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Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells.

Kim MS, Takahashi T, Lee JY, Toyama T, Hoshi T, Kuge S, Fujiwara Y, Naganuma A, Hwang GW.

Sci Rep. 2019 Mar 15;9(1):4631. doi: 10.1038/s41598-019-41127-y.


SPF-CellTracker: Tracking Multiple Cells with Strongly-Correlated Moves Using a Spatial Particle Filter.

Hirose O, Kawaguchi S, Tokunaga T, Toyoshima Y, Teramoto T, Kuge S, Ishihara T, Iino Y, Yoshida R.

IEEE/ACM Trans Comput Biol Bioinform. 2018 Nov-Dec;15(6):1822-1831. doi: 10.1109/TCBB.2017.2782255. Epub 2017 Dec 11.


Akr1 attenuates methylmercury toxicity through the palmitoylation of Meh1 as a subunit of the yeast EGO complex.

Zhang ZT, Ogiwara Y, Ito Y, Hikida A, Miura N, Kuge S, Naganuma A, Hwang GW.

Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1729-1736. doi: 10.1016/j.bbagen.2017.03.009. Epub 2017 Mar 15.


Immature Core protein of hepatitis C virus induces an unfolded protein response through inhibition of ERAD-L in a yeast model system.

Takahashi S, Sato N, Kikuchi J, Kakinuma H, Okawa J, Masuyama Y, Iwasa S, Irokawa H, Hwang GW, Naganuma A, Kohara M, Kuge S.

Genes Cells. 2017 Feb;22(2):160-173. doi: 10.1111/gtc.12464. Epub 2017 Jan 18.


Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin.

Irokawa H, Tachibana T, Watanabe T, Matsuyama Y, Motohashi H, Ogasawara A, Iwai K, Naganuma A, Kuge S.

Sci Rep. 2016 Sep 16;6:33536. doi: 10.1038/srep33536.


The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System.

Iwasa S, Sato N, Wang CW, Cheng YH, Irokawa H, Hwang GW, Naganuma A, Kuge S.

PLoS One. 2016 Jul 26;11(7):e0159324. doi: 10.1371/journal.pone.0159324. eCollection 2016.


Accurate Automatic Detection of Densely Distributed Cell Nuclei in 3D Space.

Toyoshima Y, Tokunaga T, Hirose O, Kanamori M, Teramoto T, Jang MS, Kuge S, Ishihara T, Yoshida R, Iino Y.

PLoS Comput Biol. 2016 Jun 6;12(6):e1004970. doi: 10.1371/journal.pcbi.1004970. eCollection 2016 Jun.


Whi2 enhances methylmercury toxicity in yeast via inhibition of Akr1 palmitoyltransferase activity.

Hwang GW, Fukumitsu T, Ogiwara Y, Takahashi T, Miura N, Kuge S, Naganuma A.

Biochim Biophys Acta. 2016 Jun;1860(6):1326-33. doi: 10.1016/j.bbagen.2016.03.026. Epub 2016 Mar 23.


Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication.

Kubota N, Nomoto M, Hwang GW, Watanabe T, Kohara M, Wakita T, Naganuma A, Kuge S.

World J Hepatol. 2016 Feb 18;8(5):282-90. doi: 10.4254/wjh.v8.i5.282.


Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells.

Lee JY, Ishida Y, Kuge S, Naganuma A, Hwang GW.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2720-5. doi: 10.1016/j.febslet.2015.08.016. Epub 2015 Aug 20.


Change of fatty acid composition of the lumbar longissimus during the final stage of fattening in the Japanese Black cattle.

Honda T, Ishida T, Kobayashi I, Oguri Y, Mizuno Y, Mannen H, Iwaisaki H, Kuge S, Saito K, Oyama K.

Anim Sci J. 2016 Apr;87(4):578-83. doi: 10.1111/asj.12443. Epub 2015 Aug 17. Review.


Fluorescence imaging of siRNA delivery by peptide nucleic acid-based probe.

Sato T, Sato Y, Iwai K, Kuge S, Teramae N, Nishizawa S.

Anal Sci. 2015;31(4):315-20. doi: 10.2116/analsci.31.315.


Synthetic fluorescent probes capable of selective recognition of 3'-overhanging nucleotides for siRNA delivery imaging.

Sato T, Sato Y, Iwai K, Kuge S, Nishizawa S, Teramae N.

Chem Commun (Camb). 2015 Jan 28;51(8):1421-4. doi: 10.1039/c4cc08800j.


FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation.

Du K, Takahashi T, Kuge S, Naganuma A, Hwang GW.

J Toxicol Sci. 2014;39(6):861-6.


Automated detection and tracking of many cells by using 4D live-cell imaging data.

Tokunaga T, Hirose O, Kawaguchi S, Toyoshima Y, Teramoto T, Ikebata H, Kuge S, Ishihara T, Iino Y, Yoshida R.

Bioinformatics. 2014 Jun 15;30(12):i43-51. doi: 10.1093/bioinformatics/btu271.


Requirement of peroxiredoxin on the stationary phase of yeast cell growth.

Watanabe T, Irokawa H, Ogasawara A, Iwai K, Kuge S.

J Toxicol Sci. 2014 Feb;39(1):51-8.


Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1.

Inoue K, Tsukiyama-Kohara K, Matsuda C, Yoneyama M, Fujita T, Kuge S, Yoshiba M, Kohara M.

Biochem Biophys Res Commun. 2012 Nov 30;428(4):494-9. doi: 10.1016/j.bbrc.2012.10.079. Epub 2012 Oct 30.


HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells.

Kubota N, Inayoshi Y, Satoh N, Fukuda T, Iwai K, Tomoda H, Kohara M, Kataoka K, Shimamoto A, Furuichi Y, Nomoto A, Naganuma A, Kuge S.

FEBS Lett. 2012 Jul 30;586(16):2318-25. doi: 10.1016/j.febslet.2012.05.023. Epub 2012 May 31.


siRNA-mediated AMPKalpha1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells.

Hwang GW, Tobita M, Takahashi T, Kuge S, Kita K, Naganuma A.

J Toxicol Sci. 2010 Aug;35(4):601-4.


A novel fluorescent sensor protein for visualization of redox states in the cytoplasm and in peroxisomes.

Yano T, Oku M, Akeyama N, Itoyama A, Yurimoto H, Kuge S, Fujiki Y, Sakai Y.

Mol Cell Biol. 2010 Aug;30(15):3758-66. doi: 10.1128/MCB.00121-10. Epub 2010 May 24.


Peroxiredoxin Ahp1 acts as a receptor for alkylhydroperoxides to induce disulfide bond formation in the Cad1 transcription factor.

Iwai K, Naganuma A, Kuge S.

J Biol Chem. 2010 Apr 2;285(14):10597-604. doi: 10.1074/jbc.M109.090142. Epub 2010 Feb 9.


A major peroxiredoxin-induced activation of Yap1 transcription factor is mediated by reduction-sensitive disulfide bonds and reveals a low level of transcriptional activation.

Tachibana T, Okazaki S, Murayama A, Naganuma A, Nomoto A, Kuge S.

J Biol Chem. 2009 Feb 13;284(7):4464-72. doi: 10.1074/jbc.M807583200. Epub 2008 Dec 22.


siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells.

Hwang GW, Hayashi T, Kita K, Takahashi T, Kuge S, Naganuma A.

J Toxicol Sci. 2007 Dec;32(5):581-3.


Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal.

Okazaki S, Tachibana T, Naganuma A, Mano N, Kuge S.

Mol Cell. 2007 Aug 17;27(4):675-88.


Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice.

Nakagawa S, Umehara T, Matsuda C, Kuge S, Sudoh M, Kohara M.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):882-8. Epub 2006 Dec 22.


Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast.

Okazaki S, Naganuma A, Kuge S.

Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):327-34.


Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.

Ohka S, Matsuda N, Tohyama K, Oda T, Morikawa M, Kuge S, Nomoto A.

J Virol. 2004 Jul;78(13):7186-98.


Investigation of intracellular factors involved in methylmercury toxicity.

Naganuma A, Furuchi T, Miura N, Hwang GW, Kuge S.

Tohoku J Exp Med. 2002 Feb;196(2):65-70. Review.


Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation.

Kuge S, Arita M, Murayama A, Maeta K, Izawa S, Inoue Y, Nomoto A.

Mol Cell Biol. 2001 Sep;21(18):6139-50.


Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae.

Furuchi T, Ishikawa H, Miura N, Ishizuka M, Kajiya K, Kuge S, Naganuma A.

Mol Pharmacol. 2001 Mar;59(3):470-4.


Dose-Intensified Chemotherapy for Breast Cancer: Present and Future Prospects.

Tajima T, Kuge Si, Suzuki Y, Okumura A, Ohta M, Tokuda Y, Kubota M.

Breast Cancer. 1998 Jun 30;5(1):7-23.


Autografting with peripheral blood CD34-positive cells following high-dose chemotherapy against breast cancer.

Okumura A, Tokuda Y, Ohta M, Suzuki Y, Saito Y, Kuge S, Kubota M, Makuuchi H, Tajima T, Nakamura Y, Hotta T.

Tokai J Exp Clin Med. 1999 Dec;24(4-6):141-6.


GFAT as a target molecule of methylmercury toxicity in Saccharomyces cerevisiae.

Naganuma A, Miura N, Kaneko S, Mishina T, Hosoya S, Miyairi S, Furuchi T, Kuge S.

FASEB J. 2000 May;14(7):968-72.


Overexpression of L-glutamine:D-fructose-6-phosphate amidotransferase provides resistance to methylmercury in Saccharomyces cerevisiae.

Miura N, Kaneko S, Hosoya S, Furuchi T, Miura K, Kuge S, Naganuma A.

FEBS Lett. 1999 Sep 17;458(2):215-8.


[Regulated nuclear localization of transcription factors: nuclear export of yAP-1 is sensitive to oxidative stress].

Kuge S.

Tanpakushitsu Kakusan Koso. 1999 Apr;44(5):668-75. Review. Japanese. No abstract available.


Graft-versus-host disease after intraoperative blood transfusion: a rare and lethal condition.

Ohta M, Tokuda Y, Kameya T, Suzuki Y, Kuge S, Okumura A, Kubota M, Makuuchi H, Tajima T, Shimamura K, Uchida S, Mitsunaga S, Tadokoro K, Juji T.

Surgery. 1999 May;125(5):571-4. No abstract available.


Intracellular redistribution of truncated La protein produced by poliovirus 3Cpro-mediated cleavage.

Shiroki K, Isoyama T, Kuge S, Ishii T, Ohmi S, Hata S, Suzuki K, Takasaki Y, Nomoto A.

J Virol. 1999 Mar;73(3):2193-200.


[VIP36 recognizes high-mannose type glycans in relation to apical membrane traffic].

Yamashita K, Kuge S, Ohkura T.

Tanpakushitsu Kakusan Koso. 1998 Dec;43(16 Suppl):2455-63. Review. Japanese. No abstract available.


Reconstitution of immune systems in RAG2-/- mice by transfer with interleukin-12-induced splenic hematopoietic progenitor cells.

Yahata T, Ando K, Watanabe K, Mori T, Ohta A, Ohmi Y, Iwakabe K, Kuge S, Nakui M, Ito M, Habu S, Yasuda S, Nishimura T.

Immunol Lett. 1998 Jul;62(3):165-70.


Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.

Toone WM, Kuge S, Samuels M, Morgan BA, Toda T, Jones N.

Genes Dev. 1998 May 15;12(10):1453-63. Erratum in: Genes Dev 1998 Aug 15;12(16):2650.


Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X.

Tsuchihara K, Tanaka T, Hijikata M, Kuge S, Toyoda H, Nomoto A, Yamamoto N, Shimotohno K.

J Virol. 1997 Sep;71(9):6720-6.


A case of multiple endocrine neoplasia type 2B.

Ohta M, Tokuda Y, Suzuki Y, Kuge S, Okumura A, Kubota M, Tajima T, Osamura RY, Mitomi T.

Jpn J Clin Oncol. 1997 Aug;27(4):268-73.


A case of angiosarcoma of the breast.

Ohta M, Tokuda Y, Kuge S, Okumura A, Tanaka M, Kubota M, Tajima T, Akatsuka A, Osamura RY, Tamaoki N, Mitomi T.

Jpn J Clin Oncol. 1997 Apr;27(2):91-4.


Regulation of yAP-1 nuclear localization in response to oxidative stress.

Kuge S, Jones N, Nomoto A.

EMBO J. 1997 Apr 1;16(7):1710-20.

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