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Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition.

Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H.

Biol Open. 2019 Feb 18;8(2). pii: bio035691. doi: 10.1242/bio.035691.


Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review.

Abe M, Watanabe K, Shinozaki-Ushiku A, Ushiku T, Abe T, Fujihara Y, Amano Y, Zong L, Wang CP, Kubo E, Inaki R, Kinoshita N, Yamashita S, Takai D, Ushijima T, Nagase T, Hoshi K.

BMC Cancer. 2019 Jan 11;19(1):52. doi: 10.1186/s12885-019-5277-1.


Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment.

Fukuda M, Shibata S, Shibata N, Fujita N, Miyashita H, Tanimura N, Ishida H, Kubo E, Sasaki H.

PLoS One. 2018 Nov 29;13(11):e0208198. doi: 10.1371/journal.pone.0208198. eCollection 2018.


Use of IPACK block with continuous femoral triangle block for total knee arthroplasty: A clinical experience.

Ohgoshi Y, Matsutani M, Kubo EN.

J Clin Anesth. 2019 May;54:52-54. doi: 10.1016/j.jclinane.2018.10.045. Epub 2018 Nov 2. No abstract available.


Combined use of peripheral nerve blocks for multilevel spine surgery.

Ohgoshi Y, Fujiki S, Kamata M, Kubo EN.

J Clin Anesth. 2019 Mar;53:54. doi: 10.1016/j.jclinane.2018.10.004. Epub 2018 Oct 11. No abstract available.


Roles of TGF β and FGF Signals in the Lens: Tropomyosin Regulation for Posterior Capsule Opacity.

Kubo E, Shibata T, Singh DP, Sasaki H.

Int J Mol Sci. 2018 Oct 9;19(10). pii: E3093. doi: 10.3390/ijms19103093. Review.


A new rocuronium formulation not causing vascular pain in a flexor reflex model of anesthetized rats.

Jimbo K, Itsuji Y, Kubo E, Kumagai M, Masui K, Yamamura Y.

J Anesth. 2018 Dec;32(6):806-812. doi: 10.1007/s00540-018-2557-x. Epub 2018 Sep 21.


Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress.

Chhunchha B, Kubo E, Singh P, Singh DP.

Aging (Albany NY). 2018 Sep 12;10(9):2284-2315. doi: 10.18632/aging.101547.


Trends, treatment outcomes, and determinants for attrition among adult patients in care at a large tertiary HIV clinic in Nairobi, Kenya: a 2004-2015 retrospective cohort study.

Mecha JO, Kubo EN, Nganga LW, Muiruri PN, Njagi LN, Ilovi S, Ngethe R, Mutisya I, Ngugi EW, Maleche-Obimbo E.

HIV AIDS (Auckl). 2018 Jun 29;10:103-114. doi: 10.2147/HIV.S153185. eCollection 2018.


Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells.

Xu X, Yoshizaki H, Ishigaki Y, Kubo E, Minato H, Kiyokawa E.

Mol Vis. 2017 Dec 31;23:1081-1092. eCollection 2017.


Germline variants in pancreatic cancer patients with a personal or family history of cancer fulfilling the revised Bethesda guidelines.

Ohmoto A, Morizane C, Kubo E, Takai E, Hosoi H, Sakamoto Y, Kondo S, Ueno H, Shimada K, Yachida S, Okusaka T.

J Gastroenterol. 2018 Oct;53(10):1159-1167. doi: 10.1007/s00535-018-1466-y. Epub 2018 Apr 17.


Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity.

Shibata T, Shibata S, Ishigaki Y, Kiyokawa E, Ikawa M, Singh DP, Sasaki H, Kubo E.

Mech Ageing Dev. 2018 Apr;171:24-30. doi: 10.1016/j.mad.2018.03.001. Epub 2018 Mar 3.


Inter-semispinal plane block for cervical spine surgery.

Ohgoshi Y, Kubo EN.

J Clin Anesth. 2018 May;46:94-95. doi: 10.1016/j.jclinane.2018.02.007. Epub 2018 Feb 9. No abstract available.


Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress.

Kubo E, Chhunchha B, Singh P, Sasaki H, Singh DP.

Sci Rep. 2017 Oct 26;7(1):14130. doi: 10.1038/s41598-017-14520-8.


Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients.

Nagai N, Mano Y, Otake H, Shibata T, Kubo E, Sasaki H.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3294-3302. doi: 10.1167/iovs.17-22065.


Clinical experiences of the continuous quadratus lumborum block via paramedian sagittal oblique approach.

Ohgoshi Y, Nakayama H, Kubo EN, Izawa H, Kori S, Matsukawa M.

J Clin Anesth. 2017 May;38:89-90. doi: 10.1016/j.jclinane.2017.01.030. Epub 2017 Jan 30. No abstract available.


A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells.

Nagai N, Ito Y, Shibata T, Kubo E, Sasaki H.

Toxicology. 2017 Apr 15;381:19-30. doi: 10.1016/j.tox.2017.02.014. Epub 2017 Feb 24.


Randomized phase II study of sequential carboplatin plus paclitaxel and gefitinib in chemotherapy-naïve patients with advanced or metastatic non-small-cell lung cancer: Long-term follow-up results.

Kubo E, Yamamoto N, Nokihara H, Fujiwara Y, Horinouchi H, Kanda S, Goto Y, Ohe Y.

Mol Clin Oncol. 2017 Jan;6(1):56-62. doi: 10.3892/mco.2016.1076. Epub 2016 Nov 9.


FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.

Kubo E, Shibata S, Shibata T, Kiyokawa E, Sasaki H, Singh DP.

J Cell Mol Med. 2017 May;21(5):916-928. doi: 10.1111/jcmm.13030. Epub 2016 Dec 15.


Trends in clinical characteristics and outcomes of Pre-ART care at a large HIV clinic in Nairobi, Kenya: a retrospective cohort study.

Mecha JO, Kubo EN, Nganga LW, Muiruri PN, Njagi LN, Mutisya IN, Odionyi JJ, Ilovi SC, Wambui M, Githu C, Ngethe R, Obimbo EM, Ngumi ZW.

AIDS Res Ther. 2016 Nov 14;13:38. eCollection 2016.


Safety and efficacy of nivolumab and standard chemotherapy drug combination in patients with advanced non-small-cell lung cancer: a four arms phase Ib study.

Kanda S, Goto K, Shiraishi H, Kubo E, Tanaka A, Utsumi H, Sunami K, Kitazono S, Mizugaki H, Horinouchi H, Fujiwara Y, Nokihara H, Yamamoto N, Hozumi H, Tamura T.

Ann Oncol. 2016 Dec;27(12):2242-2250. doi: 10.1093/annonc/mdw416. Epub 2016 Oct 20.


Germline mutations in Japanese familial pancreatic cancer patients.

Takai E, Yachida S, Shimizu K, Furuse J, Kubo E, Ohmoto A, Suzuki M, Hruban RH, Okusaka T, Morizane C, Furukawa T.

Oncotarget. 2016 Nov 8;7(45):74227-74235. doi: 10.18632/oncotarget.12490.


The role of Prdx6 in the protection of cells of the crystalline lens from oxidative stress induced by UV exposure.

Shibata S, Shibata N, Shibata T, Sasaki H, Singh DP, Kubo E.

Jpn J Ophthalmol. 2016 Sep;60(5):408-18. doi: 10.1007/s10384-016-0461-1. Epub 2016 Jul 5.


Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses.

Shibata T, Shibata S, Shibata N, Kiyokawa E, Sasaki H, Singh DP, Kubo E.

J Ophthalmol. 2016;2016:1917093. doi: 10.1155/2016/1917093. Epub 2016 May 8.


Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis.

Nakazato H, Takeshima H, Kishino T, Kubo E, Hattori N, Nakajima T, Yamashita S, Igaki H, Tachimori Y, Kuniyoshi Y, Ushijima T.

PLoS One. 2016 Jan 26;11(1):e0147372. doi: 10.1371/journal.pone.0147372. eCollection 2016.


Clinicopathologic Features and Germline Sequence Variants in Young Patients (≤40 Years Old) With Pancreatic Ductal Adenocarcinoma.

Ohmoto A, Yachida S, Kubo E, Takai E, Suzuki M, Shimada K, Okusaka T, Morizane C.

Pancreas. 2016 Aug;45(7):1056-61. doi: 10.1097/MPA.0000000000000574.


Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma.

Tamura Y, Fujiwara Y, Yamamoto N, Nokihara H, Horinouchi H, Kanda S, Goto Y, Kubo E, Kitahara S, Tsuruoka K, Tsuta K, Ohe Y.

BMC Res Notes. 2015 Dec 18;8:800. doi: 10.1186/s13104-015-1762-z.


Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells.

Singh SP, Chhunchha B, Fatma N, Kubo E, Singh SP, Singh DP.

Am J Physiol Cell Physiol. 2016 Jan 1;310(1):C1-16. doi: 10.1152/ajpcell.00229.2015. Epub 2015 Oct 7.


Severe liver and renal injuries following cerebral angiography: late life-threatening complications of non-ionic contrast medium administration.

da Silva PS, Kubo EY, Fonseca MC.

Childs Nerv Syst. 2016 Apr;32(4):733-7. doi: 10.1007/s00381-015-2889-x. Epub 2015 Aug 19.


Optical simulation for subsurface nanoglistening.

Takahashi Y, Kawamorita T, Mita N, Hatsusaka N, Shibata S, Shibata N, Kubo E, Sasaki H.

J Cataract Refract Surg. 2015 Jan;41(1):193-8. doi: 10.1016/j.jcrs.2014.10.021. Epub 2014 Nov 8.


Blood pressure control and satisfaction of hypertensive patients following a switch to combined drugs of an angiotensin receptor blocker and a calcium channel blocker in clinical practice of nephrology.

Kato H, Shiraishi T, Ueda S, Kubo E, Shima T, Nagura M, Yano H, Izumikawa Y, Shimada M, Tomioka S, Nosaka H, Kojima K, Tanemoto M, Uchida S.

Clin Exp Nephrol. 2015 Jun;19(3):465-73. doi: 10.1007/s10157-014-1017-7. Epub 2014 Aug 19.


[Perioperative management and postoperative complication rates of patients on dual antiplatelet therapies after coronary drug eluting stent implantation].

Komiya R, Kamintani K, Kubo E, Hattori M, Kataoka H, Iwase Y, Miyoshi H, Minami M, Kato S, Arai R, Yoshida H.

Masui. 2014 Jun;63(6):629-35. Japanese.


Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription.

Chhunchha B, Fatma N, Kubo E, Singh DP.

FEBS J. 2014 Aug;281(15):3357-81. doi: 10.1111/febs.12866. Epub 2014 Jul 1.


Emerging issues in radiogenic cataracts and cardiovascular disease.

Hamada N, Fujimichi Y, Iwasaki T, Fujii N, Furuhashi M, Kubo E, Minamino T, Nomura T, Sato H.

J Radiat Res. 2014 Sep;55(5):831-46. doi: 10.1093/jrr/rru036. Epub 2014 May 13. Review.


Inhibitory effect of cordycepin on experimental hepatic metastasis of B16-F0 mouse melanoma cells.

Sato A, Yoshikawa N, Kubo E, Kakuda M, Nishiuchi A, Kimoto Y, Takahashi Y, Kagota S, Shinozuka K, Nakamura K.

In Vivo. 2013 Nov-Dec;27(6):729-32.


Impact of an electronic medical record system on emergency department discharge instructions for patients with hypertension.

Cienki JJ, Guerrera AD, Rose Steed N, Kubo EN, Baumann BM.

Postgrad Med. 2013 Sep;125(5):59-66. doi: 10.3810/pgm.2013.09.2702.


Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens.

Kubo E, Hasanova N, Sasaki H, Singh DP.

J Cell Mol Med. 2013 Sep;17(9):1146-59. doi: 10.1111/jcmm.12094. Epub 2013 Jul 11.


Safety comparison of additives in antiglaucoma prostaglandin (PG) analog ophthalmic formulations.

Fukuda M, Shibata S, Shibata N, Hagihara K, Yaguchi H, Osada H, Takahashi N, Kubo E, Sasaki H.

Clin Ophthalmol. 2013;7:515-20. doi: 10.2147/OPTH.S40147. Epub 2013 Mar 12.


Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.

Bhargavan B, Chhunchha B, Fatma N, Kubo E, Kumar A, Singh DP.

Epigenetics. 2013 Mar;8(3):268-80. doi: 10.4161/epi.23861. Epub 2013 Feb 5.


Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation.

Chhunchha B, Fatma N, Kubo E, Rai P, Singh SP, Singh DP.

Am J Physiol Cell Physiol. 2013 Apr 1;304(7):C636-55. doi: 10.1152/ajpcell.00345.2012. Epub 2013 Jan 30. Erratum in: Am J Physiol Cell Physiol. 2013 Apr 15;304(8):C808-9.


Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells.

Kubo E, Hasanova N, Fatma N, Sasaki H, Singh DP.

J Cell Mol Med. 2013 Jan;17(1):212-21. doi: 10.1111/j.1582-4934.2012.01654.x. Epub 2012 Dec 4.


Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response.

Ishihara K, Fatma N, Bhargavan B, Chhunchha B, Kubo E, Dey S, Takamura Y, Kumar A, Singh DP.

FEBS J. 2012 Sep;279(17):3048-70. doi: 10.1111/j.1742-4658.2012.08686.x. Epub 2012 Jul 16.


LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway.

Bhargavan B, Fatma N, Chhunchha B, Singh V, Kubo E, Singh DP.

Cell Death Dis. 2012 May 31;3:e316. doi: 10.1038/cddis.2012.57.


Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter.

Singh DP, Bhargavan B, Chhunchha B, Kubo E, Kumar A, Fatma N.

PLoS One. 2012;7(5):e37012. doi: 10.1371/journal.pone.0037012. Epub 2012 May 16.


Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress.

Chhunchha B, Fatma N, Bhargavan B, Kubo E, Kumar A, Singh DP.

Cell Death Dis. 2011 Nov 24;2:e234. doi: 10.1038/cddis.2011.121.


Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis.

Fatma N, Singh P, Chhunchha B, Kubo E, Shinohara T, Bhargavan B, Singh DP.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C954-67. doi: 10.1152/ajpcell.00061.2011. Epub 2011 Jun 15.


ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.

Yamamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K.

J Exp Med. 2011 Jul 4;208(7):1533-46. doi: 10.1084/jem.20101660. Epub 2011 Jun 13.


Inhibitory effect of Cordyceps sinensis on experimental hepatic metastasis of melanoma by suppressing tumor cell invasion.

Kubo E, Yoshikawa N, Kunitomo M, Kagota S, Shinozuka K, Nakamura K.

Anticancer Res. 2010 Sep;30(9):3429-33.


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