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Items: 44

1.

The spermidine acetyltransferase SpeG regulates transcription of the small RNA rprA.

Hu LI, Filippova EV, Dang J, Pshenychnyi S, Ruan J, Kiryukhina O, Anderson WF, Kuhn ML, Wolfe AJ.

PLoS One. 2018 Dec 18;13(12):e0207563. doi: 10.1371/journal.pone.0207563. eCollection 2018.

2.

A Gcn5-related N-acetyltransferase (GNAT) capable of acetylating polymyxin B and colistin antibiotics in vitro.

Czub MP, Zhang B, Chiarelli MP, Majorek KA, Joe L, Porebski PJ, Revilla A, Wu W, Becker DP, Minor W, Kuhn ML.

Biochemistry. 2018 Nov 30. doi: 10.1021/acs.biochem.8b00946. [Epub ahead of print]

PMID:
30499668
3.

On the Roles of Wheat Endosperm ADP-Glucose Pyrophosphorylase Subunits.

Ferrero DML, Asencion Diez MD, Kuhn ML, Falaschetti CA, Piattoni CV, Iglesias AA, Ballicora MA.

Front Plant Sci. 2018 Oct 16;9:1498. doi: 10.3389/fpls.2018.01498. eCollection 2018.

4.

Resurrecting the Regulatory Properties of the Ostreococcus tauri ADP-Glucose Pyrophosphorylase Large Subunit.

Figueroa CM, Kuhn ML, Hill BL, Iglesias AA, Ballicora MA.

Front Plant Sci. 2018 Oct 30;9:1564. doi: 10.3389/fpls.2018.01564. eCollection 2018.

5.

Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli.

Christensen DG, Meyer JG, Baumgartner JT, D'Souza AK, Nelson WC, Payne SH, Kuhn ML, Schilling B, Wolfe AJ.

MBio. 2018 Oct 23;9(5). pii: e01905-18. doi: 10.1128/mBio.01905-18.

6.

Characterizing metal-binding sites in proteins with X-ray crystallography.

Handing KB, Niedzialkowska E, Shabalin IG, Kuhn ML, Zheng H, Minor W.

Nat Protoc. 2018 May;13(5):1062-1090. doi: 10.1038/nprot.2018.018. Epub 2018 Apr 19.

7.

Structure of the Bacillus anthracis dTDP-l-rhamnose biosynthetic pathway enzyme: dTDP-α-d-glucose 4,6-dehydratase, RfbB.

Gokey T, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

J Struct Biol. 2018 May;202(2):175-181. doi: 10.1016/j.jsb.2018.01.006. Epub 2018 Jan 10.

PMID:
29331609
8.

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RfbC).

Shornikov A, Tran H, Macias J, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

Acta Crystallogr F Struct Biol Commun. 2017 Dec 1;73(Pt 12):664-671. doi: 10.1107/S2053230X17015849. Epub 2017 Nov 10.

9.

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD).

Law A, Stergioulis A, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

Acta Crystallogr F Struct Biol Commun. 2017 Dec 1;73(Pt 12):644-650. doi: 10.1107/S2053230X17015746. Epub 2017 Nov 6.

10.

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA).

Baumgartner J, Lee J, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

Acta Crystallogr F Struct Biol Commun. 2017 Nov 1;73(Pt 11):621-628. doi: 10.1107/S2053230X17015357. Epub 2017 Oct 30.

11.

Generating enzyme and radical-mediated bisubstrates as tools for investigating Gcn5-related N-acetyltransferases.

Reidl C, Majorek KA, Dang J, Tran D, Jew K, Law M, Payne Y, Minor W, Becker DP, Kuhn ML.

FEBS Lett. 2017 Aug;591(15):2348-2361. doi: 10.1002/1873-3468.12753. Epub 2017 Aug 1.

12.

An "Fc-Silenced" IgG1 Format With Extended Half-Life Designed for Improved Stability.

Borrok MJ, Mody N, Lu X, Kuhn ML, Wu H, Dall'Acqua WF, Tsui P.

J Pharm Sci. 2017 Apr;106(4):1008-1017. doi: 10.1016/j.xphs.2016.12.023. Epub 2017 Jan 3.

PMID:
28057542
13.

Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.

Stogios PJ, Kuhn ML, Evdokimova E, Law M, Courvalin P, Savchenko A.

ACS Infect Dis. 2017 Feb 10;3(2):132-143. doi: 10.1021/acsinfecdis.6b00058. Epub 2016 Nov 10.

PMID:
27785912
14.

Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria.

Majorek KA, Osinski T, Tran DT, Revilla A, Anderson WF, Minor W, Kuhn ML.

Biochim Biophys Acta Proteins Proteom. 2017 Jan;1865(1):55-64. doi: 10.1016/j.bbapap.2016.10.011. Epub 2016 Oct 23.

15.

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.

Kuhn ML, Alexander E, Minasov G, Page HJ, Warwrzak Z, Shuvalova L, Flores KJ, Wilson DJ, Shi C, Aldrich CC, Anderson WF.

ACS Infect Dis. 2016 Aug 12;2(8):579-591. Epub 2016 Jul 1.

16.

A novel polyamine allosteric site of SpeG from Vibrio cholerae is revealed by its dodecameric structure.

Filippova EV, Kuhn ML, Osipiuk J, Kiryukhina O, Joachimiak A, Ballicora MA, Anderson WF.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1316-1334. doi: 10.1016/j.jmb.2015.01.009. Epub 2015 Jan 23.

17.

The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites.

AbouElfetouh A, Kuhn ML, Hu LI, Scholle MD, Sorensen DJ, Sahu AK, Becher D, Antelmann H, Mrksich M, Anderson WF, Gibson BW, Schilling B, Wolfe AJ.

Microbiologyopen. 2015 Feb;4(1):66-83. doi: 10.1002/mbo3.223. Epub 2014 Nov 22.

18.

Potential for reduction of streptogramin A resistance revealed by structural analysis of acetyltransferase VatA.

Stogios PJ, Kuhn ML, Evdokimova E, Courvalin P, Anderson WF, Savchenko A.

Antimicrob Agents Chemother. 2014 Dec;58(12):7083-92. doi: 10.1128/AAC.03743-14. Epub 2014 Sep 15.

19.

Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments.

Majorek KA, Kuhn ML, Chruszcz M, Anderson WF, Minor W.

Protein Sci. 2014 Oct;23(10):1359-68. doi: 10.1002/pro.2520. Epub 2014 Jul 30.

20.

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation.

Kuhn ML, Zemaitaitis B, Hu LI, Sahu A, Sorensen D, Minasov G, Lima BP, Scholle M, Mrksich M, Anderson WF, Gibson BW, Schilling B, Wolfe AJ.

PLoS One. 2014 Apr 22;9(4):e94816. doi: 10.1371/journal.pone.0094816. eCollection 2014.

21.

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.

Kuhn ML, Prachi P, Minasov G, Shuvalova L, Ruan J, Dubrovska I, Winsor J, Giraldi M, Biagini M, Liberatori S, Savino S, Bagnoli F, Anderson WF, Grandi G.

FASEB J. 2014 Apr;28(4):1780-93. doi: 10.1096/fj.13-241737. Epub 2014 Jan 13.

22.

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.

Smith JM, Warrington NV, Vierling RJ, Kuhn ML, Anderson WF, Koppisch AT, Freel Meyers CL.

J Antibiot (Tokyo). 2014 Jan;67(1):77-83. doi: 10.1038/ja.2013.105. Epub 2013 Oct 30.

23.

Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa.

Majorek KA, Kuhn ML, Chruszcz M, Anderson WF, Minor W.

J Biol Chem. 2013 Oct 18;288(42):30223-35. doi: 10.1074/jbc.M113.501353. Epub 2013 Sep 3.

24.

Acetylation of the response regulator RcsB controls transcription from a small RNA promoter.

Hu LI, Chi BK, Kuhn ML, Filippova EV, Walker-Peddakotla AJ, Bäsell K, Becher D, Anderson WF, Antelmann H, Wolfe AJ.

J Bacteriol. 2013 Sep;195(18):4174-86. doi: 10.1128/JB.00383-13. Epub 2013 Jul 12.

25.

Unraveling the activation mechanism of the potato tuber ADP-glucose pyrophosphorylase.

Figueroa CM, Kuhn ML, Falaschetti CA, Solamen L, Olsen KW, Ballicora MA, Iglesias AA.

PLoS One. 2013 Jun 24;8(6):e66824. doi: 10.1371/journal.pone.0066824. Print 2013.

26.

The Phytophthora parasitica RXLR effector penetration-specific effector 1 favours Arabidopsis thaliana infection by interfering with auxin physiology.

Evangelisti E, Govetto B, Minet-Kebdani N, Kuhn ML, Attard A, Ponchet M, Panabières F, Gourgues M.

New Phytol. 2013 Jul;199(2):476-89. doi: 10.1111/nph.12270. Epub 2013 Apr 17.

27.

Identification of an active site-bound nitrile hydratase intermediate through single turnover stopped-flow spectroscopy.

Gumataotao N, Kuhn ML, Hajnas N, Holz RC.

J Biol Chem. 2013 May 31;288(22):15532-6. doi: 10.1074/jbc.M112.398909. Epub 2013 Apr 15.

28.

The ancestral activation promiscuity of ADP-glucose pyrophosphorylases from oxygenic photosynthetic organisms.

Kuhn ML, Figueroa CM, Iglesias AA, Ballicora MA.

BMC Evol Biol. 2013 Feb 21;13:51. doi: 10.1186/1471-2148-13-51.

29.

Large scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis.

Filippova EV, Weston LA, Kuhn ML, Geissler B, Gehring AM, Armoush N, Adkins CT, Minasov G, Dubrovska I, Shuvalova L, Winsor JR, Lavis LD, Satchell KJ, Becker DP, Anderson WF, Johnson RJ.

J Biol Chem. 2013 Apr 12;288(15):10522-35. doi: 10.1074/jbc.M112.446625. Epub 2013 Feb 19.

30.

The unique nucleotide specificity of the sucrose synthase from Thermosynechococcus elongatus.

Figueroa CM, Asención Diez MD, Kuhn ML, McEwen S, Salerno GL, Iglesias AA, Ballicora MA.

FEBS Lett. 2013 Jan 16;587(2):165-9. doi: 10.1016/j.febslet.2012.11.011. Epub 2012 Nov 26.

31.

Broad-substrate screen as a tool to identify substrates for bacterial Gcn5-related N-acetyltransferases with unknown substrate specificity.

Kuhn ML, Majorek KA, Minor W, Anderson WF.

Protein Sci. 2013 Feb;22(2):222-30. doi: 10.1002/pro.2199. Epub 2012 Dec 17.

32.

Insights into glycogen metabolism in chemolithoautotrophic bacteria from distinctive kinetic and regulatory properties of ADP-glucose pyrophosphorylase from Nitrosomonas europaea.

Machtey M, Kuhn ML, Flasch DA, Aleanzi M, Ballicora MA, Iglesias AA.

J Bacteriol. 2012 Nov;194(22):6056-65. doi: 10.1128/JB.00810-12. Epub 2012 Sep 7.

33.

Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.

Makowska-Grzyska M, Kim Y, Wu R, Wilton R, Gollapalli DR, Wang XK, Zhang R, Jedrzejczak R, Mack JC, Maltseva N, Mulligan R, Binkowski TA, Gornicki P, Kuhn ML, Anderson WF, Hedstrom L, Joachimiak A.

Biochemistry. 2012 Aug 7;51(31):6148-63. Epub 2012 Jul 25.

34.

The Fe-type nitrile hydratase from Comamonas testosteroni Ni1 does not require an activator accessory protein for expression in Escherichia coli.

Kuhn ML, Martinez S, Gumataotao N, Bornscheuer U, Liu D, Holz RC.

Biochem Biophys Res Commun. 2012 Aug 3;424(3):365-70. doi: 10.1016/j.bbrc.2012.06.036. Epub 2012 Jun 16.

PMID:
22713452
35.

Bi-national and interdisciplinary course in enzyme engineering.

Kuhn ML, Figueroa CM, Aleanzi M, Olsen KW, Iglesias AA, Ballicora MA.

Biochem Mol Biol Educ. 2010 Nov;38(6):370-9. doi: 10.1002/bmb.20438.

36.

Ostreococcus tauri ADP-glucose pyrophosphorylase reveals alternative paths for the evolution of subunit roles.

Kuhn ML, Falaschetti CA, Ballicora MA.

J Biol Chem. 2009 Dec 4;284(49):34092-102. doi: 10.1074/jbc.M109.037614. Epub 2009 Sep 8.

37.

Repeat-induced point mutation (RIP) as an alternative mechanism of evolution toward virulence in Leptosphaeria maculans.

Fudal I, Ross S, Brun H, Besnard AL, Ermel M, Kuhn ML, Balesdent MH, Rouxel T.

Mol Plant Microbe Interact. 2009 Aug;22(8):932-41. doi: 10.1094/MPMI-22-8-0932.

38.

Leptosphaeria maculans avirulence gene AvrLm4-7 confers a dual recognition specificity by the Rlm4 and Rlm7 resistance genes of oilseed rape, and circumvents Rlm4-mediated recognition through a single amino acid change.

Parlange F, Daverdin G, Fudal I, Kuhn ML, Balesdent MH, Blaise F, Grezes-Besset B, Rouxel T.

Mol Microbiol. 2009 Feb;71(4):851-63. doi: 10.1111/j.1365-2958.2008.06547.x. Epub 2008 Dec 23.

39.

New Avirulence Genes in the Phytopathogenic Fungus Leptosphaeria maculans.

Balesdent MH, Attard A, Kühn ML, Rouxel T.

Phytopathology. 2002 Oct;92(10):1122-33. doi: 10.1094/PHYTO.2002.92.10.1122.

40.

Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic.

Ventriglia T, Kuhn ML, Ruiz MT, Ribeiro-Pedro M, Valverde F, Ballicora MA, Preiss J, Romero JM.

Plant Physiol. 2008 Sep;148(1):65-76. doi: 10.1104/pp.108.122846. Epub 2008 Jul 9.

41.

Genome structure impacts molecular evolution at the AvrLm1 avirulence locus of the plant pathogen Leptosphaeria maculans.

Gout L, Kuhn ML, Vincenot L, Bernard-Samain S, Cattolico L, Barbetti M, Moreno-Rico O, Balesdent MH, Rouxel T.

Environ Microbiol. 2007 Dec;9(12):2978-92.

PMID:
17991027
42.

Heterochromatin-like regions as ecological niches for avirulence genes in the Leptosphaeria maculans genome: map-based cloning of AvrLm6.

Fudal I, Ross S, Gout L, Blaise F, Kuhn ML, Eckert MR, Cattolico L, Bernard-Samain S, Balesdent MH, Rouxel T.

Mol Plant Microbe Interact. 2007 Apr;20(4):459-70.

43.

Lost in the middle of nowhere: the AvrLm1 avirulence gene of the Dothideomycete Leptosphaeria maculans.

Gout L, Fudal I, Kuhn ML, Blaise F, Eckert M, Cattolico L, Balesdent MH, Rouxel T.

Mol Microbiol. 2006 Apr;60(1):67-80.

44.

Analysis of molecular markers genetically linked to the Leptosphaeria maculans avirulence gene AvrLm1 in field populations indicates a highly conserved event leading to virulence on Rlm1 genotypes.

Attard A, Gout L, Gourgues M, Kühn ML, Schmit J, Laroche S, Ansan-Melayah D, Billault A, Cattolico L, Balesdent MH, Rouxel T.

Mol Plant Microbe Interact. 2002 Jul;15(7):672-82.

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