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Items: 24


A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

Ng KK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB, Rothenberg EV, Kueh HY.

Elife. 2018 Nov 20;7. pii: e37851. doi: 10.7554/eLife.37851.


Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network.

Longabaugh WJR, Zeng W, Zhang JA, Hosokawa H, Jansen CS, Li L, Romero-Wolf M, Liu P, Kueh HY, Mortazavi A, Rothenberg EV.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5800-5807. doi: 10.1073/pnas.1610617114.


Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture.

Manesso E, Kueh HY, Freedman G, Rothenberg EV, Peterson C.

PLoS One. 2016 Aug 23;11(8):e0161260. doi: 10.1371/journal.pone.0161260. eCollection 2016.


Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment.

Kueh HY, Yui MA, Ng KK, Pease SS, Zhang JA, Damle SS, Freedman G, Siu S, Bernstein ID, Elowitz MB, Rothenberg EV.

Nat Immunol. 2016 Aug;17(8):956-65. doi: 10.1038/ni.3514. Epub 2016 Jul 4.


Hematopoiesis and T-cell specification as a model developmental system.

Rothenberg EV, Kueh HY, Yui MA, Zhang JA.

Immunol Rev. 2016 May;271(1):72-97. doi: 10.1111/imr.12417. Review.


Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment.

Rothenberg EV, Champhekar A, Damle S, Del Real MM, Kueh HY, Li L, Yui MA.

Cold Spring Harb Symp Quant Biol. 2013;78:31-41. doi: 10.1101/sqb.2013.78.020271. Epub 2013 Oct 17. Review.


Positive feedback between PU.1 and the cell cycle controls myeloid differentiation.

Kueh HY, Champhekar A, Nutt SL, Elowitz MB, Rothenberg EV.

Science. 2013 Aug 9;341(6146):670-3. doi: 10.1126/science.1240831. Epub 2013 Jul 18. Erratum in: Science. 2013 Oct 18;342(6156):311. Champhekhar, Ameya [corrected to Champhekar, Ameya].


A far downstream enhancer for murine Bcl11b controls its T-cell specific expression.

Li L, Zhang JA, Dose M, Kueh HY, Mosadeghi R, Gounari F, Rothenberg EV.

Blood. 2013 Aug 8;122(6):902-11. doi: 10.1182/blood-2012-08-447839. Epub 2013 Jun 5.


Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation.

Kueh HY, Niethammer P, Mitchison TJ.

Biophys J. 2013 Mar 19;104(6):1338-48. doi: 10.1016/j.bpj.2013.01.030. Epub 2013 Mar 19.


Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence.

Manesso E, Chickarmane V, Kueh HY, Rothenberg EV, Peterson C.

J R Soc Interface. 2013 Jan 6;10(78):20120774. doi: 10.1098/rsif.2012.0774.


Regulatory gene network circuits underlying T cell development from multipotent progenitors.

Kueh HY, Rothenberg EV.

Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):79-102. doi: 10.1002/wsbm.162. Epub 2011 Oct 4. Review.


Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos.

Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ.

J Cell Sci. 2011 Jun 15;124(Pt 12):2086-95. doi: 10.1242/jcs.082263. Epub 2011 May 24.


Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover.

Kueh HY, Brieher WM, Mitchison TJ.

Biophys J. 2010 Oct 6;99(7):2153-62. doi: 10.1016/j.bpj.2010.07.038.


Structural plasticity in actin and tubulin polymer dynamics.

Kueh HY, Mitchison TJ.

Science. 2009 Aug 21;325(5943):960-3. doi: 10.1126/science.1168823. Review.


Dynamic stabilization of actin filaments.

Kueh HY, Brieher WM, Mitchison TJ.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16531-6. doi: 10.1073/pnas.0807394105. Epub 2008 Oct 17.


Monitoring actin disassembly with time-lapse microscopy.

Kueh HY.

J Vis Exp. 2006 Nov 8;(1):66. doi: 10.3791/66. No abstract available.


Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers.

Kueh HY, Charras GT, Mitchison TJ, Brieher WM.

J Cell Biol. 2008 Jul 28;182(2):341-53. doi: 10.1083/jcb.200801027.


Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm.

Niethammer P, Kueh HY, Mitchison TJ.

Curr Biol. 2008 Apr 22;18(8):586-91. doi: 10.1016/j.cub.2008.03.038. Epub 2008 Apr 10.


Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament.

Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH.

J Mol Biol. 2008 Feb 22;376(3):607-13. doi: 10.1016/j.jmb.2007.12.007. Epub 2007 Dec 8.


Intrinsic fluctuations, robustness, and tunability in signaling cycles.

Levine J, Kueh HY, Mirny L.

Biophys J. 2007 Jun 15;92(12):4473-81. Epub 2007 Mar 30.


Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1.

Brieher WM, Kueh HY, Ballif BA, Mitchison TJ.

J Cell Biol. 2006 Oct 23;175(2):315-24.


Brain architecture and social complexity in modern and ancient birds.

Burish MJ, Kueh HY, Wang SS.

Brain Behav Evol. 2004;63(2):107-24. Epub 2003 Dec 19.


Mechanisms of noise-resistance in genetic oscillators.

Vilar JM, Kueh HY, Barkai N, Leibler S.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5988-92. Epub 2002 Apr 23.

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