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Items: 1 to 50 of 259

1.

A Novel Rheological Method to Assess Drug-Polymer Interactions Regarding Miscibility and Crystallization of Drug in Amorphous Solid Dispersions for Oral Drug Delivery.

Tsakiridou G, Reppas C, Kuentz M, Kalantzi L.

Pharmaceutics. 2019 Nov 22;11(12). pii: E625. doi: 10.3390/pharmaceutics11120625.

2.

Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies.

Ditzinger F, Price DJ, Nair A, Becker-Baldus J, Glaubitz C, Dressman JB, Saal C, Kuentz M.

Pharmaceutics. 2019 Nov 4;11(11). pii: E577. doi: 10.3390/pharmaceutics11110577.

3.

Incorporation of HPMCAS during loading of glibenclamide onto mesoporous silica improves dissolution and inhibits precipitation.

Price DJ, Nair A, Becker-Baldus J, Glaubitz C, Kuentz M, Dressman J, Saal C.

Eur J Pharm Sci. 2020 Jan 1;141:105113. doi: 10.1016/j.ejps.2019.105113. Epub 2019 Oct 23.

PMID:
31655207
4.

Recommendations for the application and the follow-up of quality controls in medical biology laboratories.

Giannoli JM, Albarede S, Avellan T, Bouilloux JP, Cartier R, Cohen R, Colard N, Essemilaire L, Galinier JL, Kuentz M, Paris M, Portugal H, Scherrer F, Siest JP, Vassault A, Vialle JM.

Ann Biol Clin (Paris). 2019 Oct 1;77(5):577-597. doi: 10.1684/abc.2019.1481.

PMID:
31638588
5.

From Quantum Chemistry to Prediction of Drug Solubility in Glycerides.

Alsenz J, Kuentz M.

Mol Pharm. 2019 Nov 4;16(11):4661-4669. doi: 10.1021/acs.molpharmaceut.9b00801. Epub 2019 Sep 27.

PMID:
31518142
6.

Benefits of Fractal Approaches in Solid Dosage Form Development.

Abreu-Villela R, Kuentz M, Caraballo I.

Pharm Res. 2019 Sep 6;36(11):156. doi: 10.1007/s11095-019-2685-5. Review.

PMID:
31493266
7.

Ultra-sub-stoichiometric "Dynamic" Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization.

Gong Y, Soleymani Abyaneh H, Drossis N, Niederquell A, Kuentz M, Leroux JC, de Haan HW, Gauthier MA.

Biomacromolecules. 2019 Sep 9;20(9):3557-3565. doi: 10.1021/acs.biomac.9b00867. Epub 2019 Aug 23.

PMID:
31398010
8.

Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states.

Litou C, Patel N, Turner DB, Kostewicz E, Kuentz M, Box KJ, Dressman J.

Eur J Pharm Sci. 2019 Oct 1;138:105031. doi: 10.1016/j.ejps.2019.105031. Epub 2019 Aug 3.

PMID:
31386891
9.

Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance.

Jankovic S, O'Dwyer PJ, Box KJ, Imanidis G, Reppas C, Kuentz M.

Eur J Pharm Sci. 2019 Sep 1;137:105001. doi: 10.1016/j.ejps.2019.105001. Epub 2019 Jul 10.

PMID:
31301486
10.

A Relative Permittivity Approach for Fast Drug Solubility Screening of Solvents and Excipients in Lipid-Based Delivery.

Niederquell A, Dujovny G, Probst SE, Kuentz M.

J Pharm Sci. 2019 Oct;108(10):3457-3460. doi: 10.1016/j.xphs.2019.06.014. Epub 2019 Jun 27.

11.

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems.

Boyd BJ, Bergström CAS, Vinarov Z, Kuentz M, Brouwers J, Augustijns P, Brandl M, Bernkop-Schnürch A, Shrestha N, Préat V, Müllertz A, Bauer-Brandl A, Jannin V.

Eur J Pharm Sci. 2019 Sep 1;137:104967. doi: 10.1016/j.ejps.2019.104967. Epub 2019 Jun 25.

12.

Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France.

Bernaudin F, Dalle JH, Bories D, Peffault de Latour R, Robin M, Bertrand Y, Pondarre C, Vannier JP, Neven B, Kuentz M, Maury S, Lutz P, Paillard C, Yakouben K, Thuret I, Galambrun C, Dhedin N, Jubert C, Rohrlich P, Bay JO, Suarez F, Raus N, Vernant JP, Gluckman E, Poirot C, Socié G; Société Française de Greffe de Moelle et de Thérapie Cellulaire.

Haematologica. 2019 May 16. pii: haematol.2018.213207. doi: 10.3324/haematol.2018.213207. [Epub ahead of print]

13.

Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease.

Cappelli B, Volt F, Tozatto-Maio K, Scigliuolo GM, Ferster A, Dupont S, Simões BP, Al-Seraihy A, Aljurf MD, Almohareb F, Belendez C, Matthes S, Dhedin N, Pondarre C, Dalle JH, Bertrand Y, Vannier JP, Kuentz M, Lutz P, Michel G, Rafii H, Neven B, Zecca M, Bader P, Cavazzana M, Labopin M, Locatelli F, Magnani A, Ruggeri A, Rocha V, Bernaudin F, de La Fuente J, Corbacioglu S, Gluckman E; Eurocord, the Cellular Therapy and Immunobiology Working Party (CTIWP) and the Paediatric Diseases Working Party (PDWP) of the EBMT.

Haematologica. 2019 Dec;104(12):e543-e546. doi: 10.3324/haematol.2019.216788. Epub 2019 Apr 24. No abstract available.

14.

Polyelectrolytes in Hot Melt Extrusion: A Combined Solvent-Based and Interacting Additive Technique for Solid Dispersions.

Ditzinger F, Dejoie C, Sisak Jung D, Kuentz M.

Pharmaceutics. 2019 Apr 10;11(4). pii: E174. doi: 10.3390/pharmaceutics11040174.

15.

Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations.

Price DJ, Nair A, Kuentz M, Dressman J, Saal C.

Eur J Pharm Sci. 2019 Apr 30;132:142-156. doi: 10.1016/j.ejps.2019.03.006. Epub 2019 Mar 12.

PMID:
30877067
16.

New Insights into Using Lipid Based Suspensions for 'Brick Dust' Molecules: Case Study of Nilotinib.

Koehl NJ, Holm R, Kuentz M, Griffin BT.

Pharm Res. 2019 Feb 22;36(4):56. doi: 10.1007/s11095-019-2590-y.

PMID:
30796596
17.

Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics.

Niederquell A, Wyttenbach N, Kuentz M, Panayiotou C.

Pharmaceutics. 2019 Jan 4;11(1). pii: E17. doi: 10.3390/pharmaceutics11010017.

18.

Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative.

de la Fuente J, Dhedin N, Koyama T, Bernaudin F, Kuentz M, Karnik L, Socié G, Culos KA, Brodsky RA, DeBaun MR, Kassim AA.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1197-1209. doi: 10.1016/j.bbmt.2018.11.027. Epub 2018 Nov 28.

PMID:
30500440
19.

Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer.

Ditzinger F, Scherer U, Schönenberger M, Holm R, Kuentz M.

Mol Pharm. 2019 Jan 7;16(1):141-150. doi: 10.1021/acs.molpharmaceut.8b00920. Epub 2018 Dec 6.

PMID:
30484651
20.

Drug supersaturation during formulation digestion, including real-time analytical approaches.

Kuentz M.

Adv Drug Deliv Rev. 2019 Mar 1;142:50-61. doi: 10.1016/j.addr.2018.11.003. Epub 2018 Nov 13. Review.

PMID:
30445096
21.

Early stages of drug crystallization from amorphous solid dispersion via fractal analysis based on chemical imaging.

Abreu-Villela R, Schönenberger M, Caraballo I, Kuentz M.

Eur J Pharm Biopharm. 2018 Dec;133:122-130. doi: 10.1016/j.ejpb.2018.10.007. Epub 2018 Oct 6.

PMID:
30300718
22.

Towards a better understanding of solid dispersions in aqueous environment by a fluorescence quenching approach.

Aleandri S, Jankovic S, Kuentz M.

Int J Pharm. 2018 Oct 25;550(1-2):130-139. doi: 10.1016/j.ijpharm.2018.08.029. Epub 2018 Aug 18.

PMID:
30130607
23.

Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches - a PEARRL review.

Ditzinger F, Price DJ, Ilie AR, Köhl NJ, Jankovic S, Tsakiridou G, Aleandri S, Kalantzi L, Holm R, Nair A, Saal C, Griffin B, Kuentz M.

J Pharm Pharmacol. 2019 Apr;71(4):464-482. doi: 10.1111/jphp.12984. Epub 2018 Aug 2. Review.

PMID:
30070363
24.

Dynamic Light Scattering of Biopharmaceutics-Can Analytical Performance Be Enhanced by Laser Power?

Aleandri S, Vaccaro A, Armenta R, Völker AC, Kuentz M.

Pharmaceutics. 2018 Jul 17;10(3). pii: E94. doi: 10.3390/pharmaceutics10030094.

25.

Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review.

Jankovic S, Tsakiridou G, Ditzinger F, Koehl NJ, Price DJ, Ilie AR, Kalantzi L, Kimpe K, Holm R, Nair A, Griffin B, Saal C, Kuentz M.

J Pharm Pharmacol. 2019 Apr;71(4):441-463. doi: 10.1111/jphp.12948. Epub 2018 Jul 5. Review.

PMID:
29978475
26.

In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review.

O'Dwyer PJ, Litou C, Box KJ, Dressman JB, Kostewicz ES, Kuentz M, Reppas C.

J Pharm Pharmacol. 2019 Apr;71(4):536-556. doi: 10.1111/jphp.12951. Epub 2018 Jun 28. Review.

PMID:
29956338
27.

New prediction methods for solubility parameters based on molecular sigma profiles using pharmaceutical materials.

Niederquell A, Wyttenbach N, Kuentz M.

Int J Pharm. 2018 Jul 30;546(1-2):137-144. doi: 10.1016/j.ijpharm.2018.05.033. Epub 2018 May 18.

PMID:
29772285
28.

Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations - a PEARRL review.

Price DJ, Ditzinger F, Koehl NJ, Jankovic S, Tsakiridou G, Nair A, Holm R, Kuentz M, Dressman JB, Saal C.

J Pharm Pharmacol. 2019 Apr;71(4):483-509. doi: 10.1111/jphp.12927. Epub 2018 May 16. Review.

PMID:
29770440
29.

Temperature-Induced Surface Effects on Drug Nanosuspensions.

Aleandri S, Schönenberger M, Niederquell A, Kuentz M.

Pharm Res. 2018 Feb 21;35(3):69. doi: 10.1007/s11095-017-2300-6.

PMID:
29468420
30.

Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release in vivo.

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Eur J Pharm Biopharm. 2018 Apr;125:68-75. doi: 10.1016/j.ejpb.2018.01.006. Epub 2018 Jan 10.

PMID:
29331439
31.

Electron microscopy/energy dispersive X-ray spectroscopy of drug distribution in solid dispersions and interpretation by multifractal geometry.

Abreu-Villela R, Adler C, Caraballo I, Kuentz M.

J Pharm Biomed Anal. 2018 Feb 20;150:241-247. doi: 10.1016/j.jpba.2017.12.020. Epub 2017 Dec 11.

PMID:
29253780
32.

Unexpected Solubility Enhancement of Drug Bases in the Presence of a Dimethylaminoethyl Methacrylate Copolymer.

Saal W, Ross A, Wyttenbach N, Alsenz J, Kuentz M.

Mol Pharm. 2018 Jan 2;15(1):186-192. doi: 10.1021/acs.molpharmaceut.7b00804. Epub 2017 Dec 6.

PMID:
29164891
33.

Investigating Oral Absorption of Carbamazepine in Pediatric Populations.

Kohlmann P, Stillhart C, Kuentz M, Parrott N.

AAPS J. 2017 Nov;19(6):1864-1877. doi: 10.1208/s12248-017-0149-6. Epub 2017 Oct 2.

PMID:
28971365
34.

The quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state.

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Eur J Pharm Sci. 2018 Jan 1;111:96-103. doi: 10.1016/j.ejps.2017.09.032. Epub 2017 Sep 22.

PMID:
28943442
35.

Biorelevant Drug Solubility Enhancement Modeled by a Linear Solvation Energy Relationship.

Niederquell A, Kuentz M.

J Pharm Sci. 2018 Jan;107(1):503-506. doi: 10.1016/j.xphs.2017.08.017. Epub 2017 Aug 31.

PMID:
28864357
36.

Study of Rheology and Polymer Adsorption Onto Drug Nanoparticles in Pharmaceutical Suspensions Produced by Nanomilling.

Negrini R, Aleandri S, Kuentz M.

J Pharm Sci. 2017 Nov;106(11):3395-3401. doi: 10.1016/j.xphs.2017.07.006. Epub 2017 Jul 18.

PMID:
28732711
37.

A diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment.

Niederquell A, Machado AHE, Kuentz M.

Int J Pharm. 2017 Sep 15;530(1-2):213-223. doi: 10.1016/j.ijpharm.2017.07.038. Epub 2017 Jul 15.

PMID:
28720536
38.

[Is transplantation an alternative to the transfusional impasse in sickle cell disease?]

Bernaudin F, Kuentz M.

Transfus Clin Biol. 2017 Sep;24(3):232-236. doi: 10.1016/j.tracli.2017.06.007. Epub 2017 Jun 23. Review. French.

PMID:
28648733
39.

Can we estimate the critical micelle concentration of amphiphilic drug bases from molecular connectivity indices?

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Pharm Dev Technol. 2018 Feb;23(2):211-215. doi: 10.1080/10837450.2017.1316288. Epub 2017 Apr 21.

PMID:
28378601
40.

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks.

Rafii H, Bernaudin F, Rouard H, Vanneaux V, Ruggeri A, Cavazzana M, Gauthereau V, Stanislas A, Benkerrou M, De Montalembert M, Ferry C, Girot R, Arnaud C, Kamdem A, Gour J, Touboul C, Cras A, Kuentz M, Rieux C, Volt F, Cappelli B, Maio KT, Paviglianiti A, Kenzey C, Larghero J, Gluckman E.

Haematologica. 2017 Jun;102(6):976-983. doi: 10.3324/haematol.2016.163055. Epub 2017 Mar 16.

41.

A Systematic Study of Molecular Interactions of Anionic Drugs with a Dimethylaminoethyl Methacrylate Copolymer Regarding Solubility Enhancement.

Saal W, Ross A, Wyttenbach N, Alsenz J, Kuentz M.

Mol Pharm. 2017 Apr 3;14(4):1243-1250. doi: 10.1021/acs.molpharmaceut.6b01116. Epub 2017 Mar 21.

PMID:
28287743
42.

Multifractal and mechanical analysis of amorphous solid dispersions.

Adler C, Teleki A, Kuentz M.

Int J Pharm. 2017 May 15;523(1):91-101. doi: 10.1016/j.ijpharm.2017.03.014. Epub 2017 Mar 9.

PMID:
28286079
43.

Time domain NMR as a new process monitoring method for characterization of pharmaceutical hydrates.

Schumacher SU, Rothenhäusler B, Willmann A, Thun J, Moog R, Kuentz M.

J Pharm Biomed Anal. 2017 Apr 15;137:96-103. doi: 10.1016/j.jpba.2017.01.017. Epub 2017 Jan 9.

PMID:
28107690
44.

Medicines for Pediatric Patients-Biopharmaceutical, Developmental, and Regulatory Considerations.

Elder DP, Holm R, Kuentz M.

J Pharm Sci. 2017 Apr;106(4):950-960. doi: 10.1016/j.xphs.2016.12.018. Epub 2016 Dec 29.

PMID:
28041968
45.

Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation.

Gluckman E, Cappelli B, Bernaudin F, Labopin M, Volt F, Carreras J, Pinto Simões B, Ferster A, Dupont S, de la Fuente J, Dalle JH, Zecca M, Walters MC, Krishnamurti L, Bhatia M, Leung K, Yanik G, Kurtzberg J, Dhedin N, Kuentz M, Michel G, Apperley J, Lutz P, Neven B, Bertrand Y, Vannier JP, Ayas M, Cavazzana M, Matthes-Martin S, Rocha V, Elayoubi H, Kenzey C, Bader P, Locatelli F, Ruggeri A, Eapen M; Eurocord, the Pediatric Working Party of the European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research.

Blood. 2017 Mar 16;129(11):1548-1556. doi: 10.1182/blood-2016-10-745711. Epub 2016 Dec 13.

46.

Glass-forming ability of compounds in marketed amorphous drug products.

Wyttenbach N, Kuentz M.

Eur J Pharm Biopharm. 2017 Mar;112:204-208. doi: 10.1016/j.ejpb.2016.11.031. Epub 2016 Nov 27.

PMID:
27903457
47.

Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates.

Adler C, Teleki A, Kuentz M.

Pharm Res. 2017 Feb;34(2):321-332. doi: 10.1007/s11095-016-2064-4. Epub 2016 Nov 14.

PMID:
27844187
48.

Rapid determination of drug solubilization versus supersaturation in natural and digested lipids.

Gautschi N, Bergström CA, Kuentz M.

Int J Pharm. 2016 Nov 20;513(1-2):164-174. doi: 10.1016/j.ijpharm.2016.09.015. Epub 2016 Sep 5.

PMID:
27609663
49.

Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling.

Campiñez MD, Caraballo I, Puchkov M, Kuentz M.

AAPS PharmSciTech. 2017 Jul;18(5):1544-1553. doi: 10.1208/s12249-016-0613-0. Epub 2016 Sep 6.

PMID:
27600323
50.

Miniaturized X-ray powder diffraction assay (MixRay) for quantitative kinetic analysis of solvent-mediated phase transformations in pharmaceutics.

Kirchmeyer W, Grassmann O, Wyttenbach N, Alsenz J, Kuentz M.

J Pharm Biomed Anal. 2016 Nov 30;131:195-201. doi: 10.1016/j.jpba.2016.08.028. Epub 2016 Aug 29.

PMID:
27596832

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