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Items: 1 to 50 of 54

1.

Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial.

Kuhlen M, Bader P, Sauer M, Albert MH, Gruhn B, Güngör T, Kropshofer G, Lang P, Lawitschka A, Metzler M, Pentek F, Rossig C, Schlegel PG, Schrappe M, Schrum J, Schulz A, Schwinger W, von Stackelberg A, Strahm B, Suttorp M, Luettichau IT, Wößmann W, Borkhardt A, Meisel R, Poetschger U, Glogova E, Peters C.

Br J Haematol. 2018 Jul 20. doi: 10.1111/bjh.15511. [Epub ahead of print]

PMID:
30028016
2.

Challenges of palliative care in children with inborn metabolic diseases.

Hoell JI, Warfsmann J, Distelmaier F, Borkhardt A, Janßen G, Kuhlen M.

Orphanet J Rare Dis. 2018 Jul 9;13(1):112. doi: 10.1186/s13023-018-0868-5.

3.

Author Correction: The landscape of genomic alterations across childhood cancers.

Gröbner SN, Worst BC, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva VA, Johann PD, Balasubramanian GP, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Hübschmann D, Zipprich G, Heinold M, Eils J, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Gessler M, Wegert J, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik AE, Lohmann D, Hettmer S, Eckert C, Bielack S, Nathrath M, Niemeyer C, Richter GH, Schulte J, Siebert R, Westermann F, Molenaar JJ, Vassal G, Witt H, Burkhardt B, Kratz CP, Witt O, van Tilburg CM, Kramm CM, Fleischhack G, Dirksen U, Rutkowski S, Frühwald M, von Hoff K, Wolf S, Klingebiel T, Koscielniak E, Landgraf P, Koster J, Resnick AC, Zhang J, Liu Y, Zhou X, Waanders AJ, Zwijnenburg DA, Raman P, Brors B, Weber UD, Northcott PA, Pajtler KW, Kool M, Piro RM, Korbel JO, Schlesner M, Eils R, Jones DTW, Lichter P, Chavez L, Zapatka M, Pfister SM; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project.

Nature. 2018 Jul;559(7714):E10. doi: 10.1038/s41586-018-0167-2.

PMID:
29875405
4.

Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy.

Krull K, Kunstreich M, Bronsema A, Bleckmann K, Classen CF, Erdlenbruch B, Jorch N, Kolb R, Leipold A, Moser O, Prokop A, Scheurlen W, Steinbach D, Klasen-Sansone J, Klee D, Escherich G, Moericke A, Schrappe M, Borkhardt A, Kuhlen M.

Leuk Lymphoma. 2018 May 2:1-7. doi: 10.1080/10428194.2018.1466292. [Epub ahead of print]

PMID:
29718744
5.

Advance care planning and outcome in pediatric palliative home care.

Hoell JI, Weber HL, Balzer S, Danneberg M, Gagnon G, Trocan L, Borkhardt A, Janßen G, Kuhlen M.

Oncotarget. 2018 Apr 3;9(25):17867-17875. doi: 10.18632/oncotarget.24929. eCollection 2018 Apr 3.

6.

Trio sequencing in pediatric cancer and clinical implications.

Kuhlen M, Borkhardt A.

EMBO Mol Med. 2018 Apr;10(4). pii: e8641. doi: 10.15252/emmm.201708641. No abstract available.

7.

Lymphnode tuberculosis in a 4-year-old boy with relapsed ganglioneuroblastoma: a case report.

van de Loo K, Balzer S, MacKenzie CR, Boemers TM, Ortmann M, Schaper J, Borkhardt A, Laws HJ, Kuhlen M.

BMC Infect Dis. 2018 Mar 5;18(1):105. doi: 10.1186/s12879-018-3016-x.

8.

The landscape of genomic alterations across childhood cancers.

Gröbner SN, Worst BC, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva VA, Johann PD, Balasubramanian GP, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Hübschmann D, Zipprich G, Heinold M, Eils J, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Gessler M, Wegert J, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik AE, Lohmann D, Hettmer S, Eckert C, Bielack S, Nathrath M, Niemeyer C, Richter GH, Schulte J, Siebert R, Westermann F, Molenaar JJ, Vassal G, Witt H; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project, Burkhardt B, Kratz CP, Witt O, van Tilburg CM, Kramm CM, Fleischhack G, Dirksen U, Rutkowski S, Frühwald M, von Hoff K, Wolf S, Klingebiel T, Koscielniak E, Landgraf P, Koster J, Resnick AC, Zhang J, Liu Y, Zhou X, Waanders AJ, Zwijnenburg DA, Raman P, Brors B, Weber UD, Northcott PA, Pajtler KW, Kool M, Piro RM, Korbel JO, Schlesner M, Eils R, Jones DTW, Lichter P, Chavez L, Zapatka M, Pfister SM.

Nature. 2018 Mar 15;555(7696):321-327. doi: 10.1038/nature25480. Epub 2018 Feb 28. Erratum in: Nature. 2018 Jul;559(7714):E10.

PMID:
29489754
9.

Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6.

Taeubner J, Wimmer K, Muleris M, Lascols O, Colas C, Fauth C, Brozou T, Felsberg J, Riemer J, Gombert M, Ginzel S, Hoell JI, Borkhardt A, Kuhlen M.

Eur J Hum Genet. 2018 Mar;26(3):440-444. doi: 10.1038/s41431-017-0071-5. Epub 2018 Jan 4.

PMID:
29302048
10.

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge.

Kuhlen M, Kunstreich M, Krull K, Meisel R, Borkhardt A.

Blood Adv. 2017 Jun 13;1(14):981-994. doi: 10.1182/bloodadvances.2017007286. eCollection 2017 Jun 13. Review.

11.

Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.

Taeubner J, Brozou T, Qin N, Bartl J, Ginzel S, Schaper J, Felsberg J, Fulda S, Vokuhl C, Borkhardt A, Kuhlen M.

Eur J Hum Genet. 2018 Jan;26(1):137-142. doi: 10.1038/s41431-017-0048-4. Epub 2017 Dec 11.

PMID:
29230040
12.

Outcome of relapse after allogeneic HSCT in children with ALL enrolled in the ALL-SCT 2003/2007 trial.

Kuhlen M, Willasch AM, Dalle JH, Wachowiak J, Yaniv I, Ifversen M, Sedlacek P, Guengoer T, Lang P, Bader P, Sufliarska S, Balduzzi A, Strahm B, von Luettichau I, Hoell JI, Borkhardt A, Klingebiel T, Schrappe M, von Stackelberg A, Glogova E, Poetschger U, Meisel R, Peters C.

Br J Haematol. 2018 Jan;180(1):82-89. doi: 10.1111/bjh.14965. Epub 2017 Nov 28.

PMID:
29193007
13.

End-of-life care in children with hematologic malignancies.

Hoell JI, Warfsmann J, Balzer S, Borkhardt A, Janssen G, Kuhlen M.

Oncotarget. 2017 Sep 23;8(52):89939-89948. doi: 10.18632/oncotarget.21188. eCollection 2017 Oct 27.

14.

Smoldering Development of Acute Megakaryoblastic Leukemia with Clonal Evolution in an Infant without Down Syndrome.

Schmidt E, Fischer U, Biskup W, Haferlach C, Meisel R, Kuhlen M, Borkhardt A.

Klin Padiatr. 2017 Nov;229(6):352-354. doi: 10.1055/s-0043-113446. Epub 2017 Nov 13. No abstract available.

PMID:
29132167
15.

Correction to: Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.

Brozou T, Taeubner J, Velleuer E, Dugas M, Wieczorek D, Borkhardt A, Kuhlen M.

Eur J Pediatr. 2018 Jan;177(1):61. doi: 10.1007/s00431-017-3033-6.

PMID:
29105029
16.

Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP).

Offenmueller S, Leiter U, Bernbeck B, Garbe C, Eigentler T, Borkhardt A, Friedrich Classen C, Corbacioglu S, Dirksen U, Ebetsberger-Dachs G, Heinzerling L, Jorch N, Kuhlen M, Lawlor J, Niggli F, Streiter M, Schneider DT, Brecht I.

Klin Padiatr. 2017 Nov;229(6):322-328. doi: 10.1055/s-0043-118662. Epub 2017 Oct 10.

PMID:
29017184
17.

Autism spectrum disorder and Li-Fraumeni syndrome: purely coincidental or mechanistically associated?

Kuhlen M, Taeubner J, Wieczorek D, Borkhardt A.

Mol Cell Pediatr. 2017 Oct 5;4(1):8. doi: 10.1186/s40348-017-0075-9.

18.

Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.

Brozou T, Taeubner J, Velleuer E, Dugas M, Wieczorek D, Borkhardt A, Kuhlen M.

Eur J Pediatr. 2018 Jan;177(1):53-60. doi: 10.1007/s00431-017-2997-6. Epub 2017 Sep 19. Erratum in: Eur J Pediatr. 2018 Jan;177(1):61.

19.

Palliative care for children with a yet undiagnosed syndrome.

Hoell JI, Warfsmann J, Gagnon G, Trocan L, Balzer S, Oommen PT, Borkhardt A, Janßen G, Kuhlen M.

Eur J Pediatr. 2017 Oct;176(10):1319-1327. doi: 10.1007/s00431-017-2991-z. Epub 2017 Aug 14.

PMID:
28808789
20.

Neurotoxic side effects in children with refractory or relapsed T-cell malignancies treated with nelarabine based therapy.

Kuhlen M, Bleckmann K, Möricke A, Schrappe M, Vieth S, Escherich G, Bronsema A, Vonalt A, Queudeville M, Zwaan CM, Ebinger M, Debatin KM, Klingebiel T, Koscielniak E, Rossig C, Burkhardt B, Kolb R, Eckert C, Borkhardt A, von Stackelberg A, Chen-Santel C.

Br J Haematol. 2017 Oct;179(2):272-283. doi: 10.1111/bjh.14877. Epub 2017 Aug 2.

PMID:
28771662
21.

Hematopoietic Stem Cell Transplantation in an Infant with Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome.

Gössling KL, Schipp C, Fischer U, Babor F, Koch G, Schuster FR, Dietzel-Dahmen J, Wieczorek D, Borkhardt A, Meisel R, Kuhlen M.

Front Immunol. 2017 Jun 30;8:773. doi: 10.3389/fimmu.2017.00773. eCollection 2017.

22.

Paraneoplastic limbic encephalitis with SOX1 and PCA2 antibodies and relapsing neurological symptoms in an adolescent with Hodgkin lymphoma.

Kunstreich M, Kreth JH, Oommen PT, Schaper J, Karenfort M, Aktas O, Tibussek D, Distelmaier F, Borkhardt A, Kuhlen M.

Eur J Paediatr Neurol. 2017 Jul;21(4):661-665. doi: 10.1016/j.ejpn.2017.03.005. Epub 2017 Mar 27.

PMID:
28389060
23.

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Ripperger T, Bielack SS, Borkhardt A, Brecht IB, Burkhardt B, Calaminus G, Debatin KM, Deubzer H, Dirksen U, Eckert C, Eggert A, Erlacher M, Fleischhack G, Frühwald MC, Gnekow A, Goehring G, Graf N, Hanenberg H, Hauer J, Hero B, Hettmer S, von Hoff K, Horstmann M, Hoyer J, Illig T, Kaatsch P, Kappler R, Kerl K, Klingebiel T, Kontny U, Kordes U, Körholz D, Koscielniak E, Kramm CM, Kuhlen M, Kulozik AE, Lamottke B, Leuschner I, Lohmann DR, Meinhardt A, Metzler M, Meyer LH, Moser O, Nathrath M, Niemeyer CM, Nustede R, Pajtler KW, Paret C, Rasche M, Reinhardt D, Rieß O, Russo A, Rutkowski S, Schlegelberger B, Schneider D, Schneppenheim R, Schrappe M, Schroeder C, von Schweinitz D, Simon T, Sparber-Sauer M, Spix C, Stanulla M, Steinemann D, Strahm B, Temming P, Thomay K, von Bueren AO, Vorwerk P, Witt O, Wlodarski M, Wössmann W, Zenker M, Zimmermann S, Pfister SM, Kratz CP.

Am J Med Genet A. 2017 Apr;173(4):1017-1037. doi: 10.1002/ajmg.a.38142. Epub 2017 Feb 7. Review.

PMID:
28168833
24.

Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial.

Krull K, Kunstreich M, Klasen-Sansone J, Kloetgen A, Gruener F, Escherich G, Bleckmann K, Moericke A, Schrappe M, Jorch N, Steinbach D, Classen CF, Guggemos A, Kolb R, Klee D, Borkhardt A, Kuhlen M.

Leuk Lymphoma. 2017 Oct;58(10):2363-2369. doi: 10.1080/10428194.2017.1280605. Epub 2017 Jan 31.

PMID:
28140726
25.

Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency.

Ghosh S, Hönscheid A, Dückers G, Ginzel S, Gohlke H, Gombert M, Kempkes B, Klapper W, Kuhlen M, Laws HJ, Linka RM, Meisel R, Mielke C, Niehues T, Schindler D, Schneider D, Schuster FR, Speckmann C, Borkhardt A.

Haematologica. 2017 Feb;102(2):e69-e72. doi: 10.3324/haematol.2016.155838. Epub 2016 Dec 15. No abstract available.

26.

Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome.

Fremerey J, Balzer S, Brozou T, Schaper J, Borkhardt A, Kuhlen M.

Fam Cancer. 2017 Jul;16(3):401-405. doi: 10.1007/s10689-016-9958-5.

PMID:
27896549
27.

Massively Distended Abdomen Caused by Fibromatosis Previously Misdiagnosed as Myxofibrosarcoma.

Kuhlen M, Oommen PT, Borkhardt A.

J Oncol Pract. 2016 Nov;12(11):1192-1194. Epub 2016 Oct 31. No abstract available.

PMID:
27858546
28.

Osteonecrosis in children with acute lymphoblastic leukemia.

Kunstreich M, Kummer S, Laws HJ, Borkhardt A, Kuhlen M.

Haematologica. 2016 Nov;101(11):1295-1305. Epub 2016 Oct 14. Review.

29.

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus.

Gyárfás T, Wintgens J, Biskup W, Oschlies I, Klapper W, Siebert R, Bens S, Haferlach C, Meisel R, Kuhlen M, Borkhardt A.

Mol Cell Pediatr. 2016 Dec;3(1):30. doi: 10.1186/s40348-016-0061-7. Epub 2016 Aug 29.

30.

Effective treatment of spasticity using dronabinol in pediatric palliative care.

Kuhlen M, Hoell JI, Gagnon G, Balzer S, Oommen PT, Borkhardt A, Janßen G.

Eur J Paediatr Neurol. 2016 Nov;20(6):898-903. doi: 10.1016/j.ejpn.2016.07.021. Epub 2016 Jul 30.

PMID:
27506815
31.

Symptoms and management of pediatric patients with incurable brain tumors in palliative home care.

Kuhlen M, Hoell J, Balzer S, Borkhardt A, Janssen G.

Eur J Paediatr Neurol. 2016 Mar;20(2):261-269. doi: 10.1016/j.ejpn.2015.12.004. Epub 2015 Dec 22.

PMID:
26753538
32.

De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly.

Kuhlen M, Hönscheid A, Loizou L, Nabhani S, Fischer U, Stepensky P, Schaper J, Klapper W, Siepermann M, Schuster F, Meisel R, Borkhardt A.

Clin Immunol. 2016 Jan;162:27-30. doi: 10.1016/j.clim.2015.10.008. Epub 2015 Oct 31.

PMID:
26529633
33.

Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome.

Kuhlen M, Hönscheid A, Schemme J, Merz H, Mauz-Körholz C, Borkhardt A, Troeger A.

Eur J Pediatr. 2016 Apr;175(4):593-7. doi: 10.1007/s00431-015-2660-z. Epub 2015 Nov 3.

PMID:
26526666
34.

Experiences in palliative home care of infants with life-limiting conditions.

Kuhlen M, Höll JI, Sabir H, Borkhardt A, Janßen G.

Eur J Pediatr. 2016 Mar;175(3):321-7. doi: 10.1007/s00431-015-2637-y. Epub 2015 Sep 28.

PMID:
26411975
35.

Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease.

Nabhani S, Ginzel S, Miskin H, Revel-Vilk S, Harlev D, Fleckenstein B, Hönscheid A, Oommen PT, Kuhlen M, Thiele R, Laws HJ, Borkhardt A, Stepensky P, Fischer U.

Haematologica. 2015 Sep;100(9):1189-98. doi: 10.3324/haematol.2014.114967. Epub 2015 Jun 25.

36.

Cancer susceptibility syndromes in children in the area of broad clinical use of massive parallel sequencing.

Kuhlen M, Borkhardt A.

Eur J Pediatr. 2015 Aug;174(8):987-97. doi: 10.1007/s00431-015-2565-x. Epub 2015 May 16. Review.

37.

Critical Situations in Children, Adolescents and Young Adults with Terminal Cancer within the Home Setting.

Kuhlen M, Balzer S, Friedland C, Borkhardt A, Janßen G.

Klin Padiatr. 2015 May;227(3):137-43. doi: 10.1055/s-0034-1398630. Epub 2015 Mar 26.

PMID:
25811741
38.

A novel homozygous Fas ligand mutation leads to early protein truncation, abrogation of death receptor and reverse signaling and a severe form of the autoimmune lymphoproliferative syndrome.

Nabhani S, Hönscheid A, Oommen PT, Fleckenstein B, Schaper J, Kuhlen M, Laws HJ, Borkhardt A, Fischer U.

Clin Immunol. 2014 Dec;155(2):231-7. doi: 10.1016/j.clim.2014.10.006. Epub 2014 Oct 24.

PMID:
25451160
39.

[Palliative home care of children: an opinion survey of orphaned parents].

Kuhlen M, Schlote A, Borkhardt A, Janßen G.

Klin Padiatr. 2014 May;226(3):182-7. doi: 10.1055/s-0034-1371841. Epub 2014 May 12. German.

PMID:
24819389
40.

Osteonecrosis in paediatric patients with acute lymphoblastic leukaemia treated on Co-ALL-07-03 trial: a single centre analysis.

Kuhlen M, Moldovan A, Krull K, Meisel R, Borkhardt A.

Klin Padiatr. 2014 May;226(3):154-60. doi: 10.1055/s-0033-1358723. Epub 2014 Apr 7.

PMID:
24710762
41.

Epidemiology and clinical characteristics of pandemic (H1N1) 2009 influenza infection in pediatric hemato-oncology and hematopoietic stem cell transplantation patients.

Babor F, Grund S, Siepermann M, Oommen PT, Kuhlen M, Schuster FR, Laws HJ, Wessalowski R, Bienemann K, Janßen G, Adams O, Borkhardt A, Meisel R.

Transpl Infect Dis. 2012 Dec;14(6):589-94. doi: 10.1111/tid.12013. Epub 2012 Sep 26.

PMID:
23013490
42.

Palliative sedation in 2 children with terminal cancer - an effective treatment of last resort in a home care setting.

Kuhlen M, Schneider K, Richter U, Borkhardt A, Janssen G.

Klin Padiatr. 2011 Nov;223(6):374-5. doi: 10.1055/s-0031-1283141. Epub 2011 Nov 3. No abstract available.

PMID:
22052636
43.

Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi?

Rosen A, van Kuilenburg A, Assmann B, Kuhlen M, Borkhardt A.

Case Rep Oncol. 2011 May;4(2):371-6. doi: 10.1159/000328803. Epub 2011 Aug 10.

44.

MYH9-related disease: Report on five German families and description of a novel mutation.

Savoia A, Germeshausen M, De Rocco D, Henschel B, Kratz CP, Kuhlen M, Rath B, Steuhl KP, Wermes C, Ballmaier M.

Ann Hematol. 2010 Oct;89(10):1057-9. doi: 10.1007/s00277-010-0928-y. Epub 2010 Mar 10. No abstract available.

PMID:
20221761
45.

Exploring dark matter with Milky Way substructure.

Kuhlen M, Madau P, Silk J.

Science. 2009 Aug 21;325(5943):970-3. doi: 10.1126/science.1174881. Epub 2009 Jul 16.

46.

[Development of a specialised paediatric palliative home care service].

Kuhlen M, Balzer S, Richter U, Fritsche-Kansy M, Friedland C, Borkhardt A, Janssen G.

Klin Padiatr. 2009 May-Jun;221(3):186-92. doi: 10.1055/s-0029-1220703. Epub 2009 May 12. German.

PMID:
19437372
47.

Clumps and streams in the local dark matter distribution.

Diemand J, Kuhlen M, Madau P, Zemp M, Moore B, Potter D, Stadel J.

Nature. 2008 Aug 7;454(7205):735-8. doi: 10.1038/nature07153.

PMID:
18685701
48.
49.
50.

Radiotherapy in Ewing tumors of the vertebrae: treatment results and local relapse analysis of the CESS 81/86 and EICESS 92 trials.

Schuck A, Ahrens S, von Schorlemer I, Kuhlen M, Paulussen M, Hunold A, Gosheger G, Winkelmann W, Dunst J, Willich N, Jürgens H.

Int J Radiat Oncol Biol Phys. 2005 Dec 1;63(5):1562-7. Epub 2005 Aug 30.

PMID:
16137838

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