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Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder.

Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG.

Mol Neuropsychiatry. 2018 Oct;4(2):75-82. doi: 10.1159/000490464. Epub 2018 Jul 19.


BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise.

Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH.

Psychoneuroendocrinology. 2018 Oct 17;100:198-202. doi: 10.1016/j.psyneuen.2018.10.011. [Epub ahead of print]


Topology of brain functional connectivity networks in posttraumatic stress disorder.

Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG.

Data Brief. 2018 Sep 6;20:1658-1675. doi: 10.1016/j.dib.2018.08.198. eCollection 2018 Oct.


Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.

Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A.

Elife. 2018 Oct 25;7. pii: e35082. doi: 10.7554/eLife.35082.


Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.

Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J.

Transl Psychiatry. 2018 Oct 4;8(1):208. doi: 10.1038/s41398-018-0258-8.


Physical activity and mental health - Author's reply.

Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM.

Lancet Psychiatry. 2018 Nov;5(11):874. doi: 10.1016/S2215-0366(18)30354-7. Epub 2018 Sep 21. No abstract available.


The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder.

Abdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH.

Annu Rev Pharmacol Toxicol. 2018 Sep 14. doi: 10.1146/annurev-pharmtox-010818-021701. [Epub ahead of print]


Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers.

Zhornitsky S, Ide JS, Wang W, Chao HH, Zhang S, Hu S, Krystal JH, Li CR.

Brain Connect. 2018 Oct;8(8):487-502. doi: 10.1089/brain.2018.0633.


Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study.

Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM.

Lancet Psychiatry. 2018 Sep;5(9):739-746. doi: 10.1016/S2215-0366(18)30227-X. Epub 2018 Aug 8.


Cerebellar and prefrontal cortical alterations in PTSD: structural and functional evidence.

Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I.

Chronic Stress (Thousand Oaks). 2018 Jan-Dec;2. doi: 10.1177/2470547018786390. Epub 2018 Jul 6.


The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.

Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF.

Neuropsychopharmacology. 2018 Sep;43(10):2154-2160. doi: 10.1038/s41386-018-0136-3. Epub 2018 Jun 28.


Predicting Barriers to Treatment for Depression in a U.S. National Sample: A Cross-Sectional, Proof-of-Concept Study.

Chekroud AM, Foster D, Zheutlin AB, Gerhard DM, Roy B, Koutsouleris N, Chandra A, Esposti MD, Subramanyan G, Gueorguieva R, Paulus M, Krystal JH.

Psychiatr Serv. 2018 Aug 1;69(8):927-934. doi: 10.1176/ Epub 2018 Jul 2.


The Prescription of Benzodiazepines for Panic Disorder: Time for an Evidence-Based Educational Approach.

Nardi AE, Cosci F, Balon R, Weintraub SJ, Freire RC, Krystal JH, Roth T, Silberman EK, Sonino N, Fava GA, Starcevic V, Dubovsky SL, Salzman C, Rickels K, Greenblatt DJ, Shader RI, Chouinard G; International Task Force on Benzodiazepines.

J Clin Psychopharmacol. 2018 Aug;38(4):283-285. doi: 10.1097/JCP.0000000000000908. No abstract available.


Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use.

Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Oct;3(10):868-877. doi: 10.1016/j.bpsc.2018.04.008. Epub 2018 May 3.


Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder.

Kegeles LS, Horga G, Ghazzaoui R, Rosengard R, Ojeil N, Xu X, Slifstein M, Petrakis I, O'Malley SS, Krystal JH, Abi-Dargham A.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul;3(7):591-598. doi: 10.1016/j.bpsc.2018.03.018. Epub 2018 Apr 21.


The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Abdallah CG, Sanacora G, Duman RS, Krystal JH.

Pharmacol Ther. 2018 Oct;190:148-158. doi: 10.1016/j.pharmthera.2018.05.010. Epub 2018 May 25. Review.


International Task Force on Benzodiazepines.

Balon R, Chouinard G, Cosci F, Dubovsky SL, Fava GA, Freire RC, Greenblatt DJ, Krystal JH, Nardi AE, Rickels K, Roth T, Salzman C, Shader R, Silberman EK, Sonino N, Starcevic V, Weintraub SJ.

Psychother Psychosom. 2018;87(4):193-194. doi: 10.1159/000489538. Epub 2018 May 22. No abstract available.


Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach.

Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG.

Neuroimage. 2018 Aug 1;176:489-498. doi: 10.1016/j.neuroimage.2018.05.005. Epub 2018 May 3.


Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Fuehrlein BS, Kachadourian LK, DeVylder EK, Trevisan LA, Potenza MN, Krystal JH, Southwick SM, Pietrzak RH.

Am J Addict. 2018 Apr 18. doi: 10.1111/ajad.12731. [Epub ahead of print]


The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use.

Morean ME, DeMartini KS, Foster D, Patock-Peckham J, Garrison KA, Corlett PR, Krystal JH, Krishan-Sarin S, O'Malley SS.

Drug Alcohol Depend. 2018 May 1;186:207-214. doi: 10.1016/j.drugalcdep.2018.01.014. Epub 2018 Mar 13.


Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia.

Cheng WJ, Chen CH, Chen CK, Huang MC, Pietrzak RH, Krystal JH, Xu K.

Schizophr Res. 2018 Sep;199:313-318. doi: 10.1016/j.schres.2018.02.049. Epub 2018 Mar 3.


Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.

D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH; Yale GlyT1 Study Group.

Biol Psychiatry. 2018 Sep 15;84(6):413-421. doi: 10.1016/j.biopsych.2017.12.019. Epub 2018 Jan 31.


Locus Coeruleus Hyperactivity in Posttraumatic Stress Disorder: Answers and Questions.

Krystal JH, Abdallah CG, Pietrzak RH, Averill LA, Harpaz-Rotem I, Levy I, Kelmendi B, Southwick SM.

Biol Psychiatry. 2018 Feb 1;83(3):197-199. doi: 10.1016/j.biopsych.2017.09.027. No abstract available.


DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty.

Zhang X, Hu Y, Justice AC, Li B, Wang Z, Zhao H, Krystal JH, Xu K.

Nat Commun. 2017 Dec 21;8(1):2243. doi: 10.1038/s41467-017-02326-1.


Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.

Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, Frijling JL, Gruber SA, Harpaz-Rotem I, Jahanshad N, Koopowitz S, Levy I, Nawijn L, O'Connor L, Olff M, Salat DH, Sheridan MA, Spielberg JM, van Zuiden M, Winternitz SR, Wolff JD, Wolf EJ, Wang X, Wrocklage K, Abdallah CG, Bryant RA, Geuze E, Jovanovic T, Kaufman ML, King AP, Krystal JH, Lagopoulos J, Bennett M, Lanius R, Liberzon I, McGlinchey RE, McLaughlin KA, Milberg WP, Miller MW, Ressler KJ, Veltman DJ, Stein DJ, Thomaes K, Thompson PM, Morey RA.

Biol Psychiatry. 2018 Feb 1;83(3):244-253. doi: 10.1016/j.biopsych.2017.09.006. Epub 2017 Sep 20.


Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Mota NP, Han S, Harpaz-Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH.

Depress Anxiety. 2018 Feb;35(2):168-177. doi: 10.1002/da.22698. Epub 2017 Nov 24.


Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial.

Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman JA.

JAMA Psychiatry. 2018 Jan 1;75(1):11-19. doi: 10.1001/jamapsychiatry.2017.3572.


Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?

Krystal JH, Davis LL, Neylan TC, Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TC, Huang GD.

Biol Psychiatry. 2017 Oct 12. pii: S0006-3223(17)32055-3. doi: 10.1016/j.biopsych.2017.09.031. [Epub ahead of print] No abstract available.


GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.

Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL.

Alcohol Clin Exp Res. 2017 Dec;41(12):2025-2032. doi: 10.1111/acer.13516. Epub 2017 Nov 13.


Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies.

Esterlis I, Holmes SE, Sharma P, Krystal JH, DeLorenzo C.

Biol Psychiatry. 2017 Sep 19. pii: S0006-3223(17)31988-1. doi: 10.1016/j.biopsych.2017.08.025. [Epub ahead of print] Review.


Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.

Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH.

J Clin Psychiatry. 2017 Sep/Oct;78(8):e1058-e1059. doi: 10.4088/JCP.17l11646. No abstract available.


Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment.

Abdallah CG, Averill CL, Salas R, Averill LA, Baldwin PR, Krystal JH, Mathew SJ, Mathalon DH.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct;2(7):566-574. doi: 10.1016/j.bpsc.2017.04.006.


Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS?

Taylor JJ, Krystal JH, D'Souza DC, Gerrard JL, Corlett PR.

Schizophr Res. 2018 May;195:455-462. doi: 10.1016/j.schres.2017.09.020. Epub 2017 Sep 29.


Correlates of Nonimprovement to Pharmacotherapy for Chronic, Antidepressant-Resistant, Military Service-Related Posttraumatic Stress Disorder: Insights From the Veterans Affairs Cooperative Study No. 504.

Byrne SP, Krystal JH, Rosenheck RA, Vessicchio J, Pietrzak RH; Veterans Affairs Cooperative Study No. 504 Group.

J Clin Psychopharmacol. 2017 Dec;37(6):717-721. doi: 10.1097/JCP.0000000000000777.


Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder.

Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I.

Neuropsychopharmacology. 2018 Apr;43(5):1119-1127. doi: 10.1038/npp.2017.229. Epub 2017 Sep 25.


Biological Psychiatry: A New Approach to Reviews.

Krystal JH.

Biol Psychiatry. 2017 Nov 1;82(9):620. doi: 10.1016/j.biopsych.2017.07.025. Epub 2017 Sep 8. No abstract available.


Attachment style moderates effects of FKBP5 polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and Resilience in Veterans Study.

Tamman AJF, Sippel LM, Han S, Neria Y, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH.

World J Biol Psychiatry. 2017 Oct 5:1-12. doi: 10.1080/15622975.2017.1376114. [Epub ahead of print]


Combat Exposure Severity is Associated with Reduced Cortical Thickness in Combat Veterans: A Preliminary Report.

Averill LA, Abdallah CG, Pietrzak RH, Averill CL, Southwick SM, Krystal JH, Harpaz-Rotem I.

Chronic Stress (Thousand Oaks). 2017 Jan;1. doi: 10.1177/2470547017724714. Epub 2017 Aug 22.


Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.

Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS.

Curr Psychiatry Rep. 2017 Aug 26;19(10):74. doi: 10.1007/s11920-017-0829-z. Review.


The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities.

Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, Abdallah CG.

Chronic Stress (Thousand Oaks). 2017 Feb;1. doi: 10.1177/2470547017724069. Epub 2017 Aug 8.


Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.

Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI Jr, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S.

JAMA Psychiatry. 2017 Nov 1;74(11):1153-1160. doi: 10.1001/jamapsychiatry.2017.2269.


Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.

Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I; Traumatic Stress Brain Study Group.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8390-8395. doi: 10.1073/pnas.1701749114. Epub 2017 Jul 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Sep 5;:.


A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans.

Wisco BE, Marx BP, Miller MW, Wolf EJ, Krystal JH, Southwick SM, Pietrzak RH.

J Affect Disord. 2017 Dec 1;223:17-19. doi: 10.1016/j.jad.2017.07.006. Epub 2017 Jul 6.


Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.

Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH.

J Psychiatr Res. 2017 Nov;94:139-147. doi: 10.1016/j.jpsychires.2017.07.008. Epub 2017 Jul 8.


Mecamylamine treatment for alcohol dependence: a randomized controlled trial.

Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH.

Addiction. 2018 Jan;113(1):6-14. doi: 10.1111/add.13943. Epub 2017 Oct 12.


Minimal Clinically Important Differences (MCID) in Assessing Outcomes of Post-Traumatic Stress Disorder.

Stefanovics EA, Rosenheck RA, Jones KM, Huang G, Krystal JH.

Psychiatr Q. 2018 Mar;89(1):141-155. doi: 10.1007/s11126-017-9522-y.


Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.

Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH.

Neuropsychopharmacology. 2017 Dec;42(13):2482-2492. doi: 10.1038/npp.2017.94. Epub 2017 May 11.


Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics.

Abdallah CG, Southwick SM, Krystal JH.

Neurosci Lett. 2017 May 10;649:130-132. doi: 10.1016/j.neulet.2017.04.046. No abstract available.


It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group.

Krystal JH, Davis LL, Neylan TC, A Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TD, Huang GD.

Biol Psychiatry. 2017 Oct 1;82(7):e51-e59. doi: 10.1016/j.biopsych.2017.03.007. Epub 2017 Mar 14. No abstract available. Erratum in: Biol Psychiatry. 2018 Feb 1;83(3):296.


Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective.

Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD.

Biol Psychiatry. 2017 May 15;81(10):874-885. doi: 10.1016/j.biopsych.2017.01.004. Epub 2017 Jan 13. Review.

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