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Items: 1 to 50 of 238

1.

Single cell transcriptome analysis reveals disease-defining T cell subsets in the tumor microenvironment of classic Hodgkin lymphoma.

Aoki T, Chong LC, Takata K, Milne K, Hav M, Colombo A, Chavez EA, Nissen M, Wang X, Miyata-Takata T, Lam V, Vigano E, Woolcock BW, Telenius A, Li MY, Healy S, Ghesquiere C, Kos D, Goodyear T, Veldman J, Zhang AW, Kim J, Saberi S, Ding J, Farinha P, Weng AP, Savage KJ, Scott DW, Krystal G, Nelson BH, Mottok A, Merchant A, Shah SP, Steidl C.

Cancer Discov. 2019 Dec 19. pii: CD-19-0680. doi: 10.1158/2159-8290.CD-19-0680. [Epub ahead of print]

PMID:
31857391
2.

Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors.

Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K.

J Immunother Cancer. 2019 Jul 10;7(1):172. doi: 10.1186/s40425-019-0643-8.

3.

UV Light-inactivated HSV-1 Stimulates Natural Killer Cell-induced Killing of Prostate Cancer Cells.

Samudio I, Hofs E, Cho B, Li M, Bolduc K, Bu L, Liu G, Lam V, Rennie P, Jia W, Elisia I, Krystal G.

J Immunother. 2019 Jun;42(5):162-174. doi: 10.1097/CJI.0000000000000261.

PMID:
30933043
4.

The effect of diet and exercise on tobacco carcinogen-induced lung cancer.

Elisia I, Cho B, Hay M, Li MY, Hofs E, Lam V, Dyer RA, Lum J, Krystal G.

Carcinogenesis. 2019 May 14;40(3):448-460. doi: 10.1093/carcin/bgz060.

PMID:
30874285
5.

Effect of age on chronic inflammation and responsiveness to bacterial and viral challenges.

Elisia I, Lam V, Hofs E, Li MY, Hay M, Cho B, Brooks-Wilson A, Rosin M, Bu L, Jia W, Krystal G.

PLoS One. 2017 Nov 29;12(11):e0188881. doi: 10.1371/journal.pone.0188881. eCollection 2017.

6.

Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression.

Lochmann TL, Floros KV, Naseri M, Powell KM, Cook W, March RJ, Stein GT, Greninger P, Maves YK, Saunders LR, Dylla SJ, Costa C, Boikos SA, Leverson JD, Souers AJ, Krystal GW, Harada H, Benes CH, Faber AC.

Clin Cancer Res. 2018 Jan 15;24(2):360-369. doi: 10.1158/1078-0432.CCR-17-1606. Epub 2017 Nov 8.

7.

Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators.

Elisia I, Pae HB, Lam V, Cederberg R, Hofs E, Krystal G.

J Immunol Methods. 2018 Jan;452:26-31. doi: 10.1016/j.jim.2017.10.004. Epub 2017 Oct 16.

PMID:
29042255
8.

Auer Rods.

Gordon SW, Krystal GW.

N Engl J Med. 2017 May 25;376(21):2065. doi: 10.1056/NEJMicm1612344. No abstract available.

9.

All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages.

Ho VW, Hofs E, Elisia I, Lam V, Hsu BE, Lai J, Luk B, Samudio I, Krystal G.

PLoS One. 2016 Dec 15;11(12):e0168072. doi: 10.1371/journal.pone.0168072. eCollection 2016.

10.

Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport.

Velez J, Pan R, Lee JT, Enciso L, Suarez M, Duque JE, Jaramillo D, Lopez C, Morales L, Bornmann W, Konopleva M, Krystal G, Andreeff M, Samudio I.

Oncotarget. 2016 Aug 9;7(32):51435-51449. doi: 10.18632/oncotarget.9843.

11.

SHIP prevents metastasis.

Krystal G, Hamilton MJ, Bennewith KL.

Aging (Albany NY). 2016 May;8(5):837-8. doi: 10.18632/aging.100964. No abstract available.

12.

DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis.

Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, Hughes MR, Lee L, Jia W, Adomat HH, Guns ES, McNagny KM, Samudio I, Krystal G.

PLoS One. 2016 Mar 31;11(3):e0152538. doi: 10.1371/journal.pone.0152538. eCollection 2016.

13.

UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.

Samudio I, Rezvani K, Shaim H, Hofs E, Ngom M, Bu L, Liu G, Lee JT, Imren S, Lam V, Poon GF, Ghaedi M, Takei F, Humphries K, Jia W, Krystal G.

Blood. 2016 May 26;127(21):2575-86. doi: 10.1182/blood-2015-04-639088. Epub 2016 Mar 3.

14.

SHIP represses lung inflammation and inhibits mammary tumor metastasis in BALB/c mice.

Hamilton MJ, Halvorsen EC, LePard NE, Bosiljcic M, Ho VW, Lam V, Banáth J, Bennewith KL, Krystal G.

Oncotarget. 2016 Jan 26;7(4):3677-91. doi: 10.18632/oncotarget.6611.

15.

Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer.

Nakajima W, Sharma K, Hicks MA, Le N, Brown R, Krystal GW, Harada H.

Cancer Biol Ther. 2016;17(1):27-35. doi: 10.1080/15384047.2015.1108485.

16.

Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo.

Sharon C, Baranwal S, Patel NJ, Rodriguez-Agudo D, Pandak WM, Majumdar AP, Krystal G, Patel BB.

Oncotarget. 2015 Jun 20;6(17):15332-47.

17.

A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice.

Fokidis HB, Yieng Chin M, Ho VW, Adomat HH, Soma KK, Fazli L, Nip KM, Cox M, Krystal G, Zoubeidi A, Tomlinson Guns ES.

J Steroid Biochem Mol Biol. 2015 Jun;150:35-45. doi: 10.1016/j.jsbmb.2015.03.006. Epub 2015 Mar 19.

PMID:
25797030
18.

A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis.

Ho VW, Hamilton MJ, Dang NH, Hsu BE, Adomat HH, Guns ES, Weljie A, Samudio I, Bennewith KL, Krystal G.

Carcinogenesis. 2014 Oct;35(10):2291-9. doi: 10.1093/carcin/bgu147. Epub 2014 Jul 14.

19.

Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer.

Nakajima W, Hicks MA, Tanaka N, Krystal GW, Harada H.

Cell Death Dis. 2014 Feb 13;5:e1052. doi: 10.1038/cddis.2014.6.

20.

Macrophages are more potent immune suppressors ex vivo than immature myeloid-derived suppressor cells induced by metastatic murine mammary carcinomas.

Hamilton MJ, Bosiljcic M, Lepard NE, Halvorsen EC, Ho VW, Banáth JP, Krystal G, Bennewith KL.

J Immunol. 2014 Jan 1;192(1):512-22. doi: 10.4049/jimmunol.1300096. Epub 2013 Nov 27.

21.

Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.

Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, Makrigiannis AP.

J Immunol. 2013 Apr 15;190(8):3994-4004. doi: 10.4049/jimmunol.1200873. Epub 2013 Mar 11.

22.

Early FDG/PET scanning as a pharmacodynamic marker of anti-EGFR antibody activity in colorectal cancer.

Krystal GW, Alesi E, Tatum JL.

Mol Cancer Ther. 2012 Jul;11(7):1385-8. doi: 10.1158/1535-7163.MCT-12-0011. Epub 2012 May 4.

23.

The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells.

Ruschmann J, Antignano F, Lam V, Snyder K, Kim C, Essak M, Zhang A, Lin AH, Mali RS, Kapur R, Krystal G.

J Immunol. 2012 Apr 15;188(8):3839-50. doi: 10.4049/jimmunol.1003875. Epub 2012 Mar 19.

24.

Serum inhibits the immunosuppressive function of myeloid-derived suppressor cells isolated from 4T1 tumor-bearing mice.

Hamilton MJ, Banáth JP, Lam V, Lepard NE, Krystal G, Bennewith KL.

Cancer Immunol Immunother. 2012 May;61(5):643-54. doi: 10.1007/s00262-011-1125-0. Epub 2011 Oct 22.

PMID:
22021068
25.

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.

Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan RJ, Krystal G, Craig AW, Takemoto C, Kapur R.

Blood. 2011 Sep 29;118(13):3459-69. doi: 10.1182/blood-2011-04-351809. Epub 2011 Jul 25.

26.

SHIP-deficient dendritic cells, unlike wild type dendritic cells, suppress T cell proliferation via a nitric oxide-independent mechanism.

Antignano F, Hamilton M, Patterson S, Ho V, Cohen C, Levings MK, Krystal G.

PLoS One. 2011;6(7):e21893. doi: 10.1371/journal.pone.0021893. Epub 2011 Jul 6.

27.

Myeloid suppressor cells regulate the lung environment--letter.

Bosiljcic M, Hamilton MJ, Banath JP, Lepard NE, McDougal DC, Jia JX, Krystal G, Bennewith KL.

Cancer Res. 2011 Jul 15;71(14):5050-1; author reply 5052-3. doi: 10.1158/0008-5472.CAN-10-3982. Epub 2011 Jul 12.

28.

CIN85 interacting proteins in B cells-specific role for SHIP-1.

Büchse T, Horras N, Lenfert E, Krystal G, Körbel S, Schümann M, Krause E, Mikkat S, Tiedge M.

Mol Cell Proteomics. 2011 Oct;10(10):M110.006239. doi: 10.1074/mcp.M110.006239. Epub 2011 Jul 1.

29.

A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation.

Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, Minchinton AI, Waterhouse D, Bally MB, Lin W, Nelson BH, Sly LM, Krystal G.

Cancer Res. 2011 Jul 1;71(13):4484-93. doi: 10.1158/0008-5472.CAN-10-3973. Epub 2011 Jun 14.

30.

MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4.

Cekic C, Casella CR, Sag D, Antignano F, Kolb J, Suttles J, Hughes MR, Krystal G, Mitchell TC.

J Immunol. 2011 Apr 1;186(7):3858-65. doi: 10.4049/jimmunol.1001034. Epub 2011 Feb 21.

31.

Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells.

Hochdörfer T, Kuhny M, Zorn CN, Hendriks RW, Vanhaesebroeck B, Bohnacker T, Krystal G, Huber M.

Cell Signal. 2011 May;23(5):866-75. doi: 10.1016/j.cellsig.2011.01.012. Epub 2011 Jan 22.

PMID:
21262348
32.

SHIP represses Th2 skewing by inhibiting IL-4 production from basophils.

Kuroda E, Antignano F, Ho VW, Hughes MR, Ruschmann J, Lam V, Kawakami T, Kerr WG, McNagny KM, Sly LM, Krystal G.

J Immunol. 2011 Jan 1;186(1):323-32. doi: 10.4049/jimmunol.1002778. Epub 2010 Dec 3.

33.

Role of SHIP in cancer.

Hamilton MJ, Ho VW, Kuroda E, Ruschmann J, Antignano F, Lam V, Krystal G.

Exp Hematol. 2011 Jan;39(1):2-13. doi: 10.1016/j.exphem.2010.11.002. Epub 2010 Nov 4. Review.

PMID:
21056081
34.

Teaching an old drug new tricks: Actinomycin D synergistically enhances sensitivity to the Bcl-2 antagonist ABT-737.

Krystal GW.

Cancer Biol Ther. 2010 Nov 1;10(9):930-2. Epub 2010 Nov 1. No abstract available.

PMID:
20935462
35.

TLR agonists that induce IFN-beta abrogate resident macrophage suppression of T cells.

Hamilton MJ, Antignano F, von Rossum A, Boucher JL, Bennewith KL, Krystal G.

J Immunol. 2010 Oct 15;185(8):4545-53. doi: 10.4049/jimmunol.1002045. Epub 2010 Sep 15.

36.

Actinomycin D decreases Mcl-1 expression and acts synergistically with ABT-737 against small cell lung cancer cell lines.

Xu H, Krystal GW.

Clin Cancer Res. 2010 Sep 1;16(17):4392-400. doi: 10.1158/1078-0432.CCR-10-0640. Epub 2010 Aug 23.

37.

SHIP negatively regulates Flt3L-derived dendritic cell generation and positively regulates MyD88-independent TLR-induced maturation.

Antignano F, Ibaraki M, Ruschmann J, Jagdeo J, Krystal G.

J Leukoc Biol. 2010 Nov;88(5):925-35. doi: 10.1189/jlb.1209825. Epub 2010 Aug 18.

PMID:
20720161
38.

Comprehensive microRNA expression profiling of the hematopoietic hierarchy.

Petriv OI, Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D, Marmolejo L, Heuser M, Berg T, Copley M, Ruschmann J, Sekulovic S, Benz C, Kuroda E, Ho V, Antignano F, Halim T, Giambra V, Krystal G, Takei CJ, Weng AP, Piret J, Eaves C, Marra MA, Humphries RK, Hansen CL.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15443-8. doi: 10.1073/pnas.1009320107. Epub 2010 Aug 11.

39.

Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.

Ruschmann J, Ho V, Antignano F, Kuroda E, Lam V, Ibaraki M, Snyder K, Kim C, Flavell RA, Kawakami T, Sly L, Turhan AG, Krystal G.

Exp Hematol. 2010 May;38(5):392-402, 402.e1. doi: 10.1016/j.exphem.2010.03.010. Epub 2010 Mar 18.

PMID:
20304029
40.

SHIP is required for dendritic cell maturation.

Antignano F, Ibaraki M, Kim C, Ruschmann J, Zhang A, Helgason CD, Krystal G.

J Immunol. 2010 Mar 15;184(6):2805-13. doi: 10.4049/jimmunol.0903170. Epub 2010 Feb 12.

41.

Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-beta production.

Gabhann JN, Higgs R, Brennan K, Thomas W, Damen JE, Ben Larbi N, Krystal G, Jefferies CA.

J Immunol. 2010 Mar 1;184(5):2314-20. doi: 10.4049/jimmunol.0902589. Epub 2010 Jan 25.

42.

SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils.

Kuroda E, Ho V, Ruschmann J, Antignano F, Hamilton M, Rauh MJ, Antov A, Flavell RA, Sly LM, Krystal G.

J Immunol. 2009 Sep 15;183(6):3652-60. doi: 10.4049/jimmunol.0900864. Epub 2009 Aug 26.

43.

Activation of SHIP via a small molecule agonist kills multiple myeloma cells.

Kennah M, Yau TY, Nodwell M, Krystal G, Andersen RJ, Ong CJ, Mui AL.

Exp Hematol. 2009 Nov;37(11):1274-83. doi: 10.1016/j.exphem.2009.08.001. Epub 2009 Aug 22.

PMID:
19703514
44.

Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.

Heuser M, Sly LM, Argiropoulos B, Kuchenbauer F, Lai C, Weng A, Leung M, Lin G, Brookes C, Fung S, Valk PJ, Delwel R, Löwenberg B, Krystal G, Humphries RK.

Blood. 2009 Nov 5;114(19):3983-93. doi: 10.1182/blood-2009-06-227603. Epub 2009 Aug 10.

PMID:
19667399
45.

SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo.

Haddon DJ, Antignano F, Hughes MR, Blanchet MR, Zbytnuik L, Krystal G, McNagny KM.

J Immunol. 2009 Jul 1;183(1):228-36. doi: 10.4049/jimmunol.0900427.

46.

SHIP regulates the reciprocal development of T regulatory and Th17 cells.

Locke NR, Patterson SJ, Hamilton MJ, Sly LM, Krystal G, Levings MK.

J Immunol. 2009 Jul 15;183(2):975-83. doi: 10.4049/jimmunol.0803749. Epub 2009 Jun 19.

47.

Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta.

Fehrenbach K, Lessmann E, Zorn CN, Kuhny M, Grochowy G, Krystal G, Leitges M, Huber M.

J Immunol. 2009 Jun 15;182(12):7897-905. doi: 10.4049/jimmunol.0801773.

48.

Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737.

Hauck P, Chao BH, Litz J, Krystal GW.

Mol Cancer Ther. 2009 Apr;8(4):883-92. doi: 10.1158/1535-7163.MCT-08-1118.

49.

SHIP prevents lipopolysaccharide from triggering an antiviral response in mice.

Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G.

Blood. 2009 Mar 26;113(13):2945-54. doi: 10.1182/blood-2008-06-166082. Epub 2009 Jan 12.

50.

IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species.

Sly LM, Kalesnikoff J, Lam V, Wong D, Song C, Omeis S, Chan K, Lee CW, Siraganian RP, Rivera J, Krystal G.

J Immunol. 2008 Sep 15;181(6):3850-60.

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