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Items: 1 to 50 of 75

1.

Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation.

Keating SM, Taylor DL, Plant AL, Litwack ED, Kuhn P, Greenspan EJ, Hartshorn CM, Sigman CC, Kelloff GJ, Chang DD, Friberg G, Lee JSH, Kuida K.

Clin Transl Sci. 2018 May;11(3):267-276. doi: 10.1111/cts.12536. Epub 2018 Mar 2. Review.

2.

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.

Klauck PJ, Bagby SM, Capasso A, Bradshaw-Pierce EL, Selby HM, Spreafico A, Tentler JJ, Tan AC, Kim J, Arcaroli JJ, Purkey A, Messersmith WA, Kuida K, Eckhardt SG, Pitts TM.

BMC Cancer. 2018 Feb 5;18(1):136. doi: 10.1186/s12885-018-4036-z.

3.

A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies.

Juric D, de Bono JS, LoRusso PM, Nemunaitis J, Heath EI, Kwak EL, Macarulla Mercadé T, Geuna E, Jose de Miguel-Luken M, Patel C, Kuida K, Sankoh S, Westin EH, Zohren F, Shou Y, Tabernero J.

Clin Cancer Res. 2017 Sep 1;23(17):5015-5023. doi: 10.1158/1078-0432.CCR-16-2888. Epub 2017 May 10.

4.

An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).

Sumi H, Inazuka M, Morimoto M, Hibino R, Hashimoto K, Ishikawa T, Kuida K, Smith PG, Yoshida S, Yabuki M.

Biochem Biophys Res Commun. 2016 Nov 18;480(3):380-386. doi: 10.1016/j.bbrc.2016.10.058. Epub 2016 Oct 19.

PMID:
27771247
5.

Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells.

Nonomura K, Yamaguchi Y, Hamachi M, Koike M, Uchiyama Y, Nakazato K, Mochizuki A, Sakaue-Sawano A, Miyawaki A, Yoshida H, Kuida K, Miura M.

Dev Cell. 2013 Dec 23;27(6):621-34. doi: 10.1016/j.devcel.2013.11.015.

6.

TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens.

Hikichi Y, Honda K, Hikami K, Miyashita H, Kaieda I, Murai S, Uchiyama N, Hasegawa M, Kawamoto T, Sato T, Ichikawa T, Cao S, Nie Z, Zhang L, Yang J, Kuida K, Kupperman E.

Mol Cancer Ther. 2012 Mar;11(3):700-9. doi: 10.1158/1535-7163.MCT-11-0762. Epub 2011 Dec 21.

7.

Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.

Yamaguchi Y, Shinotsuka N, Nonomura K, Takemoto K, Kuida K, Yosida H, Miura M.

J Cell Biol. 2011 Dec 12;195(6):1047-60. doi: 10.1083/jcb.201104057.

8.

Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity.

Ohsawa S, Hamada S, Kuida K, Yoshida H, Igaki T, Miura M.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13366-71. doi: 10.1073/pnas.0910488107. Epub 2010 Jul 12.

9.

Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb.

Ohsawa S, Hamada S, Asou H, Kuida K, Uchiyama Y, Yoshida H, Miura M.

J Neurosci. 2009 Sep 9;29(36):11385-92. doi: 10.1523/JNEUROSCI.4780-08.2009.

10.

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.

Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y.

Am J Pathol. 2008 Feb;172(2):454-69. doi: 10.2353/ajpath.2008.070876. Epub 2008 Jan 10.

12.

Decreased retinal neuronal cell death in caspase-1 knockout mice.

Arai J, Katai N, Kuida K, Kikuchi T, Yoshimura N.

Jpn J Ophthalmol. 2006 Sep-Oct;50(5):417-425. doi: 10.1007/s10384-006-0352-y.

PMID:
17013693
13.

The initiator caspase, caspase-10beta, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways.

Kominami K, Takagi C, Kurata T, Kitayama A, Nozaki M, Sawasaki T, Kuida K, Endo Y, Manabe N, Ueno N, Sakamaki K.

Genes Cells. 2006 Jul;11(7):701-17.

14.

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.

Lakhani SA, Masud A, Kuida K, Porter GA Jr, Booth CJ, Mehal WZ, Inayat I, Flavell RA.

Science. 2006 Feb 10;311(5762):847-51.

15.

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.

Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR.

Nat Immunol. 2006 Mar;7(3):318-25. Epub 2006 Jan 29.

PMID:
16444259
16.

c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.

Shao Z, Bhattacharya K, Hsich E, Park L, Walters B, Germann U, Wang YM, Kyriakis J, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, Aronovitz M, Tsichlis PN, Bhattacharya S, Force T, Kilter H.

Circ Res. 2006 Jan 6;98(1):111-8. Epub 2005 Nov 23.

PMID:
16306447
17.

Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells.

Ohgushi M, Kuroki S, Fukamachi H, O'Reilly LA, Kuida K, Strasser A, Yonehara S.

Mol Cell Biol. 2005 Nov;25(22):10017-28.

18.

Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.

Oishi K, Kamakura S, Isazawa Y, Yoshimatsu T, Kuida K, Nakafuku M, Masuyama N, Gotoh Y.

Dev Biol. 2004 Dec 1;276(1):172-84.

19.

Functions of MAP kinases: insights from gene-targeting studies.

Kuida K, Boucher DM.

J Biochem. 2004 Jun;135(6):653-6. Review.

20.

Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.

Takuma H, Tomiyama T, Kuida K, Mori H.

J Neuropathol Exp Neurol. 2004 Mar;63(3):255-61.

PMID:
15055449
21.

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM.

Circulation. 2004 Mar 16;109(10):1196-205. Review.

PMID:
15023894
22.

Roles of caspase-1 in Listeria infection in mice.

Tsuji NM, Tsutsui H, Seki E, Kuida K, Okamura H, Nakanishi K, Flavell RA.

Int Immunol. 2004 Feb;16(2):335-43.

PMID:
14734619
23.

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.

Yao Y, Li W, Wu J, Germann UA, Su MS, Kuida K, Boucher DM.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12759-64. Epub 2003 Oct 17.

24.

ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.

Jimbo A, Fujita E, Kouroku Y, Ohnishi J, Inohara N, Kuida K, Sakamaki K, Yonehara S, Momoi T.

Exp Cell Res. 2003 Feb 15;283(2):156-66.

PMID:
12581736
25.

Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.

Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15188-93. Epub 2002 Nov 1.

26.

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.

Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, Roy S, Nicholson DW, Vaux DL, Bouillet P, Adams JM, Strasser A.

Nature. 2002 Oct 10;419(6907):634-7. Epub 2002 Sep 25.

PMID:
12374983
27.
28.

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9.

O'Reilly LA, Ekert P, Harvey N, Marsden V, Cullen L, Vaux DL, Hacker G, Magnusson C, Pakusch M, Cecconi F, Kuida K, Strasser A, Huang DC, Kumar S.

Cell Death Differ. 2002 Aug;9(8):832-41.

29.

Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects.

Regan CP, Li W, Boucher DM, Spatz S, Su MS, Kuida K.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9248-53. Epub 2002 Jul 1.

30.

Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation.

Kouroku Y, Fujita E, Jimbo A, Kikuchi T, Yamagata T, Momoi MY, Kominami E, Kuida K, Sakamaki K, Yonehara S, Momoi T.

Hum Mol Genet. 2002 Jun 15;11(13):1505-15.

PMID:
12045204
31.

Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo.

Fujita E, Egashira J, Urase K, Kuida K, Momoi T.

Cell Death Differ. 2001 Apr;8(4):335-44.

32.

Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss.

Takahashi K, Kamiya K, Urase K, Suga M, Takizawa T, Mori H, Yoshikawa Y, Ichimura K, Kuida K, Momoi T.

Brain Res. 2001 Mar 16;894(2):359-67.

PMID:
11251216
33.

Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta.

Seki E, Tsutsui H, Nakano H, Tsuji N, Hoshino K, Adachi O, Adachi K, Futatsugi S, Kuida K, Takeuchi O, Okamura H, Fujimoto J, Akira S, Nakanishi K.

J Immunol. 2001 Feb 15;166(4):2651-7.

34.

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.

Zaidi AU, D'Sa-Eipper C, Brenner J, Kuida K, Zheng TS, Flavell RA, Rakic P, Roth KA.

J Neurosci. 2001 Jan 1;21(1):169-75.

35.

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3.

D'Sa-Eipper C, Leonard JR, Putcha G, Zheng TS, Flavell RA, Rakic P, Kuida K, Roth KA.

Development. 2001 Jan;128(1):137-46.

36.

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.

Zheng TS, Hunot S, Kuida K, Momoi T, Srinivasan A, Nicholson DW, Lazebnik Y, Flavell RA.

Nat Med. 2000 Nov;6(11):1241-7.

PMID:
11062535
37.

Detection of caspase-9 activation in the cell death of the Bcl-x-deficient mouse embryo nervous system by cleavage sites-directed antisera.

Fujita E, Urase K, Egashira J, Miho Y, Isahara K, Uchiyama Y, Isoai A, Kumagai H, Kuida K, Motoyama N, Momoi T.

Brain Res Dev Brain Res. 2000 Aug 30;122(2):135-47.

PMID:
10960682
38.
39.

Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.

Hatai T, Matsuzawa A, Inoshita S, Mochida Y, Kuroda T, Sakamaki K, Kuida K, Yonehara S, Ichijo H, Takeda K.

J Biol Chem. 2000 Aug 25;275(34):26576-81.

40.

Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes.

Endo J, Toyama-Sorimachi N, Taya C, Kuramochi-Miyagawa S, Nagata K, Kuida K, Takashi T, Yonekawa H, Yoshizawa Y, Miyasaka N, Karasuyama H.

FEBS Lett. 2000 Feb 25;468(2-3):234-8.

41.

Caspase-9.

Kuida K.

Int J Biochem Cell Biol. 2000 Feb;32(2):121-4. Review.

PMID:
10687948
42.

Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.

Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):466-71.

43.

Caspase knockouts: matters of life and death.

Zheng TS, Hunot S, Kuida K, Flavell RA.

Cell Death Differ. 1999 Nov;6(11):1043-53. Review.

44.

Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.

Tsutsui H, Kayagaki N, Kuida K, Nakano H, Hayashi N, Takeda K, Matsui K, Kashiwamura S, Hada T, Akira S, Yagita H, Okamura H, Nakanishi K.

Immunity. 1999 Sep;11(3):359-67.

45.

Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.

Eynon EE, Livák F, Kuida K, Schatz DG, Flavell RA.

J Immunol. 1999 Feb 1;162(3):1448-59.

46.

Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor.

Tsuganezawa K, Kiyokawa N, Matsuo Y, Kitamura F, Toyama-Sorimachi N, Kuida K, Fujimoto J, Karasuyama H.

Blood. 1998 Dec 1;92(11):4317-24.

PMID:
9834238
47.

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.

Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA.

Cell. 1998 Aug 7;94(3):325-37.

48.

Interleukin-1 beta converting enzyme (ICE) is preferentially expressed in neuroblastomas with favourable prognosis.

Ikeda H, Nakamura Y, Hiwasa T, Sakiyama S, Kuida K, Su MS, Nakagawara A.

Eur J Cancer. 1997 Oct;33(12):2081-3.

PMID:
9516857
49.

[MHC class II restricted antigen presentation].

Kuida K.

Tanpakushitsu Kakusan Koso. 1997 Oct;42(14 Suppl):2376-9. Review. Japanese. No abstract available.

PMID:
9366221
50.

High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.

Nakagawara A, Nakamura Y, Ikeda H, Hiwasa T, Kuida K, Su MS, Zhao H, Cnaan A, Sakiyama S.

Cancer Res. 1997 Oct 15;57(20):4578-84.

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