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Items: 20


Optimal design for high-throughput screening via false discovery rate control.

Feng T, Basu P, Sun W, Ku HT, Mack WJ.

Stat Med. 2019 Jul 10;38(15):2816-2827. doi: 10.1002/sim.8144. Epub 2019 Mar 28.


Glucocorticoid Signaling Enhances Expression of Glucose-Sensing Molecules in Immature Pancreatic Beta-Like Cells Derived from Murine Embryonic Stem Cells In Vitro.

Ghazalli N, Wu X, Walker S, Trieu N, Hsin LY, Choe J, Chen C, Hsu J, LeBon J, Kozlowski MT, Rawson J, Tirrell DA, Yip MLR, Ku HT.

Stem Cells Dev. 2018 Jul 1;27(13):898-909. doi: 10.1089/scd.2017.0160. Epub 2018 Jun 6.


4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.

Lieblich SA, Fang KY, Cahn JKB, Rawson J, LeBon J, Ku HT, Tirrell DA.

J Am Chem Soc. 2017 Jun 28;139(25):8384-8387. doi: 10.1021/jacs.7b00794. Epub 2017 Jun 20.


Adult Murine Pancreatic Progenitors Require Epidermal Growth Factor and Nicotinamide for Self-Renewal and Differentiation in a Serum- and Conditioned Medium-Free Culture.

Wedeken L, Luo A, Tremblay JR, Rawson J, Jin L, Gao D, Quijano J, Ku HT.

Stem Cells Dev. 2017 Apr 15;26(8):599-607. doi: 10.1089/scd.2016.0328. Epub 2017 Jan 17.


Differential Expression of Ccn4 and Other Genes Between Metastatic and Non-metastatic EL4 Mouse Lymphoma Cells.

Chahal MS, Ku HT, Zhang Z, Legaspi CM, Luo A, Hopkins MM, Meier KE.

Cancer Genomics Proteomics. 2016 11-12;13(6):437-442.


In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas.

Tremblay JR, LeBon JM, Luo A, Quijano JC, Wedeken L, Jou K, Riggs AD, Tirrell DA, Ku HT.

J Vis Exp. 2016 Jun 10;(112). doi: 10.3791/54016.


Cells with surface expression of CD133highCD71low are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas.

Jin L, Gao D, Feng T, Tremblay JR, Ghazalli N, Luo A, Rawson J, Quijano JC, Chai J, Wedeken L, Hsu J, LeBon J, Walker S, Shih HP, Mahdavi A, Tirrell DA, Riggs AD, Ku HT.

Stem Cell Res. 2016 Jan;16(1):40-53. doi: 10.1016/j.scr.2015.11.015. Epub 2015 Nov 30.


Postnatal Pancreas of Mice Contains Tripotent Progenitors Capable of Giving Rise to Duct, Acinar, and Endocrine Cells In Vitro.

Ghazalli N, Mahdavi A, Feng T, Jin L, Kozlowski MT, Hsu J, Riggs AD, Tirrell DA, Ku HT.

Stem Cells Dev. 2015 Sep 1;24(17):1995-2008. doi: 10.1089/scd.2015.0007. Epub 2015 Jun 9.


Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures.

Jin L, Feng T, Chai J, Ghazalli N, Gao D, Zerda R, Li Z, Hsu J, Mahdavi A, Tirrell DA, Riggs AD, Ku HT.

Rev Diabet Stud. 2014 Spring;11(1):35-50. doi: 10.1900/RDS.2014.11.35. Epub 2014 May 10.


In vitro multilineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57BL/6 mice.

Jin L, Feng T, Zerda R, Chen CC, Riggs AD, Ku HT.

Stem Cells Dev. 2014 Apr 15;23(8):899-909. doi: 10.1089/scd.2013.0466. Epub 2014 Jan 4.


MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.

Fu X, Jin L, Wang X, Luo A, Hu J, Zheng X, Tsark WM, Riggs AD, Ku HT, Huang W.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17892-7. doi: 10.1073/pnas.1317397110. Epub 2013 Oct 10.


Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel.

Jin L, Feng T, Shih HP, Zerda R, Luo A, Hsu J, Mahdavi A, Sander M, Tirrell DA, Riggs AD, Ku HT.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3907-12. doi: 10.1073/pnas.1301889110. Epub 2013 Feb 19.


An automated microfluidic chip system for detection of piscine nodavirus and characterization of its potential carrier in grouper farms.

Kuo HC, Wang TY, Hsu HH, Lee SH, Chen YM, Tsai TJ, Ou MC, Ku HT, Lee GB, Chen TY.

PLoS One. 2012;7(8):e42203. doi: 10.1371/journal.pone.0042203. Epub 2012 Aug 9.


Nervous necrosis virus replicates following the embryo development and dual infection with iridovirus at juvenile stage in grouper.

Kuo HC, Wang TY, Hsu HH, Chen PP, Lee SH, Chen YM, Tsai TJ, Wang CK, Ku HT, Lee GB, Chen TY.

PLoS One. 2012;7(4):e36183. doi: 10.1371/journal.pone.0036183. Epub 2012 Apr 26.


A quantitative assay for insulin-expressing colony-forming progenitors.

Winkler M, Trieu N, Feng T, Jin L, Walker S, Singh L, Ku HT.

J Vis Exp. 2011 Nov 28;(57):e3148. doi: 10.3791/3148.


Characterization of an in vitro differentiation assay for pancreatic-like cell development from murine embryonic stem cells: detailed gene expression analysis.

Chen C, Chai J, Singh L, Kuo CY, Jin L, Feng T, Marzano S, Galeni S, Zhang N, Iacovino M, Qin L, Hara M, Stein R, Bromberg JS, Kyba M, Ku HT.

Assay Drug Dev Technol. 2011 Aug;9(4):403-19. doi: 10.1089/adt.2010.0314. Epub 2011 Mar 11.


Insulin gene expression is regulated by DNA methylation.

Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel F, Mullen Y, Pfeifer GP, Ferreri K.

PLoS One. 2009 Sep 9;4(9):e6953. doi: 10.1371/journal.pone.0006953. Erratum in: PLoS One. 2009;4(10) 10.1371/annotation/947a8d4a-3585-4b23-ac84-b47a255a70d9.


Minireview: pancreatic progenitor cells--recent studies.

Ku HT.

Endocrinology. 2008 Sep;149(9):4312-6. doi: 10.1210/en.2008-0546. Epub 2008 Jun 5. Review. Erratum in: Endocrinology.2009 Nov;150(11):1593.


Insulin-expressing colonies developed from murine embryonic stem cell-derived progenitors.

Ku HT, Chai J, Kim YJ, White P, Purohit-Ghelani S, Kaestner KH, Bromberg JS.

Diabetes. 2007 Apr;56(4):921-9.


Committing embryonic stem cells to early endocrine pancreas in vitro.

Ku HT, Zhang N, Kubo A, O'Connor R, Mao M, Keller G, Bromberg JS.

Stem Cells. 2004;22(7):1205-17.

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