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Integrated Imaging Methodology Detects Claudin-1 Expression in Premalignant Nonpolypoid and Polypoid Colonic Epithelium in Mice.

Wang F, Duan X, Chen J, Gao Z, Zhou J, Wu X, Chang TS, Lee M, Li G, Nusrat A, Kuick R, Appelman HD, Wang TD.

Clin Transl Gastroenterol. 2020 Jan;11(1):e00089. doi: 10.14309/ctg.0000000000000089.


Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts.

McCool KW, Freeman ZT, Zhai Y, Wu R, Hu K, Liu CJ, Tomlins SA, Fearon ER, Magnuson B, Kuick R, Cho KR.

Cancer Res. 2020 Feb 15;80(4):877-889. doi: 10.1158/0008-5472.CAN-19-2558. Epub 2019 Dec 5.


Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting cMet.

Wu X, Zhou J, Wang F, Meng X, Chen J, Chang TS, Lee M, Li G, Li X, Appelman HD, Kuick R, Wang TD.

Sci Rep. 2019 Nov 29;9(1):17917. doi: 10.1038/s41598-019-54385-7.


Correction to "Identification of Tumor Specific Peptide as EpCAM Ligand and Its Potential Diagnostic and Therapeutic Clinical Application".

Ma X, Kang X, He L, Zhou J, Zhou J, Sturm MB, Beer DG, Kuick R, Nancarrow DJ, Appelman HD, Pang Z, Li W, Zhang C, Zhang W, Zhang Y, Wang TD, Li M.

Mol Pharm. 2019 Aug 5;16(8):3726. doi: 10.1021/acs.molpharmaceut.9b00514. Epub 2019 Jul 16. No abstract available.


Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis, and gene expression in mouse colon tumorigenesis.

Tang J, Feng Y, Kuick R, Green M, Green M, Sakamoto N, Kurosu Y, Lin J, Cho KR, Fearon ER.

Lab Invest. 2019 Oct;99(10):1454-1469. doi: 10.1038/s41374-019-0269-y. Epub 2019 May 31.


Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium.

Wang Y, Sessine MS, Zhai Y, Tipton C, McCool K, Kuick R, Connolly DC, Fearon ER, Cho KR.

J Pathol. 2019 Oct;249(2):206-214. doi: 10.1002/path.5308. Epub 2019 Jul 8.


Identification of Tumor Specific Peptide as EpCAM Ligand and Its Potential Diagnostic and Therapeutic Clinical Application.

Ma X, Kang X, He L, Zhou J, Zhou J, Sturm MB, Beer DG, Kuick R, Nancarrow DJ, Appelman HD, Pang Z, Li W, Zhang C, Zhang W, Zhang Y, Wang TD, Li M.

Mol Pharm. 2019 May 6;16(5):2199-2213. doi: 10.1021/acs.molpharmaceut.9b00185. Epub 2019 Apr 18. Erratum in: Mol Pharm. 2019 Aug 5;16(8):3726.


Constitutively Higher Level of GSTT2 in Esophageal Tissues From African Americans Protects Cells Against DNA Damage.

Ferrer-Torres D, Nancarrow DJ, Steinberg H, Wang Z, Kuick R, Weh KM, Mills RE, Ray D, Ray P, Lin J, Chang AC, Reddy RM, Orringer MB, Canto MI, Shaheen NJ, Kresty LA, Chak A, Wang TD, Rubenstein JH, Beer DG.

Gastroenterology. 2019 Apr;156(5):1404-1415. doi: 10.1053/j.gastro.2018.12.004. Epub 2018 Dec 19.


Loss of AMPKα2 Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis.

Zhang H, Kuick R, Park SS, Peabody C, Yoon J, Fernández EC, Wang J, Thomas D, Viollet B, Inoki K, Camelo-Piragua S, Rual JF.

Int J Mol Sci. 2018 Oct 23;19(11). pii: E3287. doi: 10.3390/ijms19113287.


Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.

Wang Q, Yan R, Pinnell N, McCarter AC, Oh Y, Liu Y, Sha C, Garber NF, Chen Y, Wu Q, Ku CJ, Tran I, Serna Alarcon A, Kuick R, Engel JD, Maillard I, Cierpicki T, Chiang MY.

Blood. 2018 Sep 20;132(12):1279-1292. doi: 10.1182/blood-2018-02-835850. Epub 2018 Aug 3.


Multiplexed Targeting of Barrett's Neoplasia with a Heterobivalent Ligand: Imaging Study on Mouse Xenograft in Vivo and Human Specimens ex Vivo.

Chen J, Zhou J, Gao Z, Li X, Wang F, Duan X, Li G, Joshi BP, Kuick R, Appelman HD, Wang TD.

J Med Chem. 2018 Jun 28;61(12):5323-5331. doi: 10.1021/acs.jmedchem.8b00405. Epub 2018 Jun 19.


Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow.

Bowers E, Slaughter A, Frenette PS, Kuick R, Pello OM, Lucas D.

Nat Med. 2018 Jan;24(1):95-102. doi: 10.1038/nm.4448. Epub 2017 Nov 20.


Identification and validation of FGFR2 peptide for detection of early Barrett's neoplasia.

Zhou J, He L, Pang Z, Appelman HD, Kuick R, Beer DG, Li M, Wang TD.

Oncotarget. 2017 Aug 1;8(50):87095-87106. doi: 10.18632/oncotarget.19764. eCollection 2017 Oct 20.


In vivo near-infrared imaging of ErbB2 expressing breast tumors with dual-axes confocal endomicroscopy using a targeted peptide.

Gao Z, Li G, Li X, Zhou J, Duan X, Chen J, Joshi BP, Kuick R, Khoury B, Thomas DG, Fields T, Sabel MS, Appelman HD, Zhou Q, Li H, Kozloff K, Wang TD.

Sci Rep. 2017 Oct 31;7(1):14404. doi: 10.1038/s41598-017-13735-z.


RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Xu T, Park SS, Giaimo BD, Hall D, Ferrante F, Ho DM, Hori K, Anhezini L, Ertl I, Bartkuhn M, Zhang H, Milon E, Ha K, Conlon KP, Kuick R, Govindarajoo B, Zhang Y, Sun Y, Dou Y, Basrur V, Elenitoba-Johnson KS, Nesvizhskii AI, Ceron J, Lee CY, Borggrefe T, Kovall RA, Rual JF.

EMBO J. 2017 Nov 2;36(21):3232-3249. doi: 10.15252/embj.201796525. Epub 2017 Oct 13.


Ultrasmall Paramagnetic Iron Oxide Nanoprobe Targeting Epidermal Growth Factor Receptor for In Vivo Magnetic Resonance Imaging of Hepatocellular Carcinoma.

Chen Y, Zhou Q, Li X, Wang F, Heist K, Kuick R, Owens SR, Wang TD.

Bioconjug Chem. 2017 Nov 15;28(11):2794-2803. doi: 10.1021/acs.bioconjchem.7b00501. Epub 2017 Oct 20.


High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.

Zhai Y, Wu R, Kuick R, Sessine MS, Schulman S, Green M, Fearon ER, Cho KR.

J Pathol. 2017 Sep;243(1):16-25. doi: 10.1002/path.4927. Epub 2017 Jul 25. Erratum in: J Pathol. 2017 Oct;243(2):267.


Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.

Xu T, Zhang H, Park SS, Venneti S, Kuick R, Ha K, Michael LE, Santi M, Uchida C, Uchida T, Srinivasan A, Olson JM, Dlugosz AA, Camelo-Piragua S, Rual JF.

Neoplasia. 2017 Mar;19(3):216-225. doi: 10.1016/j.neo.2017.01.002. Epub 2017 Feb 3.


BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.

Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER.

Elife. 2017 Jan 10;6. pii: e20331. doi: 10.7554/eLife.20331.


Detection of Sessile Serrated Adenomas in the Proximal Colon Using Wide-Field Fluorescence Endoscopy.

Joshi BP, Dai Z, Gao Z, Lee JH, Ghimire N, Chen J, Prabhu A, Wamsteker EJ, Kwon RS, Elta GH, Stoffel EM, Pant A, Kaltenbach T, Soetikno RM, Appelman HD, Kuick R, Turgeon DK, Wang TD.

Gastroenterology. 2017 Apr;152(5):1002-1013.e9. doi: 10.1053/j.gastro.2016.12.009. Epub 2016 Dec 22.


Overexpressed Claudin-1 Can Be Visualized Endoscopically in Colonic Adenomas In Vivo.

Rabinsky EF, Joshi BP, Pant A, Zhou J, Duan X, Smith A, Kuick R, Fan S, Nusrat A, Owens SR, Appelman HD, Wang TD.

Cell Mol Gastroenterol Hepatol. 2015 Dec 13;2(2):222-237. eCollection 2016 Mar.


In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft.

Zhou Q, Li Z, Zhou J, Joshi BP, Li G, Duan X, Kuick R, Owens SR, Wang TD.

Photoacoustics. 2016 Apr 22;4(2):43-54. eCollection 2016 Jun.


Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse.

Wu R, Zhai Y, Kuick R, Karnezis AN, Garcia P, Naseem A, Hu TC, Fearon ER, Cho KR.

J Pathol. 2016 Nov;240(3):341-351. doi: 10.1002/path.4783.


Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas.

Ferrer-Torres D, Nancarrow DJ, Kuick R, Thomas DG, Nadal E, Lin J, Chang AC, Reddy RM, Orringer MB, Taylor JM, Wang TD, Beer DG.

Oncotarget. 2016 Aug 23;7(34):54867-54882. doi: 10.18632/oncotarget.10253.


EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression.

Drelon C, Berthon A, Mathieu M, Ragazzon B, Kuick R, Tabbal H, Septier A, Rodriguez S, Batisse-Lignier M, Sahut-Barnola I, Dumontet T, Pointud JC, Lefrançois-Martinez AM, Baron S, Giordano TJ, Bertherat J, Martinez A, Val P.

Hum Mol Genet. 2016 Jul 1;25(13):2789-2800. Epub 2016 May 5.


Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer.

Wang W, Kryczek I, Dostál L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W.

Cell. 2016 May 19;165(5):1092-1105. doi: 10.1016/j.cell.2016.04.009. Epub 2016 Apr 28.


Design and Synthesis of Near-Infrared Peptide for in Vivo Molecular Imaging of HER2.

Joshi BP, Zhou J, Pant A, Duan X, Zhou Q, Kuick R, Owens SR, Appelman H, Wang TD.

Bioconjug Chem. 2016 Feb 17;27(2):481-94. doi: 10.1021/acs.bioconjchem.5b00565. Epub 2015 Dec 28.


Resveratrol inhibits ovarian tumor growth in an in vivo mouse model.

Tan L, Wang W, He G, Kuick RD, Gossner G, Kueck AS, Wahl H, Opipari AW, Liu JR.

Cancer. 2016 Mar 1;122(5):722-9. doi: 10.1002/cncr.29793. Epub 2015 Nov 30.


Intra-tumor genetic heterogeneity in rectal cancer.

Hardiman KM, Ulintz PJ, Kuick RD, Hovelson DH, Gates CM, Bhasi A, Rodrigues Grant A, Liu J, Cani AK, Greenson JK, Tomlins SA, Fearon ER.

Lab Invest. 2016 Jan;96(1):4-15. doi: 10.1038/labinvest.2015.131. Epub 2015 Nov 16.


The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.

Pinnell N, Yan R, Cho HJ, Keeley T, Murai MJ, Liu Y, Alarcon AS, Qin J, Wang Q, Kuick R, Elenitoba-Johnson KS, Maillard I, Samuelson LC, Cierpicki T, Chiang MY.

Immunity. 2015 Nov 17;43(5):870-83. doi: 10.1016/j.immuni.2015.10.007. Epub 2015 Oct 27.


Multimodal endoscope can quantify wide-field fluorescence detection of Barrett's neoplasia.

Joshi BP, Duan X, Kwon RS, Piraka C, Elmunzer BJ, Lu S, Rabinsky EF, Beer DG, Appelman HD, Owens SR, Kuick R, Doguchi N, Turgeon DK, Wang TD.

Endoscopy. 2016 Feb;48(2):A1-A13. doi: 10.1055/s-0034-1392803. Epub 2015 Oct 1.


Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.

Zhai Y, Kuick R, Tipton C, Wu R, Sessine M, Wang Z, Baker SJ, Fearon ER, Cho KR.

J Pathol. 2016 Jan;238(1):21-30. doi: 10.1002/path.4599. Epub 2015 Sep 15.


Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands.

Nishimoto K, Tomlins SA, Kuick R, Cani AK, Giordano TJ, Hovelson DH, Liu CJ, Sanjanwala AR, Edwards MA, Gomez-Sanchez CE, Nanba K, Rainey WE.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4591-9. doi: 10.1073/pnas.1505529112. Epub 2015 Aug 3.


EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging.

Zhou J, Joshi BP, Duan X, Pant A, Qiu Z, Kuick R, Owens SR, Wang TD.

Clin Transl Gastroenterol. 2015 Jul 16;6:e101. doi: 10.1038/ctg.2015.28.


Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.

Walczak EM, Kuick R, Finco I, Bohin N, Hrycaj SM, Wellik DM, Hammer GD.

Mol Endocrinol. 2014 Sep;28(9):1471-86. doi: 10.1210/me.2014-1060. Epub 2014 Jul 16. Erratum in: Mol Endocrinol. 2015 Dec;29(12):1805.


Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells.

Holden VI, Lenio S, Kuick R, Ramakrishnan SK, Shah YM, Bachman MA.

Infect Immun. 2014 Sep;82(9):3826-36. doi: 10.1128/IAI.01849-14. Epub 2014 Jun 30.


Glycogen Synthase Kinase 3β in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.

Zhang Q, Bhojani MS, Ben-Josef E, Spalding AC, Kuick R, Sun Y, Morgan MA.

J Carcinog Mutagen. 2013 Aug 16;4(3):147.


Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.

Cui TX, Kryczek I, Zhao L, Zhao E, Kuick R, Roh MH, Vatan L, Szeliga W, Mao Y, Thomas DG, Kotarski J, Tarkowski R, Wicha M, Cho K, Giordano T, Liu R, Zou W.

Immunity. 2013 Sep 19;39(3):611-21. doi: 10.1016/j.immuni.2013.08.025. Epub 2013 Sep 5.


POD-1 binding to the E-box sequence inhibits SF-1 and StAR expression in human adrenocortical tumor cells.

França MM, Ferraz-de-Souza B, Santos MG, Lerario AM, Fragoso MC, Latronico AC, Kuick RD, Hammer GD, Lotfi CF.

Mol Cell Endocrinol. 2013 May 22;371(1-2):140-7. doi: 10.1016/j.mce.2012.12.029. Epub 2013 Jan 9.


Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.

Rakowski LA, Garagiola DD, Li CM, Decker M, Caruso S, Jones M, Kuick R, Cierpicki T, Maillard I, Chiang MY.

Cancer Res. 2013 Jan 15;73(2):930-41. doi: 10.1158/0008-5472.CAN-12-1389. Epub 2012 Nov 16.


Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.

Heaton JH, Wood MA, Kim AC, Lima LO, Barlaskar FM, Almeida MQ, Fragoso MC, Kuick R, Lerario AM, Simon DP, Soares IC, Starnes E, Thomas DG, Latronico AC, Giordano TJ, Hammer GD.

Am J Pathol. 2012 Sep;181(3):1017-33. doi: 10.1016/j.ajpath.2012.05.026. Epub 2012 Jul 15.


Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells.

He S, Wang J, Kato K, Xie F, Varambally S, Mineishi S, Kuick R, Mochizuki K, Liu Y, Nieves E, Mani RS, Chinnaiyan AM, Marquez VE, Zhang Y.

Blood. 2012 Feb 2;119(5):1274-82. doi: 10.1182/blood-2011-06-364422. Epub 2011 Nov 23.


Comprehensive proteomic profiling of aldehyde dehydrogenases in lung adenocarcinoma cell lines.

Zhang Q, Taguchi A, Schliekelman M, Wong CH, Chin A, Kuick R, Misek DE, Hanash S.

Int J Proteomics. 2011;2011:145010. doi: 10.1155/2011/145010. Epub 2011 Oct 29.


Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach.

Reka AK, Kuick R, Kurapati H, Standiford TJ, Omenn GS, Keshamouni VG.

J Thorac Oncol. 2011 Nov;6(11):1784-92. doi: 10.1097/JTO.0b013e31822adfb0.


TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth.

Standiford TJ, Kuick R, Bhan U, Chen J, Newstead M, Keshamouni VG.

Oncogene. 2011 May 26;30(21):2475-84. doi: 10.1038/onc.2010.619. Epub 2011 Jan 31.


CLU blocks HDACI-mediated killing of neuroblastoma.

Subramanian C, Jarzembowski JA, Halsey SM, Kuick R, Opipari AW Jr, Castle VP, Kwok RP.

Tumour Biol. 2011 Apr;32(2):285-94. doi: 10.1007/s13277-010-0120-y. Epub 2010 Nov 2.


Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA.

Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD.

Mol Endocrinol. 2010 Dec;24(12):2281-91. doi: 10.1210/me.2010-0133. Epub 2010 Oct 13.


Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease.

Kato K, Cui S, Kuick R, Mineishi S, Hexner E, Ferrara JL, Emerson SG, Zhang Y.

Biol Blood Marrow Transplant. 2010 Jun;16(6):751-71. doi: 10.1016/j.bbmt.2010.01.012. Epub 2010 Jan 29.


ConceptGen: a gene set enrichment and gene set relation mapping tool.

Sartor MA, Mahavisno V, Keshamouni VG, Cavalcoli J, Wright Z, Karnovsky A, Kuick R, Jagadish HV, Mirel B, Weymouth T, Athey B, Omenn GS.

Bioinformatics. 2010 Feb 15;26(4):456-63. doi: 10.1093/bioinformatics/btp683. Epub 2009 Dec 9.


IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.

Bommer GT, Feng Y, Iura A, Giordano TJ, Kuick R, Kadikoy H, Sikorski D, Wu R, Cho KR, Fearon ER.

J Biol Chem. 2010 Jan 15;285(3):1928-38. doi: 10.1074/jbc.M109.060319. Epub 2009 Oct 20.

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