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Serum calretinin as an independent predictor for platinum resistance and prognosis in ovarian cancer.

Link T, Passek S, Wimberger P, Frank K, Vassileva YD, Kramer M, Kuhlmann JD.

Int J Cancer. 2019 Sep 11. doi: 10.1002/ijc.32676. [Epub ahead of print]


Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer.

Kuhlmann JD, Bachmann HS, Link T, Wimberger P, Kröber E, Thomssen C, Mallé B, Bethmann D, Vetter M, Kantelhardt EJ.

Sci Rep. 2019 Aug 29;9(1):12594. doi: 10.1038/s41598-019-47601-x.


Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients.

Göbel A, Kuhlmann JD, Link T, Wimberger P, Link-Rachner C, Thiele S, Dell'Endice S, Furesi G, Breining D, Rauner M, Hofbauer LC, Rachner TD.

J Bone Oncol. 2019 Apr 4;16:100237. doi: 10.1016/j.jbo.2019.100237. eCollection 2019 Jun.


Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer.

Link T, Kuhlmann JD, Kobelt D, Herrmann P, Vassileva YD, Kramer M, Frank K, Göckenjan M, Wimberger P, Stein U.

Mol Oncol. 2019 May;13(5):1268-1279. doi: 10.1002/1878-0261.12484. Epub 2019 Apr 15.


Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide α-cypermethrin in Chironomus riparius: Investigating the importance of toxicokinetics and enzyme interactions.

Kuhlmann J, Kretschmann AC, Bester K, Bollmann UE, Dalhoff K, Cedergreen N.

Chemosphere. 2019 Jun;225:166-173. doi: 10.1016/j.chemosphere.2019.03.023. Epub 2019 Mar 6.


Extracellular vesicle-associated miRNAs in ovarian cancer - design of an integrated NGS-based workflow for the identification of blood-based biomarkers for platinum-resistance.

Kuhlmann JD, Chebouti I, Kimmig R, Buderath P, Reuter M, Puppel SH, Wimberger P, Kasimir-Bauer S.

Clin Chem Lab Med. 2019 Jun 26;57(7):1053-1062. doi: 10.1515/cclm-2018-1048.


Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales.

Ludwig AK, De Miroschedji K, Doeppner TR, Börger V, Ruesing J, Rebmann V, Durst S, Jansen S, Bremer M, Behrmann E, Singer BB, Jastrow H, Kuhlmann JD, El Magraoui F, Meyer HE, Hermann DM, Opalka B, Raunser S, Epple M, Horn PA, Giebel B.

J Extracell Vesicles. 2018 Oct 17;7(1):1528109. doi: 10.1080/20013078.2018.1528109. eCollection 2018.


Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements.

Andreasson U, Kuhlmann J, Pannee J, Umek RM, Stoops E, Vanderstichele H, Matzen A, Vandijck M, Dauwe M, Leinenbach A, Rutz S, Portelius E, Zegers I, Zetterberg H, Blennow K.

Clin Chem Lab Med. 2018 Nov 27;56(12):2058-2066. doi: 10.1515/cclm-2018-0147.


PICCA study: panitumumab in combination with cisplatin/gemcitabine chemotherapy in KRAS wild-type patients with biliary cancer-a randomised biomarker-driven clinical phase II AIO study.

Vogel A, Kasper S, Bitzer M, Block A, Sinn M, Schulze-Bergkamen H, Moehler M, Pfarr N, Endris V, Goeppert B, Merx K, Schnoy E, Siveke JT, Michl P, Waldschmidt D, Kuhlmann J, Geissler M, Kahl C, Evenkamp R, Schmidt T, Kuhlmann A, Weichert W, Kubicka S.

Eur J Cancer. 2018 Mar;92:11-19. doi: 10.1016/j.ejca.2017.12.028. Epub 2018 Feb 3.


A Cost-of-Illness Study of Patients with HIV/AIDS in Bogotá, Colombia.

Kuhlmann J, Keaei M, Conde R, Evers SMAA, Gonzalez J, Govers M, Hiligsmann M.

Value Health Reg Issues. 2017 Dec;14:103-107. doi: 10.1016/j.vhri.2017.09.002. Epub 2017 Nov 1.


SNARE-Mediated Single-Vesicle Fusion Events with Supported and Freestanding Lipid Membranes.

Kuhlmann JW, Junius M, Diederichsen U, Steinem C.

Biophys J. 2017 Dec 5;113(11):2573-2574. doi: 10.1016/j.bpj.2017.10.039. No abstract available.


Reconstitution of SNARE proteins into solid-supported lipid bilayer stacks and X-ray structure analysis.

Xu Y, Kuhlmann J, Brennich M, Komorowski K, Jahn R, Steinem C, Salditt T.

Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):566-578. doi: 10.1016/j.bbamem.2017.10.023. Epub 2017 Nov 28.


The conjugated antimetabolite 5-FdU-ECyd and its cellular and molecular effects on platinum-sensitive vs. -resistant ovarian cancer cells in vitro.

Schott S, Wimberger P, Klink B, Grützmann K, Puppe J, Wauer US, Klotz DM, Schröck E, Kuhlmann JD.

Oncotarget. 2017 Aug 14;8(44):76935-76948. doi: 10.18632/oncotarget.20260. eCollection 2017 Sep 29.


A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow.

Rossnagl S, Ghura H, Groth C, Altrock E, Jakob F, Schott S, Wimberger P, Link T, Kuhlmann JD, Stenzl A, Hennenlotter J, Todenhöfer T, Rojewski M, Bieback K, Nakchbandi IA.

Cancer Res. 2018 Jan 1;78(1):129-142. doi: 10.1158/0008-5472.CAN-16-3507. Epub 2017 Oct 24.


Exploratory investigation of PSCA-protein expression in primary breast cancer patients reveals a link to HER2/neu overexpression.

Link T, Kuithan F, Ehninger A, Kuhlmann JD, Kramer M, Werner A, Gatzweiler A, Richter B, Ehninger G, Baretton G, Bachmann M, Wimberger P, Friedrich K.

Oncotarget. 2017 Apr 29;8(33):54592-54603. doi: 10.18632/oncotarget.17523. eCollection 2017 Aug 15.


SNARE-Mediated Single-Vesicle Fusion Events with Supported and Freestanding Lipid Membranes.

Kuhlmann JW, Junius M, Diederichsen U, Steinem C.

Biophys J. 2017 Jun 6;112(11):2348-2356. doi: 10.1016/j.bpj.2017.04.032. Erratum in: Biophys J. 2017 Dec 5;113(11):2573-2574.


Adjuvant tamoxifen but not aromatase inhibitor therapy decreases serum levels of the Wnt inhibitor dickkopf-1 while not affecting sclerostin in breast cancer patients.

Göbel A, Kuhlmann JD, Link T, Wimberger P, Browne AJ, Rauner M, Hofbauer LC, Rachner TD.

Breast Cancer Res Treat. 2017 Aug;164(3):737-743. doi: 10.1007/s10549-017-4296-3. Epub 2017 May 19.


EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy.

Chebouti I, Kasimir-Bauer S, Buderath P, Wimberger P, Hauch S, Kimmig R, Kuhlmann JD.

Oncotarget. 2017 Jul 25;8(30):48820-48831. doi: 10.18632/oncotarget.16179.


ERCC1-expressing circulating tumor cells as a potential diagnostic tool for monitoring response to platinum-based chemotherapy and for predicting post-therapeutic outcome of ovarian cancer.

Chebouti I, Kuhlmann JD, Buderath P, Weber S, Wimberger P, Bokeloh Y, Hauch S, Kimmig R, Kasimir-Bauer S.

Oncotarget. 2017 Apr 11;8(15):24303-24313. doi: 10.18632/oncotarget.13286.


Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer.

Dewi DL, Mohapatra SR, Blanco Cabañes S, Adam I, Somarribas Patterson LF, Berdel B, Kahloon M, Thürmann L, Loth S, Heilmann K, Weichenhan D, Mücke O, Heiland I, Wimberger P, Kuhlmann JD, Kellner KH, Schott S, Plass C, Platten M, Gerhäuser C, Trump S, Opitz CA.

Oncoimmunology. 2017 Jan 3;6(2):e1274477. doi: 10.1080/2162402X.2016.1274477. eCollection 2017.


Anatomic modeling using 3D printing: quality assurance and optimization.

Leng S, McGee K, Morris J, Alexander A, Kuhlmann J, Vrieze T, McCollough CH, Matsumoto J.

3D Print Med. 2017;3(1):6. doi: 10.1186/s41205-017-0014-3. Epub 2017 Apr 26.


Health-Related Quality of Life of Patients with HIV/AIDS in Bogotá, Colombia.

Keaei M, Kuhlmann J, Conde R, Evers SM, Gonzalez J, Govers M, Hiligsmann M.

Value Health Reg Issues. 2016 Dec;11:68-72. doi: 10.1016/j.vhri.2016.05.001. Epub 2016 Oct 21.


Calcium-mediated actin reset (CaAR) mediates acute cell adaptations.

Wales P, Schuberth CE, Aufschnaiter R, Fels J, García-Aguilar I, Janning A, Dlugos CP, Schäfer-Herte M, Klingner C, Wälte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstädt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Söldner R.

Elife. 2016 Dec 6;5. pii: e19850. doi: 10.7554/eLife.19850.


Esophageal involvement is frequent in lichen planus: study in 32 patients with suggestion of clinicopathologic diagnostic criteria and therapeutic implications.

Kern JS, Technau-Hafsi K, Schwacha H, Kuhlmann J, Hirsch G, Brass V, Deibert P, Schmitt-Graeff A, Kreisel W.

Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1374-1382.


2- and 3-Monochloropropanediols in paper products and their transfer to foods.

Becalski A, Zhao T, Breton F, Kuhlmann J.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Sep;33(9):1499-508. doi: 10.1080/19440049.2016.1223353. Epub 2016 Sep 6.


Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.

Kuhlmann JD, Bankfalvi A, Schmid KW, Callies R, Kimmig R, Wimberger P, Siffert W, Bachmann HS.

BMC Cancer. 2016 Aug 9;16:618. doi: 10.1186/s12885-016-2662-x.


Identification and Functional Testing of ERCC2 Mutations in a Multi-national Cohort of Patients with Familial Breast- and Ovarian Cancer.

Rump A, Benet-Pages A, Schubert S, Kuhlmann JD, Janavičius R, Macháčková E, Foretová L, Kleibl Z, Lhota F, Zemankova P, Betcheva-Krajcir E, Mackenroth L, Hackmann K, Lehmann J, Nissen A, DiDonato N, Opitz R, Thiele H, Kast K, Wimberger P, Holinski-Feder E, Emmert S, Schröck E, Klink B.

PLoS Genet. 2016 Aug 9;12(8):e1006248. doi: 10.1371/journal.pgen.1006248. eCollection 2016 Aug.


Construction of realistic phantoms from patient images and a commercial three-dimensional printer.

Leng S, Chen B, Vrieze T, Kuhlmann J, Yu L, Alexander A, Matsumoto J, Morris J, McCollough CH.

J Med Imaging (Bellingham). 2016 Jul;3(3):033501. doi: 10.1117/1.JMI.3.3.033501. Epub 2016 Jul 7.


CSF Aβ1-42 - an excellent but complicated Alzheimer's biomarker - a route to standardisation.

Kuhlmann J, Andreasson U, Pannee J, Bjerke M, Portelius E, Leinenbach A, Bittner T, Korecka M, Jenkins RG, Vanderstichele H, Stoops E, Lewczuk P, Shaw LM, Zegers I, Schimmel H, Zetterberg H, Blennow K; IFCC Working Group on Standardization of CSF proteins (WG-CSF).

Clin Chim Acta. 2017 Apr;467:27-33. doi: 10.1016/j.cca.2016.05.014. Epub 2016 May 20. Review.


Gene expression profiling of single circulating tumor cells in ovarian cancer - Establishment of a multi-marker gene panel.

Blassl C, Kuhlmann JD, Webers A, Wimberger P, Fehm T, Neubauer H.

Mol Oncol. 2016 Aug;10(7):1030-42. doi: 10.1016/j.molonc.2016.04.002. Epub 2016 Apr 20.


In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor.

Zhao D, Wang T, Kuhlmann J, Dong Z, Chen S, Joshi M, Salunke P, Shanov VN, Hong D, Kumta PN, Heineman WR.

Acta Biomater. 2016 May;36:361-8. doi: 10.1016/j.actbio.2016.03.039. Epub 2016 Mar 30.


Three-dimensional Physical Modeling: Applications and Experience at Mayo Clinic.

Matsumoto JS, Morris JM, Foley TA, Williamson EE, Leng S, McGee KP, Kuhlmann JL, Nesberg LE, Vrtiska TJ.

Radiographics. 2015 Nov-Dec;35(7):1989-2006. doi: 10.1148/rg.2015140260.


Assessing the commutability of reference material formats for the harmonization of amyloid-β measurements.

Bjerke M, Andreasson U, Kuhlmann J, Portelius E, Pannee J, Lewczuk P, Umek RM, Vanmechelen E, Vanderstichele H, Stoops E, Lewis J, Vandijck M, Kostanjevecki V, Jeromin A, Salamone SJ, Schmidt O, Matzen A, Madin K, Eichenlaub U, Bittner T, Shaw LM, Zegers I, Zetterberg H, Blennow K.

Clin Chem Lab Med. 2016 Jul 1;54(7):1177-91. doi: 10.1515/cclm-2015-0733.


Targeting Cancer Stem Cells: Promises and Challenges.

Kuhlmann JD, Hein L, Kurth I, Wimberger P, Dubrovska A.

Anticancer Agents Med Chem. 2016;16(1):38-58. Review.


The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients.

Bachmann HS, Meier W, du Bois A, Kimmig R, Kuhlmann JD, Siffert W, Sehouli J, Wollschlaeger K, Huober J, Hillemanns P, Burges A, Schmalfeldt B, Aminossadati B, Wimberger P.

Br J Clin Pharmacol. 2015 Nov;80(5):1139-48. doi: 10.1111/bcp.12688. Epub 2015 Jul 22.


Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma.

Homburg U, Renz H, Timmer W, Hohlfeld JM, Seitz F, Lüer K, Mayer A, Wacker A, Schmidt O, Kuhlmann J, Turowska A, Roller J, Kutz K, Schlüter G, Krug N, Garn H.

J Allergy Clin Immunol. 2015 Sep;136(3):797-800. doi: 10.1016/j.jaci.2015.02.018. Epub 2015 Apr 2. No abstract available.


Increased level of circulating U2 small nuclear RNA fragments indicates metastasis in melanoma patients.

Kuhlmann JD, Wimberger P, Wilsch K, Fluck M, Suter L, Brunner G.

Clin Chem Lab Med. 2015 Mar;53(4):605-11. doi: 10.1515/cclm-2014-1064.


Construction of Realistic Liver Phantoms from Patient Images using 3D Printer and Its Application in CT Image Quality Assessment.

Leng S, Yu L, Vrieze T, Kuhlmann J, Chen B, McCollough CH.

Proc SPIE Int Soc Opt Eng. 2015;2015. pii: 94124E. Epub 2015 Mar 18.


2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: cytotoxicity, metabolism, and transport by human intestinal Caco-2 cells.

Buhrke T, Frenzel F, Kuhlmann J, Lampen A.

Arch Toxicol. 2015 Dec;89(12):2243-51. doi: 10.1007/s00204-014-1395-3. Epub 2014 Oct 30.


ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance.

Kuhlmann JD, Wimberger P, Bankfalvi A, Keller T, Schöler S, Aktas B, Buderath P, Hauch S, Otterbach F, Kimmig R, Kasimir-Bauer S.

Clin Chem. 2014 Oct;60(10):1282-9. doi: 10.1373/clinchem.2014.224808. Epub 2014 Jul 11.


Modulating the lateral tension of solvent-free pore-spanning membranes.

Kuhlmann JW, Mey IP, Steinem C.

Langmuir. 2014 Jul 15;30(27):8186-92. doi: 10.1021/la5019086. Epub 2014 Jul 1.


Effects of elevated magnesium and substrate on neuronal numbers and neurite outgrowth of neural stem/progenitor cells in vitro.

Vennemeyer JJ, Hopkins T, Kuhlmann J, Heineman WR, Pixley SK.

Neurosci Res. 2014 Jul;84:72-8. doi: 10.1016/j.neures.2014.05.001. Epub 2014 May 9.


FOLFIRI and sunitinib as first-line treatment in metastatic colorectal cancer patients with liver metastases--a CESAR phase II study including pharmacokinetic, biomarker, and imaging data.

Mross K, Scheulen M, Strumberg D, Kuhlmann J, Kanefendt F, Sörgel F, Jaehde U, Burkholder I, Moritz B, Büchert M.

Int J Clin Pharmacol Ther. 2014 Aug;52(8):642-52. doi: 10.5414/CP202109.


Explorative investigation of vascular endothelial growth factor receptor expression in primary ovarian cancer and its clinical relevance.

Wimberger P, Chebouti I, Kasimir-Bauer S, Lachmann R, Kuhlisch E, Kimmig R, Süleyman E, Kuhlmann JD.

Gynecol Oncol. 2014 Jun;133(3):467-72. doi: 10.1016/j.ygyno.2014.03.574. Epub 2014 Apr 5.


Current state of nonsurgical therapies for cholangiocarcinoma.

Brass V, Kuhlmann JB, Blum HE.

Hepat Oncol. 2014 Jan;1(1):135-142. doi: 10.2217/hep.13.9. Epub 2013 Dec 20. Review.


Correlation of genotype, phenotype, and mRNA expression of CYP2D6 and CYP2C19 in peripheral blood leukocytes (PBLs).

Kuhlmann JB, Wensing G, Kuhlmann J.

Int J Clin Pharmacol Ther. 2014 Feb;52(2):143-50. doi: 10.5414/CP201966.


Circulating U2 small nuclear RNA fragments as a novel diagnostic tool for patients with epithelial ovarian cancer.

Kuhlmann JD, Baraniskin A, Hahn SA, Mosel F, Bredemeier M, Wimberger P, Kimmig R, Kasimir-Bauer S.

Clin Chem. 2014 Jan;60(1):206-13. doi: 10.1373/clinchem.2013.213066. Epub 2013 Nov 8.


A system for characterizing Mg corrosion in aqueous solutions using electrochemical sensors and impedance spectroscopy.

Doepke A, Kuhlmann J, Guo X, Voorhees RT, Heineman WR.

Acta Biomater. 2013 Nov;9(11):9211-9. doi: 10.1016/j.actbio.2013.07.011. Epub 2013 Jul 18.


Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs.

Turowska A, Librizzi D, Baumgartl N, Kuhlmann J, Dicke T, Merkel O, Homburg U, Höffken H, Renz H, Garn H.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):365-72. doi: 10.1016/j.taap.2013.06.020. Epub 2013 Jun 29.


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