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Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice.

Angoa-Pérez M, Zagorac B, Winters AD, Greenberg JM, Ahmad M, Theis KR, Kuhn DM.

PLoS One. 2020 Jan 24;15(1):e0227774. doi: 10.1371/journal.pone.0227774. eCollection 2020.


Abuse potential and toxicity of the synthetic cathinones (i.e., "Bath salts").

Riley AL, Nelson KH, To P, López-Arnau R, Xu P, Wang D, Wang Y, Shen HW, Kuhn DM, Angoa-Perez M, Anneken JH, Muskiewicz D, Hall FS.

Neurosci Biobehav Rev. 2019 May 14. pii: S0149-7634(18)30319-1. doi: 10.1016/j.neubiorev.2018.07.015. [Epub ahead of print] Review.


Aspirin-Exacerbated Respiratory Disease.

Kuhn DM.

N Engl J Med. 2018 Dec 6;379(23):2281. doi: 10.1056/NEJMc1813469. No abstract available.


Low-Income Texas Women's Experiences Accessing Their Desired Contraceptive Method at the First Postpartum Visit.

Coleman-Minahan K, Dillaway CH, Canfield C, Kuhn DM, Strandberg KS, Potter JE.

Perspect Sex Reprod Health. 2018 Dec;50(4):189-198. doi: 10.1363/psrh.12083. Epub 2018 Dec 3.


Genetic depletion of 5-HT increases central apnea frequency and duration and dampens arousal but does not impact the circadian modulation of these variables.

Mateika JH, Komnenov D, Pop A, Kuhn DM.

J Appl Physiol (1985). 2019 Jan 1;126(1):1-10. doi: 10.1152/japplphysiol.00724.2018. Epub 2018 Oct 18.


Dissociation between hypothermia and neurotoxicity caused by mephedrone and methcathinone in TPH2 knockout mice.

Anneken JH, Angoa-Perez M, Sati GC, Crich D, Kuhn DM.

Psychopharmacology (Berl). 2019 Mar;236(3):1097-1106. doi: 10.1007/s00213-018-4991-8. Epub 2018 Aug 3.


Assessing the role of dopamine in the differential neurotoxicity patterns of methamphetamine, mephedrone, methcathinone and 4-methylmethamphetamine.

Anneken JH, Angoa-Perez M, Sati GC, Crich D, Kuhn DM.

Neuropharmacology. 2018 May 15;134(Pt A):46-56. doi: 10.1016/j.neuropharm.2017.08.033. Epub 2017 Aug 26.


Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.

Acabchuk R, Briggs DI, Angoa-Pérez M, Powers M, Wolferz R Jr, Soloway M, Stern M, Talbot LR, Kuhn DM, Conover JC.

Concussion. 2016 Dec;1(3). doi: 10.2217/cnc-2015-0001. Epub 2016 May 25.


Prolonged Repetitive Head Trauma Induces a Singular Chronic Traumatic Encephalopathy-Like Pathology in White Matter Despite Transient Behavioral Abnormalities.

Briggs DI, Angoa-Pérez M, Kuhn DM.

Am J Pathol. 2016 Nov;186(11):2869-2886. doi: 10.1016/j.ajpath.2016.07.013. Epub 2016 Sep 20.


Neurotoxicology of Synthetic Cathinone Analogs.

Angoa-Pérez M, Anneken JH, Kuhn DM.

Curr Top Behav Neurosci. 2017;32:209-230. doi: 10.1007/7854_2016_21. Review.


Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system.

Komnenov D, Solarewicz JZ, Afzal F, Nantwi KD, Kuhn DM, Mateika JH.

J Appl Physiol (1985). 2016 Aug 1;121(2):545-57. doi: 10.1152/japplphysiol.00448.2016. Epub 2016 Jul 8.


Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI.

Perrine SA, Ghoddoussi F, Desai K, Kohler RJ, Eapen AT, Lisieski MJ, Angoa-Perez M, Kuhn DM, Bosse KE, Conti AC, Bissig D, Berkowitz BA.

NMR Biomed. 2015 Nov;28(11):1480-8. doi: 10.1002/nbm.3409. Epub 2015 Sep 28.


Neuroanatomical dichotomy of sexual behaviors in rodents: a special emphasis on brain serotonin.

Angoa-Pérez M, Kuhn DM.

Behav Pharmacol. 2015 Sep;26(6):595-606. doi: 10.1097/FBP.0000000000000157. Review.


Brain serotonin signaling does not determine sexual preference in male mice.

Angoa-Pérez M, Herrera-Mundo N, Kane MJ, Sykes CE, Anneken JH, Francescutti DM, Kuhn DM.

PLoS One. 2015 Feb 23;10(2):e0118603. doi: 10.1371/journal.pone.0118603. eCollection 2015.


Neuronal serotonin in the regulation of maternal behavior in rodents.

Angoa-Pérez M, Kuhn DM.

Neurotransmitter (Houst). 2015;2. pii: e615. Epub 2015 Mar 2.


The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

Solarewicz JZ, Angoa-Perez M, Kuhn DM, Mateika JH.

Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R10-7. doi: 10.1152/ajpregu.00400.2014. Epub 2014 Nov 12.


Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.

Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Sykes CE, Francescutti DM, Kuhn DM.

ACS Chem Neurosci. 2014 Oct 15;5(10):908-19. doi: 10.1021/cn500096g. Epub 2014 Aug 12.


Brain serotonin determines maternal behavior and offspring survival.

Angoa-Pérez M, Kane MJ, Sykes CE, Perrine SA, Church MW, Kuhn DM.

Genes Brain Behav. 2014 Sep;13(7):579-91. doi: 10.1111/gbb.12159. Epub 2014 Aug 28.


Diagnosis and management of Enterococcus spp infections during rehabilitation of cold-stunned Kemp's ridley turtles (Lepidochelys kempii): 50 cases (2006-2012).

Innis CJ, Braverman H, Cavin JM, Ceresia ML, Baden LR, Kuhn DM, Frasca S Jr, McGowan JP, Hirokawa K, Weber ES 3rd, Stacy B, Merigo C.

J Am Vet Med Assoc. 2014 Aug 1;245(3):315-23. doi: 10.2460/javma.245.3.315.


Animal models of sports-related head injury: bridging the gap between pre-clinical research and clinical reality.

Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Viano DC, Kuhn DM.

J Neurochem. 2014 Jun;129(6):916-31. doi: 10.1111/jnc.12690. Epub 2014 Mar 19. Review.


Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice.

Angoa-Pérez M, Kane MJ, Briggs DI, Francescutti DM, Kuhn DM.

J Vis Exp. 2013 Dec 24;(82):50978. doi: 10.3791/50978.


Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin.

Hickner S, Hussain N, Angoa-Perez M, Francescutti DM, Kuhn DM, Mateika JH.

J Appl Physiol (1985). 2014 Feb 1;116(3):240-50. doi: 10.1152/japplphysiol.01197.2013. Epub 2013 Dec 12.


Effects of combined treatment with mephedrone and methamphetamine or 3,4-methylenedioxymethamphetamine on serotonin nerve endings of the hippocampus.

Angoa-Pérez M, Kane MJ, Herrera-Mundo N, Francescutti DM, Kuhn DM.

Life Sci. 2014 Feb 27;97(1):31-6. doi: 10.1016/j.lfs.2013.07.015. Epub 2013 Jul 24.


Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA.

Angoa-Pérez M, Kane MJ, Briggs DI, Francescutti DM, Sykes CE, Shah MM, Thomas DM, Kuhn DM.

J Neurochem. 2013 Apr;125(1):102-10. doi: 10.1111/jnc.12114. Epub 2013 Jan 8.


Development and preliminary validation of the Patient Perceptions of Integrated Care survey.

Singer SJ, Friedberg MW, Kiang MV, Dunn T, Kuhn DM.

Med Care Res Rev. 2013 Apr;70(2):143-64. doi: 10.1177/1077558712465654. Epub 2012 Nov 15.


Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism.

Kane MJ, Angoa-Peréz M, Briggs DI, Sykes CE, Francescutti DM, Rosenberg DR, Kuhn DM.

PLoS One. 2012;7(11):e48975. doi: 10.1371/journal.pone.0048975. Epub 2012 Nov 6.


Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility.

Jiménez-Trejo F, Tapia-Rodríguez M, Cerbón M, Kuhn DM, Manjarrez-Gutiérrez G, Mendoza-Rodríguez CA, Picazo O.

Reproduction. 2012 Dec;144(6):677-85. doi: 10.1530/REP-12-0145. Epub 2012 Oct 1.


Altered gene expression in cultured microglia in response to simulated blast overpressure: possible role of pulse duration.

Kane MJ, Angoa-Pérez M, Francescutti DM, Sykes CE, Briggs DI, Leung LY, VandeVord PJ, Kuhn DM.

Neurosci Lett. 2012 Jul 26;522(1):47-51. doi: 10.1016/j.neulet.2012.06.012. Epub 2012 Jun 12.


Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity.

Angoa-Pérez M, Kane MJ, Briggs DI, Sykes CE, Shah MM, Francescutti DM, Rosenberg DR, Thomas DM, Kuhn DM.

J Neurochem. 2012 Jun;121(6):974-84. doi: 10.1111/j.1471-4159.2012.07739.x. Epub 2012 Apr 13.


The Candida glabrata adhesin Epa1p causes adhesion, phagocytosis, and cytokine secretion by innate immune cells.

Kuhn DM, Vyas VK.

FEMS Yeast Res. 2012 Jun;12(4):398-414. doi: 10.1111/j.1567-1364.2011.00785.x. Epub 2012 Jan 23.


Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum.

Angoa-Pérez M, Kane MJ, Francescutti DM, Sykes KE, Shah MM, Mohammed AM, Thomas DM, Kuhn DM.

J Neurochem. 2012 Mar;120(6):1097-107. doi: 10.1111/j.1471-4159.2011.07632.x. Epub 2012 Feb 9.


A mouse model of human repetitive mild traumatic brain injury.

Kane MJ, Angoa-Pérez M, Briggs DI, Viano DC, Kreipke CW, Kuhn DM.

J Neurosci Methods. 2012 Jan 15;203(1):41-9. doi: 10.1016/j.jneumeth.2011.09.003. Epub 2011 Sep 12.


Nucleus accumbens invulnerability to methamphetamine neurotoxicity.

Kuhn DM, Angoa-Pérez M, Thomas DM.

ILAR J. 2011;52(3):352-65. doi: 10.1093/ilar.52.3.352. Review.


Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease.

Kuhn DM, Sykes CE, Geddes TJ, Jaunarajs KL, Bishop C.

J Neurochem. 2011 Feb;116(3):426-37. doi: 10.1111/j.1471-4159.2010.07123.x. Epub 2010 Dec 13.


MDMA administration decreases serotonin but not N-acetylaspartate in the rat brain.

Perrine SA, Ghoddoussi F, Michaels MS, Hyde EM, Kuhn DM, Galloway MP.

Neurotoxicology. 2010 Dec;31(6):654-61. doi: 10.1016/j.neuro.2010.08.005. Epub 2010 Aug 26.


The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum.

Thomas DM, Angoa Pérez M, Francescutti-Verbeem DM, Shah MM, Kuhn DM.

J Neurochem. 2010 Nov;115(3):595-605. doi: 10.1111/j.1471-4159.2010.06950.x. Epub 2010 Sep 6.


Potential mechanisms underlying anxiety and depression in Parkinson's disease: consequences of l-DOPA treatment.

Eskow Jaunarajs KL, Angoa-Perez M, Kuhn DM, Bishop C.

Neurosci Biobehav Rev. 2011 Jan;35(3):556-64. doi: 10.1016/j.neubiorev.2010.06.007. Epub 2010 Jul 6. Review.


Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damage.

Angoa-Pérez M, Kreipke CW, Thomas DM, Van Shura KE, Lyman M, McDonough JH, Kuhn DM.

Neurotoxicology. 2010 Dec;31(6):738-46. doi: 10.1016/j.neuro.2010.06.007. Epub 2010 Jul 1.


Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity.

Thomas DM, Francescutti-Verbeem DM, Kuhn DM.

J Neurochem. 2009 Jun;109(6):1745-55. doi: 10.1111/j.1471-4159.2009.06094.x. Epub 2009 Apr 28.


Dopamine disposition in the presynaptic process regulates the severity of methamphetamine-induced neurotoxicity.

Kuhn DM, Francescutti-Verbeem DM, Thomas DM.

Ann N Y Acad Sci. 2008 Oct;1139:118-26. doi: 10.1196/annals.1432.026.


The existence of a local 5-hydroxytryptaminergic system in peripheral arteries.

Ni W, Geddes TJ, Priestley JR, Szasz T, Kuhn DM, Watts SW.

Br J Pharmacol. 2008 Jun;154(3):663-74. doi: 10.1038/bjp.2008.111. Epub 2008 Apr 14.


Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling.

Thomas DM, Francescutti-Verbeem DM, Kuhn DM.

J Neurochem. 2008 Jul;106(2):696-705. doi: 10.1111/j.1471-4159.2008.05421.x. Epub 2008 Apr 12.


A serotonergic system in veins: serotonin transporter-independent uptake.

Linder AE, Ni W, Szasz T, Burnett R, Diaz J, Geddes TJ, Kuhn DM, Watts SW.

J Pharmacol Exp Ther. 2008 Jun;325(3):714-22. doi: 10.1124/jpet.107.135699. Epub 2008 Mar 5.


The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity.

Thomas DM, Francescutti-Verbeem DM, Kuhn DM.

J Neurochem. 2008 May;105(3):605-16. Epub 2007 Dec 6.


Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II.

Kuhn DM, Sakowski SA, Geddes TJ, Wilkerson C, Haycock JW.

J Neurochem. 2007 Nov;103(4):1567-73. Epub 2007 Aug 28.


MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation.

Bishop C, Taylor JL, Kuhn DM, Eskow KL, Park JY, Walker PD.

Eur J Neurosci. 2006 May;23(10):2669-76.


Problem doctors: is there a system-level solution?

Kuhn DM.

Ann Intern Med. 2006 Jun 6;144(11):861; author reply 863. No abstract available.


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