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Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET.

Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I.

J Cereb Blood Flow Metab. 2019 Nov 19:271678X19886316. doi: 10.1177/0271678X19886316. [Epub ahead of print] No abstract available.


The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences.

Haeny AM, Gueorguieva R, Morean ME, Krishnan-Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O'Malley SS.

Alcohol Clin Exp Res. 2019 Nov 6. doi: 10.1111/acer.14230. [Epub ahead of print]


Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial.

Krishnan-Sarin S, O'Malley SS, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH.

Neuropsychopharmacology. 2019 Oct 7. doi: 10.1038/s41386-019-0536-z. [Epub ahead of print]


Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study.

Mota NP, Cook JM, Smith NB, Tsai J, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH.

J Psychiatr Res. 2019 Dec;119:23-31. doi: 10.1016/j.jpsychires.2019.09.005. Epub 2019 Sep 12.


Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo-control study.

Chen MH, Cheng CM, Gueorguieva R, Lin WC, Li CT, Hong CJ, Tu PC, Bai YM, Tsai SJ, Krystal JH, Su TP.

Neuropsychopharmacology. 2019 Nov;44(12):2112-2118. doi: 10.1038/s41386-019-0480-y. Epub 2019 Aug 17.


Epigenome-Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans.

Xu K, Montalvo-Ortiz JL, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J.

Alcohol Clin Exp Res. 2019 Oct;43(10):2111-2121. doi: 10.1111/acer.14168. Epub 2019 Aug 30.


Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.

Averill LA, Abdallah CG, Levey DF, Han S, Harpaz-Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH.

Depress Anxiety. 2019 Sep;36(9):834-845. doi: 10.1002/da.22912. Epub 2019 Aug 6.


Selective serotonin reuptake inhibitors and benzodiazepines in panic disorder: A meta-analysis of common side effects in acute treatment.

Quagliato LA, Cosci F, Shader RI, Silberman EK, Starcevic V, Balon R, Dubovsky SL, Salzman C, Krystal JH, Weintraub SJ, Freire RC, Nardi AE; International Task Force on Benzodiazepines.

J Psychopharmacol. 2019 Nov;33(11):1340-1351. doi: 10.1177/0269881119859372. Epub 2019 Jul 15.


Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development.

Kaffman A, White JD, Wei L, Johnson FK, Krystal JH.

Methods Mol Biol. 2019;2011:3-22. doi: 10.1007/978-1-4939-9554-7_1.


Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers.

Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR.

J Psychiatr Res. 2019 Sep;116:74-82. doi: 10.1016/j.jpsychires.2019.06.005. Epub 2019 Jun 8.


Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits.

Ji JL, Diehl C, Schleifer C, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA, Hill SK, Pearlson G, Yang G, Creatura G, Krystal JH, Repovs G, Murray J, Winkler A, Anticevic A.

Cereb Cortex. 2019 Jun 3. pii: bhy306. doi: 10.1093/cercor/bhy306. [Epub ahead of print]


Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder.

Abdallah CG, Averill CL, Ramage AE, Averill LA, Goktas S, Nemati S, Krystal JH, Roache JD, Resick PA, Young-McCaughan S, Peterson AL, Fox P; STRONG STAR Consortium.

Chronic Stress (Thousand Oaks). 2019 Jan-Dec;3. doi: 10.1177/2470547019850467. Epub 2019 May 15.


Insomnia symptom trajectories among adult survivors of childhood sexual abuse: A longitudinal study.

Steine IM, Skogen JC, Krystal JH, Winje D, Milde AM, Grønli J, Nordhus IH, Bjorvatn B, Pallesen S.

Child Abuse Negl. 2019 Jul;93:263-276. doi: 10.1016/j.chiabu.2019.05.009. Epub 2019 May 23.


In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.

Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Carson RE, Krystal JH, Esterlis I.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11490-11495. doi: 10.1073/pnas.1818871116. Epub 2019 May 13. Erratum in: Proc Natl Acad Sci U S A. 2019 Jun 17;:.


Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect-Reply.

Krystal JH, Yoon G, Petrakis IL.

JAMA Psychiatry. 2019 Jun 1;76(6):658-659. doi: 10.1001/jamapsychiatry.2019.0763. No abstract available.


Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment.

Abdallah CG, Averill CL, Ramage AE, Averill LA, Alkin E, Nemati S, Krystal JH, Roache JD, Resick P, Young-McCaughan S, Peterson AL, Fox P; STRONG STAR Consortium.

Chronic Stress (Thousand Oaks). 2019 Jan-Feb;3. doi: 10.1177/2470547019838971. Epub 2019 Apr 15.


Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial.

Abdallah CG, Roache JD, Averill LA, Young-McCaughan S, Martini B, Gueorguieva R, Amoroso T, Southwick SM, Guthmiller K, López-Roca AL, Lautenschlager K, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH; Consortium to Alleviate PTSD.

Contemp Clin Trials. 2019 Jun;81:11-18. doi: 10.1016/j.cct.2019.04.009. Epub 2019 Apr 15.


Lower synaptic density is associated with depression severity and network alterations.

Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I.

Nat Commun. 2019 Apr 4;10(1):1529. doi: 10.1038/s41467-019-09562-7.


Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Duman RS, Sanacora G, Krystal JH.

Neuron. 2019 Apr 3;102(1):75-90. doi: 10.1016/j.neuron.2019.03.013. Review.


A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms.

Fleming LM, Javitt DC, Carter CS, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman J, Krystal JH, Corlett PR.

Neuroimage Clin. 2019;22:101739. doi: 10.1016/j.nicl.2019.101739. Epub 2019 Feb 28.


Ketamine: A Paradigm Shift for Depression Research and Treatment.

Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS.

Neuron. 2019 Mar 6;101(5):774-778. doi: 10.1016/j.neuron.2019.02.005. Review.


Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study.

Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH.

Am J Geriatr Psychiatry. 2019 May;27(5):528-532. doi: 10.1016/j.jagp.2019.01.001. Epub 2019 Jan 7.


Author Correction: Neural computations of threat in the aftermath of combat trauma.

Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D.

Nat Neurosci. 2019 May;22(5):840-841. doi: 10.1038/s41593-019-0356-9.


Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers.

Zhornitsky S, Zhang S, Ide JS, Chao HH, Wang W, Le TM, Leeman RF, Bi J, Krystal JH, Li CR.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 May;4(5):493-504. doi: 10.1016/j.bpsc.2018.11.012. Epub 2018 Dec 12.


Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk.

Tang Y, Zhou Q, Chang M, Chekroud A, Gueorguieva R, Jiang X, Zhou Y, He G, Rowland M, Wang D, Fu S, Yin Z, Leng H, Wei S, Xu K, Wang F, Krystal JH, Driesen NR.

Schizophr Res. 2019 Aug;210:172-179. doi: 10.1016/j.schres.2018.12.041. Epub 2019 Jan 23.


Neural computations of threat in the aftermath of combat trauma.

Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D.

Nat Neurosci. 2019 Mar;22(3):470-476. doi: 10.1038/s41593-018-0315-x. Epub 2019 Jan 21. Erratum in: Nat Neurosci. 2019 Feb 13;:.


Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder.

Yoon G, Petrakis IL, Krystal JH.

JAMA Psychiatry. 2019 Mar 1;76(3):337-338. doi: 10.1001/jamapsychiatry.2018.3990. No abstract available.


Time well spent.

Krystal JI.

Pediatr Blood Cancer. 2019 Apr;66(4):e27582. doi: 10.1002/pbc.27582. Epub 2018 Dec 11. No abstract available.


Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality.

Zhang X, Hu Y, Aouizerat BE, Peng G, Marconi VC, Corley MJ, Hulgan T, Bryant KJ, Zhao H, Krystal JH, Justice AC, Xu K.

Clin Epigenetics. 2018 Dec 13;10(1):155. doi: 10.1186/s13148-018-0591-z.


Celebrating 50 Years of Biological Psychiatry: To the Future, and Beyond.

Krystal JH.

Biol Psychiatry. 2019 Jan 1;85(1):2-4. doi: 10.1016/j.biopsych.2018.08.015. Epub 2018 Aug 31. No abstract available.


Correction: Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.

Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH.

Neuropsychopharmacology. 2019 Feb;44(3):655-656. doi: 10.1038/s41386-018-0253-z.


Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder.

Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG.

Mol Neuropsychiatry. 2018 Oct;4(2):75-82. doi: 10.1159/000490464. Epub 2018 Jul 19.


BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise.

Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH.

Psychoneuroendocrinology. 2019 Feb;100:198-202. doi: 10.1016/j.psyneuen.2018.10.011. Epub 2018 Oct 17.


Topology of brain functional connectivity networks in posttraumatic stress disorder.

Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG.

Data Brief. 2018 Sep 6;20:1658-1675. doi: 10.1016/j.dib.2018.08.198. eCollection 2018 Oct.


Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.

Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A.

Elife. 2018 Oct 25;7. pii: e35082. doi: 10.7554/eLife.35082.


Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.

Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J.

Transl Psychiatry. 2018 Oct 4;8(1):208. doi: 10.1038/s41398-018-0258-8.


Physical activity and mental health - Author's reply.

Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM.

Lancet Psychiatry. 2018 Nov;5(11):874. doi: 10.1016/S2215-0366(18)30354-7. Epub 2018 Sep 21. No abstract available.


The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder.

Abdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:171-189. doi: 10.1146/annurev-pharmtox-010818-021701. Epub 2018 Sep 14.


Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers.

Zhornitsky S, Ide JS, Wang W, Chao HH, Zhang S, Hu S, Krystal JH, Li CR.

Brain Connect. 2018 Oct;8(8):487-502. doi: 10.1089/brain.2018.0633.


Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study.

Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM.

Lancet Psychiatry. 2018 Sep;5(9):739-746. doi: 10.1016/S2215-0366(18)30227-X. Epub 2018 Aug 8.


Cerebellar and prefrontal cortical alterations in PTSD: structural and functional evidence.

Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I.

Chronic Stress (Thousand Oaks). 2018 Jan-Dec;2. doi: 10.1177/2470547018786390. Epub 2018 Jul 6.


The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.

Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF.

Neuropsychopharmacology. 2018 Sep;43(10):2154-2160. doi: 10.1038/s41386-018-0136-3. Epub 2018 Jun 28.


Predicting Barriers to Treatment for Depression in a U.S. National Sample: A Cross-Sectional, Proof-of-Concept Study.

Chekroud AM, Foster D, Zheutlin AB, Gerhard DM, Roy B, Koutsouleris N, Chandra A, Esposti MD, Subramanyan G, Gueorguieva R, Paulus M, Krystal JH.

Psychiatr Serv. 2018 Aug 1;69(8):927-934. doi: 10.1176/ Epub 2018 Jul 2.


Discitis in Adults.

Shenoy K, Singla A, Krystal JD, Razi AE, Kim YH, Sharan AD.

JBJS Rev. 2018 Jun;6(6):e6. doi: 10.2106/JBJS.RVW.17.00104. No abstract available.


The Prescription of Benzodiazepines for Panic Disorder: Time for an Evidence-Based Educational Approach.

Nardi AE, Cosci F, Balon R, Weintraub SJ, Freire RC, Krystal JH, Roth T, Silberman EK, Sonino N, Fava GA, Starcevic V, Dubovsky SL, Salzman C, Rickels K, Greenblatt DJ, Shader RI, Chouinard G; International Task Force on Benzodiazepines.

J Clin Psychopharmacol. 2018 Aug;38(4):283-285. doi: 10.1097/JCP.0000000000000908. No abstract available.


Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use.

Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Oct;3(10):868-877. doi: 10.1016/j.bpsc.2018.04.008. Epub 2018 May 3.


Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder.

Kegeles LS, Horga G, Ghazzaoui R, Rosengard R, Ojeil N, Xu X, Slifstein M, Petrakis I, O'Malley SS, Krystal JH, Abi-Dargham A.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul;3(7):591-598. doi: 10.1016/j.bpsc.2018.03.018. Epub 2018 Apr 21.


The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Abdallah CG, Sanacora G, Duman RS, Krystal JH.

Pharmacol Ther. 2018 Oct;190:148-158. doi: 10.1016/j.pharmthera.2018.05.010. Epub 2018 May 25. Review.


International Task Force on Benzodiazepines.

Balon R, Chouinard G, Cosci F, Dubovsky SL, Fava GA, Freire RC, Greenblatt DJ, Krystal JH, Nardi AE, Rickels K, Roth T, Salzman C, Shader R, Silberman EK, Sonino N, Starcevic V, Weintraub SJ.

Psychother Psychosom. 2018;87(4):193-194. doi: 10.1159/000489538. Epub 2018 May 22. No abstract available.


Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach.

Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG.

Neuroimage. 2018 Aug 1;176:489-498. doi: 10.1016/j.neuroimage.2018.05.005. Epub 2018 May 3.

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