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Items: 38

1.

Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression.

Lochmann TL, Floros KV, Naseri M, Powell KM, Cook W, March RJ, Stein GT, Greninger P, Maves YK, Saunders LR, Dylla SJ, Costa C, Boikos SA, Leverson JD, Souers AJ, Krystal GW, Harada H, Benes CH, Faber AC.

Clin Cancer Res. 2018 Jan 15;24(2):360-369. doi: 10.1158/1078-0432.CCR-17-1606. Epub 2017 Nov 8.

PMID:
29118061
Free PMC Article

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2.

Auer Rods.

Gordon SW, Krystal GW.

N Engl J Med. 2017 May 25;376(21):2065. doi: 10.1056/NEJMicm1612344. No abstract available.

PMID:
28538120
Free Article

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3.

Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer.

Nakajima W, Sharma K, Hicks MA, Le N, Brown R, Krystal GW, Harada H.

Cancer Biol Ther. 2016;17(1):27-35. doi: 10.1080/15384047.2015.1108485.

PMID:
26575826
Free PMC Article

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4.

Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer.

Nakajima W, Hicks MA, Tanaka N, Krystal GW, Harada H.

Cell Death Dis. 2014 Feb 13;5:e1052. doi: 10.1038/cddis.2014.6.

PMID:
24525728
Free PMC Article

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5.

Early FDG/PET scanning as a pharmacodynamic marker of anti-EGFR antibody activity in colorectal cancer.

Krystal GW, Alesi E, Tatum JL.

Mol Cancer Ther. 2012 Jul;11(7):1385-8. doi: 10.1158/1535-7163.MCT-12-0011. Epub 2012 May 4.

PMID:
22562987
Free Article

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6.

Teaching an old drug new tricks: Actinomycin D synergistically enhances sensitivity to the Bcl-2 antagonist ABT-737.

Krystal GW.

Cancer Biol Ther. 2010 Nov 1;10(9):930-2. Epub 2010 Nov 1. No abstract available.

PMID:
20935462

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7.

Actinomycin D decreases Mcl-1 expression and acts synergistically with ABT-737 against small cell lung cancer cell lines.

Xu H, Krystal GW.

Clin Cancer Res. 2010 Sep 1;16(17):4392-400. doi: 10.1158/1078-0432.CCR-10-0640. Epub 2010 Aug 23.

PMID:
20732961
Free Article

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8.

Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737.

Hauck P, Chao BH, Litz J, Krystal GW.

Mol Cancer Ther. 2009 Apr;8(4):883-92. doi: 10.1158/1535-7163.MCT-08-1118.

PMID:
19372561
Free Article

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9.

Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt.

Yeh J, Litz J, Hauck P, Ludwig DL, Krystal GW.

Lung Cancer. 2008 May;60(2):166-74. Epub 2007 Nov 14.

PMID:
18006183

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10.

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G.

Nat Chem Biol. 2007 Aug;3(8):498-507. Epub 2007 Jul 1.

PMID:
17603540

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11.

Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells.

Litz J, Krystal GW.

Mol Cancer Ther. 2006 Jun;5(6):1415-22.

PMID:
16818499
Free Article

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12.

Receptor tyrosine kinase mutations: molecular indicators for therapeutic response or signposts marking important signaling pathways?

Krystal GW.

Cancer Biol Ther. 2005 Dec;4(12):1417-8. Epub 2005 Dec 29. No abstract available.

PMID:
16322688

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13.

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.

Dent P, Han SI, Mitchell C, Studer E, Yacoub A, Grandis J, Grant S, Krystal GW, Hylemon PB.

Biochem Pharmacol. 2005 Nov 25;70(11):1685-96. Epub 2005 Oct 3.

PMID:
16207485

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14.

The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy.

Warshamana-Greene GS, Litz J, Buchdunger E, García-Echeverría C, Hofmann F, Krystal GW.

Clin Cancer Res. 2005 Feb 15;11(4):1563-71.

PMID:
15746061
Free Article

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15.

The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression.

Litz J, Sakuntala Warshamana-Greene G, Sulanke G, Lipson KE, Krystal GW.

Lung Cancer. 2004 Dec;46(3):283-91.

PMID:
15541812

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16.

The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling.

Warshamana-Greene GS, Litz J, Buchdunger E, Hofmann F, García-Echeverría C, Krystal GW.

Mol Cancer Ther. 2004 May;3(5):527-35.

PMID:
15141010
Free Article

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17.

Imatinib mesylate (STI571) for myeloid malignancies other than CML.

Krystal GW.

Leuk Res. 2004 May;28 Suppl 1:S53-9. Review.

PMID:
15036942

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18.

Role of small-molecule kit receptor tyrosine kinase inhibitors in the treatment of small-cell lung cancer.

Lloyd KP, Krystal GW.

Clin Lung Cancer. 2002 Feb;3(3):213-8.

PMID:
14662046

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19.

Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.

Litz J, Carlson P, Warshamana-Greene GS, Grant S, Krystal GW.

Clin Cancer Res. 2003 Oct 1;9(12):4586-94.

PMID:
14555534
Free Article

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20.

Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy.

Krystal GW, Sulanke G, Litz J.

Mol Cancer Ther. 2002 Sep;1(11):913-22.

PMID:
12481412
Free Article

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21.

Secretion of a unique peptide from interleukin-2-stimulated natural killer cells that induces endomitosis in immature human megakaryocytes.

Angchaisuksiri P, Grigus SR, Carlson PL, Krystal GW, Dessypris EN.

Blood. 2002 Jan 1;99(1):130-6.

PMID:
11756162
Free Article

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22.

Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents.

Krystal GW.

Drug Resist Updat. 2001 Feb;4(1):16-21. Review.

PMID:
11512148

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23.

Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.

Krystal GW, Honsawek S, Kiewlich D, Liang C, Vasile S, Sun L, McMahon G, Lipson KE.

Cancer Res. 2001 May 1;61(9):3660-8.

PMID:
11325836
Free Article

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24.

A novel assay for the measurement of Raf-1 kinase activity.

Bondzi C, Grant S, Krystal GW.

Oncogene. 2000 Oct 12;19(43):5030-3.

PMID:
11042690
Free Article

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25.

The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.

Krystal GW, Honsawek S, Litz J, Buchdunger E.

Clin Cancer Res. 2000 Aug;6(8):3319-26.

PMID:
10955819
Free Article

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26.

Src family kinase activity is required for Kit-mediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells.

Bondzi C, Litz J, Dent P, Krystal GW.

Cell Growth Differ. 2000 Jun;11(6):305-14.

PMID:
10910097
Free Article

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27.

Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors.

Hines SJ, Litz JS, Krystal GW.

Breast Cancer Res Treat. 1999 Nov;58(1):1-10.

PMID:
10634512

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28.

Activating c-kit gene mutations in human germ cell tumors.

Tian Q, Frierson HF Jr, Krystal GW, Moskaluk CA.

Am J Pathol. 1999 Jun;154(6):1643-7.

PMID:
10362788
Free PMC Article

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29.

Selective Sp1 binding is critical for maximal activity of the human c-kit promoter.

Park GH, Plummer HK 3rd, Krystal GW.

Blood. 1998 Dec 1;92(11):4138-49.

PMID:
9834219
Free Article

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30.

Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1.

Krystal GW, DeBerry CS, Linnekin D, Litz J.

Cancer Res. 1998 Oct 15;58(20):4660-6.

PMID:
9788619
Free Article

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31.

Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins.

Krystal GW, Carlson P, Litz J.

Cancer Res. 1997 Jun 1;57(11):2203-8.

PMID:
9187122
Free Article

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32.

Identification of novel human tumor cell-specific CaMK-II variants.

Tombes RM, Krystal GW.

Biochim Biophys Acta. 1997 Mar 1;1355(3):281-92.

PMID:
9060999
Free Article

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33.

Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor.

Krystal GW, Hines SJ, Organ CP.

Cancer Res. 1996 Jan 15;56(2):370-6.

PMID:
8542594
Free Article

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34.

Coexpression of the c-kit and stem cell factor genes in breast carcinomas.

Hines SJ, Organ C, Kornstein MJ, Krystal GW.

Cell Growth Differ. 1995 Jun;6(6):769-79.

PMID:
7545433
Free Article

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35.

Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.

Armstrong BC, Krystal GW.

Cell Growth Differ. 1992 Jun;3(6):385-90.

PMID:
1419902
Free Article

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36.

N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.

Krystal GW, Armstrong BC, Battey JF.

Mol Cell Biol. 1990 Aug;10(8):4180-91.

PMID:
1695323
Free PMC Article

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37.

Phosphorylation of cleavage stage histone H1 in mitotic and prematurely condensed chromosomes.

Krystal GW, Poccia DL.

Exp Cell Res. 1981 Jul;134(1):41-8. No abstract available.

PMID:
6265251

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38.

Control of chromosome condensation in the sea urchin egg.

Krystal GW, Poccia D.

Exp Cell Res. 1979 Oct 15;123(2):207-19. No abstract available.

PMID:
574089

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