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Items: 1 to 50 of 194

1.

Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure.

Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS, Kuebler WM.

Pulm Circ. 2019 Nov 20;9(4):2045894019889775. doi: 10.1177/2045894019889775. eCollection 2019 Oct-Dec.

2.

Gap junctions regulate vessel diameter in chick chorioallantoic membrane vasculature by both tone-dependent and structural mechanisms.

Maibier M, Bintig W, Goede A, Höpfner M, Kuebler WM, Secomb TW, Nitzsche B, Pries AR.

Microcirculation. 2019 Sep 13. doi: 10.1111/micc.12590. [Epub ahead of print]

PMID:
31520425
3.

Transfusion-related Acute Lung Injury in the Perioperative Patient.

McVey MJ, Kapur R, Cserti-Gazdewich C, Semple JW, Karkouti K, Kuebler WM.

Anesthesiology. 2019 Sep;131(3):693-715. doi: 10.1097/ALN.0000000000002687.

PMID:
31408449
4.

Alveolar dynamics during mechanical ventilation in the healthy and injured lung.

Grune J, Tabuchi A, Kuebler WM.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):34. doi: 10.1186/s40635-019-0226-5. Review.

5.

Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.

Beyhoff N, Lohr D, Foryst-Ludwig A, Klopfleisch R, Brix S, Grune J, Thiele A, Erfinanda L, Tabuchi A, Kuebler WM, Pieske B, Schreiber LM, Kintscher U.

Hypertension. 2019 Aug;74(2):295-304. doi: 10.1161/HYPERTENSIONAHA.119.12956. Epub 2019 Jul 10.

6.

Investigation into the diversity in the fractal dimensions of arterioles and venules in a microvascular network - A quantitative analysis.

Wang R, Li P, Pan Q, Li JK, Kuebler WM, Pries AR, Ning G.

Microvasc Res. 2019 Sep;125:103882. doi: 10.1016/j.mvr.2019.103882. Epub 2019 May 7.

PMID:
31075242
7.

Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction.

Grune J, Ritter D, Kräker K, Pappritz K, Beyhoff N, Schütte T, Ott C, John C, van Linthout S, Tschöpe C, Dechend R, Muller DN, Haase N, Grune T, Kintscher U, Kuebler WM.

Cardiovasc Ultrasound. 2019 Apr 22;17(1):7. doi: 10.1186/s12947-019-0156-0.

8.

Therapeutic Targeting of High-Mobility Group Box-1 in Pulmonary Arterial Hypertension.

Goldenberg NM, Hu Y, Hu X, Volchuk A, Zhao YD, Kucherenko MM, Knosalla C, de Perrot M, Tracey KJ, Al-Abed Y, Steinberg BE, Kuebler WM.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1566-1569. doi: 10.1164/rccm.201808-1597LE. No abstract available.

PMID:
30939030
9.

Cardiovascular sequelae of pneumonia.

Brack MC, Lienau J, Kuebler WM, Witzenrath M.

Curr Opin Pulm Med. 2019 May;25(3):257-262. doi: 10.1097/MCP.0000000000000584.

PMID:
30893107
10.

Extracellular vesicles in lung health, disease, and therapy.

McVey MJ, Maishan M, Blokland KEC, Bartlett N, Kuebler WM.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L977-L989. doi: 10.1152/ajplung.00546.2018. Epub 2019 Mar 20.

PMID:
30892076
11.

Go West: translational physiology for noninvasive measurement of pulmonary gas exchange in patients with hypoxemic lung disease.

Pickerodt PA, Kuebler WM.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L701-L702. doi: 10.1152/ajplung.00515.2018. Epub 2019 Mar 6. No abstract available.

PMID:
30838868
12.

Extracellular vesicles: biomarkers and regulators of vascular function during extracorporeal circulation.

McVey MJ, Kuebler WM.

Oncotarget. 2018 Dec 14;9(98):37229-37251. doi: 10.18632/oncotarget.26433. eCollection 2018 Dec 14. Review.

13.

Acute Respiratory Distress Syndrome: Biomarkers, Mechanisms, and Water Channels.

Kuebler WM.

Anesthesiology. 2019 Mar;130(3):364-366. doi: 10.1097/ALN.0000000000002607. No abstract available.

PMID:
30624248
14.

Smooth Muscle Cells: A Novel Site of P-Selectin Expression with Pathophysiological and Therapeutic Relevance in Pulmonary Hypertension.

Sundd P, Kuebler WM.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1307-1309. doi: 10.1164/rccm.201812-2242ED. No abstract available.

15.

Reply to Santini et al.: High Positive End-Expiratory Pressure: Only a Dam against Edema Formation? Probably Not (Again).

Katira BH, Kuebler WM, Connelly KA, Kavanagh BP.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):544. doi: 10.1164/rccm.201810-2000LE. No abstract available.

PMID:
30398892
16.

Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Dec 1;272S:4-10. doi: 10.1016/j.ijcard.2018.09.070. Epub 2018 Sep 20. Review.

PMID:
30314839
17.

Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.

Yin J, Lv L, Zhai P, Long T, Zhou Q, Pan H, Botwe G, Wang L, Wang Q, Tan L, Kuebler WM.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L35-L44. doi: 10.1152/ajplung.00012.2018. Epub 2018 Sep 20.

PMID:
30234377
18.

Is there a role for endothelin-1 receptor antagonists in the treatment of lung fibrosis associated with pulmonary hypertension?

Grune J, Kuebler WM.

Eur Respir J. 2018 Aug 30;52(2). pii: 1801287. doi: 10.1183/13993003.01287-2018. Print 2018 Aug. No abstract available.

PMID:
30166496
19.

Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation.

Simmons S, Erfinanda L, Bartz C, Kuebler WM.

J Physiol. 2019 Feb;597(4):997-1021. doi: 10.1113/JP276245. Epub 2018 Aug 13.

PMID:
30015354
20.

Evaluation of a commercial multi-dimensional echocardiography technique for ventricular volumetry in small animals.

Grune J, Blumrich A, Brix S, Jeuthe S, Drescher C, Grune T, Foryst-Ludwig A, Messroghli D, Kuebler WM, Ott C, Kintscher U.

Cardiovasc Ultrasound. 2018 Jul 3;16(1):10. doi: 10.1186/s12947-018-0128-9.

21.

Coronary Microcirculation in Ischemic Heart Disease.

Pries AR, Kuebler WM, Habazettl H.

Curr Pharm Des. 2018;24(25):2893-2899. doi: 10.2174/1381612824666180625142341. Review.

PMID:
29938611
22.

Abrupt Deflation after Sustained Inflation Causes Lung Injury.

Katira BH, Engelberts D, Otulakowski G, Giesinger RE, Yoshida T, Post M, Kuebler WM, Connelly KA, Kavanagh BP.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1165-1176. doi: 10.1164/rccm.201801-0178OC.

PMID:
29902384
23.

A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.

Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart D, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E.

Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L502-L516. doi: 10.1152/ajplung.00150.2018. Epub 2018 Jun 7. Review.

24.

Optimising experimental research in respiratory diseases: an ERS statement.

Bonniaud P, Fabre A, Frossard N, Guignabert C, Inman M, Kuebler WM, Maes T, Shi W, Stampfli M, Uhlig S, White E, Witzenrath M, Bellaye PS, Crestani B, Eickelberg O, Fehrenbach H, Guenther A, Jenkins G, Joos G, Magnan A, Maitre B, Maus UA, Reinhold P, Vernooy JHJ, Richeldi L, Kolb M.

Eur Respir J. 2018 May 17;51(5). pii: 1702133. doi: 10.1183/13993003.02133-2017. Print 2018 May.

25.

Pulse wave velocity in the microcirculation reflects both vascular compliance and resistance: Insights from computational approaches.

Pan Q, Wang R, Reglin B, Fang L, Yan J, Cai G, Kuebler WM, Pries AR, Ning G.

Microcirculation. 2018 Jul;25(5):e12458. doi: 10.1111/micc.12458. Epub 2018 May 31.

PMID:
29729094
26.

Improved resolution in extracellular vesicle populations using 405 instead of 488 nm side scatter.

McVey MJ, Spring CM, Kuebler WM.

J Extracell Vesicles. 2018 Mar 22;7(1):1454776. doi: 10.1080/20013078.2018.1454776. eCollection 2018.

27.

Shedding First Light on the Alveolar Epithelial Glycocalyx.

Weidenfeld S, Kuebler WM.

Am J Respir Cell Mol Biol. 2018 Sep;59(3):283-284. doi: 10.1165/rcmb.2018-0108ED. No abstract available.

PMID:
29694231
28.

Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome.

Sugiyama MG, Mintsopoulos V, Raheel H, Goldenberg NM, Batt JE, Brochard L, Kuebler WM, Leong-Poi H, Karshafian R, Lee WL.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):404-408. doi: 10.1164/rccm.201711-2259LE. No abstract available.

PMID:
29638143
29.

The Role of the Human Immune System in Chronic Hypoxic Pulmonary Hypertension.

Hu Y, Zabini D, Gu W, Goldenberg NM, Breitling S, Kabir G, Connelly KA, Kuebler WM.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):528-531. doi: 10.1164/rccm.201711-2175LE. No abstract available.

PMID:
29630848
30.

Experimental Right Ventricular Hypertension Induces Regional β1-Integrin-Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling.

Sun M, Ishii R, Okumura K, Krauszman A, Breitling S, Gomez O, Hinek A, Boo S, Hinz B, Connelly KA, Kuebler WM, Friedberg MK.

J Am Heart Assoc. 2018 Mar 29;7(7). pii: e007928. doi: 10.1161/JAHA.117.007928.

31.

Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion.

Mannaa M, Markó L, Balogh A, Vigolo E, N'diaye G, Kaßmann M, Michalick L, Weichelt U, Schmidt-Ott KM, Liedtke WB, Huang Y, Müller DN, Kuebler WM, Gollasch M.

Sci Rep. 2018 Mar 20;8(1):4878. doi: 10.1038/s41598-018-23165-0.

32.

Difficulties in modelling ARDS (2017 Grover Conference Series).

Uhlig S, Kuebler WM.

Pulm Circ. 2018 Apr-Jun;8(2):2045894018766737. doi: 10.1177/2045894018766737. Epub 2018 Mar 9.

33.

Inflammation and autoimmunity in pulmonary hypertension: is there a role for endothelial adhesion molecules? (2017 Grover Conference Series).

Kuebler WM, Bonnet S, Tabuchi A.

Pulm Circ. 2018 Apr-Jun;8(2):2045893218757596. doi: 10.1177/2045893218757596. Epub 2018 Feb 26.

34.

Vascular-induced lung injury: another advocate for personalized ARDS management : Discussion on "Inspiratory preload obliteration may injure lungs via cyclical 'on-off' vascular flow".

Roshdy A, Katira BH, Kuebler WM, Kavanagh BP.

Intensive Care Med. 2018 Apr;44(4):540-541. doi: 10.1007/s00134-018-5077-0. Epub 2018 Feb 15. No abstract available.

PMID:
29450595
35.

Lessons from Cancer: Subcellular Drug Targeting of Mitochondrial HSP90 in Pulmonary Arterial Hypertension.

Kuebler WM.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):9-11. doi: 10.1164/rccm.201801-0200ED. No abstract available.

PMID:
29438624
36.

Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies.

Semple JW, McVey MJ, Kim M, Rebetz J, Kuebler WM, Kapur R.

Crit Care Med. 2018 May;46(5):e452-e458. doi: 10.1097/CCM.0000000000002989. Review.

PMID:
29384784
37.

Letter by Kuebler and Friedberg Regarding Article, "Pulmonary Artery Denervation by Determining Targeted Ablation Sites for Treatment of Pulmonary Arterial Hypertension".

Kuebler WM, Friedberg MK.

Circ Cardiovasc Interv. 2018 Feb;11(2):e006148. doi: 10.1161/CIRCINTERVENTIONS.117.006148. No abstract available.

PMID:
29371213
38.

Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group.

Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916.

PMID:
29298188
39.

Inspiratory preload obliteration may injure lungs via cyclical "on-off" vascular flow.

Katira BH, Kuebler WM, Kavanagh BP.

Intensive Care Med. 2018 Sep;44(9):1521-1523. doi: 10.1007/s00134-017-5024-5. Epub 2017 Dec 21. No abstract available.

PMID:
29270678
40.

Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.

Yu FPS, Islam D, Sikora J, Dworski S, Gurka J, López-Vásquez L, Liu M, Kuebler WM, Levade T, Zhang H, Medin JA.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L406-L420. doi: 10.1152/ajplung.00223.2017. Epub 2017 Nov 22.

41.

Multiple image x-radiography for functional lung imaging.

Aulakh GK, Mann A, Belev G, Wiebe S, Kuebler WM, Singh B, Chapman D.

Phys Med Biol. 2017 Dec 14;63(1):015009. doi: 10.1088/1361-6560/aa9904.

PMID:
29116051
42.

Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC. Erratum in: Am J Respir Crit Care Med. 2019 Apr 1;199(7):932.

PMID:
29095649
43.

Tides of Blood: Cyclic Changes in Lung Blood Volume during a Single Breath.

Kuebler WM.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):386-387. doi: 10.1165/rcmb.2017-0219ED. No abstract available.

PMID:
28960103
44.

Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9.

Blázquez-Prieto J, López-Alonso I, Amado-Rodríguez L, Huidobro C, González-López A, Kuebler WM, Albaiceta GM.

Thorax. 2018 Apr;73(4):321-330. doi: 10.1136/thoraxjnl-2017-210105. Epub 2017 Sep 25.

PMID:
28947666
45.

The endothelium in hypoxic pulmonary vasoconstriction.

Grimmer B, Kuebler WM.

J Appl Physiol (1985). 2017 Dec 1;123(6):1635-1646. doi: 10.1152/japplphysiol.00120.2017. Epub 2017 Aug 31. Review.

46.

Coagulation factor XII regulates inflammatory responses in human lungs.

Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M.

Thromb Haemost. 2017 Oct 5;117(10):1896-1907. doi: 10.1160/TH16-12-0904. Epub 2017 Aug 17.

PMID:
28816340
47.

Adverse Heart-Lung Interactions in Ventilator-induced Lung Injury.

Katira BH, Giesinger RE, Engelberts D, Zabini D, Kornecki A, Otulakowski G, Yoshida T, Kuebler WM, McNamara PJ, Connelly KA, Kavanagh BP.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1411-1421. doi: 10.1164/rccm.201611-2268OC.

PMID:
28795839
48.

Modeling of pulsatile flow-dependent nitric oxide regulation in a realistic microvascular network.

Wang R, Pan Q, Kuebler WM, Li JK, Pries AR, Ning G.

Microvasc Res. 2017 Sep;113:40-49. doi: 10.1016/j.mvr.2017.05.001. Epub 2017 May 3.

PMID:
28478072
49.
50.

Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction.

Krauszman A, Mak TW, Szaszi K, Kuebler WM.

Cardiovasc Res. 2017 Jul 1;113(8):869-878. doi: 10.1093/cvr/cvx076.

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