK, Kuklin N, Rouse BT.

Microbes Infect. 2003 Jun;5(7):571-8.


Effect of vaccine delivery system on the induction of HPV16L1-specific humoral and cell-mediated immune responses in immunized rhesus macaques.

Tobery TW, Smith JF, Kuklin N, Skulsky D, Ackerson C, Huang L, Chen L, Cook JC, McClements WL, Jansen KU.

Vaccine. 2003 Mar 28;21(13-14):1539-47.


Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6-specific IgA mAb.

Feng N, Lawton JA, Gilbert J, Kuklin N, Vo P, Prasad BV, Greenberg HB.

J Clin Invest. 2002 May;109(9):1203-13.


The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells.

Bowman EP, Kuklin NA, Youngman KR, Lazarus NH, Kunkel EJ, Pan J, Greenberg HB, Butcher EC.

J Exp Med. 2002 Jan 21;195(2):269-75.


Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production.

Kuklin NA, Rott L, Feng N, Conner ME, Wagner N, Müller W, Greenberg HB.

J Immunol. 2001 Feb 1;166(3):1894-902.


alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus.

Kuklin NA, Rott L, Darling J, Campbell JJ, Franco M, Feng N, Müller W, Wagner N, Altman J, Butcher EC, Greenberg HB.

J Clin Invest. 2000 Dec;106(12):1541-52.


CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.

Cook DN, Prosser DM, Forster R, Zhang J, Kuklin NA, Abbondanzo SJ, Niu XD, Chen SC, Manfra DJ, Wiekowski MT, Sullivan LM, Smith SR, Greenberg HB, Narula SK, Lipp M, Lira SA.

Immunity. 2000 May;12(5):495-503.


Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice.

Daheshia M, Deshpande S, Chun S, Kuklin NA, Rouse BT.

Virology. 1999 Apr 25;257(1):168-76.


Modulation of virus-induced delayed-type hypersensitivity by plasmid DNA encoding the cytokine interleukin-10.

Manickan E, Daheshia M, Kuklin N, Chun S, Rouse BT.

Immunology. 1998 Jun;94(2):129-34.


Immune induction and modulation by topical ocular administration of plasmid DNA encoding antigens and cytokines.

Daheshia M, Kuklin N, Manickan E, Chun S, Rouse BT.

Vaccine. 1998 Jul;16(11-12):1103-10.


Immunomodulation by mucosal gene transfer using TGF-beta DNA.

Kuklin NA, Daheshia M, Chun S, Rouse BT.

J Clin Invest. 1998 Jul 15;102(2):438-44.


Role of mucosal immunity in herpes simplex virus infection.

Kuklin NA, Daheshia M, Chun S, Rouse BT.

J Immunol. 1998 Jun 15;160(12):5998-6003.


DNA vaccines and immunity to herpes simplex virus.

Rouse BT, Nair S, Rouse RJ, Yu Z, Kuklin N, Karem K, Manickan E.

Curr Top Microbiol Immunol. 1998;226:69-78. Review. No abstract available.


Modulation of mucosal and systemic immunity by enteric administration of nonreplicating herpes simplex virus expressing cytokines.

Kuklin NA, Daheshia M, Marconi PC, Krisky DM, Rouse RJ, Glorioso JC, Manican E, Rouse BT.

Virology. 1998 Jan 20;240(2):245-53.


Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10.

Daheshia M, Kuklin N, Kanangat S, Manickan E, Rouse BT.

J Immunol. 1997 Aug 15;159(4):1945-52.


Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization.

Kuklin N, Daheshia M, Karem K, Manickan E, Rouse BT.

J Virol. 1997 Apr;71(4):3138-45.


Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

Banks TA, Rouse BT, Kerley MK, Blair PJ, Godfrey VL, Kuklin NA, Bouley DM, Thomas J, Kanangat S, Mucenski ML.

J Immunol. 1995 Aug 15;155(4):1685-93.


Vaccination with recombinant vaccinia viruses expressing ICP27 induces protective immunity against herpes simplex virus through CD4+ Th1+ T cells.

Manickan E, Francotte M, Kuklin N, Dewerchin M, Molitor C, Gheysen D, Slaoui M, Rouse BT.

J Virol. 1995 Aug;69(8):4711-6.


[Results of the clinical examination of the cosmonauts after a 63-day flight].

Beregovkin AV, Krupina TN, Syrykh GD, Korotaev MM, Kuklin NA.

Kosm Biol Aviakosm Med. 1977 Mar-Apr;11(2):19-22. Russian.


[An attachment for the Riva-Rocci apparatus for determination of capillary resistance].


Voen Med Zh. 1960 Mar;3:86-7. Russian. No abstract available.


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