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Items: 1 to 50 of 198


A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.

Krystal AD, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J Jr, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Calabrese JR, Sanacora G, Hermes G, Keefe RSE, Song A, Goodman W, Szabo ST, Whitton AE, Gao K, Potter WZ.

Nat Med. 2020 Mar 30. doi: 10.1038/s41591-020-0806-7. [Epub ahead of print]


Efficacy of Digital Cognitive Behavioral Therapy for the Treatment of Insomnia Symptoms Among Pregnant Women: A Randomized Clinical Trial.

Felder JN, Epel ES, Neuhaus J, Krystal AD, Prather AA.

JAMA Psychiatry. 2020 Jan 22. doi: 10.1001/jamapsychiatry.2019.4491. [Epub ahead of print]


Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.

McCall WV, Benca RM, Rosenquist PB, Youssef NA, McCloud L, Newman JC, Case D, Rumble ME, Szabo ST, Phillips M, Krystal AD.

Am J Psychiatry. 2019 Nov 1;176(11):957-965. doi: 10.1176/appi.ajp.2019.19030267. Epub 2019 Sep 20.


The assessment and management of insomnia: an update.

Krystal AD, Prather AA, Ashbrook LH.

World Psychiatry. 2019 Oct;18(3):337-352. doi: 10.1002/wps.20674.


A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors.

Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptáček LJ, Fu YH.

Neuron. 2019 Sep 25;103(6):1044-1055.e7. doi: 10.1016/j.neuron.2019.07.026. Epub 2019 Aug 28.


Genetics of the human circadian clock and sleep homeostat.

Ashbrook LH, Krystal AD, Fu YH, Ptáček LJ.

Neuropsychopharmacology. 2020 Jan;45(1):45-54. doi: 10.1038/s41386-019-0476-7. Epub 2019 Aug 10. Review.


Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.

Scangos KW, Ahmad HS, Shafi A, Sellers KK, Dawes HE, Krystal A, Chang EF.

J Neuropsychiatry Clin Neurosci. 2019 Aug 9:appineuropsych19030081. doi: 10.1176/appi.neuropsych.19030081. [Epub ahead of print]


Sleep therapeutics and neuropsychiatric illness.

Krystal AD.

Neuropsychopharmacology. 2020 Jan;45(1):166-175. doi: 10.1038/s41386-019-0474-9. Epub 2019 Aug 3. Review.


Sleep Pharmacogenetics: The Promise of Precision Medicine.

Krystal AD, Prather AA.

Sleep Med Clin. 2019 Sep;14(3):317-331. doi: 10.1016/j.jsmc.2019.05.003. Epub 2019 Jun 14. Review.


British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.

Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A.

J Psychopharmacol. 2019 Aug;33(8):923-947. doi: 10.1177/0269881119855343. Epub 2019 Jul 4.


Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder.

McCall WV, Benca RM, Rumble ME, Case D, Rosenquist PB, Krystal AD.

J Psychiatr Res. 2019 Sep;116:147-150. doi: 10.1016/j.jpsychires.2019.06.015. Epub 2019 Jun 19.


Circadian Preference as a Moderator of Depression Outcome Following Cognitive Behavioral Therapy for Insomnia Plus Antidepressant Medications: A Report From the TRIAD Study.

Asarnow LD, Bei B, Krystal A, Buysse DJ, Thase ME, Edinger JD, Manber R.

J Clin Sleep Med. 2019 Apr 15;15(4):573-580. doi: 10.5664/jcsm.7716.


Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers.

La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E.

J Alzheimers Dis. 2019;67(3):911-921. doi: 10.3233/JAD-181145.


The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.

Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J Jr, Szabo S, Murrough J, Shekhar A, Potter W.

Nat Rev Drug Discov. 2018 Dec 28;18(1):82-84. doi: 10.1038/nrd.2018.222. No abstract available.


An Electrophysiological Biomarker That May Predict Treatment Response to ECT.

Scangos KW, Weiner RD, Coffey EC, Krystal AD.

J ECT. 2019 Jun;35(2):95-102. doi: 10.1097/YCT.0000000000000557.


Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families.

Ohayon MM, Black J, Krystal AD, Shapiro CM, Swick TJ, Bogan R, Wells CC.

Sleep Med. 2019 Jan;53:88-93. doi: 10.1016/j.sleep.2018.06.015. Epub 2018 Jul 6.


An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome.

Beppler EC, Dieffenderfer J, Songkakul T, Krystal A, Bozkurt A.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:2877-2880. doi: 10.1109/EMBC.2018.8513038.


Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications.

Herring WJ, Roth T, Krystal AD, Michelson D.

J Sleep Res. 2019 Apr;28(2):e12782. doi: 10.1111/jsr.12782. Epub 2018 Oct 18. Review.


Screening extremely obese pregnant women for obstructive sleep apnea.

Dominguez JE, Grotegut CA, Cooter M, Krystal AD, Habib AS.

Am J Obstet Gynecol. 2018 Dec;219(6):613.e1-613.e10. doi: 10.1016/j.ajog.2018.09.001. Epub 2018 Sep 11.


Effect of γ-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy.

Szabo ST, Kandra K, Krystal AD.

Int J Clin Pharmacol Ther. 2018 Dec;56(12):620-622. doi: 10.5414/CP202661. No abstract available.


A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease.

Dominguez JE, Habib AS, Krystal AD.

Sleep Med Rev. 2018 Dec;42:37-46. doi: 10.1016/j.smrv.2018.05.004. Epub 2018 May 28. Review.


Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management.

Dominguez JE, Krystal AD, Habib AS.

Anesth Analg. 2018 Nov;127(5):1167-1177. doi: 10.1213/ANE.0000000000003335. Review.


Dr McClintock and Colleagues Reply.

McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson S, Morales O, Nelson BG, George MS, Lisanby SH.

J Clin Psychiatry. 2018 Jan/Feb;79(1). pii: 17lr11851a. doi: 10.4088/JCP.17lr11851a. No abstract available.


Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories.

Bei B, Asarnow LD, Krystal A, Edinger JD, Buysse DJ, Manber R.

J Consult Clin Psychol. 2018 Mar;86(3):282-293. doi: 10.1037/ccp0000282.


The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review.

Rumble ME, Dickson D, McCall WV, Krystal AD, Case D, Rosenquist PB, Benca RM.

J Affect Disord. 2018 Feb;227:721-730. doi: 10.1016/j.jad.2017.11.078. Epub 2017 Nov 14. Review.


Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation?

Goucher Miranda H, Krystal AD, Fierro MA.

Anesthesiology. 2017 Aug;127(2):397-398. doi: 10.1097/ALN.0000000000001721. No abstract available.


Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium.

Evans JL, Nadler JW, Preud'homme XA, Fang E, Daughtry RL, Chapman JB, Attarian D, Wellman S, Krystal AD.

Clin Neurophysiol. 2017 Aug;128(8):1421-1425. doi: 10.1016/j.clinph.2017.05.004. Epub 2017 May 17.


Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder.

Connor KM, Ceesay P, Hutzelmann J, Snavely D, Krystal AD, Trivedi MH, Thase M, Lines C, Herring WJ, Michelson D.

Int J Neuropsychopharmacol. 2017 Aug 1;20(8):613-618. doi: 10.1093/ijnp/pyx033.


Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression.

McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal AD, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH; National Network of Depression Centers rTMS Task Group; American Psychiatric Association Council on Research Task Force on Novel Biomarkers and Treatments.

J Clin Psychiatry. 2018 Jan/Feb;79(1). pii: 16cs10905. doi: 10.4088/JCP.16cs10905.


Adverse Effects of Hypnotic Medications.

Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN.

J Clin Sleep Med. 2017 Jun 15;13(6):839. doi: 10.5664/jcsm.6634. No abstract available.


Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.

Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D.

Am J Geriatr Psychiatry. 2017 Jul;25(7):791-802. doi: 10.1016/j.jagp.2017.03.004. Epub 2017 Mar 8.


National Sleep Foundation's sleep quality recommendations: first report.

Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV.

Sleep Health. 2017 Feb;3(1):6-19. doi: 10.1016/j.sleh.2016.11.006. Epub 2016 Dec 23.


Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data.

Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D.

Psychopharmacology (Berl). 2017 Jun;234(11):1703-1711. doi: 10.1007/s00213-017-4573-1. Epub 2017 Mar 7.


A randomised trial of peri-operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty.

Nadler JW, Evans JL, Fang E, Preud'Homme XA, Daughtry RL, Chapman JB, Bolognesi MP, Attarian DE, Wellman SS, Krystal AD.

Anaesthesia. 2017 Jun;72(6):729-736. doi: 10.1111/anae.13833. Epub 2017 Mar 2.


Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial.

Carney CE, Edinger JD, Kuchibhatla M, Lachowski AM, Bogouslavsky O, Krystal AD, Shapiro CM.

Sleep. 2017 Apr 1;40(4). doi: 10.1093/sleep/zsx019.


Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar.

Samson DR, Manus MB, Krystal AD, Fakir E, Yu JJ, Nunn CL.

Am J Hum Biol. 2017 Jul 8;29(4). doi: 10.1002/ajhb.22979. Epub 2017 Feb 9.


Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.

Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL.

J Clin Sleep Med. 2017 Feb 15;13(2):307-349. doi: 10.5664/jcsm.6470.


Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research.

Lunsford-Avery JR, Krystal AD, Kollins SH.

Clin Psychol Rev. 2016 Dec;50:159-174. doi: 10.1016/j.cpr.2016.10.004. Epub 2016 Oct 23. Review.


Sleep and Mood: Chicken or Egg?

Ptáǒek LJ, Fu YH, Krystal AD.

Biol Psychiatry. 2016 Dec 1;80(11):810-811. doi: 10.1016/j.biopsych.2016.09.012. No abstract available.


Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi.

Krystal AD, Prather AA.

JAMA Psychiatry. 2017 Jan 1;74(1):15-16. doi: 10.1001/jamapsychiatry.2016.3431. No abstract available.


Hibernation in a primate: does sleep occur?

Blanco MB, Dausmann KH, Faherty SL, Klopfer P, Krystal AD, Schopler R, Yoder AD.

R Soc Open Sci. 2016 Aug 10;3(8):160282. eCollection 2016 Aug.


Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study.

Krystal AD, Mittoux A, Meisels P, Baker RA.

Prim Care Companion CNS Disord. 2016 Sep 8;18(5). doi: 10.4088/PCC.15m01914.


Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial.

Manber R, Buysse DJ, Edinger J, Krystal A, Luther JF, Wisniewski SR, Trockel M, Kraemer HC, Thase ME.

J Clin Psychiatry. 2016 Oct;77(10):e1316-e1323. doi: 10.4088/JCP.15m10244.


Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study.

Edinger JD, Manber R, Buysse DJ, Krystal AD, Thase ME, Gehrman P, Fairholme CP, Luther J, Wisniewski S.

J Clin Sleep Med. 2017 Feb 15;13(2):205-213. doi: 10.5664/jcsm.6448.


Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.

Jacobsen JPR, Krystal AD, Krishnan KRR, Caron MG.

Trends Pharmacol Sci. 2016 Nov;37(11):933-944. doi: 10.1016/ Epub 2016 Sep 28. Review.


Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.

Carlezon WA Jr, Krystal AD.

Depress Anxiety. 2016 Oct;33(10):895-906. doi: 10.1002/da.22500. Review.


Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA.

McCall WV, Benca RM, Rosenquist PB, Riley MA, McCloud L, Newman JC, Case D, Rumble M, Krystal AD.

Am J Psychiatry. 2017 Jan 1;174(1):18-25. doi: 10.1176/appi.ajp.2016.16030336. Epub 2016 Sep 9. Review.


Shining evolutionary light on human sleep and sleep disorders.

Nunn CL, Samson DR, Krystal AD.

Evol Med Public Health. 2016 Aug 3;2016(1):227-43. doi: 10.1093/emph/eow018. Print 2016. Review.

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