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Items: 1 to 50 of 392

1.

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.

Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJ.

Immunity. 2019 Oct 15;51(4):696-708.e9. doi: 10.1016/j.immuni.2019.09.004.

PMID:
31618654
2.

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.

Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK.

Immunity. 2019 Oct 15;51(4):709-723.e6. doi: 10.1016/j.immuni.2019.09.005. Epub 2019 Oct 8.

PMID:
31604686
3.

Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance.

Tang R, Rangachari M, Kuchroo VK.

Semin Immunol. 2019 Apr;42:101302. doi: 10.1016/j.smim.2019.101302. Review.

PMID:
31604535
4.

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.

Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT.

Nat Immunol. 2019 Oct;20(10):1360-1371. doi: 10.1038/s41590-019-0472-4. Epub 2019 Sep 2.

PMID:
31477921
5.

Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics.

Sungnak W, Wang C, Kuchroo VK.

Adv Immunol. 2019;141:1-31. doi: 10.1016/bs.ai.2018.12.001. Epub 2019 Jan 3.

PMID:
30904130
6.

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells.

Kurtulus S, Madi A, Escobar G, Klapholz M, Nyman J, Christian E, Pawlak M, Dionne D, Xia J, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC.

Immunity. 2019 Jan 15;50(1):181-194.e6. doi: 10.1016/j.immuni.2018.11.014. Epub 2019 Jan 8.

PMID:
30635236
7.

High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.

Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS.

Sci Rep. 2018 Nov 30;8(1):17512. doi: 10.1038/s41598-018-35754-0.

8.

Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells.

Aschenbrenner D, Foglierini M, Jarrossay D, Hu D, Weiner HL, Kuchroo VK, Lanzavecchia A, Notarbartolo S, Sallusto F.

Nat Immunol. 2019 Jan;20(1):109. doi: 10.1038/s41590-018-0264-2.

PMID:
30448856
9.

Human disease mutations highlight the inhibitory function of TIM-3.

Dixon KO, Das M, Kuchroo VK.

Nat Genet. 2018 Dec;50(12):1640-1641. doi: 10.1038/s41588-018-0289-3. No abstract available.

10.

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ.

Cell. 2018 Nov 15;175(5):1307-1320.e22. doi: 10.1016/j.cell.2018.10.008. Epub 2018 Nov 1.

PMID:
30392957
11.

Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation.

Wallrapp A, Riesenfeld SJ, Burkett PR, Kuchroo VK.

Immunol Rev. 2018 Nov;286(1):53-73. doi: 10.1111/imr.12702. Review.

PMID:
30294962
12.

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells.

Aschenbrenner D, Foglierini M, Jarrossay D, Hu D, Weiner HL, Kuchroo VK, Lanzavecchia A, Notarbartolo S, Sallusto F.

Nat Immunol. 2018 Oct;19(10):1126-1136. doi: 10.1038/s41590-018-0200-5. Epub 2018 Sep 10. Erratum in: Nat Immunol. 2019 Jan;20(1):109.

13.

Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.

Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM.

Nat Med. 2018 Oct;24(10):1625-1626. doi: 10.1038/s41591-018-0093-8.

PMID:
30013196
14.

Induction and transcriptional regulation of the co-inhibitory gene module in T cells.

Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, Kurtulus S, Law T, Etminan Y, Nevin J, Buckley CD, Burkett PR, Buenrostro JD, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK.

Nature. 2018 Jun;558(7710):454-459. doi: 10.1038/s41586-018-0206-z. Epub 2018 Jun 13.

15.

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.

Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB.

Nat Commun. 2018 May 3;9(1):1779. doi: 10.1038/s41467-018-03670-6.

16.

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1.

Meyer Zu Horste G, Przybylski D, Schramm MA, Wang C, Schnell A, Lee Y, Sobel R, Regev A, Kuchroo VK.

Immunity. 2018 Mar 20;48(3):556-569.e7. doi: 10.1016/j.immuni.2018.03.008.

17.

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH.

J Immunol. 2018 Apr 15;200(8):2592-2602. doi: 10.4049/jimmunol.1701231. Epub 2018 Mar 12.

18.

Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma.

Nakashima H, Nguyen T, Kasai K, Passaro C, Ito H, Goins WF, Shaikh I, Erdelyi R, Nishihara R, Nakano I, Reardon DA, Anderson AC, Kuchroo V, Chiocca EA.

Clin Cancer Res. 2018 Jun 1;24(11):2574-2584. doi: 10.1158/1078-0432.CCR-17-2954. Epub 2018 Mar 6.

19.

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.

Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM.

Nat Med. 2018 May;24(4):417-426. doi: 10.1038/nm.4501. Epub 2018 Mar 5. Erratum in: Nat Med. 2018 Oct;24(10):1625-1626.

20.

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N.

J Immunol. 2018 Apr 15;200(8):3000-3007. doi: 10.4049/jimmunol.1700407. Epub 2018 Mar 2.

21.

SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells.

Wu C, Chen Z, Xiao S, Thalhamer T, Madi A, Han T, Kuchroo V.

Cell Rep. 2018 Jan 16;22(3):653-665. doi: 10.1016/j.celrep.2017.12.068.

22.

Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells.

Nakashima H, Alayo QA, Penaloza-MacMaster P, Freeman GJ, Kuchroo VK, Reardon DA, Fernandez S, Caligiuri M, Chiocca EA.

Sci Rep. 2018 Jan 9;8(1):208. doi: 10.1038/s41598-017-18540-2.

23.

Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.

Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC.

Oncoimmunology. 2017 Nov 9;7(2):e1385690. doi: 10.1080/2162402X.2017.1385690. eCollection 2018.

24.

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.

Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL.

Nat Commun. 2017 Nov 17;8(1):1600. doi: 10.1038/s41467-017-01571-8.

25.

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.

Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC.

Cell. 2017 Nov 16;171(5):1221-1223. doi: 10.1016/j.cell.2017.11.006. No abstract available.

26.

Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK.

Nature. 2017 Nov 30;551(7682):658. doi: 10.1038/nature24480. Epub 2017 Nov 15.

PMID:
29143821
27.

Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.

Brauner S, Jiang X, Thorlacius GE, Lundberg AM, Östberg T, Yan ZQ, Kuchroo VK, Hansson GK, Wahren-Herlenius M.

Cardiovasc Res. 2018 Jan 1;114(1):158-167. doi: 10.1093/cvr/cvx181.

PMID:
29016728
28.

Predictors of responses to immune checkpoint blockade in advanced melanoma.

Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Ternès N, Jegou S, Woods DM, Sodré AL, Hansen M, Meirow Y, Sade-Feldman M, Burra A, Kwek SS, Flament C, Messaoudene M, Duong CPM, Chen L, Kwon BS, Anderson AC, Kuchroo VK, Weide B, Aubin F, Borg C, Dalle S, Beatrix O, Ayyoub M, Balme B, Tomasic G, Di Giacomo AM, Maio M, Schadendorf D, Melero I, Dréno B, Khammari A, Dummer R, Levesque M, Koguchi Y, Fong L, Lotem M, Baniyash M, Schmidt H, Svane IM, Kroemer G, Marabelle A, Michiels S, Cavalcanti A, Smyth MJ, Weber JS, Eggermont AM, Zitvogel L.

Nat Commun. 2017 Sep 19;8(1):592. doi: 10.1038/s41467-017-00608-2.

29.

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK.

Nature. 2017 Sep 21;549(7672):351-356. doi: 10.1038/nature24029. Epub 2017 Sep 13. Erratum in: Nature. 2017 Nov 15;:.

30.

Tim-3, Lag-3, and TIGIT.

Joller N, Kuchroo VK.

Curr Top Microbiol Immunol. 2017;410:127-156. doi: 10.1007/82_2017_62. Review.

31.

Podoplanin is a negative regulator of Th17 inflammation.

Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA.

JCI Insight. 2017 Sep 7;2(17). pii: 92321. doi: 10.1172/jci.insight.92321. eCollection 2017 Sep 7.

32.

TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.

Ding Q, Mohib K, Kuchroo VK, Rothstein DM.

J Immunol. 2017 Oct 1;199(7):2585-2595. doi: 10.4049/jimmunol.1602107. Epub 2017 Aug 28.

33.

Targeting latency-associated peptide promotes antitumor immunity.

Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL.

Sci Immunol. 2017 May 19;2(11). pii: eaaj1738. doi: 10.1126/sciimmunol.aaj1738.

34.

H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production.

Brauner S, Folkersen L, Kvarnström M, Meisgen S, Petersen S, Franzén-Malmros M, Mofors J, Brokstad KA, Klareskog L, Jonsson R, Westerberg LS, Trollmo C, Malmström V, Ambrosi A, Kuchroo VK, Nordmark G, Wahren-Herlenius M.

Ann Rheum Dis. 2017 Oct;76(10):1755-1763. doi: 10.1136/annrheumdis-2016-210509. Epub 2017 Jul 31.

35.

Phagocytosis imprints heterogeneity in tissue-resident macrophages.

A-Gonzalez N, Quintana JA, García-Silva S, Mazariegos M, González de la Aleja A, Nicolás-Ávila JA, Walter W, Adrover JM, Crainiciuc G, Kuchroo VK, Rothlin CV, Peinado H, Castrillo A, Ricote M, Hidalgo A.

J Exp Med. 2017 May 1;214(5):1281-1296. doi: 10.1084/jem.20161375. Epub 2017 Apr 21.

36.

Tim-3 and its role in regulating anti-tumor immunity.

Das M, Zhu C, Kuchroo VK.

Immunol Rev. 2017 Mar;276(1):97-111. doi: 10.1111/imr.12520. Review.

37.

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.

Karwacz K, Miraldi ER, Pokrovskii M, Madi A, Yosef N, Wortman I, Chen X, Watters A, Carriero N, Awasthi A, Regev A, Bonneau R, Littman D, Kuchroo VK.

Nat Immunol. 2017 Apr;18(4):412-421. doi: 10.1038/ni.3683. Epub 2017 Feb 6.

38.

The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program.

Wu C, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, Madi A, Franca RF, Han T, Oukka M, Kuchroo V.

Nat Immunol. 2017 Mar;18(3):344-353. doi: 10.1038/ni.3667. Epub 2017 Jan 23.

39.

IL-17 Blockade in Psoriasis.

Burkett PR, Kuchroo VK.

Cell. 2016 Dec 15;167(7):1669. doi: 10.1016/j.cell.2016.11.044.

40.

Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.

Kishi Y, Kondo T, Xiao S, Yosef N, Gaublomme J, Wu C, Wang C, Chihara N, Regev A, Joller N, Kuchroo VK.

J Exp Med. 2016 Oct 17;213(11):2489-2501. Epub 2016 Sep 26.

41.

T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia.

Suzuki E, Maverakis E, Sarin R, Bouchareychas L, Kuchroo VK, Nestle FO, Adamopoulos IE.

J Immunol. 2016 Dec 1;197(11):4403-4412. Epub 2016 Oct 24.

42.

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH.

Nat Immunol. 2016 Dec;17(12):1436-1446. doi: 10.1038/ni.3578. Epub 2016 Oct 3.

43.

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.

Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC.

Cell. 2016 Sep 8;166(6):1500-1511.e9. doi: 10.1016/j.cell.2016.08.052. Erratum in: Cell. 2017 Nov 16;171(5):1221-1223.

44.

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.

Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS.

J Exp Med. 2016 Sep 19;213(10):2147-66. doi: 10.1084/jem.20150376. Epub 2016 Aug 22.

45.

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.

Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK.

Cell Rep. 2016 Jul 12;16(2):392-404. doi: 10.1016/j.celrep.2016.05.088. Epub 2016 Jun 23.

46.

Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.

Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7596-601. doi: 10.1073/pnas.1600934113. Epub 2016 Jun 16.

47.

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

Anderson AC, Joller N, Kuchroo VK.

Immunity. 2016 May 17;44(5):989-1004. doi: 10.1016/j.immuni.2016.05.001. Review.

48.

Differentiation and Characterization of Tr1 Cells.

Chihara N, Madi A, Karwacz K, Awasthi A, Kuchroo VK.

Curr Protoc Immunol. 2016 Apr 1;113:3.27.1-3.27.10. doi: 10.1002/0471142735.im0327s113.

49.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.

50.

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.

Jayaraman P, Jacques MK, Zhu C, Steblenko KM, Stowell BL, Madi A, Anderson AC, Kuchroo VK, Behar SM.

PLoS Pathog. 2016 Mar 11;12(3):e1005490. doi: 10.1371/journal.ppat.1005490. eCollection 2016 Mar.

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