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Items: 1 to 50 of 239

1.

Early stages of drug crystallization from amorphous solid dispersion via fractal analysis based on chemical imaging.

Abreu-Villela R, Schönenberger M, Caraballo I, Kuentz M.

Eur J Pharm Biopharm. 2018 Oct 6. pii: S0939-6411(18)30875-0. doi: 10.1016/j.ejpb.2018.10.007. [Epub ahead of print]

PMID:
30300718
2.

Towards a better understanding of solid dispersions in aqueous environment by a fluorescence quenching approach.

Aleandri S, Jankovic S, Kuentz M.

Int J Pharm. 2018 Oct 25;550(1-2):130-139. doi: 10.1016/j.ijpharm.2018.08.029. Epub 2018 Aug 18.

PMID:
30130607
3.

Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches - a PEARRL review.

Ditzinger F, Price DJ, Ilie AR, Köhl NJ, Jankovic S, Tsakiridou G, Aleandri S, Kalantzi L, Holm R, Nair A, Saal C, Griffin B, Kuentz M.

J Pharm Pharmacol. 2018 Aug 2. doi: 10.1111/jphp.12984. [Epub ahead of print] Review.

PMID:
30070363
4.

Dynamic Light Scattering of Biopharmaceutics-Can Analytical Performance Be Enhanced by Laser Power?

Aleandri S, Vaccaro A, Armenta R, Völker AC, Kuentz M.

Pharmaceutics. 2018 Jul 17;10(3). pii: E94. doi: 10.3390/pharmaceutics10030094.

5.

Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review.

Jankovic S, Tsakiridou G, Ditzinger F, Koehl NJ, Price DJ, Ilie AR, Kalantzi L, Kimpe K, Holm R, Nair A, Griffin B, Saal C, Kuentz M.

J Pharm Pharmacol. 2018 Jul 5. doi: 10.1111/jphp.12948. [Epub ahead of print] Review.

PMID:
29978475
6.

In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review.

O'Dwyer PJ, Litou C, Box KJ, Dressman JB, Kostewicz ES, Kuentz M, Reppas C.

J Pharm Pharmacol. 2018 Jun 28. doi: 10.1111/jphp.12951. [Epub ahead of print] Review.

PMID:
29956338
7.

New prediction methods for solubility parameters based on molecular sigma profiles using pharmaceutical materials.

Niederquell A, Wyttenbach N, Kuentz M.

Int J Pharm. 2018 Jul 30;546(1-2):137-144. doi: 10.1016/j.ijpharm.2018.05.033. Epub 2018 May 18.

PMID:
29772285
8.

Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations - a PEARRL review.

Price DJ, Ditzinger F, Koehl NJ, Jankovic S, Tsakiridou G, Nair A, Holm R, Kuentz M, Dressman JB, Saal C.

J Pharm Pharmacol. 2018 May 16. doi: 10.1111/jphp.12927. [Epub ahead of print] Review.

PMID:
29770440
9.

Temperature-Induced Surface Effects on Drug Nanosuspensions.

Aleandri S, Schönenberger M, Niederquell A, Kuentz M.

Pharm Res. 2018 Feb 21;35(3):69. doi: 10.1007/s11095-017-2300-6.

PMID:
29468420
10.

Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release in vivo.

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Eur J Pharm Biopharm. 2018 Apr;125:68-75. doi: 10.1016/j.ejpb.2018.01.006. Epub 2018 Jan 10.

PMID:
29331439
11.

Electron microscopy/energy dispersive X-ray spectroscopy of drug distribution in solid dispersions and interpretation by multifractal geometry.

Abreu-Villela R, Adler C, Caraballo I, Kuentz M.

J Pharm Biomed Anal. 2018 Feb 20;150:241-247. doi: 10.1016/j.jpba.2017.12.020. Epub 2017 Dec 11.

PMID:
29253780
12.

Unexpected Solubility Enhancement of Drug Bases in the Presence of a Dimethylaminoethyl Methacrylate Copolymer.

Saal W, Ross A, Wyttenbach N, Alsenz J, Kuentz M.

Mol Pharm. 2018 Jan 2;15(1):186-192. doi: 10.1021/acs.molpharmaceut.7b00804. Epub 2017 Dec 6.

PMID:
29164891
13.

Investigating Oral Absorption of Carbamazepine in Pediatric Populations.

Kohlmann P, Stillhart C, Kuentz M, Parrott N.

AAPS J. 2017 Nov;19(6):1864-1877. doi: 10.1208/s12248-017-0149-6. Epub 2017 Oct 2.

PMID:
28971365
14.

The quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state.

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Eur J Pharm Sci. 2018 Jan 1;111:96-103. doi: 10.1016/j.ejps.2017.09.032. Epub 2017 Sep 22.

PMID:
28943442
15.

Biorelevant Drug Solubility Enhancement Modeled by a Linear Solvation Energy Relationship.

Niederquell A, Kuentz M.

J Pharm Sci. 2018 Jan;107(1):503-506. doi: 10.1016/j.xphs.2017.08.017. Epub 2017 Aug 31.

PMID:
28864357
16.

Study of Rheology and Polymer Adsorption Onto Drug Nanoparticles in Pharmaceutical Suspensions Produced by Nanomilling.

Negrini R, Aleandri S, Kuentz M.

J Pharm Sci. 2017 Nov;106(11):3395-3401. doi: 10.1016/j.xphs.2017.07.006. Epub 2017 Jul 18.

PMID:
28732711
17.

A diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment.

Niederquell A, Machado AHE, Kuentz M.

Int J Pharm. 2017 Sep 15;530(1-2):213-223. doi: 10.1016/j.ijpharm.2017.07.038. Epub 2017 Jul 15.

PMID:
28720536
18.

[Is transplantation an alternative to the transfusional impasse in sickle cell disease?]

Bernaudin F, Kuentz M.

Transfus Clin Biol. 2017 Sep;24(3):232-236. doi: 10.1016/j.tracli.2017.06.007. Epub 2017 Jun 23. Review. French.

PMID:
28648733
19.

Can we estimate the critical micelle concentration of amphiphilic drug bases from molecular connectivity indices?

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Pharm Dev Technol. 2018 Feb;23(2):211-215. doi: 10.1080/10837450.2017.1316288. Epub 2017 Apr 21.

PMID:
28378601
20.

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks.

Rafii H, Bernaudin F, Rouard H, Vanneaux V, Ruggeri A, Cavazzana M, Gauthereau V, Stanislas A, Benkerrou M, De Montalembert M, Ferry C, Girot R, Arnaud C, Kamdem A, Gour J, Touboul C, Cras A, Kuentz M, Rieux C, Volt F, Cappelli B, Maio KT, Paviglianiti A, Kenzey C, Larghero J, Gluckman E.

Haematologica. 2017 Jun;102(6):976-983. doi: 10.3324/haematol.2016.163055. Epub 2017 Mar 16.

21.

A Systematic Study of Molecular Interactions of Anionic Drugs with a Dimethylaminoethyl Methacrylate Copolymer Regarding Solubility Enhancement.

Saal W, Ross A, Wyttenbach N, Alsenz J, Kuentz M.

Mol Pharm. 2017 Apr 3;14(4):1243-1250. doi: 10.1021/acs.molpharmaceut.6b01116. Epub 2017 Mar 21.

PMID:
28287743
22.

Multifractal and mechanical analysis of amorphous solid dispersions.

Adler C, Teleki A, Kuentz M.

Int J Pharm. 2017 May 15;523(1):91-101. doi: 10.1016/j.ijpharm.2017.03.014. Epub 2017 Mar 9.

PMID:
28286079
23.

Time domain NMR as a new process monitoring method for characterization of pharmaceutical hydrates.

Schumacher SU, Rothenhäusler B, Willmann A, Thun J, Moog R, Kuentz M.

J Pharm Biomed Anal. 2017 Apr 15;137:96-103. doi: 10.1016/j.jpba.2017.01.017. Epub 2017 Jan 9.

PMID:
28107690
24.

Medicines for Pediatric Patients-Biopharmaceutical, Developmental, and Regulatory Considerations.

Elder DP, Holm R, Kuentz M.

J Pharm Sci. 2017 Apr;106(4):950-960. doi: 10.1016/j.xphs.2016.12.018. Epub 2016 Dec 29.

PMID:
28041968
25.

Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation.

Gluckman E, Cappelli B, Bernaudin F, Labopin M, Volt F, Carreras J, Pinto Simões B, Ferster A, Dupont S, de la Fuente J, Dalle JH, Zecca M, Walters MC, Krishnamurti L, Bhatia M, Leung K, Yanik G, Kurtzberg J, Dhedin N, Kuentz M, Michel G, Apperley J, Lutz P, Neven B, Bertrand Y, Vannier JP, Ayas M, Cavazzana M, Matthes-Martin S, Rocha V, Elayoubi H, Kenzey C, Bader P, Locatelli F, Ruggeri A, Eapen M; Eurocord, the Pediatric Working Party of the European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research.

Blood. 2017 Mar 16;129(11):1548-1556. doi: 10.1182/blood-2016-10-745711. Epub 2016 Dec 13.

26.

Glass-forming ability of compounds in marketed amorphous drug products.

Wyttenbach N, Kuentz M.

Eur J Pharm Biopharm. 2017 Mar;112:204-208. doi: 10.1016/j.ejpb.2016.11.031. Epub 2016 Nov 27.

PMID:
27903457
27.

Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates.

Adler C, Teleki A, Kuentz M.

Pharm Res. 2017 Feb;34(2):321-332. doi: 10.1007/s11095-016-2064-4. Epub 2016 Nov 14.

PMID:
27844187
28.

Rapid determination of drug solubilization versus supersaturation in natural and digested lipids.

Gautschi N, Bergström CA, Kuentz M.

Int J Pharm. 2016 Nov 20;513(1-2):164-174. doi: 10.1016/j.ijpharm.2016.09.015. Epub 2016 Sep 5.

PMID:
27609663
29.

Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling.

Campiñez MD, Caraballo I, Puchkov M, Kuentz M.

AAPS PharmSciTech. 2017 Jul;18(5):1544-1553. doi: 10.1208/s12249-016-0613-0. Epub 2016 Sep 6.

PMID:
27600323
30.

Miniaturized X-ray powder diffraction assay (MixRay) for quantitative kinetic analysis of solvent-mediated phase transformations in pharmaceutics.

Kirchmeyer W, Grassmann O, Wyttenbach N, Alsenz J, Kuentz M.

J Pharm Biomed Anal. 2016 Nov 30;131:195-201. doi: 10.1016/j.jpba.2016.08.028. Epub 2016 Aug 29.

PMID:
27596832
31.

Antibiotic Resistance: The Need For a Global Strategy.

Elder DP, Kuentz M, Holm R.

J Pharm Sci. 2016 Aug;105(8):2278-87. doi: 10.1016/j.xphs.2016.06.002. Epub 2016 Jul 7.

PMID:
27397433
32.

Molecular insights into the formation of drug-monoacyl phosphatidylcholine solid dispersions for oral delivery.

Gautschi N, Van Hoogevest P, Kuentz M.

Eur J Pharm Sci. 2017 Oct 15;108:93-100. doi: 10.1016/j.ejps.2016.05.023. Epub 2016 May 28.

PMID:
27240778
33.

A microstructural study of water effects in lipid-based pharmaceutical formulations for liquid filling of capsules.

Machado AH, Kokubo T, Dujovny G, Jones B, Scialdone C, Bravo R, Kuentz M.

Eur J Pharm Sci. 2016 Jul 30;90:64-75. doi: 10.1016/j.ejps.2016.04.035. Epub 2016 Apr 28.

PMID:
27132811
34.

Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations.

Villiger A, Stillhart C, Parrott N, Kuentz M.

AAPS J. 2016 Jul;18(4):933-47. doi: 10.1208/s12248-016-9896-z. Epub 2016 Apr 8.

PMID:
27060007
35.

Trends in the Assessment of Drug Supersaturation and Precipitation In Vitro Using Lipid-Based Delivery Systems.

Stillhart C, Kuentz M.

J Pharm Sci. 2016 Sep;105(9):2468-2476. doi: 10.1016/j.xphs.2016.01.010. Epub 2016 Feb 28.

PMID:
26935881
36.

On prilled Nanotubes-in-Microgel Oral Systems for protein delivery.

de Kruif JK, Ledergerber G, Garofalo C, Fasler-Kan E, Kuentz M.

Eur J Pharm Biopharm. 2016 Apr;101:90-102. doi: 10.1016/j.ejpb.2016.01.014. Epub 2016 Feb 4.

PMID:
26851504
37.

Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion.

Adler C, Schönenberger M, Teleki A, Kuentz M.

Int J Pharm. 2016 Feb 29;499(1-2):90-100. doi: 10.1016/j.ijpharm.2015.12.057. Epub 2015 Dec 22.

PMID:
26721729
38.

Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations.

Elder DP, Kuentz M, Holm R.

Eur J Pharm Sci. 2016 May 25;87:88-99. doi: 10.1016/j.ejps.2015.12.018. Epub 2015 Dec 14. Review.

PMID:
26699228
39.

Methodology of oral formulation selection in the pharmaceutical industry.

Kuentz M, Holm R, Elder DP.

Eur J Pharm Sci. 2016 May 25;87:136-63. doi: 10.1016/j.ejps.2015.12.008. Epub 2015 Dec 11. Review.

PMID:
26687443
40.

Theoretical Considerations of the Prigogine-Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts.

Wyttenbach N, Kirchmeyer W, Alsenz J, Kuentz M.

Mol Pharm. 2016 Jan 4;13(1):241-50. doi: 10.1021/acs.molpharmaceut.5b00688. Epub 2015 Dec 10.

PMID:
26587865
41.

Flow-through cross-polarized imaging as a new tool to overcome the analytical sensitivity challenges of a low-dose crystalline compound in a lipid matrix.

Adler C, Schönenberger M, Teleki A, Leuenberger B, Kuentz M.

J Pharm Biomed Anal. 2015 Nov 10;115:20-30. doi: 10.1016/j.jpba.2015.06.033. Epub 2015 Jun 24.

PMID:
26142560
42.

Amorphous drug dispersions with mono- and diacyl lecithin: On molecular categorization of their feasibility and UV dissolution imaging.

Gautschi N, Van Hoogevest P, Kuentz M.

Int J Pharm. 2015 Aug 1;491(1-2):218-30. doi: 10.1016/j.ijpharm.2015.06.039. Epub 2015 Jun 27.

PMID:
26129840
43.

A Systematic Study on Manufacturing of Prilled Microgels into Lipids for Oral Protein Delivery.

De Kruif JK, Varum F, Bravo R, Kuentz M.

J Pharm Sci. 2015 Oct;104(10):3351-65. doi: 10.1002/jps.24526. Epub 2015 Jun 24.

PMID:
26108711
44.

Introducing diffusing wave spectroscopy as a process analytical tool for pharmaceutical emulsion manufacturing.

Reufer M, Machado AHE, Niederquell A, Bohnenblust K, Müller B, Völker AC, Kuentz M.

J Pharm Sci. 2014 Dec;103(12):3902-3913. doi: 10.1002/jps.24197. Epub 2014 Oct 9.

PMID:
25302803
45.

On prilling of hydrophilic microgels in lipid dispersions using mono-N-carboxymethyl chitosan for oral biologicals delivery.

De Kruif JK, Fasler-Kan E, Varum F, Bravo R, Kuentz M.

J Pharm Sci. 2014 Nov;103(11):3675-3687. doi: 10.1002/jps.24172. Epub 2014 Sep 19.

PMID:
25241928
46.

Biopharmaceutical modeling of drug supersaturation during lipid-based formulation digestion considering an absorption sink.

Stillhart C, Imanidis G, Griffin BT, Kuentz M.

Pharm Res. 2014 Dec;31(12):3426-44. doi: 10.1007/s11095-014-1432-1. Epub 2014 Jun 25.

PMID:
24962509
47.

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale.

Kuentz M.

J Pharm Pharmacol. 2015 Feb;67(2):143-59. doi: 10.1111/jphp.12271. Epub 2014 May 18. Review.

PMID:
24834963
48.

Toward an improved understanding of the precipitation behavior of weakly basic drugs from oral lipid-based formulations.

Stillhart C, Dürr D, Kuentz M.

J Pharm Sci. 2014 Apr;103(4):1194-203. doi: 10.1002/jps.23892. Epub 2014 Feb 11.

PMID:
24515977
49.

Biorelevant dissolution of poorly soluble weak acids studied by UV imaging reveals ranges of fractal-like kinetics.

Niederquell A, Kuentz M.

Int J Pharm. 2014 Mar 10;463(1):38-49. doi: 10.1016/j.ijpharm.2013.12.049. Epub 2014 Jan 7.

PMID:
24406675
50.

Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate.

Griffin BT, Kuentz M, Vertzoni M, Kostewicz ES, Fei Y, Faisal W, Stillhart C, O'Driscoll CM, Reppas C, Dressman JB.

Eur J Pharm Biopharm. 2014 Apr;86(3):427-37. doi: 10.1016/j.ejpb.2013.10.016. Epub 2013 Oct 31.

PMID:
24184675

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