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Items: 1 to 50 of 145

1.

Serum neurofilament light chain is increased in hereditary spastic paraplegias.

Wilke C, Rattay TW, Hengel H, Zimmermann M, Brockmann K, Schöls L, Kuhle J, Schüle R, Synofzik M.

Ann Clin Transl Neurol. 2018 May 21;5(7):876-882. doi: 10.1002/acn3.583. eCollection 2018 Jul.

2.

What are the factors to affect outcome and healing of meniscus bucket handle tears?

Hupperich A, Salzmann GM, Niemeyer P, Feucht M, Eberbach H, Südkamp NP, Kühle J.

Arch Orthop Trauma Surg. 2018 Jun 29. doi: 10.1007/s00402-018-2989-7. [Epub ahead of print]

PMID:
29959519
3.

Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden.

Duering M, Konieczny MJ, Tiedt S, Baykara E, Tuladhar AM, Leijsen EV, Lyrer P, Engelter ST, Gesierich B, Achmüller M, Barro C, Adam R, Ewers M, Dichgans M, Kuhle J, de Leeuw FE, Peters N.

J Stroke. 2018 May;20(2):228-238. doi: 10.5853/jos.2017.02565. Epub 2018 May 31.

4.

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis.

Barro C, Benkert P, Disanto G, Tsagkas C, Amann M, Naegelin Y, Leppert D, Gobbi C, Granziera C, Yaldizli Ö, Michalak Z, Wuerfel J, Kappos L, Parmar K, Kuhle J.

Brain. 2018 May 30. doi: 10.1093/brain/awy154. [Epub ahead of print]

PMID:
29860296
5.

A digitally facilitated citizen-science driven approach accelerates participant recruitment and increases study population diversity.

Puhan MA, Steinemann N, Kamm CP, Müller S, Kuhle J, Kurmann R, Calabrese P, Kesselring J, von Wyl V, Swiss Multiple Sclerosis Registry Smsr.

Swiss Med Wkly. 2018 May 16;148:w14623. doi: 10.4414/smw.2018.14623. eCollection 2018 May 16.

6.

Prodromal symptoms of multiple sclerosis in primary care.

Disanto G, Zecca C, MacLachlan S, Sacco R, Handunnetthi L, Meier UC, Simpson A, McDonald L, Rossi A, Benkert P, Kuhle J, Ramagopalan SV, Gobbi C.

Ann Neurol. 2018 May 8. doi: 10.1002/ana.25247. [Epub ahead of print]

PMID:
29740872
7.

Longitudinal MRI dynamics of recent small subcortical infarcts and possible predictors.

Pinter D, Gattringer T, Enzinger C, Seifert-Held T, Kneihsl M, Fandler S, Pichler A, Barro C, Eppinger S, Pirpamer L, Bachmaier G, Ropele S, Wardlaw JM, Kuhle J, Khalil M, Fazekas F.

J Cereb Blood Flow Metab. 2018 Jan 1:271678X18775215. doi: 10.1177/0271678X18775215. [Epub ahead of print]

PMID:
29737904
8.

Serum neurofilament light is increased in multiple system atrophy of cerebellar type and in repeat-expansion spinocerebellar ataxias: a pilot study.

Wilke C, Bender F, Hayer SN, Brockmann K, Schöls L, Kuhle J, Synofzik M.

J Neurol. 2018 Jul;265(7):1618-1624. doi: 10.1007/s00415-018-8893-9. Epub 2018 May 8.

PMID:
29737427
9.

Neurofilament as Neuronal Injury Blood Marker in Preeclampsia.

Evers KS, Atkinson A, Barro C, Fisch U, Pfister M, Huhn EA, Lapaire O, Kuhle J, Wellmann S.

Hypertension. 2018 Jun;71(6):1178-1184. doi: 10.1161/HYPERTENSIONAHA.117.10314. Epub 2018 Apr 23.

PMID:
29686016
10.

Comparative analysis of natalizumab versus fingolimod as second-line treatment in relapsing-remitting multiple sclerosis.

Lorscheider J, Benkert P, Lienert C, Hänni P, Derfuss T, Kuhle J, Kappos L, Yaldizli Ö.

Mult Scler. 2018 May;24(6):777-785. doi: 10.1177/1352458518768433. Epub 2018 Apr 24.

PMID:
29685071
11.

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.

Siller N, Kuhle J, Muthuraman M, Barro C, Uphaus T, Groppa S, Kappos L, Zipp F, Bittner S.

Mult Scler. 2018 Mar 1:1352458518765666. doi: 10.1177/1352458518765666. [Epub ahead of print]

PMID:
29542376
12.

Racial and Ethnic Disparities in Meeting MTM Eligibility Criteria Based on Star Ratings Compared with the Medicare Modernization Act.

Spivey CA, Wang J, Qiao Y, Shih YT, Wan JY, Kuhle J, Dagogo-Jack S, Cushman WC, Chisholm-Burns M.

J Manag Care Spec Pharm. 2018 Feb;24(2):97-107. doi: 10.18553/jmcp.2018.24.2.97.

13.

Serum neurofilament light chain in patients with acute cerebrovascular events.

De Marchis GM, Katan M, Barro C, Fladt J, Traenka C, Seiffge DJ, Hert L, Gensicke H, Disanto G, Sutter R, Peters N, Sarikaya H, Goeggel-Simonetti B, El-Koussy M, Engelter S, Lyrer PA, Christ-Crain M, Arnold M, Kuhle J, Bonati LH.

Eur J Neurol. 2018 Mar;25(3):562-568. doi: 10.1111/ene.13554. Epub 2018 Jan 24.

PMID:
29281157
14.

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

Feneberg E, Oeckl P, Steinacker P, Verde F, Barro C, Van Damme P, Gray E, Grosskreutz J, Jardel C, Kuhle J, Koerner S, Lamari F, Amador MDM, Mayer B, Morelli C, Muckova P, Petri S, Poesen K, Raaphorst J, Salachas F, Silani V, Stubendorff B, Turner MR, Verbeek MM, Weishaupt JH, Weydt P, Ludolph AC, Otto M.

Neurology. 2018 Jan 2;90(1):e22-e30. doi: 10.1212/WNL.0000000000004761. Epub 2017 Dec 6.

PMID:
29212830
15.

Neurofilament light chain predicts disease activity in relapsing-remitting MS.

Varhaug KN, Barro C, Bjørnevik K, Myhr KM, Torkildsen Ø, Wergeland S, Bindoff LA, Kuhle J, Vedeler C.

Neurol Neuroimmunol Neuroinflamm. 2017 Nov 28;5(1):e422. doi: 10.1212/NXI.0000000000000422. eCollection 2018 Jan.

16.

Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV.

Blokhuis C, Doeleman S, Cohen S, Demirkaya N, Scherpbier HJ, Kootstra NA, Kuhle J, Teunissen CE, Verbraak FD, Pajkrt D.

Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5985-5992. doi: 10.1167/iovs.17-22252.

PMID:
29183044
17.

Serum neurofilament light is sensitive to active cerebral small vessel disease.

Gattringer T, Pinter D, Enzinger C, Seifert-Held T, Kneihsl M, Fandler S, Pichler A, Barro C, Gröbke S, Voortman M, Pirpamer L, Hofer E, Ropele S, Schmidt R, Kuhle J, Fazekas F, Khalil M.

Neurology. 2017 Nov 14;89(20):2108-2114. doi: 10.1212/WNL.0000000000004645. Epub 2017 Oct 18.

PMID:
29046363
18.

Fluid biomarker and electrophysiological outcome measures for progressive MS trials.

Barro C, Leocani L, Leppert D, Comi G, Kappos L, Kuhle J.

Mult Scler. 2017 Oct;23(12):1600-1613. doi: 10.1177/1352458517732844. Review.

PMID:
29041870
19.

Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis.

Diebold M, Sievers C, Bantug G, Sanderson N, Kappos L, Kuhle J, Lindberg RLP, Derfuss T.

J Autoimmun. 2018 Jan;86:39-50. doi: 10.1016/j.jaut.2017.09.009. Epub 2017 Sep 27.

PMID:
28958667
20.

Thoracic trauma severity contributes to differences in intensive care therapy and mortality of severely injured patients: analysis based on the TraumaRegister DGU®.

Bayer J, Lefering R, Reinhardt S, Kühle J, Zwingmann J, Südkamp NP, Hammer T; TraumaRegister DGU.

World J Emerg Surg. 2017 Sep 2;12:43. doi: 10.1186/s13017-017-0154-1. eCollection 2017.

21.

[Real-world evidence : Benefits and limitations in multiple sclerosis research].

Ziemssen T, Rothenbacher D, Kuhle J, Berger T.

Nervenarzt. 2017 Oct;88(10):1153-1158. doi: 10.1007/s00115-017-0387-y. Review. German.

PMID:
28776214
22.

Serum neurofilament light chain: a biomarker of neuronal injury in vasculitic neuropathy.

Bischof A, Manigold T, Barro C, Heijnen I, Berger CT, Derfuss T, Kuhle J, Daikeler T.

Ann Rheum Dis. 2018 Jul;77(7):1093-1094. doi: 10.1136/annrheumdis-2017-212045. Epub 2017 Jul 25. No abstract available.

PMID:
28743789
23.

Exploring the effect of vitamin D3 supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis.

Rolf L, Muris AH, Mathias A, Du Pasquier R, Koneczny I, Disanto G, Kuhle J, Ramagopalan S, Damoiseaux J, Smolders J, Hupperts R.

Mult Scler. 2017 Jul 1:1352458517722646. doi: 10.1177/1352458517722646. [Epub ahead of print]

PMID:
28731372
24.

Consensus guidelines for lumbar puncture in patients with neurological diseases.

Engelborghs S, Niemantsverdriet E, Struyfs H, Blennow K, Brouns R, Comabella M, Dujmovic I, van der Flier W, Frölich L, Galimberti D, Gnanapavan S, Hemmer B, Hoff E, Hort J, Iacobaeus E, Ingelsson M, Jan de Jong F, Jonsson M, Khalil M, Kuhle J, Lleó A, de Mendonça A, Molinuevo JL, Nagels G, Paquet C, Parnetti L, Roks G, Rosa-Neto P, Scheltens P, Skårsgard C, Stomrud E, Tumani H, Visser PJ, Wallin A, Winblad B, Zetterberg H, Duits F, Teunissen CE.

Alzheimers Dement (Amst). 2017 May 18;8:111-126. doi: 10.1016/j.dadm.2017.04.007. eCollection 2017.

25.

Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro.

Bridel C, Koel-Simmelink MJA, Peferoen L, Derada Troletti C, Durieux S, Gorter R, Nutma E, Gami P, Iacobaeus E, Brundin L, Kuhle J, Vrenken H, Killestein J, Piersma SR, Pham TV, De Vries HE, Amor S, Jimenez CR, Teunissen CE.

Neuropathol Appl Neurobiol. 2018 Jun;44(4):404-416. doi: 10.1111/nan.12412. Epub 2017 Jun 28.

PMID:
28543098
26.

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, Giardiello A, Zecca C, Blennow K, Zetterberg H, Leppert D, Kappos L, Gobbi C, Kuhle J; Swiss Multiple Sclerosis Cohort Study Group.

Ann Neurol. 2017 Jun;81(6):857-870. doi: 10.1002/ana.24954.

27.

Epstein-Barr-negative MS: a true phenomenon?

Dobson R, Kuhle J, Middeldorp J, Giovannoni G.

Neurol Neuroimmunol Neuroinflamm. 2017 Feb 3;4(2):e318. doi: 10.1212/NXI.0000000000000318. eCollection 2017 Mar. No abstract available.

28.

Serum neurofilament is associated with progression of brain atrophy and disability in early MS.

Kuhle J, Nourbakhsh B, Grant D, Morant S, Barro C, Yaldizli Ö, Pelletier D, Giovannoni G, Waubant E, Gnanapavan S.

Neurology. 2017 Feb 28;88(9):826-831. doi: 10.1212/WNL.0000000000003653. Epub 2017 Feb 1.

29.

Severity-dependent differences in early management of thoracic trauma in severely injured patients - Analysis based on the TraumaRegister DGU®.

Bayer J, Lefering R, Reinhardt S, Kühle J, Südkamp NP, Hammer T; TraumaRegister DGU.

Scand J Trauma Resusc Emerg Med. 2017 Feb 2;25(1):10. doi: 10.1186/s13049-017-0354-4.

30.

Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease.

Steinacker P, Blennow K, Halbgebauer S, Shi S, Ruf V, Oeckl P, Giese A, Kuhle J, Slivarichova D, Zetterberg H, Otto M.

Sci Rep. 2016 Dec 8;6:38737. doi: 10.1038/srep38737.

31.

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients.

Crick PJ, Griffiths WJ, Zhang J, Beibel M, Abdel-Khalik J, Kuhle J, Sailer AW, Wang Y.

Mol Neurobiol. 2017 Dec;54(10):8009-8020. doi: 10.1007/s12035-016-0281-9. Epub 2016 Nov 23.

32.

Diagnostic and prognostic significance of neurofilament light chain NF-L, but not progranulin and S100B, in the course of amyotrophic lateral sclerosis: Data from the German MND-net.

Steinacker P, Huss A, Mayer B, Grehl T, Grosskreutz J, Borck G, Kuhle J, Lulé D, Meyer T, Oeckl P, Petri S, Weishaupt J, Ludolph AC, Otto M.

Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):112-119. doi: 10.1080/21678421.2016.1241279. Epub 2016 Nov 5.

PMID:
27819158
33.

Neurofilament light chain: a biomarker for genetic frontotemporal dementia.

Meeter LH, Dopper EG, Jiskoot LC, Sanchez-Valle R, Graff C, Benussi L, Ghidoni R, Pijnenburg YA, Borroni B, Galimberti D, Laforce RJ, Masellis M, Vandenberghe R, Ber IL, Otto M, van Minkelen R, Papma JM, Rombouts SA, Balasa M, Öijerstedt L, Jelic V, Dick KM, Cash DM, Harding SR, Jorge Cardoso M, Ourselin S, Rossor MN, Padovani A, Scarpini E, Fenoglio C, Tartaglia MC, Lamari F, Barro C, Kuhle J, Rohrer JD, Teunissen CE, van Swieten JC.

Ann Clin Transl Neurol. 2016 Jul 1;3(8):623-36. doi: 10.1002/acn3.325. eCollection 2016 Aug.

34.

The association between retinal nerve fibre layer thickness and N-acetyl aspartate levels in multiple sclerosis brain normal-appearing white matter: a longitudinal study using magnetic resonance spectroscopy and optical coherence tomography.

Pardini M, Botzkowski D, Müller S, Vehoff J, Kuhle J, Ruberte E, Würfel J, Gass A, Valmaggia C, Tettenborn B, Putzki N, Yaldizli Ö.

Eur J Neurol. 2016 Dec;23(12):1769-1774. doi: 10.1111/ene.13116. Epub 2016 Sep 3.

PMID:
27591406
35.

Comment: "If you can't measure it, you can't improve it" (Lord Kelvin).

Kuhle J.

Neurology. 2016 Sep 27;87(13):1335. doi: 10.1212/WNL.0000000000003164. Epub 2016 Aug 31. No abstract available.

PMID:
27581215
36.

Neurofilament light chain level is a weak risk factor for the development of MS.

Arrambide G, Espejo C, Eixarch H, Villar LM, Alvarez-Cermeño JC, Picón C, Kuhle J, Disanto G, Kappos L, Sastre-Garriga J, Pareto D, Simon E, Comabella M, Río J, Nos C, Tur C, Castilló J, Vidal-Jordana A, Galán I, Arévalo MJ, Auger C, Rovira A, Montalban X, Tintore M.

Neurology. 2016 Sep 13;87(11):1076-84. doi: 10.1212/WNL.0000000000003085. Epub 2016 Aug 12. Erratum in: Neurology. 2016 Nov 8;87(19):2068.

37.

Data quality evaluation for observational multiple sclerosis registries.

Kalincik T, Kuhle J, Pucci E, Rojas JI, Tsolaki M, Sirbu CA, Slee M, Butzkueven H; MSBase Scientific Leadership Group and MSBase Study Group.

Mult Scler. 2017 Apr;23(5):647-655. doi: 10.1177/1352458516662728. Epub 2016 Aug 5.

PMID:
27481209
38.

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M.

Neuron. 2016 Jul 20;91(2):494-496. doi: 10.1016/j.neuron.2016.07.007. Epub 2016 Jul 20. No abstract available.

39.

Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis.

Lu CH, Allen K, Oei F, Leoni E, Kuhle J, Tree T, Fratta P, Sharma N, Sidle K, Howard R, Orrell R, Fish M, Greensmith L, Pearce N, Gallo V, Malaspina A.

Neurol Neuroimmunol Neuroinflamm. 2016 Jun 1;3(4):e244. doi: 10.1212/NXI.0000000000000244. eCollection 2016 Aug.

40.

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M.

Neuron. 2016 Jul 6;91(1):56-66. doi: 10.1016/j.neuron.2016.05.018. Epub 2016 Jun 9. Erratum in: Neuron. 2016 Jul 20;91(2):494-496.

41.

Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum.

Wilke C, Preische O, Deuschle C, Roeben B, Apel A, Barro C, Maia L, Maetzler W, Kuhle J, Synofzik M.

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1270-1272. doi: 10.1136/jnnp-2015-312972. Epub 2016 May 17. No abstract available.

PMID:
27188986
42.

Natalizumab-induced POU2AF1/Spi-B upregulation: A possible route for PML development.

Meira M, Sievers C, Hoffmann F, Haghikia A, Rasenack M, Décard BF, Kuhle J, Derfuss T, Kappos L, Lindberg RL.

Neurol Neuroimmunol Neuroinflamm. 2016 Mar 31;3(3):e223. doi: 10.1212/NXI.0000000000000223. eCollection 2016 Jun.

43.

Multiple Sclerosis and Antibodies against KIR4.1.

Pröbstel AK, Kuhle J, Lecourt AC, Vock I, Sanderson NS, Kappos L, Derfuss T.

N Engl J Med. 2016 Apr 14;374(15):1496-8. doi: 10.1056/NEJMc1507131. No abstract available.

44.

Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa.

Kuhle J, Barro C, Andreasson U, Derfuss T, Lindberg R, Sandelius Å, Liman V, Norgren N, Blennow K, Zetterberg H.

Clin Chem Lab Med. 2016 Oct 1;54(10):1655-61. doi: 10.1515/cclm-2015-1195.

PMID:
27071153
45.

The Swiss Multiple Sclerosis Cohort-Study (SMSC): A Prospective Swiss Wide Investigation of Key Phases in Disease Evolution and New Treatment Options.

Disanto G, Benkert P, Lorscheider J, Mueller S, Vehoff J, Zecca C, Ramseier S, Achtnichts L, Findling O, Nedeltchev K, Radue EW, Sprenger T, Stippich C, Derfuss T, Louvion JF, Kamm CP, Mattle HP, Lotter C, Du Pasquier R, Schluep M, Pot C, Lalive PH, Yaldizli Ö, Gobbi C, Kappos L, Kuhle J; SMSC Scientific Board.

PLoS One. 2016 Mar 31;11(3):e0152347. doi: 10.1371/journal.pone.0152347. eCollection 2016.

46.

Severe exacerbation of relapsing-remitting multiple sclerosis after G-CSF therapy.

Rust H, Kuhle J, Kappos L, Derfuss T.

Neurol Neuroimmunol Neuroinflamm. 2016 Mar 9;3(2):e215. doi: 10.1212/NXI.0000000000000215. eCollection 2016 Apr. No abstract available.

47.

Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.

Van Dalen YW, Blokhuis C, Cohen S, Ter Stege JA, Teunissen CE, Kuhle J, Kootstra NA, Scherpbier HJ, Kuijpers TW, Reiss P, Majoie CB, Caan MW, Pajkrt D.

Medicine (Baltimore). 2016 Mar;95(12):e3093. doi: 10.1097/MD.0000000000003093.

48.

Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity.

Kuhle J, Barro C, Disanto G, Mathias A, Soneson C, Bonnier G, Yaldizli Ö, Regeniter A, Derfuss T, Canales M, Schluep M, Du Pasquier R, Krueger G, Granziera C.

Mult Scler. 2016 Oct;22(12):1550-1559. Epub 2016 Jan 11.

PMID:
26754800
49.

Quantified CSF antibody reactivity against myelin in multiple sclerosis.

Sun X, Bakhti M, Fitzner D, Schnaars M, Kruse N, Coskun Ü, Kremser C, Willecke K, Kappos L, Kuhle J, Simons M.

Ann Clin Transl Neurol. 2015 Nov 9;2(12):1116-23. doi: 10.1002/acn3.264. eCollection 2015 Dec.

50.

The association between olfactory bulb volume, cognitive dysfunction, physical disability and depression in multiple sclerosis.

Yaldizli Ö, Penner IK, Yonekawa T, Naegelin Y, Kuhle J, Pardini M, Chard DT, Stippich C, Kira JI, Bendfeldt K, Amann M, Radue EW, Kappos L, Sprenger T.

Eur J Neurol. 2016 Mar;23(3):510-9. doi: 10.1111/ene.12891. Epub 2015 Nov 19.

PMID:
26699999

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