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Items: 20


Targeting chemokine receptors in HIV: a status report.

Kuhmann SE, Hartley O.

Annu Rev Pharmacol Toxicol. 2008;48:425-61. Review.


Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss.

Anastassopoulou CG, Marozsan AJ, Matet A, Snyder AD, Arts EJ, Kuhmann SE, Moore JP.

PLoS Pathog. 2007 Jun;3(6):e79.


Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands.

Ketas TJ, Kuhmann SE, Palmer A, Zurita J, He W, Ahuja SK, Klasse PJ, Moore JP.

Virology. 2007 Aug 1;364(2):281-90. Epub 2007 Apr 10.


HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry.

Pugach P, Marozsan AJ, Ketas TJ, Landes EL, Moore JP, Kuhmann SE.

Virology. 2007 Apr 25;361(1):212-28. Epub 2006 Dec 12.


Interaction of small molecule inhibitors of HIV-1 entry with CCR5.

Seibert C, Ying W, Gavrilov S, Tsamis F, Kuhmann SE, Palani A, Tagat JR, Clader JW, McCombie SW, Baroudy BM, Smith SO, Dragic T, Moore JP, Sakmar TP.

Virology. 2006 May 25;349(1):41-54. Epub 2006 Feb 21.


Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D).

Marozsan AJ, Kuhmann SE, Morgan T, Herrera C, Rivera-Troche E, Xu S, Baroudy BM, Strizki J, Moore JP.

Virology. 2005 Jul 20;338(1):182-99.


HIV-1 entry inhibitor entrances.

Kuhmann SE, Moore JP.

Trends Pharmacol Sci. 2004 Mar;25(3):117-20. Review. No abstract available.


The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors.

Billick E, Seibert C, Pugach P, Ketas T, Trkola A, Endres MJ, Murgolo NJ, Coates E, Reyes GR, Baroudy BM, Sakmar TP, Moore JP, Kuhmann SE.

J Virol. 2004 Apr;78(8):4134-44.


The prolonged culture of human immunodeficiency virus type 1 in primary lymphocytes increases its sensitivity to neutralization by soluble CD4.

Pugach P, Kuhmann SE, Taylor J, Marozsan AJ, Snyder A, Ketas T, Wolinsky SM, Korber BT, Moore JP.

Virology. 2004 Mar 30;321(1):8-22.


Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor.

Kuhmann SE, Pugach P, Kunstman KJ, Taylor J, Stanfield RL, Snyder A, Strizki JM, Riley J, Baroudy BM, Wilson IA, Korber BT, Wolinsky SM, Moore JP.

J Virol. 2004 Mar;78(6):2790-807. Erratum in: J Virol. 2005 Jun;78(12):6706.


Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.

Veazey RS, Klasse PJ, Ketas TJ, Reeves JD, Piatak M Jr, Kunstman K, Kuhmann SE, Marx PA, Lifson JD, Dufour J, Mefford M, Pandrea I, Wolinsky SM, Doms RW, DeMartino JA, Siciliano SJ, Lyons K, Springer MS, Moore JP.

J Exp Med. 2003 Nov 17;198(10):1551-62.


HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use.

Trkola A, Kuhmann SE, Strizki JM, Maxwell E, Ketas T, Morgan T, Pugach P, Xu S, Wojcik L, Tagat J, Palani A, Shapiro S, Clader JW, McCombie S, Reyes GR, Baroudy BM, Moore JP.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):395-400.


Frequent substitution polymorphisms in African green monkey CCR5 cluster at critical sites for infections by simian immunodeficiency virus SIVagm, implying ancient virus-host coevolution.

Kuhmann SE, Madani N, Diop OM, Platt EJ, Morvan J, Müller-Trutwin MC, Barré-Sinoussi F, Kabat D.

J Virol. 2001 Sep;75(18):8449-60.


A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.

Siciliano SJ, Kuhmann SE, Weng Y, Madani N, Springer MS, Lineberger JE, Danzeisen R, Miller MD, Kavanaugh MP, DeMartino JA, Kabat D.

J Biol Chem. 1999 Jan 22;274(4):1905-13.


Modulation of ecotropic murine retroviruses by N-linked glycosylation of the cell surface receptor/amino acid transporter.

Wang H, Klamo E, Kuhmann SE, Kozak SL, Kavanaugh MP, Kabat D.

J Virol. 1996 Oct;70(10):6884-91.

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