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Global, pathway and gene coverage of three Illumina arrays with respect to inflammatory and immune-related pathways.

Tozzi V, Rosenberger A, Kube D, Bickeböller H.

Eur J Hum Genet. 2019 Nov;27(11):1716-1723. doi: 10.1038/s41431-019-0441-2. Epub 2019 Jun 21.


Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma.

Vockerodt M, Vrzalikova K, Ibrahim M, Nagy E, Margielewska S, Hollows R, Lupino L, Tooze R, Care M, Simmons W, Schrader A, Perry T, Abdullah M, Foster S, Reynolds G, Dowell A, Rudzki Z, Krappmann D, Kube D, Woodman C, Wei W, Taylor G, Murray PG.

J Pathol. 2019 Jun;248(2):142-154. doi: 10.1002/path.5237. Epub 2019 Mar 22.


A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.

Wolff A, Bayerlová M, Gaedcke J, Kube D, Beißbarth T.

PLoS One. 2018 May 16;13(5):e0197162. doi: 10.1371/journal.pone.0197162. eCollection 2018.


Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.

Feist M, Schwarzfischer P, Heinrich P, Sun X, Kemper J, von Bonin F, Perez-Rubio P, Taruttis F, Rehberg T, Dettmer K, Gronwald W, Reinders J, Engelmann JC, Dudek J, Klapper W, Trümper L, Spang R, Oefner PJ, Kube D.

Nat Commun. 2018 Apr 17;9(1):1514. doi: 10.1038/s41467-018-03803-x.


External calibration with Drosophila whole-cell spike-ins delivers absolute mRNA fold changes from human RNA-Seq and qPCR data.

Taruttis F, Feist M, Schwarzfischer P, Gronwald W, Kube D, Spang R, Engelmann JC.

Biotechniques. 2017 Feb 1;62(2):53-61. doi: 10.2144/000114514.


Comprehensive Metaboproteomics of Burkitt's and Diffuse Large B-Cell Lymphoma Cell Lines and Primary Tumor Tissues Reveals Distinct Differences in Pyruvate Content and Metabolism.

Schwarzfischer P, Reinders J, Dettmer K, Kleo K, Dimitrova L, Hummel M, Feist M, Kube D, Szczepanowski M, Klapper W, Taruttis F, Engelmann JC, Spang R, Gronwald W, Oefner PJ.

J Proteome Res. 2017 Mar 3;16(3):1105-1120. doi: 10.1021/acs.jproteome.6b00164. Epub 2017 Feb 16.


Long-term pediatrician outcomes of a parent led curriculum in developmental disabilities.

Keisling BL, Bishop EA, Kube DA, Roth JM, Palmer FB.

Res Dev Disabil. 2017 Jan;60:16-23. doi: 10.1016/j.ridd.2016.11.004. Epub 2016 Nov 19.


Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis.

Feist M, Kemper J, Taruttis F, Rehberg T, Engelmann JC, Gronwald W, Hummel M, Spang R, Kube D.

Int J Cancer. 2017 Mar 1;140(5):1147-1158. doi: 10.1002/ijc.30444. Epub 2016 Oct 17.


Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma.

Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafčíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D.

Leukemia. 2017 Feb;31(2):361-372. doi: 10.1038/leu.2016.232. Epub 2016 Aug 18.


WNT5A: a motility-promoting factor in Hodgkin lymphoma.

Linke F, Zaunig S, Nietert MM, von Bonin F, Lutz S, Dullin C, Janovská P, Beissbarth T, Alves F, Klapper W, Bryja V, Pukrop T, Trümper L, Wilting J, Kube D.

Oncogene. 2017 Jan 5;36(1):13-23. doi: 10.1038/onc.2016.183. Epub 2016 Jun 6.


Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data.

Schrader A, Meyer K, Walther N, Stolz A, Feist M, Hand E, von Bonin F, Evers M, Kohler C, Shirneshan K, Vockerodt M, Klapper W, Szczepanowski M, Murray PG, Bastians H, Trümper L, Spang R, Kube D.

Oncotarget. 2016 Jul 26;7(30):47061-47081. doi: 10.18632/oncotarget.9219.


Physical Activity and Exercise Interventions in the Workplace Impacting Work Outcomes: A Stakeholder-Centered Best Evidence Synthesis of Systematic Reviews.

White MI, Dionne CE, Wärje O, Koehoorn M, Wagner SL, Schultz IZ, Koehn C, Williams-Whitt K, Harder HG, Pasca R, Hsu V, McGuire L, Schulz W, Kube D, Wright MD.

Int J Occup Environ Med. 2016 Apr;7(2):61-74. doi: 10.15171/ijoem.2016.739. Review.


Mental Health Interventions in the Workplace and Work Outcomes: A Best-Evidence Synthesis of Systematic Reviews.

Wagner SL, Koehn C, White MI, Harder HG, Schultz IZ, Williams-Whitt K, Warje O, Dionne CE, Koehoorn M, Pasca R, Hsu V, McGuire L, Schulz W, Kube D, Wright MD.

Int J Occup Environ Med. 2016 Jan;7(1):1-14. doi: 10.15171/ijoem.2016.607. Review.


Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models.

Pirkl M, Hand E, Kube D, Spang R.

Bioinformatics. 2016 Mar 15;32(6):893-900. doi: 10.1093/bioinformatics/btv680. Epub 2015 Nov 17.


Social Support and Supervisory Quality Interventions in the Workplace: A Stakeholder-Centered Best-Evidence Synthesis of Systematic Reviews on Work Outcomes.

Wagner SL, White MI, Schultz IZ, Williams-Whitt K, Koehn C, Dionne CE, Koehoorn M, Harder HG, Pasca R, Wärje O, Hsu V, McGuire L, Lama I, Schulz W, Kube D, Wright MD.

Int J Occup Environ Med. 2015 Oct;6(4):189-204. doi: 10.15171/ijoem.2015.608. Review.


The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation.

Isernhagen A, Malzahn D, Viktorova E, Elsner L, Monecke S, von Bonin F, Kilisch M, Wermuth JM, Walther N, Balavarca Y, Stahl-Hennig C, Engelke M, Walter L, Bickeböller H, Kube D, Wulf G, Dressel R.

EMBO Mol Med. 2015 Nov;7(11):1480-502. doi: 10.15252/emmm.201505246.


Job demand and control interventions: a stakeholder-centered best-evidence synthesis of systematic reviews on workplace disability.

Williams-Whitt K, White MI, Wagner SL, Schultz IZ, Koehn C, Dionne CE, Koehoorn M, Harder H, Pasca R, Warje O, Hsu V, McGuire L, Schulz W, Kube D, Hook A, Wright MD.

Int J Occup Environ Med. 2015 Apr;6(2):61-78. doi: 10.15171/ijoem.2015.553. Review.


The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma.

Klingenberg M, Becker J, Eberth S, Kube D, Wilting J.

BMC Cancer. 2014 May 18;14:339. doi: 10.1186/1471-2407-14-339.


The NADPH oxidase inhibitor imipramine-blue in the treatment of Burkitt lymphoma.

Klingenberg M, Becker J, Eberth S, Kube D, Wilting J.

Mol Cancer Ther. 2014 Apr;13(4):833-41. doi: 10.1158/1535-7163.MCT-13-0688. Epub 2014 Jan 30.


Suppression of the LMP2A target gene, EGR-1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle.

Vockerodt M, Wei W, Nagy E, Prouzova Z, Schrader A, Kube D, Rowe M, Woodman CB, Murray PG.

J Pathol. 2013 Aug;230(4):399-409. doi: 10.1002/path.4198.


Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma.

Walther N, Ulrich A, Vockerodt M, von Bonin F, Klapper W, Meyer K, Eberth S, Pukrop T, Spang R, Trümper L, Kube D.

Am J Pathol. 2013 Apr;182(4):1092-8. doi: 10.1016/j.ajpath.2012.12.013. Epub 2013 Jan 31.


Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma.

Schoof N, Franklin J, Fürst R, Zander T, von Bonin F, Peyrade F, Trümper L, Diehl V, Engert A, Kube D, Re D.

Oncologist. 2013;18(1):80-9. doi: 10.1634/theoncologist.2012-0291. Epub 2013 Jan 8.


Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas.

Schrader A, Meyer K, von Bonin F, Vockerodt M, Walther N, Hand E, Ulrich A, Matulewicz K, Lenze D, Hummel M, Kieser A, Engelke M, Trümper L, Kube D.

Cell Commun Signal. 2012 Dec 20;10(1):43. doi: 10.1186/1478-811X-10-43.


Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.

Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RA, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R; ICGC MMML-Seq Project.

Nat Genet. 2012 Dec;44(12):1316-20. doi: 10.1038/ng.2469. Epub 2012 Nov 11.


Evaluation of a parent led curriculum in developmental disabilities for pediatric and medicine/pediatric residents.

Kube DA, Bishop EA, Roth JM, Palmer FB.

Matern Child Health J. 2013 Sep;17(7):1304-8. doi: 10.1007/s10995-012-1133-5.


Epstein-Barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology.

Heath E, Begue-Pastor N, Chaganti S, Croom-Carter D, Shannon-Lowe C, Kube D, Feederle R, Delecluse HJ, Rickinson AB, Bell AI.

PLoS Pathog. 2012;8(5):e1002697. doi: 10.1371/journal.ppat.1002697. Epub 2012 May 10.


Circulating levels of TNF receptor II are prognostic for patients with peripheral T-cell non-Hodgkin lymphoma.

Heemann C, Kreuz M, Stoller I, Schoof N, von Bonin F, Ziepert M, Löffler M, Jung W, Pfreundschuh M, Trümper L, Kube D.

Clin Cancer Res. 2012 Jul 1;18(13):3637-47. doi: 10.1158/1078-0432.CCR-11-3299. Epub 2012 May 9.


Specific tumor-stroma interactions of EBV-positive Burkitt's lymphoma cells in the chick chorioallantoic membrane.

Becker J, Covelo-Fernandez A, von Bonin F, Kube D, Wilting J.

Vasc Cell. 2012 Mar 9;4(1):3. doi: 10.1186/2045-824X-4-3.


p53 protein expression in chronic lymphocytic leukemia.

Sellmann L, Carpinteiro A, Nückel H, Scholtysik R, Siemer D, Klein-Hipass L, Kube D, Dürig J, Dührsen U, Stanelle J, Küppers R.

Leuk Lymphoma. 2012 Jul;53(7):1282-8. doi: 10.3109/10428194.2011.654115. Epub 2012 Feb 13.


High Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas.

Schrader A, Bentink S, Spang R, Lenze D, Hummel M, Kuo M, Arrand JR, Murray PG, Trümper L, Kube D, Vockerodt M.

Int J Cancer. 2012 Aug 15;131(4):E348-61. doi: 10.1002/ijc.26423. Epub 2011 Oct 23.


Genomic data integration using guided clustering.

Maneck M, Schrader A, Kube D, Spang R.

Bioinformatics. 2011 Aug 15;27(16):2231-8. doi: 10.1093/bioinformatics/btr363. Epub 2011 Jun 17.


Down-regulation of BLIMP1α by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas.

Vrzalikova K, Vockerodt M, Leonard S, Bell A, Wei W, Schrader A, Wright KL, Kube D, Rowe M, Woodman CB, Murray PG.

Blood. 2011 Jun 2;117(22):5907-17. doi: 10.1182/blood-2010-09-307710. Epub 2011 Mar 16.


Flight diversions due to onboard medical emergencies on an international commercial airline.

Valani R, Cornacchia M, Kube D.

Aviat Space Environ Med. 2010 Nov;81(11):1037-40.


A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma.

Hoffmann M, Schirmer MA, Tzvetkov MV, Kreuz M, Ziepert M, Wojnowski L, Kube D, Pfreundschuh M, Trümper L, Loeffler M, Brockmöller J; German Study Group for High-Grade Non-Hodgkin Lymphoma.

Cancer Res. 2010 Mar 15;70(6):2328-38. doi: 10.1158/0008-5472.CAN-09-2388. Epub 2010 Mar 9.


HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells.

Schoof N, von Bonin F, Trümper L, Kube D.

Cell Commun Signal. 2009 Jul 16;7:17. doi: 10.1186/1478-811X-7-17.


Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial.

Schoof N, von Bonin F, Zeynalova S, Ziepert M, Jung W, Loeffler M, Pfreundschuh M, Trümper L, Kube D.

Ann Oncol. 2009 Sep;20(9):1548-54. doi: 10.1093/annonc/mdp110. Epub 2009 Jun 10.


Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.

Schoof N, von Bonin F, König IR, Mössner R, Krüger U, Reich K, Berking C, Volkenandt M, Ziegler A, Böckmann L, Kuschal C, Thoms KM, Kube D, Emmert S.

Genes Immun. 2009 Sep;10(6):586-90. doi: 10.1038/gene.2009.40. Epub 2009 May 21.


Prevalence of developmental and behavioral disorders in a pediatric hospital.

Petersen MC, Kube DA, Whitaker TM, Graff JC, Palmer FB.

Pediatrics. 2009 Mar;123(3):e490-5. doi: 10.1542/peds.2008-2750.


The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype.

Vockerodt M, Morgan SL, Kuo M, Wei W, Chukwuma MB, Arrand JR, Kube D, Gordon J, Young LS, Woodman CB, Murray PG.

J Pathol. 2008 Sep;216(1):83-92. doi: 10.1002/path.2384.


Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.

Kube D, Hua TD, von Bonin F, Schoof N, Zeynalova S, Klöss M, Gocht D, Potthoff B, Tzvetkov M, Brockmöller J, Löffler M, Pfreundschuh M, Trümper L.

Clin Cancer Res. 2008 Jun 15;14(12):3777-84. doi: 10.1158/1078-0432.CCR-07-5182.


Identification of prognostic biomarkers for prostate cancer.

Kosari F, Munz JM, Savci-Heijink CD, Spiro C, Klee EW, Kube DM, Tillmans L, Slezak J, Karnes RJ, Cheville JC, Vasmatzis G.

Clin Cancer Res. 2008 Mar 15;14(6):1734-43. doi: 10.1158/1078-0432.CCR-07-1494.


Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.

Alig L, Alsenz J, Andjelkovic M, Bendels S, Bénardeau A, Bleicher K, Bourson A, David-Pierson P, Guba W, Hildbrand S, Kube D, Lübbers T, Mayweg AV, Narquizian R, Neidhart W, Nettekoven M, Plancher JM, Rocha C, Rogers-Evans M, Röver S, Schneider G, Taylor S, Waldmeier P.

J Med Chem. 2008 Apr 10;51(7):2115-27. doi: 10.1021/jm701487t. Epub 2008 Mar 13.


Cell surface nucleolin serves as receptor for DNA nanoparticles composed of pegylated polylysine and DNA.

Chen X, Kube DM, Cooper MJ, Davis PB.

Mol Ther. 2008 Feb;16(2):333-42. Epub 2007 Dec 4.


Genetic variation in IL-10 is associated with atopic reactivity in Gabonese schoolchildren.

van den Biggelaar AH, Hua TD, Rodrigues LC, Kremsner PG, Yazdanbakhsh M, Kube D.

J Allergy Clin Immunol. 2007 Oct;120(4):973-5. Epub 2007 Sep 7. No abstract available.


Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.

Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nürnberg P, Schultheiss HP, Schaper W, Schaper J, Bos E, Den Hertog J, van Eeden FJ, Peters PJ, Hasenfuss G, Chien KR, Bakkers J.

Circulation. 2007 Jul 31;116(5):515-25. Epub 2007 Jul 23.


Quantitating tissue specificity of human genes to facilitate biomarker discovery.

Vasmatzis G, Klee EW, Kube DM, Therneau TM, Kosari F.

Bioinformatics. 2007 Jun 1;23(11):1348-55. Epub 2007 Mar 23.


Optimization of laser capture microdissection and RNA amplification for gene expression profiling of prostate cancer.

Kube DM, Savci-Heijink CD, Lamblin AF, Kosari F, Vasmatzis G, Cheville JC, Connelly DP, Klee GG.

BMC Mol Biol. 2007 Mar 21;8:25.


The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.

Kube D, Hua TD, Klöss M, Kulle B, Brockmöller J, Wojnowski L, Löffler M, Pfreundschuh M, Trümper L.

Genes Immun. 2007 Mar;8(2):164-7. Epub 2007 Jan 11.


Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.

Feuerborn A, Möritz C, Von Bonin F, Dobbelstein M, Trümper L, Stürzenhofecker B, Kube D.

Leuk Lymphoma. 2006 Sep;47(9):1932-40.


Persistent Epstein-Barr viral reactivation in young African children with a history of severe Plasmodium falciparum malaria.

Yone CL, Kube D, Kremsner PG, Luty AJ.

Trans R Soc Trop Med Hyg. 2006 Jul;100(7):669-76. Epub 2005 Nov 28.


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