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Items: 1 to 50 of 257

1.

Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope.

Long F, Doyle M, Fernandez E, Miller AS, Klose T, Sevvana M, Bryan A, Davidson E, Doranz BJ, Kuhn RJ, Diamond MS, Crowe JE Jr, Rossmann MG.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1591-1596. doi: 10.1073/pnas.1815432116. Epub 2019 Jan 14.

PMID:
30642974
2.

Amikacin target achievement in adult cystic fibrosis patients utilizing Monte Carlo simulation.

Nolt VD, Pijut KD, Autry EB, Williams WC, Burgess DS, Burgess DR, Arora V, Kuhn RJ.

Pediatr Pulmonol. 2019 Jan;54(1):33-39. doi: 10.1002/ppul.24194. Epub 2018 Dec 3.

PMID:
30507069
3.

Cesarean section in Australian women with epilepsy.

Vajda FJE, O'Brien TJ, Graham JE, Hitchcock AA, Kuhn RJP, Lander CM, Eadie MJ.

Epilepsy Behav. 2018 Dec;89:126-129. doi: 10.1016/j.yebeh.2018.10.008. Epub 2018 Nov 7.

PMID:
30414529
4.

Flaviviruses have imperfect icosahedral symmetry.

Therkelsen MD, Klose T, Vago F, Jiang W, Rossmann MG, Kuhn RJ.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11608-11612. doi: 10.1073/pnas.1809304115. Epub 2018 Oct 22.

5.

Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution.

Sevvana M, Long F, Miller AS, Klose T, Buda G, Sun L, Kuhn RJ, Rossmann MG.

Structure. 2018 Sep 4;26(9):1169-1177.e3. doi: 10.1016/j.str.2018.05.006. Epub 2018 Jun 26.

PMID:
29958768
6.

Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site.

Narwal M, Singh H, Pratap S, Malik A, Kuhn RJ, Kumar P, Tomar S.

Int J Biol Macromol. 2018 Sep;116:451-462. doi: 10.1016/j.ijbiomac.2018.05.007. Epub 2018 May 4.

PMID:
29730006
7.

Zika Virus Can Strongly Infect and Disrupt Secondary Organizers in the Ventricular Zone of the Embryonic Chicken Brain.

Thawani A, Sirohi D, Kuhn RJ, Fekete DM.

Cell Rep. 2018 Apr 17;23(3):692-700. doi: 10.1016/j.celrep.2018.03.080.

8.

Alphavirus Nucleocapsid Packaging and Assembly.

Mendes A, Kuhn RJ.

Viruses. 2018 Mar 20;10(3). pii: E138. doi: 10.3390/v10030138. Review.

9.

Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes.

Chotiwan N, Andre BG, Sanchez-Vargas I, Islam MN, Grabowski JM, Hopf-Jannasch A, Gough E, Nakayasu E, Blair CD, Belisle JT, Hill CA, Kuhn RJ, Perera R.

PLoS Pathog. 2018 Feb 15;14(2):e1006853. doi: 10.1371/journal.ppat.1006853. eCollection 2018 Feb.

10.

Structural biology of Zika virus and other flaviviruses.

Hasan SS, Sevvana M, Kuhn RJ, Rossmann MG.

Nat Struct Mol Biol. 2018 Jan;25(1):13-20. doi: 10.1038/s41594-017-0010-8. Epub 2018 Jan 8. Review.

PMID:
29323278
11.

The Zika virus envelope protein glycan loop regulates virion antigenicity.

Goo L, DeMaso CR, Pelc RS, Ledgerwood JE, Graham BS, Kuhn RJ, Pierson TC.

Virology. 2018 Feb;515:191-202. doi: 10.1016/j.virol.2017.12.032. Epub 2018 Jan 2.

12.

Zika Virus Structure, Maturation, and Receptors.

Sirohi D, Kuhn RJ.

J Infect Dis. 2017 Dec 16;216(suppl_10):S935-S944. doi: 10.1093/infdis/jix515. Review.

13.

Can an FDA-Approved Alzheimer's Drug Be Repurposed for Alleviating Neuronal Symptoms of Zika Virus?

Sirohi D, Kuhn RJ.

MBio. 2017 Jun 27;8(3). pii: e00916-17. doi: 10.1128/mBio.00916-17.

14.

A human antibody against Zika virus crosslinks the E protein to prevent infection.

Hasan SS, Miller A, Sapparapu G, Fernandez E, Klose T, Long F, Fokine A, Porta JC, Jiang W, Diamond MS, Crowe JE Jr, Kuhn RJ, Rossmann MG.

Nat Commun. 2017 Mar 16;8:14722. doi: 10.1038/ncomms14722.

15.

Spatial and Temporal Analysis of Alphavirus Replication and Assembly in Mammalian and Mosquito Cells.

Jose J, Taylor AB, Kuhn RJ.

MBio. 2017 Feb 14;8(1). pii: e02294-16. doi: 10.1128/mBio.02294-16.

16.

RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells.

Grabowski JM, Gulia-Nuss M, Kuhn RJ, Hill CA.

Parasit Vectors. 2017 Jan 13;10(1):24. doi: 10.1186/s13071-016-1944-0.

17.

Structure of the immature Zika virus at 9 Å resolution.

Prasad VM, Miller AS, Klose T, Sirohi D, Buda G, Jiang W, Kuhn RJ, Rossmann MG.

Nat Struct Mol Biol. 2017 Feb;24(2):184-186. doi: 10.1038/nsmb.3352. Epub 2017 Jan 9.

18.

Extended surface for membrane association in Zika virus NS1 structure.

Brown WC, Akey DL, Konwerski JR, Tarrasch JT, Skiniotis G, Kuhn RJ, Smith JL.

Nat Struct Mol Biol. 2016 Sep;23(9):865-7. doi: 10.1038/nsmb.3268. Epub 2016 Jul 25.

19.

Enhancing dengue virus maturation using a stable furin over-expressing cell line.

Mukherjee S, Sirohi D, Dowd KA, Chen Z, Diamond MS, Kuhn RJ, Pierson TC.

Virology. 2016 Oct;497:33-40. doi: 10.1016/j.virol.2016.06.022. Epub 2016 Jul 13.

20.

The 3.8 Å resolution cryo-EM structure of Zika virus.

Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ.

Science. 2016 Apr 22;352(6284):467-70. doi: 10.1126/science.aaf5316. Epub 2016 Mar 31.

21.

Changes in the Proteome of Langat-Infected Ixodes scapularis ISE6 Cells: Metabolic Pathways Associated with Flavivirus Infection.

Grabowski JM, Perera R, Roumani AM, Hedrick VE, Inerowicz HD, Hill CA, Kuhn RJ.

PLoS Negl Trop Dis. 2016 Feb 9;10(2):e0004180. doi: 10.1371/journal.pntd.0004180. eCollection 2016 Feb.

22.

Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J, Ribeiro JM, Megy K, Thimmapuram J, Miller JR, Walenz BP, Koren S, Hostetler JB, Thiagarajan M, Joardar VS, Hannick LI, Bidwell S, Hammond MP, Young S, Zeng Q, Abrudan JL, Almeida FC, Ayllón N, Bhide K, Bissinger BW, Bonzon-Kulichenko E, Buckingham SD, Caffrey DR, Caimano MJ, Croset V, Driscoll T, Gilbert D, Gillespie JJ, Giraldo-Calderón GI, Grabowski JM, Jiang D, Khalil SMS, Kim D, Kocan KM, Koči J, Kuhn RJ, Kurtti TJ, Lees K, Lang EG, Kennedy RC, Kwon H, Perera R, Qi Y, Radolf JD, Sakamoto JM, Sánchez-Gracia A, Severo MS, Silverman N, Šimo L, Tojo M, Tornador C, Van Zee JP, Vázquez J, Vieira FG, Villar M, Wespiser AR, Yang Y, Zhu J, Arensburger P, Pietrantonio PV, Barker SC, Shao R, Zdobnov EM, Hauser F, Grimmelikhuijzen CJP, Park Y, Rozas J, Benton R, Pedra JHF, Nelson DR, Unger MF, Tubio JMC, Tu Z, Robertson HM, Shumway M, Sutton G, Wortman JR, Lawson D, Wikel SK, Nene VM, Fraser CM, Collins FH, Birren B, Nelson KE, Caler E, Hill CA.

Nat Commun. 2016 Feb 9;7:10507. doi: 10.1038/ncomms10507.

23.

Pharmacokinetic and Pharmacodynamic Analyses of Ceftaroline in Adults with Cystic Fibrosis.

Autry EB, Rybak JM, Leung NR, Gardner BM, Burgess DR, Anstead MI, Kuhn RJ.

Pharmacotherapy. 2016 Jan;36(1):13-8. doi: 10.1002/phar.1681. Epub 2016 Jan 9.

PMID:
26748559
24.

Fluorescent Protein-Tagged Sindbis Virus E2 Glycoprotein Allows Single Particle Analysis of Virus Budding from Live Cells.

Jose J, Tang J, Taylor AB, Baker TS, Kuhn RJ.

Viruses. 2015 Nov 27;7(12):6182-99. doi: 10.3390/v7122926.

25.

A fast cross-validation method for alignment of electron tomography images based on Beer-Lambert law.

Yan R, Edwards TJ, Pankratz LM, Kuhn RJ, Lanman JK, Liu J, Jiang W.

J Struct Biol. 2015 Nov;192(2):297-306. doi: 10.1016/j.jsb.2015.10.004. Epub 2015 Oct 9.

26.

Simultaneous determination of sample thickness, tilt, and electron mean free path using tomographic tilt images based on Beer-Lambert law.

Yan R, Edwards TJ, Pankratz LM, Kuhn RJ, Lanman JK, Liu J, Jiang W.

J Struct Biol. 2015 Nov;192(2):287-96. doi: 10.1016/j.jsb.2015.09.019. Epub 2015 Oct 9.

27.

Characterization of the proteome of cytoplasmic lipid droplets in mouse enterocytes after a dietary fat challenge.

D'Aquila T, Sirohi D, Grabowski JM, Hedrick VE, Paul LN, Greenberg AS, Kuhn RJ, Buhman KK.

PLoS One. 2015 May 18;10(5):e0126823. doi: 10.1371/journal.pone.0126823. eCollection 2015.

28.

Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host.

Kuhn RJ, Dowd KA, Beth Post C, Pierson TC.

Virology. 2015 May;479-480:508-17. doi: 10.1016/j.virol.2015.03.025. Epub 2015 Mar 30. Review.

29.

Severe Malaria Complicated by G6PD Deficiency in a Pediatric Tanzanian Immigrant.

Damhoff HN, Kuhn RJ, Stadler LP.

J Pediatr Pharmacol Ther. 2014 Oct-Dec;19(4):325-34. doi: 10.5863/1551-6776-19.4.325.

30.

Structure-guided insights on the role of NS1 in flavivirus infection.

Akey DL, Brown WC, Jose J, Kuhn RJ, Smith JL.

Bioessays. 2015 May;37(5):489-94. doi: 10.1002/bies.201400182. Epub 2015 Mar 11.

31.

Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.

Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG.

Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962.

32.

Coupling of replication and assembly in flaviviruses.

Apte-Sengupta S, Sirohi D, Kuhn RJ.

Curr Opin Virol. 2014 Dec;9:134-42. doi: 10.1016/j.coviro.2014.09.020. Epub 2014 Oct 18. Review.

33.

Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers.

Zhang X, Sheng J, Austin SK, Hoornweg TE, Smit JM, Kuhn RJ, Diamond MS, Rossmann MG.

J Virol. 2015 Jan;89(1):743-50. doi: 10.1128/JVI.02411-14. Epub 2014 Oct 29.

34.

A Filtration System That Greatly Reduces Aluminum in Calcium Gluconate Injection, USP Used to Prepare Parenteral Nutrition Solutions.

Yokel RA, Harris WR, Spilling CD, Abramov VP, Lone JM, Kuhn RJ.

J Pediatr Pharmacol Ther. 2014 Jul;19(3):189-95. doi: 10.5863/1551-6776-19.3.189.

35.

Medication preparation in pediatric emergencies: comparison of a web-based, standard-dose, bar code-enabled system and a traditional approach.

Damhoff HN, Kuhn RJ, Baker-Justice SN.

J Pediatr Pharmacol Ther. 2014 Jul;19(3):174-81. doi: 10.5863/1551-6776-19.3.174.

36.

trans-Protease activity and structural insights into the active form of the alphavirus capsid protease.

Aggarwal M, Dhindwal S, Kumar P, Kuhn RJ, Tomar S.

J Virol. 2014 Nov;88(21):12242-53. doi: 10.1128/JVI.01692-14. Epub 2014 Aug 6.

37.

Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognition.

Dowd KA, Mukherjee S, Kuhn RJ, Pierson TC.

J Virol. 2014 Oct;88(20):11726-37. doi: 10.1128/JVI.01140-14. Epub 2014 Jul 30.

38.

A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice.

Yun SI, Song BH, Kim JK, Yun GN, Lee EY, Li L, Kuhn RJ, Rossmann MG, Morrey JD, Lee YM.

PLoS Pathog. 2014 Jul 31;10(7):e1004290. doi: 10.1371/journal.ppat.1004290. eCollection 2014 Jul. Erratum in: PLoS Pathog. 2014 Sep;10(9):e1004465.

39.

Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses.

Schnettler E, Tykalová H, Watson M, Sharma M, Sterken MG, Obbard DJ, Lewis SH, McFarlane M, Bell-Sakyi L, Barry G, Weisheit S, Best SM, Kuhn RJ, Pijlman GP, Chase-Topping ME, Gould EA, Grubhoffer L, Fazakerley JK, Kohl A.

Nucleic Acids Res. 2014 Aug;42(14):9436-46. doi: 10.1093/nar/gku657. Epub 2014 Jul 22.

40.

Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies.

Porta J, Jose J, Roehrig JT, Blair CD, Kuhn RJ, Rossmann MG.

J Virol. 2014 Sep 1;88(17):9616-23. doi: 10.1128/JVI.01286-14. Epub 2014 Jun 11.

41.

Single-step antibody-based affinity cryo-electron microscopy for imaging and structural analysis of macromolecular assemblies.

Yu G, Vago F, Zhang D, Snyder JE, Yan R, Zhang C, Benjamin C, Jiang X, Kuhn RJ, Serwer P, Thompson DH, Jiang W.

J Struct Biol. 2014 Jul;187(1):1-9. doi: 10.1016/j.jsb.2014.04.006. Epub 2014 Apr 26.

42.

Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells.

Junjhon J, Pennington JG, Edwards TJ, Perera R, Lanman J, Kuhn RJ.

J Virol. 2014 May;88(9):4687-97. doi: 10.1128/JVI.00118-14. Epub 2014 Feb 12.

43.

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL.

Science. 2014 Feb 21;343(6173):881-5. doi: 10.1126/science.1247749. Epub 2014 Feb 6.

44.

Neutralizing antibodies can initiate genome release from human enterovirus 71.

Plevka P, Lim PY, Perera R, Cardosa J, Suksatu A, Kuhn RJ, Rossmann MG.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2134-9. doi: 10.1073/pnas.1320624111. Epub 2014 Jan 27.

45.

Impact of azithromycin treatment on macrophage gene expression in subjects with cystic fibrosis.

Cory TJ, Birket SE, Murphy BS, Hayes D Jr, Anstead MI, Kanga JF, Kuhn RJ, Bush HM, Feola DJ.

J Cyst Fibros. 2014 Mar;13(2):164-71. doi: 10.1016/j.jcf.2013.08.007. Epub 2013 Sep 7.

46.

Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor.

Dai HS, Liu Z, Jiang W, Kuhn RJ.

J Virol. 2013 Oct;87(20):11231-43. doi: 10.1128/JVI.01054-13. Epub 2013 Aug 7.

47.

West Nile virus methyltransferase domain interacts with protein kinase G.

Keating JA, Bhattacharya D, Lim PY, Falk S, Weisblum B, Bernard KA, Sharma M, Kuhn RJ, Striker R.

Virol J. 2013 Jul 22;10:242. doi: 10.1186/1743-422X-10-242.

48.

Functional characterization of the alphavirus TF protein.

Snyder JE, Kulcsar KA, Schultz KL, Riley CP, Neary JT, Marr S, Jose J, Griffin DE, Kuhn RJ.

J Virol. 2013 Aug;87(15):8511-23. doi: 10.1128/JVI.00449-13. Epub 2013 May 29.

49.

Ultrastructural analysis of hepatitis C virus particles.

Catanese MT, Uryu K, Kopp M, Edwards TJ, Andrus L, Rice WJ, Silvestry M, Kuhn RJ, Rice CM.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9505-10. doi: 10.1073/pnas.1307527110. Epub 2013 May 20.

50.

Membrane curvature in flaviviruses.

Zhang W, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG.

J Struct Biol. 2013 Jul;183(1):86-94. doi: 10.1016/j.jsb.2013.04.005. Epub 2013 Apr 18.

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