Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 66

1.

Analysis of Proteasome-Generated Antigenic Peptides by Mass Spectrometry.

Textoris-Taube K, Kuckelkorn U, Beier C, Kloetzel PM.

Methods Mol Biol. 2019;1988:15-29. doi: 10.1007/978-1-4939-9450-2_2.

PMID:
31147929
2.

Proteolytic dynamics of human 20S thymoproteasome.

Kuckelkorn U, Stübler S, Textoris-Taube K, Kilian C, Niewienda A, Henklein P, Janek K, Stumpf MPH, Mishto M, Liepe J.

J Biol Chem. 2019 May 10;294(19):7740-7754. doi: 10.1074/jbc.RA118.007347. Epub 2019 Mar 26.

PMID:
30914481
3.

Changes in spatio-temporal localization of tripeptidyl peptidase II (TPPII) in murine colon adenocarcinoma cells during aggresome formation: a microscopy study based on a novel fluorescent proteasome inhibitor.

Bialy LP, Kuckelkorn U, Henklein P, Fayet J, Wilczyński GM, Kamiński A, Mlynarczuk-Bialy I.

Histol Histopathol. 2019 Apr;34(4):359-372. doi: 10.14670/HH-18-042. Epub 2018 Sep 18.

PMID:
30226264
4.

Systemic Proteasome Inhibition Induces Sustained Post-stroke Neurological Recovery and Neuroprotection via Mechanisms Involving Reversal of Peripheral Immunosuppression and Preservation of Blood-Brain-Barrier Integrity.

Doeppner TR, Kaltwasser B, Kuckelkorn U, Henkelein P, Bretschneider E, Kilic E, Hermann DM.

Mol Neurobiol. 2016 Nov;53(9):6332-6341. doi: 10.1007/s12035-015-9533-3. Epub 2015 Nov 16.

PMID:
26572637
5.

Elastase-like Activity Is Dominant to Chymotrypsin-like Activity in 20S Proteasome's β5 Catalytic Subunit.

Bensinger D, Neumann T, Scholz C, Voss C, Knorr S, Kuckelkorn U, Hamacher K, Kloetzel PM, Schmidt B.

ACS Chem Biol. 2016 Jul 15;11(7):1800-4. doi: 10.1021/acschembio.6b00023. Epub 2016 May 2.

PMID:
27111844
6.

The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.

Keller M, Ebstein F, Bürger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Dannenberg T, Sucker A, Keller C, Saveanu L, Krüger E, Rothkötter HJ, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel PM, Seifert U.

Eur J Immunol. 2015 Dec;45(12):3257-68. doi: 10.1002/eji.201445243. Epub 2015 Oct 19.

7.

LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118.

Yao G, Zhang Q, Doeppner TR, Niu F, Li Q, Yang Y, Kuckelkorn U, Hagemann N, Li W, Hermann DM, Dai Y, Zhou W, Jin F.

Oncotarget. 2015 Oct 6;6(30):30251-62. doi: 10.18632/oncotarget.4943.

8.

Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma.

Zang M, Li Z, Liu L, Li F, Li X, Dai Y, Li W, Kuckelkorn U, Doeppner TR, Hermann DM, Zhou W, Qiu L, Jin F.

Cancer Lett. 2015 Oct 1;366(2):173-81. doi: 10.1016/j.canlet.2015.06.011. Epub 2015 Jun 23.

PMID:
26116344
9.

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model.

Mlynarczuk-Bialy I, Doeppner TR, Golab J, Nowis D, Wilczynski GM, Parobczak K, Wigand ME, Hajdamowicz M, Biały LP, Aniolek O, Henklein P, Bähr M, Schmidt B, Kuckelkorn U, Kloetzel PM.

Transl Oncol. 2014 Oct 24;7(5):570-9. doi: 10.1016/j.tranon.2014.07.002. eCollection 2014 Oct.

10.

Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation.

Mishto M, Liepe J, Textoris-Taube K, Keller C, Henklein P, Weberruß M, Dahlmann B, Enenkel C, Voigt A, Kuckelkorn U, Stumpf MP, Kloetzel PM.

Eur J Immunol. 2014 Dec;44(12):3508-21. doi: 10.1002/eji.201444902. Epub 2014 Nov 20.

11.

α-Keto phenylamides as P1'-extended proteasome inhibitors.

Voss C, Scholz C, Knorr S, Beck P, Stein ML, Zall A, Kuckelkorn U, Kloetzel PM, Groll M, Hamacher K, Schmidt B.

ChemMedChem. 2014 Nov;9(11):2557-64. doi: 10.1002/cmdc.201402244. Epub 2014 Aug 1.

PMID:
25087721
12.

Trypanosoma cruzi infection down-modulates the immunoproteasome biosynthesis and the MHC class I cell surface expression in HeLa cells.

Camargo R, Faria LO, Kloss A, Favali CB, Kuckelkorn U, Kloetzel PM, de Sá CM, Lima BD.

PLoS One. 2014 Apr 21;9(4):e95977. doi: 10.1371/journal.pone.0095977. eCollection 2014.

13.

Rapid degradation of solid-phase bound peptides by the 20S proteasome.

Hovestädt M, Kuckelkorn U, Niewienda A, Keller C, Goede A, Ay B, Günther S, Janek K, Volkmer R, Holzhütter HG.

J Pept Sci. 2013 Sep;19(9):588-97. doi: 10.1002/psc.2536. Epub 2013 Jul 28.

PMID:
23893543
14.

Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome.

Martinez-Gamboa L, Lesemann K, Kuckelkorn U, Scheffler S, Ghannam K, Hahne M, Gaber-Elsner T, Egerer K, Naumann L, Buttgereit F, Dörner T, Kloetzel PM, Burmester GR, Faustman DL, Feist E.

J Rheumatol. 2013 May;40(5):663-73. doi: 10.3899/jrheum.120680. Epub 2013 Mar 15.

PMID:
23504381
15.

Immunoproteasomes are important for proteostasis in immune responses.

Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E.

Cell. 2013 Feb 28;152(5):935-7. doi: 10.1016/j.cell.2013.02.018. No abstract available.

16.

Analysis of proteasome generated antigenic peptides by mass spectrometry.

Textoris-Taube K, Keller C, Kuckelkorn U, Kloetzel PM.

Methods Mol Biol. 2013;960:15-29. doi: 10.1007/978-1-62703-218-6_2.

PMID:
23329475
17.

The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis.

Doeppner TR, Mlynarczuk-Bialy I, Kuckelkorn U, Kaltwasser B, Herz J, Hasan MR, Hermann DM, Bähr M.

Brain. 2012 Nov;135(Pt 11):3282-97. doi: 10.1093/brain/aws269.

PMID:
23169919
18.

The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes.

Joeris T, Schmidt N, Ermert D, Krienke P, Visekruna A, Kuckelkorn U, Kaufmann SH, Steinhoff U.

PLoS One. 2012;7(6):e39827. doi: 10.1371/journal.pone.0039827. Epub 2012 Jun 29.

19.

Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag.

Overath T, Kuckelkorn U, Henklein P, Strehl B, Bonar D, Kloss A, Siele D, Kloetzel PM, Janek K.

Mol Cell Proteomics. 2012 Aug;11(8):467-77. doi: 10.1074/mcp.M111.015966. Epub 2012 May 3.

20.

Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

Opitz E, Koch A, Klingel K, Schmidt F, Prokop S, Rahnefeld A, Sauter M, Heppner FL, Völker U, Kandolf R, Kuckelkorn U, Stangl K, Krüger E, Kloetzel PM, Voigt A.

PLoS Pathog. 2011 Sep;7(9):e1002233. doi: 10.1371/journal.ppat.1002233. Epub 2011 Sep 1.

21.

Antigen-presentation capacity of dendritic cells is impaired in ongoing enterovirus myocarditis.

Rahnefeld A, Ebstein F, Albrecht N, Opitz E, Kuckelkorn U, Stangl K, Rehm A, Kloetzel PM, Voigt A.

Eur J Immunol. 2011 Sep;41(9):2774-81. doi: 10.1002/eji.201041039. Epub 2011 Jul 29.

22.

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress.

Seifert U, Bialy LP, Ebstein F, Bech-Otschir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel PM, Krüger E.

Cell. 2010 Aug 20;142(4):613-24. doi: 10.1016/j.cell.2010.07.036.

23.

BSc2118 is a novel proteasome inhibitor with activity against multiple myeloma.

Sterz J, Jakob C, Kuckelkorn U, Heider U, Mieth M, Kleeberg L, Kaiser M, Kloetzel PM, Sezer O, von Metzler I.

Eur J Haematol. 2010 Aug;85(2):99-107. doi: 10.1111/j.1600-0609.2010.01450.x. Epub 2010 Mar 31.

PMID:
20374272
24.

Lack of evidence for a pathogenic role of proteasome-directed autoimmunity in dilated cardiomyopathy.

Voigt A, Trimpert C, Bartel K, Egerer K, Kuckelkorn U, Feist E, Gericke C, Klingel K, Kandolf R, Felix SB, Baumann G, Kloetzel PM, Stangl K, Staudt A.

Basic Res Cardiol. 2010 Jul;105(4):557-67. doi: 10.1007/s00395-010-0096-1. Epub 2010 Mar 25.

PMID:
20336303
25.

Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes.

Voigt A, Jäkel S, Textoris-Taube K, Keller C, Drung I, Szalay G, Klingel K, Henklein P, Stangl K, Kloetzel PM, Kuckelkorn U.

Amino Acids. 2010 Jun;39(1):243-55. doi: 10.1007/s00726-009-0434-5. Epub 2009 Dec 9.

PMID:
19997756
26.

Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome.

Morawietz L, Martinez-Gamboa L, Scheffler S, Hausdorf G, Dankof A, Kuckelkorn U, Doerner T, Egerer K, Burmester GR, Faustman DL, Feist E.

J Rheumatol. 2009 Dec;36(12):2694-703. doi: 10.3899/jrheum.081098. Epub 2009 Oct 15.

PMID:
19833746
27.

Humoral anti-proteasomal autoimmunity in dilated cardiomyopathy.

Voigt A, Bartel K, Egerer K, Trimpert C, Feist E, Gericke C, Kandolf R, Klingel K, Kuckelkorn U, Stangl K, Felix SB, Baumann G, Kloetzel PM, Staudt A.

Basic Res Cardiol. 2010 Jan;105(1):9-18. doi: 10.1007/s00395-009-0061-z.

PMID:
19760349
28.

Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis.

Jäkel S, Kuckelkorn U, Szalay G, Plötz M, Textoris-Taube K, Opitz E, Klingel K, Stevanovic S, Kandolf R, Kotsch K, Stangl K, Kloetzel PM, Voigt A.

Am J Pathol. 2009 Aug;175(2):510-8. doi: 10.2353/ajpath.2009.090033. Epub 2009 Jul 9.

29.

Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated I kappaB kinase.

von Metzler I, Krebbel H, Kuckelkorn U, Heider U, Jakob C, Kaiser M, Fleissner C, Terpos E, Sezer O.

J Cancer Res Clin Oncol. 2009 Feb;135(2):173-9. doi: 10.1007/s00432-008-0461-8. Epub 2008 Sep 3.

PMID:
18766375
30.

Antitopes define preferential proteasomal cleavage site usage.

Strehl B, Textoris-Taube K, Jäkel S, Voigt A, Henklein P, Steinhoff U, Kloetzel PM, Kuckelkorn U.

J Biol Chem. 2008 Jun 27;283(26):17891-7. doi: 10.1074/jbc.M710042200. Epub 2008 Apr 18.

31.

Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta1i), MECL1 (beta2i) and LMP7 (beta5i).

Scheffler S, Kuckelkorn U, Egerer K, Dörner T, Reiter K, Soza A, Burmester GR, Feist E.

Rheumatology (Oxford). 2008 May;47(5):622-6. doi: 10.1093/rheumatology/ken042. Epub 2008 Mar 27.

PMID:
18375405
32.

Pioglitazone, a PPAR-gamma ligand, exerts cytostatic/cytotoxic effects against cancer cells, that do not result from inhibition of proteasome.

Mrówka P, Głodkowska E, Młynarczuk-Biały I, Biały L, Kuckelkorn U, Nowis D, Makowski M, Legat M, Gołab J.

Acta Biochim Pol. 2008;55(1):75-84. Epub 2008 Mar 10.

33.

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.

Heider U, von Metzler I, Kaiser M, Rosche M, Sterz J, Rötzer S, Rademacher J, Jakob C, Fleissner C, Kuckelkorn U, Kloetzel PM, Sezer O.

Eur J Haematol. 2008 Feb;80(2):133-42. Epub 2007 Dec 20.

PMID:
18005386
34.

Heme oxygenase-1 ameliorates ischemia/reperfusion injury by targeting dendritic cell maturation and migration.

Kotsch K, Martins PN, Klemz R, Janssen U, Gerstmayer B, Dernier A, Reutzel-Selke A, Kuckelkorn U, Tullius SG, Volk HD.

Antioxid Redox Signal. 2007 Dec;9(12):2049-63.

PMID:
17854277
35.

The N-terminal flanking region of the TRP2360-368 melanoma antigen determines proteasome activator PA28 requirement for epitope liberation.

Textoris-Taube K, Henklein P, Pollmann S, Bergann T, Weisshoff H, Seifert U, Drung I, Mügge C, Sijts A, Kloetzel PM, Kuckelkorn U.

J Biol Chem. 2007 Apr 27;282(17):12749-54. Epub 2007 Feb 16.

36.

20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2L(d) epitope from a recombinant protein.

Voigt A, Salzmann U, Seifert U, Dathe M, Soza A, Kloetzel PM, Kuckelkorn U.

Biochem Biophys Res Commun. 2007 Apr 6;355(2):549-54. Epub 2007 Feb 8.

PMID:
17303071
37.

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma.

Jakob C, Egerer K, Liebisch P, Türkmen S, Zavrski I, Kuckelkorn U, Heider U, Kaiser M, Fleissner C, Sterz J, Kleeberg L, Feist E, Burmester GR, Kloetzel PM, Sezer O.

Blood. 2007 Mar 1;109(5):2100-5. Epub 2006 Nov 9.

PMID:
17095627
38.

Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells.

Strehl B, Joeris T, Rieger M, Visekruna A, Textoris-Taube K, Kaufmann SH, Kloetzel PM, Kuckelkorn U, Steinhoff U.

J Immunol. 2006 Nov 1;177(9):6238-44.

39.

Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells.

Młynarczuk-Biały I, Roeckmann H, Kuckelkorn U, Schmidt B, Umbreen S, Gołab J, Ludwig A, Montag C, Wiebusch L, Hagemeier C, Schadendorf D, Kloetzel PM, Seifert U.

Cancer Res. 2006 Aug 1;66(15):7598-605.

40.

Anti-proteasome autoantibodies contribute to anti-nuclear antibody patterns on human larynx carcinoma cells.

Feist E, Brychcy M, Hausdorf G, Hoyer B, Egerer K, Dörner T, Kuckelkorn U, Burmester GR.

Ann Rheum Dis. 2007 Jan;66(1):5-11. Epub 2006 Jun 30.

41.

Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28.

Brychcy M, Kuckelkorn U, Hausdorf G, Egerer K, Kloetzel PM, Burmester GR, Feist E.

Arthritis Rheum. 2006 Jul;54(7):2175-83. Erratum in: Arthritis Rheum. 2006 Aug;54(8):2702.

42.

Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes.

Szalay G, Meiners S, Voigt A, Lauber J, Spieth C, Speer N, Sauter M, Kuckelkorn U, Zell A, Klingel K, Stangl K, Kandolf R.

Am J Pathol. 2006 May;168(5):1542-52.

43.

Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders.

Krause S, Kuckelkorn U, Dörner T, Burmester GR, Feist E, Kloetzel PM.

Ann Rheum Dis. 2006 Aug;65(8):1021-7. Epub 2006 Jan 13.

44.

Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.

Strehl B, Seifert U, Krüger E, Heink S, Kuckelkorn U, Kloetzel PM.

Immunol Rev. 2005 Oct;207:19-30. Review.

PMID:
16181324
45.

Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines.

Braun HA, Umbreen S, Groll M, Kuckelkorn U, Mlynarczuk I, Wigand ME, Drung I, Kloetzel PM, Schmidt B.

J Biol Chem. 2005 Aug 5;280(31):28394-401. Epub 2005 May 26.

46.

Prevalence of 20S proteasome, anti-nuclear and thyroid antibodies in young patients at onset of type 1 diabetes mellitus and the risk of autoimmune thyroiditis.

Kordonouri O, Meyer K, Egerer K, Hartmann R, Scheffler S, Burmester GR, Kuckelkorn U, Danne T, Feist E.

J Pediatr Endocrinol Metab. 2004 Jul;17(7):975-81.

PMID:
15301045
47.

The components of the proteasome system and their role in MHC class I antigen processing.

Krüger E, Kuckelkorn U, Sijts A, Kloetzel PM.

Rev Physiol Biochem Pharmacol. 2003;148:81-104. Epub 2003 Mar 25. Review.

PMID:
12687403
48.

Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases.

Egerer K, Kuckelkorn U, Rudolph PE, Rückert JC, Dörner T, Burmester GR, Kloetzel PM, Feist E.

J Rheumatol. 2002 Oct;29(10):2045-52.

PMID:
12375310
49.

Assessment of proteasomal cleavage probabilities from kinetic analysis of time-dependent product formation.

Peters B, Janek K, Kuckelkorn U, Holzhütter HG.

J Mol Biol. 2002 May 3;318(3):847-62.

PMID:
12054828

Supplemental Content

Loading ...
Support Center