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Items: 1 to 50 of 137

1.

A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species.

Tscherner M, Kuchler K.

Microorganisms. 2019 Jul 15;7(7). pii: E201. doi: 10.3390/microorganisms7070201.

2.

The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways.

Shivarathri R, Tscherner M, Zwolanek F, Singh NK, Chauhan N, Kuchler K.

Sci Rep. 2019 Jul 1;9(1):9445. doi: 10.1038/s41598-019-45817-5.

3.

Klebsiella pneumoniae prevents spore germination and hyphal development of Aspergillus species.

Nogueira MF, Pereira L, Jenull S, Kuchler K, Lion T.

Sci Rep. 2019 Jan 18;9(1):218. doi: 10.1038/s41598-018-36524-8.

4.

TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease.

Neelagandan N, Gonnella G, Dang S, Janiesch PC, Miller KK, Küchler K, Marques RF, Indenbirken D, Alawi M, Grundhoff A, Kurtz S, Duncan KE.

Nucleic Acids Res. 2019 Jan 10;47(1):341-361. doi: 10.1093/nar/gky972.

5.

Methionine is required for cAMP-PKA mediated morphogenesis and virulence of Candida albicans.

Schrevens S, Van Zeebroeck G, Riedelberger M, Tournu H, Kuchler K, Van Dijck P.

Mol Microbiol. 2018 Aug;109(3):415-416. doi: 10.1111/mmi.14065. Epub 2018 Jul 24. No abstract available.

PMID:
30187986
6.

Analysis of the 3D microstructure of experimental cathode films for lithium-ion batteries under increasing compaction.

Kuchler K, Prifling B, Schmidt D, Markötter H, Manke I, Bernthaler T, Knoblauch V, Schmidt V.

J Microsc. 2018 Nov;272(2):96-110. doi: 10.1111/jmi.12749. Epub 2018 Aug 8.

PMID:
30088276
7.

Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response.

Charlet R, Pruvost Y, Tumba G, Istel F, Poulain D, Kuchler K, Sendid B, Jawhara S.

Sci Rep. 2018 Feb 20;8(1):3316. doi: 10.1038/s41598-018-21422-w.

8.

Methionine is required for cAMP-PKA-mediated morphogenesis and virulence of Candida albicans.

Schrevens S, Van Zeebroeck G, Riedelberger M, Tournu H, Kuchler K, Van Dijck P.

Mol Microbiol. 2018 May;108(3):258-275. doi: 10.1111/mmi.13933. Epub 2018 Mar 6. Erratum in: Mol Microbiol. 2018 Aug;109(3):415-416.

PMID:
29453849
9.

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion.

Khunweeraphong N, Stockner T, Kuchler K.

Sci Rep. 2017 Oct 23;7(1):13767. doi: 10.1038/s41598-017-11794-w.

10.

The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals.

Jenull S, Tscherner M, Gulati M, Nobile CJ, Chauhan N, Kuchler K.

Sci Rep. 2017 Aug 16;7(1):8308. doi: 10.1038/s41598-017-08239-9.

11.

The Paralogous Histone Deacetylases Rpd3 and Rpd31 Play Opposing Roles in Regulating the White-Opaque Switch in the Fungal Pathogen Candida albicans.

Xie J, Jenull S, Tscherner M, Kuchler K.

MBio. 2016 Nov 15;7(6). pii: e01807-16. doi: 10.1128/mBio.01807-16.

12.

Immunological Identification of Fungal Species.

Nogueira F, Istel F, Pereira L, Tscherner M, Kuchler K.

Methods Mol Biol. 2017;1508:339-359.

PMID:
27837515
13.

Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?

Kuchler K, Jenull S, Shivarathri R, Chauhan N.

PLoS Pathog. 2016 Nov 10;12(11):e1005938. doi: 10.1371/journal.ppat.1005938. eCollection 2016 Nov. Review. No abstract available.

14.

Inhibition of CBLB protects from lethal Candida albicans sepsis.

Wirnsberger G, Zwolanek F, Asaoka T, Kozieradzki I, Tortola L, Wimmer RA, Kavirayani A, Fresser F, Baier G, Langdon WY, Ikeda F, Kuchler K, Penninger JM.

Nat Med. 2016 Aug;22(8):915-23. doi: 10.1038/nm.4134. Epub 2016 Jul 18.

15.

Dectin-1 is required for miR155 upregulation in murine macrophages in response to Candida albicans.

Agustinho DP, de Oliveira MA, Tavares AH, Derengowski L, Stolz V, Guilhelmelli F, Mortari MR, Kuchler K, Silva-Pereira I.

Virulence. 2017 Jan 2;8(1):41-52. doi: 10.1080/21505594.2016.1200215. Epub 2016 Jun 13.

16.

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).

Schwarz T, Montanari F, Cseke A, Wlcek K, Visvader L, Palme S, Chiba P, Kuchler K, Urban E, Ecker GF.

ChemMedChem. 2016 Jun 20;11(12):1380-94. doi: 10.1002/cmdc.201500592. Epub 2016 Mar 10.

17.

Flagging Drugs That Inhibit the Bile Salt Export Pump.

Montanari F, Pinto M, Khunweeraphong N, Wlcek K, Sohail MI, Noeske T, Boyer S, Chiba P, Stieger B, Kuchler K, Ecker GF.

Mol Pharm. 2016 Jan 4;13(1):163-71. doi: 10.1021/acs.molpharmaceut.5b00594. Epub 2015 Dec 21.

18.

The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways.

Tscherner M, Zwolanek F, Jenull S, Sedlazeck FJ, Petryshyn A, Frohner IE, Mavrianos J, Chauhan N, von Haeseler A, Kuchler K.

PLoS Pathog. 2015 Oct 16;11(10):e1005218. doi: 10.1371/journal.ppat.1005218. eCollection 2015 Oct.

19.

Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate.

Mota S, Alves R, Carneiro C, Silva S, Brown AJ, Istel F, Kuchler K, Sampaio P, Casal M, Henriques M, Paiva S.

Front Microbiol. 2015 Sep 4;6:919. doi: 10.3389/fmicb.2015.00919. eCollection 2015.

20.

Genetic Transformation of Candida glabrata by Electroporation.

Istel F, Schwarzmüller T, Tscherner M, Kuchler K.

Bio Protoc. 2015 Jul 20;5(14). pii: e1528. doi: 10.21769/BioProtoc.1528.

21.

Large-scale Phenotypic Profiling of Gene Deletion Mutants in Candida glabrata.

Istel F, Schwarzmüller T, Tscherner M, Kuchler K.

Bio Protoc. 2015 Jul 20;5(14). pii: e1530. doi: 10.21769/BioProtoc.1530.

22.

Genetic Transformation of Candida glabrata by Heat Shock.

Istel F, Schwarzmüller T, Tscherner M, Kuchler K.

Bio Protoc. 2015 Jul 20;5(14). pii: e1529. doi: 10.21769/BioProtoc.1529.

23.

Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts.

Brunke S, Quintin J, Kasper L, Jacobsen ID, Richter ME, Hiller E, Schwarzmüller T, d'Enfert C, Kuchler K, Rupp S, Hube B, Ferrandon D.

Dis Model Mech. 2015 May;8(5):473-86. doi: 10.1242/dmm.019901. Epub 2015 Mar 18.

24.

The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.

Zwolanek F, Riedelberger M, Stolz V, Jenull S, Istel F, Köprülü AD, Ellmeier W, Kuchler K.

PLoS Pathog. 2014 Dec 4;10(12):e1004525. doi: 10.1371/journal.ppat.1004525. eCollection 2014 Dec.

25.

Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant.

Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B.

PLoS Genet. 2014 Dec 4;10(12):e1004824. doi: 10.1371/journal.pgen.1004824. eCollection 2014 Dec.

26.

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.

Wirnsberger G, Zwolanek F, Stadlmann J, Tortola L, Liu SW, Perlot T, Järvinen P, Dürnberger G, Kozieradzki I, Sarao R, De Martino A, Boztug K, Mechtler K, Kuchler K, Klein C, Elling U, Penninger JM.

Nat Genet. 2014 Sep;46(9):1028-33. doi: 10.1038/ng.3070. Epub 2014 Aug 17.

27.

Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes.

Schwarzmüller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, Marcet-Houben M, Jacobsen ID, Quintin J, Seider K, Frohner I, Glaser W, Jungwirth H, Bachellier-Bassi S, Chauvel M, Zeidler U, Ferrandon D, Gabaldón T, Hube B, d'Enfert C, Rupp S, Cormack B, Haynes K, Kuchler K.

PLoS Pathog. 2014 Jun 19;10(6):e1004211. doi: 10.1371/journal.ppat.1004211. eCollection 2014 Jun.

28.

A histone deacetylase complex mediates biofilm dispersal and drug resistance in Candida albicans.

Nobile CJ, Fox EP, Hartooni N, Mitchell KF, Hnisz D, Andes DR, Kuchler K, Johnson AD.

MBio. 2014 Jun 10;5(3):e01201-14. doi: 10.1128/mBio.01201-14.

29.

Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages.

Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B.

PLoS One. 2014 May 1;9(5):e96015. doi: 10.1371/journal.pone.0096015. eCollection 2014.

30.

Positions and numbers of FKS mutations in Candida albicans selectively influence in vitro and in vivo susceptibilities to echinocandin treatment.

Lackner M, Tscherner M, Schaller M, Kuchler K, Mair C, Sartori B, Istel F, Arendrup MC, Lass-Flörl C.

Antimicrob Agents Chemother. 2014 Jul;58(7):3626-35. doi: 10.1128/AAC.00123-14. Epub 2014 Apr 14.

31.

Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages.

Seider K, Gerwien F, Kasper L, Allert S, Brunke S, Jablonowski N, Schwarzmüller T, Barz D, Rupp S, Kuchler K, Hube B.

Eukaryot Cell. 2014 Jan;13(1):170-83. doi: 10.1128/EC.00262-13. Epub 2013 Dec 20.

32.

MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators.

Lee J, Reiter W, Dohnal I, Gregori C, Beese-Sims S, Kuchler K, Ammerer G, Levin DE.

Genes Dev. 2013 Dec 1;27(23):2590-601. doi: 10.1101/gad.229310.113.

33.

The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection.

Köprülü AD, Kastner R, Wienerroither S, Lassnig C, Putz EM, Majer O, Reutterer B, Sexl V, Kuchler K, Müller M, Decker T, Ellmeier W.

PLoS One. 2013;8(3):e60476. doi: 10.1371/journal.pone.0060476. Epub 2013 Mar 27.

34.

A histone deacetylase adjusts transcription kinetics at coding sequences during Candida albicans morphogenesis.

Hnisz D, Bardet AF, Nobile CJ, Petryshyn A, Glaser W, Schöck U, Stark A, Kuchler K.

PLoS Genet. 2012;8(12):e1003118. doi: 10.1371/journal.pgen.1003118. Epub 2012 Dec 6.

35.

Fungal pathogens-a sweet and sour treat for toll-like receptors.

Bourgeois C, Kuchler K.

Front Cell Infect Microbiol. 2012 Nov 22;2:142. doi: 10.3389/fcimb.2012.00142. eCollection 2012. Review.

36.

The histone acetyltransferase Hat1 facilitates DNA damage repair and morphogenesis in Candida albicans.

Tscherner M, Stappler E, Hnisz D, Kuchler K.

Mol Microbiol. 2012 Dec;86(5):1197-214. doi: 10.1111/mmi.12051. Epub 2012 Oct 17.

37.

Global gene deletion analysis exploring yeast filamentous growth.

Ryan O, Shapiro RS, Kurat CF, Mayhew D, Baryshnikova A, Chin B, Lin ZY, Cox MJ, Vizeacoumar F, Cheung D, Bahr S, Tsui K, Tebbji F, Sellam A, Istel F, Schwarzmüller T, Reynolds TB, Kuchler K, Gifford DK, Whiteway M, Giaever G, Nislow C, Costanzo M, Gingras AC, Mitra RD, Andrews B, Fink GR, Cowen LE, Boone C.

Science. 2012 Sep 14;337(6100):1353-6. doi: 10.1126/science.1224339.

38.

Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections.

Majer O, Bourgeois C, Zwolanek F, Lassnig C, Kerjaschki D, Mack M, Müller M, Kuchler K.

PLoS Pathog. 2012;8(7):e1002811. doi: 10.1371/journal.ppat.1002811. Epub 2012 Jul 26.

39.

Systems biology of host-fungus interactions: turning complexity into simplicity.

Tierney L, Kuchler K, Rizzetto L, Cavalieri D.

Curr Opin Microbiol. 2012 Aug;15(4):440-6. doi: 10.1016/j.mib.2012.05.001. Epub 2012 Jun 19. Review.

40.

An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells.

Tierney L, Linde J, Müller S, Brunke S, Molina JC, Hube B, Schöck U, Guthke R, Kuchler K.

Front Microbiol. 2012 Mar 12;3:85. doi: 10.3389/fmicb.2012.00085. eCollection 2012.

41.

Transcription factor Efg1 shows a haploinsufficiency phenotype in modulating the cell wall architecture and immunogenicity of Candida albicans.

Zavrel M, Majer O, Kuchler K, Rupp S.

Eukaryot Cell. 2012 Feb;11(2):129-40. doi: 10.1128/EC.05206-11. Epub 2011 Dec 2.

42.

Targeting chromatin in fungal pathogens as a novel therapeutic strategy: histone modification gets infectious.

Hnisz D, Tscherner M, Kuchler K.

Epigenomics. 2011 Apr;3(2):129-32. doi: 10.2217/epi.11.7. No abstract available.

PMID:
22122275
43.

Efg1 Controls caspofungin-induced cell aggregation of Candida albicans through the adhesin Als1.

Gregori C, Glaser W, Frohner IE, Reinoso-Martín C, Rupp S, Schüller C, Kuchler K.

Eukaryot Cell. 2011 Dec;10(12):1694-704. doi: 10.1128/EC.05187-11. Epub 2011 Oct 28.

44.

ABC proteins in yeast and fungal pathogens.

Klein C, Kuchler K, Valachovic M.

Essays Biochem. 2011 Sep 7;50(1):101-19. doi: 10.1042/bse0500101. Review.

PMID:
21967054
45.

Estradiol impairs the Th17 immune response against Candida albicans.

Relloso M, Aragoneses-Fenoll L, Lasarte S, Bourgeois C, Romera G, Kuchler K, Corbí AL, Muñoz-Fernández MA, Nombela C, Rodríguez-Fernández JL, Diez-Orejas R.

J Leukoc Biol. 2012 Jan;91(1):159-65. doi: 10.1189/jlb.1110645. Epub 2011 Sep 30.

PMID:
21965175
46.

The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation.

Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, Hube B.

J Immunol. 2011 Sep 15;187(6):3072-86. doi: 10.4049/jimmunol.1003730. Epub 2011 Aug 17.

47.

Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule.

Lesiak-Markowicz I, Vogl G, Schwarzmüller T, Speth C, Lass-Flörl C, Dierich MP, Kuchler K, Würzner R.

J Infect Dis. 2011 Sep 1;204(5):802-9. doi: 10.1093/infdis/jir455.

48.

The ABC of ABCs: multidrug resistance and genetic diseases.

Kuchler K.

FEBS J. 2011 Sep;278(18):3189. doi: 10.1111/j.1742-4658.2011.08234.x. Epub 2011 Aug 1. No abstract available.

49.

Cdr2p contributes to fluconazole resistance in Candida dubliniensis clinical isolates.

Borecká S, Pinjon E, Sullivan DJ, Kuchler K, Blaško J, Kulková N, Bujdáková H.

Can J Microbiol. 2011 May;57(5):416-26. doi: 10.1139/W11-025. Epub 2011 May 5.

PMID:
21542785
50.

Morphological and molecular genetic analysis of epigenetic switching of the human fungal pathogen Candida albicans.

Hnisz D, Tscherner M, Kuchler K.

Methods Mol Biol. 2011;734:303-15. doi: 10.1007/978-1-61779-086-7_15.

PMID:
21468996

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