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Items: 21

1.

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.

Khor B, Conway KL, Omar AS, Biton M, Haber AL, Rogel N, Baxt LA, Begun J, Kuballa P, Gagnon JD, Lassen KG, Regev A, Xavier RJ.

J Immunol. 2019 Oct 1;203(7):1820-1829. doi: 10.4049/jimmunol.1800419. Epub 2019 Aug 26.

PMID:
31451676
2.

Use of CRISPR/Cas9 for the Modification of the Mouse Genome.

Klimke A, Güttler S, Kuballa P, Janzen S, Ortmann S, Flora A.

Methods Mol Biol. 2019;1953:213-230. doi: 10.1007/978-1-4939-9145-7_13.

PMID:
30912024
3.

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dančík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, Xavier RJ.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7. doi: 10.1073/pnas.1512289112. Epub 2015 Jul 20.

4.

Induction of heat shock protein HSPA6 (HSP70B') upon HSP90 inhibition in cancer cell lines.

Kuballa P, Baumann AL, Mayer K, Bär U, Burtscher H, Brinkmann U.

FEBS Lett. 2015 Jun 4;589(13):1450-8. doi: 10.1016/j.febslet.2015.04.053. Epub 2015 May 7.

5.

Discovery of a Small-Molecule Probe for V-ATPase Function.

Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ.

J Am Chem Soc. 2015 Apr 29;137(16):5563-8. doi: 10.1021/jacs.5b02150. Epub 2015 Apr 20.

6.

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12.

7.

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ.

ACS Chem Biol. 2013 Dec 20;8(12):2724-2733. doi: 10.1021/cb400352d. Epub 2013 Oct 29.

8.

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ.

Gastroenterology. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21.

9.

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.

Yuan Y, Tang AJ, Castoreno AB, Kuo SY, Wang Q, Kuballa P, Xavier R, Shamji AF, Schreiber SL, Wagner BK.

Cell Death Dis. 2013 Jun 27;4:e690. doi: 10.1038/cddis.2013.191.

10.

ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.

O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G.

Genes Dev. 2013 Feb 15;27(4):429-40. doi: 10.1101/gad.205294.112. Epub 2013 Feb 7.

11.

ATG5 regulates plasma cell differentiation.

Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ.

Autophagy. 2013 Apr;9(4):528-37. doi: 10.4161/auto.23484. Epub 2013 Jan 17.

12.

Autophagy and the immune system.

Kuballa P, Nolte WM, Castoreno AB, Xavier RJ.

Annu Rev Immunol. 2012;30:611-46. doi: 10.1146/annurev-immunol-020711-074948. Review.

PMID:
22449030
13.

Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival.

Kuballa P, Xavier RJ.

Semin Immunopathol. 2010 Dec;32(4):319-22. doi: 10.1007/s00281-010-0229-5. Epub 2010 Nov 25. No abstract available.

PMID:
21107575
14.

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ.

J Immunol. 2009 Apr 15;182(8):4917-30. doi: 10.4049/jimmunol.0803050.

15.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Rioux JD, Altshuler D, Daly MJ, Xavier RJ.

Nat Genet. 2008 Sep;40(9):1107-12. doi: 10.1038/ng.215.

16.

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ.

PLoS One. 2008;3(10):e3391. doi: 10.1371/journal.pone.0003391. Epub 2008 Oct 13.

17.

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ.

Cell Signal. 2008 Jan;20(1):73-82. Epub 2007 Sep 12.

18.

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR.

Nat Genet. 2007 May;39(5):596-604. Epub 2007 Apr 15.

19.

The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins.

Kuballa P, Matentzoglu K, Scheffner M.

J Biol Chem. 2007 Jan 5;282(1):65-71. Epub 2006 Nov 3.

20.

Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.

Hengstermann A, D'silva MA, Kuballa P, Butz K, Hoppe-Seyler F, Scheffner M.

J Virol. 2005 Jul;79(14):9296-300.

21.

Porcine purple acid phosphatase: heterologous expression, characterization, and proteolytic analysis.

Naseri JI, Truong NT, Hörentrup J, Kuballa P, Vogel A, Rompel A, Spener F, Krebs B.

Arch Biochem Biophys. 2004 Dec 1;432(1):25-36.

PMID:
15519293

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