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Items: 1 to 50 of 248

1.

Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France.

Bernaudin F, Dalle JH, Bories D, Peffault de Latour R, Robin M, Bertrand Y, Pondarre C, Vannier JP, Neven B, Kuentz M, Maury S, Lutz P, Paillard C, Yakouben K, Thuret I, Galambrun C, Dhedin N, Jubert C, Rohrlich P, Bay JO, Suarez F, Raus N, Vernant JP, Gluckman E, Poirot C, Socié G; Société Française de Greffe de Moelle et de Thérapie Cellulaire.

Haematologica. 2019 May 16. pii: haematol.2018.213207. doi: 10.3324/haematol.2018.213207. [Epub ahead of print]

2.

Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease.

Cappelli B, Volt F, Tozatto-Maio K, Scigliuolo GM, Ferster A, Dupont S, Pinto Simões B, Al-Seraihy A, Aljurf MD, Almohareb F, Belendez C, Matthes S, Dhedin N, Pondarre C, Dalle JH, Bertrand Y, Vannier JP, Kuentz M, Lutz P, Michel G, Rafii H, Neven B, Zecca M, Bader P, Cavazzana M, Labopin M, Locatelli F, Magnani A, Ruggeri A, Rocha V, Bernaudin F, de La Fuente J, Corbacioglu S, Gluckman E.

Haematologica. 2019 Apr 24. pii: haematol.2019.216788. doi: 10.3324/haematol.2019.216788. [Epub ahead of print]

3.

Polyelectrolytes in Hot Melt Extrusion: A Combined Solvent-Based and Interacting Additive Technique for Solid Dispersions.

Ditzinger F, Dejoie C, Sisak Jung D, Kuentz M.

Pharmaceutics. 2019 Apr 10;11(4). pii: E174. doi: 10.3390/pharmaceutics11040174.

4.

Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations.

Price DJ, Nair A, Kuentz M, Dressman J, Saal C.

Eur J Pharm Sci. 2019 Apr 30;132:142-156. doi: 10.1016/j.ejps.2019.03.006. Epub 2019 Mar 12.

PMID:
30877067
5.

New Insights into Using Lipid Based Suspensions for 'Brick Dust' Molecules: Case Study of Nilotinib.

Koehl NJ, Holm R, Kuentz M, Griffin BT.

Pharm Res. 2019 Feb 22;36(4):56. doi: 10.1007/s11095-019-2590-y.

PMID:
30796596
6.

Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics.

Niederquell A, Wyttenbach N, Kuentz M, Panayiotou C.

Pharmaceutics. 2019 Jan 4;11(1). pii: E17. doi: 10.3390/pharmaceutics11010017.

7.

Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative.

de la Fuente J, Dhedin N, Koyama T, Bernaudin F, Kuentz M, Karnik L, Socié G, Culos KA, Brodsky RA, DeBaun MR, Kassim AA.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1197-1209. doi: 10.1016/j.bbmt.2018.11.027. Epub 2018 Nov 28.

PMID:
30500440
8.

Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer.

Ditzinger F, Scherer U, Schönenberger M, Holm R, Kuentz M.

Mol Pharm. 2019 Jan 7;16(1):141-150. doi: 10.1021/acs.molpharmaceut.8b00920. Epub 2018 Dec 6.

PMID:
30484651
9.

Drug supersaturation during formulation digestion, including real-time analytical approaches.

Kuentz M.

Adv Drug Deliv Rev. 2018 Nov 13. pii: S0169-409X(18)30290-4. doi: 10.1016/j.addr.2018.11.003. [Epub ahead of print] Review.

PMID:
30445096
10.

Early stages of drug crystallization from amorphous solid dispersion via fractal analysis based on chemical imaging.

Abreu-Villela R, Schönenberger M, Caraballo I, Kuentz M.

Eur J Pharm Biopharm. 2018 Dec;133:122-130. doi: 10.1016/j.ejpb.2018.10.007. Epub 2018 Oct 6.

PMID:
30300718
11.

Towards a better understanding of solid dispersions in aqueous environment by a fluorescence quenching approach.

Aleandri S, Jankovic S, Kuentz M.

Int J Pharm. 2018 Oct 25;550(1-2):130-139. doi: 10.1016/j.ijpharm.2018.08.029. Epub 2018 Aug 18.

PMID:
30130607
12.

Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches - a PEARRL review.

Ditzinger F, Price DJ, Ilie AR, Köhl NJ, Jankovic S, Tsakiridou G, Aleandri S, Kalantzi L, Holm R, Nair A, Saal C, Griffin B, Kuentz M.

J Pharm Pharmacol. 2019 Apr;71(4):464-482. doi: 10.1111/jphp.12984. Epub 2018 Aug 2. Review.

PMID:
30070363
13.

Dynamic Light Scattering of Biopharmaceutics-Can Analytical Performance Be Enhanced by Laser Power?

Aleandri S, Vaccaro A, Armenta R, Völker AC, Kuentz M.

Pharmaceutics. 2018 Jul 17;10(3). pii: E94. doi: 10.3390/pharmaceutics10030094.

14.

Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review.

Jankovic S, Tsakiridou G, Ditzinger F, Koehl NJ, Price DJ, Ilie AR, Kalantzi L, Kimpe K, Holm R, Nair A, Griffin B, Saal C, Kuentz M.

J Pharm Pharmacol. 2019 Apr;71(4):441-463. doi: 10.1111/jphp.12948. Epub 2018 Jul 5. Review.

PMID:
29978475
15.

In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review.

O'Dwyer PJ, Litou C, Box KJ, Dressman JB, Kostewicz ES, Kuentz M, Reppas C.

J Pharm Pharmacol. 2019 Apr;71(4):536-556. doi: 10.1111/jphp.12951. Epub 2018 Jun 28. Review.

PMID:
29956338
16.

New prediction methods for solubility parameters based on molecular sigma profiles using pharmaceutical materials.

Niederquell A, Wyttenbach N, Kuentz M.

Int J Pharm. 2018 Jul 30;546(1-2):137-144. doi: 10.1016/j.ijpharm.2018.05.033. Epub 2018 May 18.

PMID:
29772285
17.

Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations - a PEARRL review.

Price DJ, Ditzinger F, Koehl NJ, Jankovic S, Tsakiridou G, Nair A, Holm R, Kuentz M, Dressman JB, Saal C.

J Pharm Pharmacol. 2019 Apr;71(4):483-509. doi: 10.1111/jphp.12927. Epub 2018 May 16. Review.

PMID:
29770440
18.

Temperature-Induced Surface Effects on Drug Nanosuspensions.

Aleandri S, Schönenberger M, Niederquell A, Kuentz M.

Pharm Res. 2018 Feb 21;35(3):69. doi: 10.1007/s11095-017-2300-6.

PMID:
29468420
19.

Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release in vivo.

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Eur J Pharm Biopharm. 2018 Apr;125:68-75. doi: 10.1016/j.ejpb.2018.01.006. Epub 2018 Jan 10.

PMID:
29331439
20.

Electron microscopy/energy dispersive X-ray spectroscopy of drug distribution in solid dispersions and interpretation by multifractal geometry.

Abreu-Villela R, Adler C, Caraballo I, Kuentz M.

J Pharm Biomed Anal. 2018 Feb 20;150:241-247. doi: 10.1016/j.jpba.2017.12.020. Epub 2017 Dec 11.

PMID:
29253780
21.

Unexpected Solubility Enhancement of Drug Bases in the Presence of a Dimethylaminoethyl Methacrylate Copolymer.

Saal W, Ross A, Wyttenbach N, Alsenz J, Kuentz M.

Mol Pharm. 2018 Jan 2;15(1):186-192. doi: 10.1021/acs.molpharmaceut.7b00804. Epub 2017 Dec 6.

PMID:
29164891
22.

Investigating Oral Absorption of Carbamazepine in Pediatric Populations.

Kohlmann P, Stillhart C, Kuentz M, Parrott N.

AAPS J. 2017 Nov;19(6):1864-1877. doi: 10.1208/s12248-017-0149-6. Epub 2017 Oct 2.

PMID:
28971365
23.

The quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state.

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Eur J Pharm Sci. 2018 Jan 1;111:96-103. doi: 10.1016/j.ejps.2017.09.032. Epub 2017 Sep 22.

PMID:
28943442
24.

Biorelevant Drug Solubility Enhancement Modeled by a Linear Solvation Energy Relationship.

Niederquell A, Kuentz M.

J Pharm Sci. 2018 Jan;107(1):503-506. doi: 10.1016/j.xphs.2017.08.017. Epub 2017 Aug 31.

PMID:
28864357
25.

Study of Rheology and Polymer Adsorption Onto Drug Nanoparticles in Pharmaceutical Suspensions Produced by Nanomilling.

Negrini R, Aleandri S, Kuentz M.

J Pharm Sci. 2017 Nov;106(11):3395-3401. doi: 10.1016/j.xphs.2017.07.006. Epub 2017 Jul 18.

PMID:
28732711
26.

A diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment.

Niederquell A, Machado AHE, Kuentz M.

Int J Pharm. 2017 Sep 15;530(1-2):213-223. doi: 10.1016/j.ijpharm.2017.07.038. Epub 2017 Jul 15.

PMID:
28720536
27.

[Is transplantation an alternative to the transfusional impasse in sickle cell disease?]

Bernaudin F, Kuentz M.

Transfus Clin Biol. 2017 Sep;24(3):232-236. doi: 10.1016/j.tracli.2017.06.007. Epub 2017 Jun 23. Review. French.

PMID:
28648733
28.

Can we estimate the critical micelle concentration of amphiphilic drug bases from molecular connectivity indices?

Saal W, Wyttenbach N, Alsenz J, Kuentz M.

Pharm Dev Technol. 2018 Feb;23(2):211-215. doi: 10.1080/10837450.2017.1316288. Epub 2017 Apr 21.

PMID:
28378601
29.

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks.

Rafii H, Bernaudin F, Rouard H, Vanneaux V, Ruggeri A, Cavazzana M, Gauthereau V, Stanislas A, Benkerrou M, De Montalembert M, Ferry C, Girot R, Arnaud C, Kamdem A, Gour J, Touboul C, Cras A, Kuentz M, Rieux C, Volt F, Cappelli B, Maio KT, Paviglianiti A, Kenzey C, Larghero J, Gluckman E.

Haematologica. 2017 Jun;102(6):976-983. doi: 10.3324/haematol.2016.163055. Epub 2017 Mar 16.

30.

A Systematic Study of Molecular Interactions of Anionic Drugs with a Dimethylaminoethyl Methacrylate Copolymer Regarding Solubility Enhancement.

Saal W, Ross A, Wyttenbach N, Alsenz J, Kuentz M.

Mol Pharm. 2017 Apr 3;14(4):1243-1250. doi: 10.1021/acs.molpharmaceut.6b01116. Epub 2017 Mar 21.

PMID:
28287743
31.

Multifractal and mechanical analysis of amorphous solid dispersions.

Adler C, Teleki A, Kuentz M.

Int J Pharm. 2017 May 15;523(1):91-101. doi: 10.1016/j.ijpharm.2017.03.014. Epub 2017 Mar 9.

PMID:
28286079
32.

Time domain NMR as a new process monitoring method for characterization of pharmaceutical hydrates.

Schumacher SU, Rothenhäusler B, Willmann A, Thun J, Moog R, Kuentz M.

J Pharm Biomed Anal. 2017 Apr 15;137:96-103. doi: 10.1016/j.jpba.2017.01.017. Epub 2017 Jan 9.

PMID:
28107690
33.

Medicines for Pediatric Patients-Biopharmaceutical, Developmental, and Regulatory Considerations.

Elder DP, Holm R, Kuentz M.

J Pharm Sci. 2017 Apr;106(4):950-960. doi: 10.1016/j.xphs.2016.12.018. Epub 2016 Dec 29.

PMID:
28041968
34.

Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation.

Gluckman E, Cappelli B, Bernaudin F, Labopin M, Volt F, Carreras J, Pinto Simões B, Ferster A, Dupont S, de la Fuente J, Dalle JH, Zecca M, Walters MC, Krishnamurti L, Bhatia M, Leung K, Yanik G, Kurtzberg J, Dhedin N, Kuentz M, Michel G, Apperley J, Lutz P, Neven B, Bertrand Y, Vannier JP, Ayas M, Cavazzana M, Matthes-Martin S, Rocha V, Elayoubi H, Kenzey C, Bader P, Locatelli F, Ruggeri A, Eapen M; Eurocord, the Pediatric Working Party of the European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research.

Blood. 2017 Mar 16;129(11):1548-1556. doi: 10.1182/blood-2016-10-745711. Epub 2016 Dec 13.

35.

Glass-forming ability of compounds in marketed amorphous drug products.

Wyttenbach N, Kuentz M.

Eur J Pharm Biopharm. 2017 Mar;112:204-208. doi: 10.1016/j.ejpb.2016.11.031. Epub 2016 Nov 27.

PMID:
27903457
36.

Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates.

Adler C, Teleki A, Kuentz M.

Pharm Res. 2017 Feb;34(2):321-332. doi: 10.1007/s11095-016-2064-4. Epub 2016 Nov 14.

PMID:
27844187
37.

Rapid determination of drug solubilization versus supersaturation in natural and digested lipids.

Gautschi N, Bergström CA, Kuentz M.

Int J Pharm. 2016 Nov 20;513(1-2):164-174. doi: 10.1016/j.ijpharm.2016.09.015. Epub 2016 Sep 5.

PMID:
27609663
38.

Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling.

Campiñez MD, Caraballo I, Puchkov M, Kuentz M.

AAPS PharmSciTech. 2017 Jul;18(5):1544-1553. doi: 10.1208/s12249-016-0613-0. Epub 2016 Sep 6.

PMID:
27600323
39.

Miniaturized X-ray powder diffraction assay (MixRay) for quantitative kinetic analysis of solvent-mediated phase transformations in pharmaceutics.

Kirchmeyer W, Grassmann O, Wyttenbach N, Alsenz J, Kuentz M.

J Pharm Biomed Anal. 2016 Nov 30;131:195-201. doi: 10.1016/j.jpba.2016.08.028. Epub 2016 Aug 29.

PMID:
27596832
40.

Antibiotic Resistance: The Need For a Global Strategy.

Elder DP, Kuentz M, Holm R.

J Pharm Sci. 2016 Aug;105(8):2278-87. doi: 10.1016/j.xphs.2016.06.002. Epub 2016 Jul 7.

PMID:
27397433
41.

Molecular insights into the formation of drug-monoacyl phosphatidylcholine solid dispersions for oral delivery.

Gautschi N, Van Hoogevest P, Kuentz M.

Eur J Pharm Sci. 2017 Oct 15;108:93-100. doi: 10.1016/j.ejps.2016.05.023. Epub 2016 May 28.

PMID:
27240778
42.

A microstructural study of water effects in lipid-based pharmaceutical formulations for liquid filling of capsules.

Machado AH, Kokubo T, Dujovny G, Jones B, Scialdone C, Bravo R, Kuentz M.

Eur J Pharm Sci. 2016 Jul 30;90:64-75. doi: 10.1016/j.ejps.2016.04.035. Epub 2016 Apr 28.

PMID:
27132811
43.

Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations.

Villiger A, Stillhart C, Parrott N, Kuentz M.

AAPS J. 2016 Jul;18(4):933-47. doi: 10.1208/s12248-016-9896-z. Epub 2016 Apr 8.

PMID:
27060007
44.

Trends in the Assessment of Drug Supersaturation and Precipitation In Vitro Using Lipid-Based Delivery Systems.

Stillhart C, Kuentz M.

J Pharm Sci. 2016 Sep;105(9):2468-2476. doi: 10.1016/j.xphs.2016.01.010. Epub 2016 Feb 28.

PMID:
26935881
45.

On prilled Nanotubes-in-Microgel Oral Systems for protein delivery.

de Kruif JK, Ledergerber G, Garofalo C, Fasler-Kan E, Kuentz M.

Eur J Pharm Biopharm. 2016 Apr;101:90-102. doi: 10.1016/j.ejpb.2016.01.014. Epub 2016 Feb 4.

PMID:
26851504
46.

Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion.

Adler C, Schönenberger M, Teleki A, Kuentz M.

Int J Pharm. 2016 Feb 29;499(1-2):90-100. doi: 10.1016/j.ijpharm.2015.12.057. Epub 2015 Dec 22.

PMID:
26721729
47.

Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations.

Elder DP, Kuentz M, Holm R.

Eur J Pharm Sci. 2016 May 25;87:88-99. doi: 10.1016/j.ejps.2015.12.018. Epub 2015 Dec 14. Review.

PMID:
26699228
48.

Methodology of oral formulation selection in the pharmaceutical industry.

Kuentz M, Holm R, Elder DP.

Eur J Pharm Sci. 2016 May 25;87:136-63. doi: 10.1016/j.ejps.2015.12.008. Epub 2015 Dec 11. Review.

PMID:
26687443
49.

Theoretical Considerations of the Prigogine-Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts.

Wyttenbach N, Kirchmeyer W, Alsenz J, Kuentz M.

Mol Pharm. 2016 Jan 4;13(1):241-50. doi: 10.1021/acs.molpharmaceut.5b00688. Epub 2015 Dec 10.

PMID:
26587865
50.

Flow-through cross-polarized imaging as a new tool to overcome the analytical sensitivity challenges of a low-dose crystalline compound in a lipid matrix.

Adler C, Schönenberger M, Teleki A, Leuenberger B, Kuentz M.

J Pharm Biomed Anal. 2015 Nov 10;115:20-30. doi: 10.1016/j.jpba.2015.06.033. Epub 2015 Jun 24.

PMID:
26142560

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