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The Prevention of Infections in Older Adults: Vaccination.

Coll PP, Costello VW, Kuchel GA, Bartley J, McElhaney JE.

J Am Geriatr Soc. 2019 Oct 15. doi: 10.1111/jgs.16205. [Epub ahead of print] Review.


Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.

Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D.

Aging Cell. 2019 Dec;18(6):e13017. doi: 10.1111/acel.13017. Epub 2019 Aug 24.


The Longevity Associated Sh2b3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries L, Pilling LC, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Aug 20. pii: glz191. doi: 10.1093/gerona/glz191. [Epub ahead of print]


Editorial Comment.

Kuchel GA.

J Urol. 2019 Aug 12:10109701JU00005803687322725. doi: 10.1097/01.JU.0000580368.73227.25. [Epub ahead of print] No abstract available.


Creating the Next Generation of Translational Geroscientists.

Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ.

J Am Geriatr Soc. 2019 Sep;67(9):1934-1939. doi: 10.1111/jgs.16055. Epub 2019 Jul 9.


Interaction between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-year Follow-up Data of Older Adults from InCHIANTI.

Kositsawat J, Kuo CL, Barry L, Melzer D, Bandinelli S, Ferrucci L, Wu R, Kuchel GA.

J Gerontol A Biol Sci Med Sci. 2019 Jul 6. pii: glz165. doi: 10.1093/gerona/glz165. [Epub ahead of print]


Associations of Adverse Childhood Experiences with Past-Year DSM-5 Psychiatric and Substance Use Disorders in Older Adults.

Rhee TG, Barry LC, Kuchel GA, Steffens DC, Wilkinson ST.

J Am Geriatr Soc. 2019 Oct;67(10):2085-2093. doi: 10.1111/jgs.16032. Epub 2019 Jun 17.


Development of Clinical Trials to Extend Healthy Lifespan.

Justice JN, Niedernhofer L, Robbins PD, Aroda VR, Espeland MA, Kritchevsky SB, Kuchel GA, Barzilai N.

Cardiovasc Endocrinol Metab. 2018 Dec;7(4):80-83. doi: 10.1097/XCE.0000000000000159.


Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.

Bowman K, Jones L, Pilling LC, Delgado J, Kuchel GA, Ferrucci L, Fortinsky RH, Melzer D.

Neurology. 2019 Mar 19;92(12):e1387-e1394. doi: 10.1212/WNL.0000000000007136. Epub 2019 Feb 15.


Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.

Bowman K, Thambisetty M, Kuchel GA, Ferrucci L, Melzer D.

Age Ageing. 2019 May 1;48(3):367-373. doi: 10.1093/ageing/afz002.


Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.

Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R.

J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29.


Inclusion of Older Adults in Research: Ensuring Relevance, Feasibility, and Rigor.

Kuchel GA.

J Am Geriatr Soc. 2019 Feb;67(2):203-204. doi: 10.1111/jgs.15802. Epub 2019 Jan 29. No abstract available.


Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants.

Tamosauskaite J, Atkins JL, Pilling LC, Kuo CL, Kuchel GA, Ferrucci L, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):337-342. doi: 10.1093/gerona/gly270.


Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.

Pilling LC, Tamosauskaite J, Jones G, Wood AR, Jones L, Kuo CL, Kuchel GA, Ferrucci L, Melzer D.

BMJ. 2019 Jan 16;364:k5222. doi: 10.1136/bmj.k5222. Erratum in: BMJ. 2019 Oct 23;367:l6157.


Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications.

Andrew MK, Bowles SK, Pawelec G, Haynes L, Kuchel GA, McNeil SA, McElhaney JE.

Drugs Aging. 2019 Jan;36(1):29-37. doi: 10.1007/s40266-018-0597-4. Review.


Clinical Outcomes of CADASIL-Associated NOTCH3 Mutations in 451,424 European Ancestry Community Volunteers.

Masoli JAH, Pilling LC, Kuchel GA, Melzer D.

Transl Stroke Res. 2019 Aug;10(4):339-341. doi: 10.1007/s12975-018-0671-6. Epub 2018 Oct 18. No abstract available.


Reply to: Hands-free but Nonwearable Technology Needed for Outpatient Clinical Gait-speed Assessment.

Barry LC, Hatchman L, Fan Z, Guralnik JM, Gao RX, Kuchel GA.

J Am Geriatr Soc. 2019 Jan;67(1):184-185. doi: 10.1111/jgs.15589. Epub 2018 Oct 9. No abstract available.


Implementing "Patient-Centered Care": A Revolutionary Change in Health Care Delivery.

Applegate WB, Ouslander JG, Kuchel GA.

J Am Geriatr Soc. 2018 Oct;66(10):1863-1865. doi: 10.1111/jgs.15536. Epub 2018 Oct 3. No abstract available.


Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years.

Pilling LC, Atkins JL, Kuchel GA, Ferrucci L, Melzer D.

PLoS One. 2018 Sep 13;13(9):e0203504. doi: 10.1371/journal.pone.0203504. eCollection 2018.


A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.

Justice JN, Ferrucci L, Newman AB, Aroda VR, Bahnson JL, Divers J, Espeland MA, Marcovina S, Pollak MN, Kritchevsky SB, Barzilai N, Kuchel GA.

Geroscience. 2018 Dec;40(5-6):419-436. doi: 10.1007/s11357-018-0042-y. Epub 2018 Aug 27. Review.


HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation.

Al-Naggar IM, Hardy CC, Taweh OG, Grabauskas T, Mulkey DK, Kuchel GA, Smith PP.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):325-329. doi: 10.1093/gerona/gly137.


Frailty and Resilience as Outcome Measures in Clinical Trials and Geriatric Care: Are We Getting Any Closer?

Kuchel GA.

J Am Geriatr Soc. 2018 Aug;66(8):1451-1454. doi: 10.1111/jgs.15441. Epub 2018 Aug 9. No abstract available.


Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts.

Atkins JL, Delgado J, Pilling LC, Bowman K, Masoli JAH, Kuchel GA, Ferrucci L, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):350-357. doi: 10.1093/gerona/gly083.


Reduce the burden of dementia now.

Hayden KM, Inouye SK, Cunningham C, Jones RN, Avidan MS, Davis D, Kuchel GA, Tang Y, Khachaturian AS.

Alzheimers Dement. 2018 Jul;14(7):845-847. doi: 10.1016/j.jalz.2018.06.3039. Epub 2018 Jun 28. No abstract available.


Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Hadley EC, Kuchel GA, Newman AB, Allore HG, Bartley JM, Bergeman CS, Blinov ML, Colon-Emeric CS, Dabhar FS, Dugan LL, Dutta C, Eldadah BA, Ferrucci L, Kirkland JL, Kritchevsky SB, Lipsitz LA, Nadkarni NK, Reed MJ, Schmader KE, Sierra F, Studenski SA, Varadhan R, Walston JD, Whitson HE, Yung R.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):995. doi: 10.1093/gerona/glx172. No abstract available.


A Relationship Between Blood Levels of Otolin-1 and Vitamin D.

Parham K, Kuchel GA, McElhaney JE, Haynes L.

Otol Neurotol. 2018 Apr;39(4):e269-e273. doi: 10.1097/MAO.0000000000001747.


Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.

Vasunilashorn SM, Ngo LH, Chan NY, Zhou W, Dillon ST, Otu HH, Inouye SK, Wyrobnik I, Kuchel GA, McElhaney JE, Xie Z, Alsop DC, Jones RN, Libermann TA, Marcantonio ER.

J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):261-268. doi: 10.1093/gerona/gly036.


Design and Validation of a Radio-Frequency Identification-Based Device for Routinely Assessing Gait Speed in a Geriatrics Clinic.

Barry LC, Hatchman L, Fan Z, Guralnik JM, Gao RX, Kuchel GA.

J Am Geriatr Soc. 2018 May;66(5):982-986. doi: 10.1111/jgs.15315. Epub 2018 Feb 23.


Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.

Pilling LC, Kuo CL, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D.

Aging (Albany NY). 2017 Dec 6;9(12):2504-2520. doi: 10.18632/aging.101334.


Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Urinary Incontinence in Older Adults: A Translational Research Agenda for a Complex Geriatric Syndrome.

Vaughan CP, Markland AD, Smith PP, Burgio KL, Kuchel GA; American Geriatrics Society/National Institute on Aging Urinary Incontinence Conference Planning Committee and Faculty.

J Am Geriatr Soc. 2018 Apr;66(4):773-782. doi: 10.1111/jgs.15157. Epub 2017 Dec 4. Review.


Blood Pressure Trajectories in the 20 Years Before Death.

Delgado J, Bowman K, Ble A, Masoli J, Han Y, Henley W, Welsh S, Kuchel GA, Ferrucci L, Melzer D.

JAMA Intern Med. 2018 Jan 1;178(1):93-99. doi: 10.1001/jamainternmed.2017.7023.


Risk Factors for Falls Among Older Adults Following Transition From Nursing Home to the Community.

Marrero J, Fortinsky RH, Kuchel GA, Robison J.

Med Care Res Rev. 2019 Feb;76(1):73-88. doi: 10.1177/1077558717697012. Epub 2017 Mar 6.


Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses.

Bartley JM, Zhou X, Kuchel GA, Weinstock GM, Haynes L.

Front Immunol. 2017 Sep 20;8:1164. doi: 10.3389/fimmu.2017.01164. eCollection 2017.


Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.

Merani S, Kuchel GA, Kleppinger A, McElhaney JE.

Exp Gerontol. 2018 Jul 1;107:116-125. doi: 10.1016/j.exger.2017.09.015. Epub 2017 Sep 27.


Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Murray A, Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D.

PLoS One. 2017 Sep 28;12(9):e0185083. doi: 10.1371/journal.pone.0185083. eCollection 2017.


The chromatin accessibility signature of human immune aging stems from CD8+ T cells.

Ucar D, Márquez EJ, Chung CH, Marches R, Rossi RJ, Uyar A, Wu TC, George J, Stitzel ML, Palucka AK, Kuchel GA, Banchereau J.

J Exp Med. 2017 Oct 2;214(10):3123-3144. doi: 10.1084/jem.20170416. Epub 2017 Sep 13.


Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.

Merani S, Pawelec G, Kuchel GA, McElhaney JE.

Front Immunol. 2017 Jul 17;8:784. doi: 10.3389/fimmu.2017.00784. eCollection 2017. Review.


Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium.

Ngo LH, Inouye SK, Jones RN, Travison TG, Libermann TA, Dillon ST, Kuchel GA, Vasunilashorn SM, Alsop DC, Marcantonio ER.

BMC Med Res Methodol. 2017 Jun 6;17(1):88. doi: 10.1186/s12874-017-0359-8.


Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants.

Bowman K, Atkins JL, Delgado J, Kos K, Kuchel GA, Ble A, Ferrucci L, Melzer D.

Am J Clin Nutr. 2017 Jul;106(1):130-135. doi: 10.3945/ajcn.116.147157. Epub 2017 May 31.


Age-Related Increase in Blood Levels of Otolin-1 in Humans.

Tabtabai R, Haynes L, Kuchel GA, Parham K.

Otol Neurotol. 2017 Jul;38(6):865-869. doi: 10.1097/MAO.0000000000001426.


Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Hadley EC, Kuchel GA, Newman AB; Workshop Speakers and Participants.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):980-990. doi: 10.1093/gerona/glx015. Erratum in: J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):995.


Function Begets Function and Resilience in Old Age: Is Precision Gerontology Possible?

Kuchel GA.

J Am Geriatr Soc. 2017 Jun;65(6):1141-1144. doi: 10.1111/jgs.14901. Epub 2017 May 3. No abstract available.


MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice.

Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW.

Sci Rep. 2017 Mar 17;7:44620. doi: 10.1038/srep44620.


Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals.

Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A; As part of the Ageing Well Programme of the NIHR School for Public Health Research, England.

J Am Geriatr Soc. 2017 May;65(5):995-1003. doi: 10.1111/jgs.14712. Epub 2016 Dec 30.


Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning.

Fung CH, Vitiello MV, Alessi CA, Kuchel GA; AGS/NIA Sleep Conference Planning Committee and Faculty.

J Am Geriatr Soc. 2016 Dec;64(12):e238-e247. doi: 10.1111/jgs.14493. Epub 2016 Nov 14.


IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.

Zhou X, Hopkins JW, Wang C, Brahmakshatriya V, Swain SL, Kuchel GA, Haynes L, McElhaney JE.

Oncotarget. 2016 Jun 28;7(26):39171-39183. doi: 10.18632/oncotarget.10047.


Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up In 186,000 U.K. Biobank Participants.

Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine JM, Kuchel GA, Ferrucci L, Melzer D.

J Am Coll Cardiol. 2016 Aug 23;68(8):874-5. doi: 10.1016/j.jacc.2016.05.072. No abstract available.


Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients.

Bowman K, Delgado J, Henley WE, Masoli JA, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel GA, Ble A, Melzer D; as part of the Ageing Well Programme of the NIHR School for Public Health Research, England.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):203-209. doi: 10.1093/gerona/glw147. Epub 2016 Aug 4.


Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW.

Aging Cell. 2016 Oct;15(5):903-13. doi: 10.1111/acel.12499. Epub 2016 Jun 30.


Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study.

Dillon ST, Vasunilashorn SM, Ngo L, Otu HH, Inouye SK, Jones RN, Alsop DC, Kuchel GA, Metzger ED, Arnold SE, Marcantonio ER, Libermann TA.

Biol Psychiatry. 2017 Jan 15;81(2):145-153. doi: 10.1016/j.biopsych.2016.03.2098. Epub 2016 Mar 25.

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