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A compendium of promoter-centered long-range chromatin interactions in the human genome.

Jung I, Schmitt A, Diao Y, Lee AJ, Liu T, Yang D, Tan C, Eom J, Chan M, Chee S, Chiang Z, Kim C, Masliah E, Barr CL, Li B, Kuan S, Kim D, Ren B.

Nat Genet. 2019 Oct;51(10):1442-1449. doi: 10.1038/s41588-019-0494-8. Epub 2019 Sep 9.


Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways.

Kuan SP, Liao YJ, Davis KM, Messer JG, Zubcevic J, Aguirre JI, Reznikov LR.

iScience. 2019 Sep 27;19:737-748. doi: 10.1016/j.isci.2019.08.011. Epub 2019 Aug 8.


PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654.

Gao C, Chen G, Zhang DH, Zhang J, Kuan SF, Hu W, Esni F, Gao X, Guan JL, Chu E, Hu J.

Cell Mol Gastroenterol Hepatol. 2019 Jul 19. pii: S2352-345X(19)30091-8. doi: 10.1016/j.jcmgh.2019.07.004. [Epub ahead of print]


Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution.

Wu Y, Li L, Frank L, Wagner J, Andreozzi P, Hammer B, D'Alicarnasso M, Pelliccia M, Liu W, Chakrabortty S, Krol S, Simon J, Landfester K, Kuan SL, Stellacci F, Müllen K, Kreppel F, Weil T.

ACS Nano. 2019 Aug 27;13(8):8749-8759. doi: 10.1021/acsnano.9b01484. Epub 2019 Jul 29.


Supramolecular Toxin Complexes for Targeted Pharmacological Modulation of Polymorphonuclear Leukocyte Functions.

Heck AJ, Ostertag T, Schnell L, Fischer S, Agrawalla BK, Winterwerber P, Wirsching E, Fauler M, Frick M, Kuan SL, Weil T, Barth H.

Adv Healthc Mater. 2019 Sep;8(17):e1900665. doi: 10.1002/adhm.201900665. Epub 2019 Jul 18.


Skin-inspired, open mesh electrochemical sensors for lactate and oxygen monitoring.

Ashley BK, Brown MS, Park Y, Kuan S, Koh A.

Biosens Bioelectron. 2019 May 1;132:343-351. doi: 10.1016/j.bios.2019.02.041. Epub 2019 Feb 21.


Functional protein nanostructures: a chemical toolbox.

Kuan SL, Bergamini FRG, Weil T.

Chem Soc Rev. 2018 Dec 21;47(24):9069-9105. doi: 10.1039/c8cs00590g. Epub 2018 Nov 19. Review.


Sex-specific airway hyperreactivity and sex-specific transcriptome remodeling in neonatal piglets challenged with intra-airway acid.

Reznikov LR, Liao YSJ, Gu T, Davis KM, Kuan SP, Atanasova KR, Dadural JS, Collins EN, Guevara MV, Vogt K.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L131-L143. doi: 10.1152/ajplung.00417.2018. Epub 2018 Nov 8.


Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins.

Kuan SL, Fischer S, Hafner S, Wang T, Syrovets T, Liu W, Tokura Y, Ng DYW, Riegger A, Förtsch C, Jäger D, Barth TFE, Simmet T, Barth H, Weil T.

Adv Sci (Weinh). 2018 Jun 14;5(8):1701036. doi: 10.1002/advs.201701036. eCollection 2018 Aug.


Antimicrobial and Anti-Biofilm Activities of Surface Engineered Polycationic Albumin Nanoparticles with Reduced Hemolytic Activity.

Obuobi S, Wang Y, Khara JS, Riegger A, Kuan SL, Ee PLR.

Macromol Biosci. 2018 Oct;18(10):e1800196. doi: 10.1002/mabi.201800196. Epub 2018 Aug 1.


Dynamic Core-Shell Bioconjugates for Targeted Protein Delivery and Release.

Seidler C, Zegota MM, Raabe M, Kuan SL, Ng DYW, Weil T.

Chem Asian J. 2018 Nov 16;13(22):3474-3479. doi: 10.1002/asia.201800843. Epub 2018 Aug 17.


"Tag and Modify" Protein Conjugation with Dynamic Covalent Chemistry.

Zegota MM, Wang T, Seidler C, Wah Ng DY, Kuan SL, Weil T.

Bioconjug Chem. 2018 Aug 15;29(8):2665-2670. doi: 10.1021/acs.bioconjchem.8b00358. Epub 2018 Jul 24.


Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions.

Morsbach S, Gonella G, Mailänder V, Wegner S, Wu S, Weidner T, Berger R, Koynov K, Vollmer D, Encinas N, Kuan SL, Bereau T, Kremer K, Weil T, Bonn M, Butt HJ, Landfester K.

Angew Chem Int Ed Engl. 2018 Sep 24;57(39):12626-12648. doi: 10.1002/anie.201712448. Epub 2018 Aug 30. Review.


The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity.

Reznikov LR, Meyerholz DK, Abou Alaiwa M, Kuan SP, Liao YJ, Bormann NL, Bair TB, Price M, Stoltz DA, Welsh MJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L133-L148. doi: 10.1152/ajplung.00557.2017. Epub 2018 Apr 5.


Author Correction: Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation.

Preissl S, Fang R, Huang H, Zhao Y, Raviram R, Gorkin DU, Zhang Y, Sos BC, Afzal V, Dickel DE, Kuan S, Visel A, Pennacchio LA, Zhang K, Ren B.

Nat Neurosci. 2018 Jul;21(7):1015. doi: 10.1038/s41593-018-0114-4.


Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation.

Preissl S, Fang R, Huang H, Zhao Y, Raviram R, Gorkin DU, Zhang Y, Sos BC, Afzal V, Dickel DE, Kuan S, Visel A, Pennacchio LA, Zhang K, Ren B.

Nat Neurosci. 2018 Mar;21(3):432-439. doi: 10.1038/s41593-018-0079-3. Epub 2018 Feb 12. Erratum in: Nat Neurosci. 2018 Mar 1;:.


Solitary Cholinergic Stimulation Induces Airway Hyperreactivity and Transcription of Distinct Pro-inflammatory Pathways.

Reznikov LR, Meyerholz DK, Kuan SP, Guevara MV, Atanasova KR, Abou Alaiwa MH.

Lung. 2018 Apr;196(2):219-229. doi: 10.1007/s00408-018-0091-0. Epub 2018 Jan 29.


Chemoselective Dual Labeling of Native and Recombinant Proteins.

Agrawalla BK, Wang T, Riegger A, Domogalla MP, Steinbrink K, Dörfler T, Chen X, Boldt F, Lamla M, Michaelis J, Kuan SL, Weil T.

Bioconjug Chem. 2018 Jan 17;29(1):29-34. doi: 10.1021/acs.bioconjchem.7b00675. Epub 2017 Dec 20.


Wnt/β-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer.

Chen G, Gao C, Gao X, Zhang DH, Kuan SF, Burns TF, Hu J.

Mol Cancer Ther. 2018 Apr;17(4):806-813. doi: 10.1158/1535-7163.MCT-17-0561. Epub 2017 Nov 22.


Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein-DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity.

Gačanin J, Kovtun A, Fischer S, Schwager V, Quambusch J, Kuan SL, Liu W, Boldt F, Li C, Yang Z, Liu D, Wu Y, Weil T, Barth H, Ignatius A.

Adv Healthc Mater. 2017 Nov;6(21). doi: 10.1002/adhm.201700392. Epub 2017 Jul 31.


MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.

Gao X, Chen G, Gao C, Zhang DH, Kuan SF, Stabile LP, Liu G, Hu J.

Mol Oncol. 2017 Jun;11(6):628-639. doi: 10.1002/1878-0261.12055. Epub 2017 May 2.


Neoadjuvant therapy in microsatellite-stable colorectal carcinoma induces concomitant loss of MSH6 and Ki-67 expression.

Kuan SF, Ren B, Brand R, Dudley B, Pai RK.

Hum Pathol. 2017 May;63:33-39. doi: 10.1016/j.humpath.2017.02.003. Epub 2017 Feb 21.


THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.

Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2307-2312. doi: 10.1073/pnas.1614265114. Epub 2017 Feb 13.


Views of faculty members in a medical school with regards to error disclosure and reporting to parents and/or higher authorities.

Wong CH, Phuah AC, Naik NS, Choo WS, Ting HS, Kuan SM, Teng CL, Sivalingam N.

Med J Malaysia. 2016 Oct;71(5):244-249.


Opposing roles of KIT and ABL1 in the therapeutic response of gastrointestinal stromal tumor (GIST) cells to imatinib mesylate.

Rausch JL, Boichuk S, Ali AA, Patil SS, Liu L, Lee DM, Brown MF, Makielski KR, Liu Y, Taguchi T, Kuan SF, Duensing A.

Oncotarget. 2017 Jan 17;8(3):4471-4483. doi: 10.18632/oncotarget.13882.


Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome.

Kuan SL, Wang T, Weil T.

Chemistry. 2016 Nov 21;22(48):17112-17129. doi: 10.1002/chem.201602298. Epub 2016 Oct 25. Review.


Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A.

Nature. 2016 Sep 22;537(7621):548-552. doi: 10.1038/nature19360. Epub 2016 Sep 14.


MLH1-deficient Colorectal Carcinoma With Wild-type BRAF and MLH1 Promoter Hypermethylation Harbor KRAS Mutations and Arise From Conventional Adenomas.

Farchoukh L, Kuan SF, Dudley B, Brand R, Nikiforova M, Pai RK.

Am J Surg Pathol. 2016 Oct;40(10):1390-9. doi: 10.1097/PAS.0000000000000695.


Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides.

Wang T, Riegger A, Lamla M, Wiese S, Oeckl P, Otto M, Wu Y, Fischer S, Barth H, Kuan SL, Weil T.

Chem Sci. 2016 May 1;7(5):3234-3239. doi: 10.1039/c6sc00005c. Epub 2016 Jan 29.


Effect of BBX-B8 overexpression on development, body weight, silk protein synthesis and egg diapause of Bombyx mori.

Zheng X, Gong Y, Kumar D, Chen F, Kuan S, Liang Z, Hu X, Cao G, Xue R, Gong C.

Transgenic Res. 2016 Aug;25(4):507-16. doi: 10.1007/s11248-016-9947-3. Epub 2016 Mar 7.


A Supramolecular Approach toward Bioinspired PAMAM-Dendronized Fusion Toxins.

Kuan SL, Förtsch C, Ng DY, Fischer S, Tokura Y, Liu W, Wu Y, Koynov K, Barth H, Weil T.

Macromol Biosci. 2016 Jun;16(6):803-10. doi: 10.1002/mabi.201500417. Epub 2016 Feb 2.


Colorectal poorly differentiated neuroendocrine carcinomas frequently exhibit BRAF mutations and are associated with poor overall survival.

Olevian DC, Nikiforova MN, Chiosea S, Sun W, Bahary N, Kuan SF, Pai RK.

Hum Pathol. 2016 Mar;49:124-34. doi: 10.1016/j.humpath.2015.11.004. Epub 2015 Nov 17.


EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.

Liu F, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CL, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee WK, Ren B, Mischel PS.

Mol Cell. 2015 Oct 15;60(2):307-18. doi: 10.1016/j.molcel.2015.09.002. Epub 2015 Oct 8.


FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β.

Gao C, Chen G, Kuan SF, Zhang DH, Schlaepfer DD, Hu J.

Elife. 2015 Sep 3;4. doi: 10.7554/eLife.10072.


Protein-polymer therapeutics: a macromolecular perspective.

Wu Y, Ng DY, Kuan SL, Weil T.

Biomater Sci. 2015 Feb;3(2):214-30. doi: 10.1039/c4bm00270a. Epub 2014 Oct 13.


Improvement of bio-corrosion resistance for Ti42Zr40Si15Ta3 metallic glasses in simulated body fluid by annealing within supercooled liquid region.

Huang CH, Lai JJ, Wei TY, Chen YH, Wang X, Kuan SY, Huang JC.

Mater Sci Eng C Mater Biol Appl. 2015;52:144-50. doi: 10.1016/j.msec.2015.03.056. Epub 2015 Mar 26.


Integrative analysis of haplotype-resolved epigenomes across human tissues.

Leung D, Jung I, Rajagopal N, Schmitt A, Selvaraj S, Lee AY, Yen CA, Lin S, Lin Y, Qiu Y, Xie W, Yue F, Hariharan M, Ray P, Kuan S, Edsall L, Yang H, Chi NC, Zhang MQ, Ecker JR, Ren B.

Nature. 2015 Feb 19;518(7539):350-354. doi: 10.1038/nature14217.


A comparative encyclopedia of DNA elements in the mouse genome.

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B; Mouse ENCODE Consortium.

Nature. 2014 Nov 20;515(7527):355-64. doi: 10.1038/nature13992.


A disulfide intercalator toolbox for the site-directed modification of polypeptides.

Wang T, Wu Y, Kuan SL, Dumele O, Lamla M, Ng DY, Arzt M, Thomas J, Mueller JO, Barner-Kowollik C, Weil T.

Chemistry. 2015 Jan 2;21(1):228-38. doi: 10.1002/chem.201403965. Epub 2014 Oct 30.


Programming supramolecular biohybrids as precision therapeutics.

Ng DY, Wu Y, Kuan SL, Weil T.

Acc Chem Res. 2014 Dec 16;47(12):3471-80. doi: 10.1021/ar5002445. Epub 2014 Oct 30.


Programmable protein-DNA hybrid hydrogels for the immobilization and release of functional proteins.

Wu Y, Li C, Boldt F, Wang Y, Kuan SL, Tran TT, Mikhalevich V, Förtsch C, Barth H, Yang Z, Liu D, Weil T.

Chem Commun (Camb). 2014 Dec 4;50(93):14620-2. doi: 10.1039/c4cc07144a.


5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation.

Hon GC, Song CX, Du T, Jin F, Selvaraj S, Lee AY, Yen CA, Ye Z, Mao SQ, Wang BA, Kuan S, Edsall LE, Zhao BS, Xu GL, He C, Ren B.

Mol Cell. 2014 Oct 23;56(2):286-297. doi: 10.1016/j.molcel.2014.08.026. Epub 2014 Sep 25.


Crystal structure of a conserved hypothetical protein MJ0927 from Methanocaldococcus jannaschii reveals a novel quaternary assembly in the Nif3 family.

Chen SC, Huang CH, Yang CS, Kuan SM, Lin CT, Chou SH, Chen Y.

Biomed Res Int. 2014;2014:171263. doi: 10.1155/2014/171263. Epub 2014 Aug 28.


Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients.

Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Mirvish E, Crespo MM, Yadav D, Fasanella KE, Proksell S, Kuan SF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y.

J Infect Dis. 2015 May 15;211(10):1560-5. doi: 10.1093/infdis/jiu524. Epub 2014 Sep 17.


A polyphenylene dendrimer drug transporter with precisely positioned amphiphilic surface patches.

Stangenberg R, Wu Y, Hedrich J, Kurzbach D, Wehner D, Weidinger G, Kuan SL, Jansen MI, Jelezko F, Luhmann HJ, Hinderberger D, Weil T, Müllen K.

Adv Healthc Mater. 2015 Feb 18;4(3):377-84. doi: 10.1002/adhm.201400291. Epub 2014 Sep 2.


BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical expression.

Landau MS, Kuan SF, Chiosea S, Pai RK.

Hum Pathol. 2014 Aug;45(8):1704-12. doi: 10.1016/j.humpath.2014.04.008. Epub 2014 Apr 24.


Hematochezia Associated with Sevalamer-Induced Mucosal Injury.

Chintamaneni P, Das R, Kuan SF, Kermanshahi TR, Hashash JG.

ACG Case Rep J. 2014 Apr 4;1(3):145-7. doi: 10.14309/crj.2014.32. eCollection 2014 Apr.


Immunohistochemical detection of BRAF V600E mutant protein using the VE1 antibody in colorectal carcinoma is highly concordant with molecular testing but requires rigorous antibody optimization.

Kuan SF, Navina S, Cressman KL, Pai RK.

Hum Pathol. 2014 Mar;45(3):464-72. doi: 10.1016/j.humpath.2013.10.026. Epub 2013 Nov 4.


Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc.

Chen SC, Huang CH, Yang CS, Liu JS, Kuan SM, Chen Y.

Proteins. 2014 Jul;82(7):1519-26. doi: 10.1002/prot.24516. Epub 2014 Feb 18.


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