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Items: 19

1.

A proof of concept for structure-based vaccine design targeting RSV in humans.

Crank MC, Ruckwardt TJ, Chen M, Morabito KM, Phung E, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Gordon IJ, Yamshchikov GV, Gaudinski MR, Kumar A, Chang LA, Moin SM, Hill JP, DiPiazza AT, Schwartz RM, Kueltzo L, Cooper JW, Chen P, Stein JA, Carlton K, Gall JG, Nason MC, Kwong PD, Chen GL, Mascola JR, McLellan JS, Ledgerwood JE, Graham BS; VRC 317 Study Team.

Science. 2019 Aug 2;365(6452):505-509. doi: 10.1126/science.aav9033.

PMID:
31371616
2.

Structural Characterization and Formulation Development of a Trivalent Equine Encephalitis Virus-Like Particle Vaccine Candidate.

Toprani VM, Cheng Y, Wahome N, Khasa H, Kueltzo LA, Schwartz RM, Middaugh CR, Joshi SB, Volkin DB.

J Pharm Sci. 2018 Oct;107(10):2544-2558. doi: 10.1016/j.xphs.2018.05.022. Epub 2018 Jun 5.

PMID:
29883665
3.

Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry.

Clarkson BR, Chaudhuri R, Schön A, Cooper JW, Kueltzo L, Freire E.

Anal Biochem. 2018 Aug 1;554:61-69. doi: 10.1016/j.ab.2018.05.008. Epub 2018 May 8.

PMID:
29750942
4.

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.

Kwon YD, Chuang GY, Zhang B, Bailer RT, Doria-Rose NA, Gindin TS, Lin B, Louder MK, McKee K, O'Dell S, Pegu A, Schmidt SD, Asokan M, Chen X, Choe M, Georgiev IS, Jin V, Pancera M, Rawi R, Wang K, Chaudhuri R, Kueltzo LA, Manceva SD, Todd JP, Scorpio DG, Kim M, Reinherz EL, Wagh K, Korber BM, Connors M, Shapiro L, Mascola JR, Kwong PD.

Cell Rep. 2018 Feb 13;22(7):1798-1809. doi: 10.1016/j.celrep.2018.01.023.

5.

Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.

Francica JR, Lynn GM, Laga R, Joyce MG, Ruckwardt TJ, Morabito KM, Chen M, Chaudhuri R, Zhang B, Sastry M, Druz A, Ko K, Choe M, Pechar M, Georgiev IS, Kueltzo LA, Seymour LW, Mascola JR, Kwong PD, Graham BS, Seder RA.

Bioconjug Chem. 2016 Oct 19;27(10):2372-2385. Epub 2016 Sep 22.

PMID:
27583777
6.

A Micro-Polyethylene Glycol Precipitation Assay as a Relative Solubility Screening Tool for Monoclonal Antibody Design and Formulation Development.

Toprani VM, Joshi SB, Kueltzo LA, Schwartz RM, Middaugh CR, Volkin DB.

J Pharm Sci. 2016 Aug;105(8):2319-27. doi: 10.1016/j.xphs.2016.05.021. Epub 2016 Jun 29.

PMID:
27368120
7.

Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions.

Kramer RM, Zeng Y, Sahni N, Kueltzo LA, Schwartz RM, Srivastava IK, Crane L, Joshi SB, Volkin DB, Middaugh CR.

J Pharm Sci. 2013 Dec;102(12):4305-14. doi: 10.1002/jps.23749. Epub 2013 Oct 15.

8.
9.

Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions.

Lucas LH, Ersoy BA, Kueltzo LA, Joshi SB, Brandau DT, Thyagarajapuram N, Peek LJ, Middaugh CR.

Protein Sci. 2006 Oct;15(10):2228-43. Epub 2006 Sep 8.

10.

Characterization of VP22 in herpes simplex virus-infected cells.

Mouzakitis G, McLauchlan J, Barreca C, Kueltzo L, O'Hare P.

J Virol. 2005 Oct;79(19):12185-98.

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13.

Nonclassical transport proteins and peptides: an alternative to classical macromolecule delivery systems.

Kueltzo LA, Middaugh CR.

J Pharm Sci. 2003 Sep;92(9):1754-72. Review.

PMID:
12949995
14.

Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri.

Kueltzo LA, Osiecki J, Barker J, Picking WL, Ersoy B, Picking WD, Middaugh CR.

J Biol Chem. 2003 Jan 31;278(5):2792-8. Epub 2002 Nov 8.

15.

Complex effects of molecular chaperones on the aggregation and refolding of fibroblast growth factor-1.

Edwards KL, Kueltzo LA, Fisher MT, Middaugh CR.

Arch Biochem Biophys. 2001 Sep 1;393(1):14-21.

PMID:
11516157
16.

Characterization of synthetic gene delivery vectors by infrared spectroscopy.

Choosakoonkriang S, Wiethoff CM, Kueltzo LA, Russell Middaugh C.

Methods Mol Med. 2001;65:285-317. doi: 10.1385/1-59259-139-6:285.

PMID:
21318760
17.

Ultraviolet absorption and circular dichroism spectroscopy of nonviral gene delivery complexes.

Braun CS, Kueltzo LA, Russell Middaugh C.

Methods Mol Med. 2001;65:253-84. doi: 10.1385/1-59259-139-6:253.

PMID:
21318759
18.

Potential use of non-classical pathways for the transport of macromolecular drugs.

Kueltzo LA, Middaugh CR.

Expert Opin Investig Drugs. 2000 Sep;9(9):2039-50. Review.

PMID:
11060791
19.

Conformational lability of herpesvirus protein VP22.

Kueltzo LA, Normand N, O'Hare P, Middaugh CR.

J Biol Chem. 2000 Oct 27;275(43):33213-21.

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