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Items: 37

1.

Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.

Flanagan ME, Blumenkopf TA, Brissette WH, Brown MF, Casavant JM, Shang-Poa C, Doty JL, Elliott EA, Fisher MB, Hines M, Kent C, Kudlacz EM, Lillie BM, Magnuson KS, McCurdy SP, Munchhof MJ, Perry BD, Sawyer PS, Strelevitz TJ, Subramanyam C, Sun J, Whipple DA, Changelian PS.

J Med Chem. 2010 Dec 23;53(24):8468-84. doi: 10.1021/jm1004286. Epub 2010 Nov 24.

PMID:
21105711
2.

PF-03475952: a potent and neutralizing fully human anti-CD44 antibody for therapeutic applications in inflammatory diseases.

Runnels HA, Weber GL, Min J, Kudlacz EM, Zobel JF, Donovan CB, Thiede MA, Zhang J, Alpert RB, Salafia MA, Milici AJ, Burdette D, Bell RR, Beebe JS, Xu X.

Adv Ther. 2010 Mar;27(3):168-80. doi: 10.1007/s12325-010-0010-0. Epub 2010 Apr 26.

PMID:
20429046
3.

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis.

Milici AJ, Kudlacz EM, Audoly L, Zwillich S, Changelian P.

Arthritis Res Ther. 2008;10(1):R14. doi: 10.1186/ar2365. Epub 2008 Jan 30.

4.

The specificity of JAK3 kinase inhibitors.

Changelian PS, Moshinsky D, Kuhn CF, Flanagan ME, Munchhof MJ, Harris TM, Whipple DA, Doty JL, Sun J, Kent CR, Magnuson KS, Perregaux DG, Sawyer PS, Kudlacz EM.

Blood. 2008 Feb 15;111(4):2155-7. Epub 2007 Dec 19. Erratum in: Blood. 2009 Oct 1;114(14):3132. Dosage error in article text; Whipple, David A [added].

5.

Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates.

Borie DC, Larson MJ, Flores MG, Campbell A, Rousvoal G, Zhang S, Higgins JP, Ball DJ, Kudlacz EM, Brissette WH, Elliott EA, Reitz BA, Changelian PS.

Transplantation. 2005 Dec 27;80(12):1756-64.

PMID:
16378072
6.

Combined tachykinin receptor antagonists for the treatment of respiratory diseases.

Kudlacz EM.

Expert Opin Investig Drugs. 1998 Jul;7(7):1055-62.

PMID:
15992015
7.

Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates.

Borie DC, Changelian PS, Larson MJ, Si MS, Paniagua R, Higgins JP, Holm B, Campbell A, Lau M, Zhang S, Flores MG, Rousvoal G, Hawkins J, Ball DA, Kudlacz EM, Brissette WH, Elliott EA, Reitz BA, Morris RE.

Transplantation. 2005 Apr 15;79(7):791-801.

PMID:
15818321
8.

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

Changelian PS, Flanagan ME, Ball DJ, Kent CR, Magnuson KS, Martin WH, Rizzuti BJ, Sawyer PS, Perry BD, Brissette WH, McCurdy SP, Kudlacz EM, Conklyn MJ, Elliott EA, Koslov ER, Fisher MB, Strelevitz TJ, Yoon K, Whipple DA, Sun J, Munchhof MJ, Doty JL, Casavant JM, Blumenkopf TA, Hines M, Brown MF, Lillie BM, Subramanyam C, Shang-Poa C, Milici AJ, Beckius GE, Moyer JD, Su C, Woodworth TG, Gaweco AS, Beals CR, Littman BH, Fisher DA, Smith JF, Zagouras P, Magna HA, Saltarelli MJ, Johnson KS, Nelms LF, Des Etages SG, Hayes LS, Kawabata TT, Finco-Kent D, Baker DL, Larson M, Si MS, Paniagua R, Higgins J, Holm B, Reitz B, Zhou YJ, Morris RE, O'Shea JJ, Borie DC.

Science. 2003 Oct 31;302(5646):875-8.

9.

Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs.

Selman M, Cisneros-Lira J, Gaxiola M, Ramírez R, Kudlacz EM, Mitchell PG, Pardo A.

Chest. 2003 May;123(5):1633-41.

PMID:
12740284
10.

Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists.

Duplantier AJ, Beckius GE, Chambers RJ, Chupak LS, Jenkinson TH, Klein AS, Kraus KG, Kudlacz EM, McKechney MW, Pettersson MP, Whitney CA, Milici AJ.

Bioorg Med Chem Lett. 2001 Oct 8;11(19):2593-6.

PMID:
11551757
11.

Genetic ablation of the src kinase p59fynT exacerbates pulmonary inflammation in an allergic mouse model.

Kudlacz EM, Andresen CJ, Salafia M, Whitney CA, Naclerio B, Changelian PS.

Am J Respir Cell Mol Biol. 2001 Apr;24(4):469-74.

PMID:
11306441
12.

Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat.

Kudlacz EM, Whitney CA, Andresen CJ, Umland JP, Cheng JB.

Br J Pharmacol. 1999 Oct;128(3):788-94.

13.

The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs.

Kudlacz EM, Knippenberg RW, Shatzer SA, Kehne JH, McCloskey TC, Burkholder TP.

J Auton Pharmacol. 1997 Apr;17(2):109-19.

PMID:
9234081
14.
15.

Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model.

Kudlacz EM, Knippenberg RW, Logan DE, Burkholder TP.

J Pharmacol Exp Ther. 1996 Nov;279(2):732-9.

PMID:
8930178
16.

In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.

Kudlacz EM, Shatzer SA, Knippenberg RW, Logan DE, Poirot M, van Giersbergen PL, Burkholder TP.

J Pharmacol Exp Ther. 1996 May;277(2):840-51.

PMID:
8627566
17.
18.
19.

In vitro and in vivo effects of tachykinins on immune cell function in guinea pig airways.

Kudlacz EM, Knippenberg RW.

J Neuroimmunol. 1994 Mar;50(2):119-25.

PMID:
8120132
20.

A time-course study of airway hyperresponsiveness in conscious parainfluenza virus type 3-infected guinea pigs.

Kudlacz EM, Baugh LE, Porter WP, Kenny MT, Farrell AM.

Lab Anim Sci. 1993 Oct;43(5):445-53.

PMID:
8277724
21.

Tachykinin-mediated respiratory effects in conscious guinea pigs: modulation by NK1 and NK2 receptor antagonists.

Kudlacz EM, Logan DE, Shatzer SA, Farrell AM, Baugh LE.

Eur J Pharmacol. 1993 Sep 7;241(1):17-25.

PMID:
7693493
22.
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29.

Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding.

Slotkin TA, Kudlacz EM, Lappi SE, Tayyeb MI, Seidler FJ.

Life Sci. 1990;47(22):2051-7.

PMID:
2177130
31.

Prenatal dexamethasone administration disrupts the pattern of cellular development in rat lung.

Navarro HA, Kudlacz EM, Eylers JP, Slotkin TA.

Teratology. 1989 Nov;40(5):433-8.

PMID:
2623631
32.
34.

Effects of prenatal terbutaline exposure on cellular development in lung and liver of neonatal rat: ornithine decarboxylase activity and macromolecules.

Kudlacz EM, Navarro HA, Eylers JP, Lappi SE, Dobbins SS, Slotkin TA.

Pediatr Res. 1989 Jun;25(6):617-22.

PMID:
2472593
35.

Effects of diabetes and diuresis on contraction and relaxation mechanisms in rat urinary bladder.

Kudlacz EM, Gerald MC, Wallace LJ.

Diabetes. 1989 Mar;38(3):278-84.

PMID:
2563711
36.

Sensory nerves and urinary bladder function: effects of diabetes, capsaicin and acrylamide treatment.

Kudlacz EM, Gerald MC, Wallace LJ.

Gen Pharmacol. 1989;20(1):31-4.

PMID:
2707569
37.

Diabetes and diuretic-induced alterations in function of rat urinary bladder.

Kudlacz EM, Chun AL, Skau KA, Gerald MC, Wallace LJ.

Diabetes. 1988 Jul;37(7):949-55.

PMID:
3384189

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