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Candida auris: The Canary in the Mine of Antifungal Drug Resistance.

Montoya MC, Moye-Rowley WS, Krysan DJ.

ACS Infect Dis. 2019 Sep 13;5(9):1487-1492. doi: 10.1021/acsinfecdis.9b00239. Epub 2019 Aug 1.


Host Carbon Dioxide Concentration Is an Independent Stress for Cryptococcus neoformans That Affects Virulence and Antifungal Susceptibility.

Krysan DJ, Zhai B, Beattie SR, Misel KM, Wellington M, Lin X.

MBio. 2019 Jul 2;10(4). pii: e01410-19. doi: 10.1128/mBio.01410-19.


Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE.

Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w.


Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease.

Montoya MC, Krysan DJ.

MBio. 2018 Dec 18;9(6). pii: e02272-18. doi: 10.1128/mBio.02272-18. Review.


Candida-streptococcal interactions in biofilm-associated oral diseases.

Koo H, Andes DR, Krysan DJ.

PLoS Pathog. 2018 Dec 13;14(12):e1007342. doi: 10.1371/journal.ppat.1007342. eCollection 2018 Dec. Review. No abstract available.


A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis.

Koselny K, Mutlu N, Minard AY, Kumar A, Krysan DJ, Wellington M.

MBio. 2018 Jul 31;9(4). pii: e01204-18. doi: 10.1128/mBio.01204-18.


Systematic Complex Haploinsufficiency-Based Genetic Analysis of Candida albicans Transcription Factors: Tools and Applications to Virulence-Associated Phenotypes.

Glazier VE, Murante T, Koselny K, Murante D, Esqueda M, Wall GA, Wellington M, Hung CY, Kumar A, Krysan DJ.

G3 (Bethesda). 2018 Mar 28;8(4):1299-1314. doi: 10.1534/g3.117.300515.


Transcription factor network efficiency in the regulation of Candida albicans biofilms: it is a small world.

Glazier VE, Krysan DJ.

Curr Genet. 2018 Aug;64(4):883-888. doi: 10.1007/s00294-018-0804-1. Epub 2018 Jan 9.


Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity.

Montoya MC, DiDone L, Heier RF, Meyers MJ, Krysan DJ.

ACS Infect Dis. 2018 Apr 13;4(4):499-507. doi: 10.1021/acsinfecdis.7b00157. Epub 2017 Nov 2.


The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.

Xie JL, Qin L, Miao Z, Grys BT, Diaz JC, Ting K, Krieger JR, Tong J, Tan K, Leach MD, Ketela T, Moran MF, Krysan DJ, Boone C, Andrews BJ, Selmecki A, Ho Wong K, Robbins N, Cowen LE.

Nat Commun. 2017 Sep 11;8(1):499. doi: 10.1038/s41467-017-00547-y.


Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency.

Glazier VE, Murante T, Murante D, Koselny K, Liu Y, Kim D, Koo H, Krysan DJ.

PLoS Genet. 2017 Aug 9;13(8):e1006948. doi: 10.1371/journal.pgen.1006948. eCollection 2017 Aug.


Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo.

Hwang G, Liu Y, Kim D, Li Y, Krysan DJ, Koo H.

PLoS Pathog. 2017 Jun 15;13(6):e1006407. doi: 10.1371/journal.ppat.1006407. eCollection 2017 Jun.


The unmet clinical need of novel antifungal drugs.

Krysan DJ.

Virulence. 2017 Feb 17;8(2):135-137. doi: 10.1080/21505594.2016.1276692. No abstract available.


The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.

Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7115-7127. Print 2016 Dec.


Challenges in the development of novel anticryptococcal agents.

Krysan DJ.

Future Med Chem. 2016 Aug;8(12):1375-7. doi: 10.4155/fmc-2016-0123. Epub 2016 Aug 3. No abstract available.


Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans.

Saputo S, Norman KL, Murante T, Horton BN, Diaz Jde L, DiDone L, Colquhoun J, Schroeder JW, Simmons LA, Kumar A, Krysan DJ.

Genetics. 2016 Jul;203(3):1217-33. doi: 10.1534/genetics.116.188029. Epub 2016 May 20.


Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.

Koselny K, Green J, Favazzo L, Glazier VE, DiDone L, Ransford S, Krysan DJ.

ACS Infect Dis. 2016 Apr 8;2(4):268-280. Epub 2016 Feb 23.


High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.

Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ.

ACS Infect Dis. 2016 Jan 8;2(1):93-102. Epub 2015 Nov 6.


A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.

Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ.

PLoS One. 2015 Jun 22;10(6):e0129234. doi: 10.1371/journal.pone.0129234. eCollection 2015.


Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen.

Butts A, Martin JA, DiDone L, Bradley EK, Mutz M, Krysan DJ.

PLoS One. 2015 May 27;10(5):e0125927. doi: 10.1371/journal.pone.0125927. eCollection 2015.


Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs.

Krysan DJ.

Fungal Genet Biol. 2015 May;78:93-8. doi: 10.1016/j.fgb.2014.12.001. Epub 2014 Dec 13. Review.


Unraveling the biology of a fungal meningitis pathogen using chemical genetics.

Brown JCS, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD.

Cell. 2014 Nov 20;159(5):1168-1187. doi: 10.1016/j.cell.2014.10.044.


Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.

Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP.

J Med Chem. 2014 Oct 23;57(20):8540-62. doi: 10.1021/jm5010682. Epub 2014 Oct 6.


Voriconazole Therapeutic Drug Monitoring.

Hoy Z, Dodds Ashley ES, Weinberg GA, Krysan DJ.

J Pediatric Infect Dis Soc. 2014 Sep;3(3):270-1. doi: 10.1093/jpids/piu019. Epub 2014 Mar 30. No abstract available.


Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.

Saputo S, Kumar A, Krysan DJ.

Eukaryot Cell. 2014 Sep;13(9):1169-80. doi: 10.1128/EC.00148-14. Epub 2014 Jul 7.


Catching fire: Candida albicans, macrophages, and pyroptosis.

Krysan DJ, Sutterwala FS, Wellington M.

PLoS Pathog. 2014 Jun 26;10(6):e1004139. doi: 10.1371/journal.ppat.1004139. eCollection 2014 Jun. No abstract available.


Antifungal drug development: challenges, unmet clinical needs, and new approaches.

Roemer T, Krysan DJ.

Cold Spring Harb Perspect Med. 2014 May 1;4(5). pii: a019703. doi: 10.1101/cshperspect.a019703. Review.


Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo.

Falsetta ML, Klein MI, Colonne PM, Scott-Anne K, Gregoire S, Pai CH, Gonzalez-Begne M, Watson G, Krysan DJ, Bowen WH, Koo H.

Infect Immun. 2014 May;82(5):1968-81. doi: 10.1128/IAI.00087-14. Epub 2014 Feb 24.


Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.

Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE Jr, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ.

MBio. 2014 Feb 11;5(1):e00765-13. doi: 10.1128/mBio.00765-13.


Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.

Wellington M, Koselny K, Sutterwala FS, Krysan DJ.

Eukaryot Cell. 2014 Feb;13(2):329-40. doi: 10.1128/EC.00336-13. Epub 2013 Dec 27.


Candida albicans morphogenesis is not required for macrophage interleukin 1β production.

Wellington M, Koselny K, Krysan DJ.

MBio. 2012 Dec 26;4(1):e00433-12. doi: 10.1128/mBio.00433-12.


A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.

Butts A, DiDone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ.

Eukaryot Cell. 2013 Feb;12(2):278-87. doi: 10.1128/EC.00314-12. Epub 2012 Dec 14.


Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes.

Chabrier-Roselló Y, Gerik KJ, Koselny K, DiDone L, Lodge JK, Krysan DJ.

Eukaryot Cell. 2013 Jan;12(1):12-22. doi: 10.1128/EC.00235-12. Epub 2012 Oct 19.


Antifungal drug discovery: something old and something new.

Butts A, Krysan DJ.

PLoS Pathog. 2012 Sep;8(9):e1002870. doi: 10.1371/journal.ppat.1002870. Epub 2012 Sep 6. Review. No abstract available.


The RAM network in pathogenic fungi.

Saputo S, Chabrier-Rosello Y, Luca FC, Kumar A, Krysan DJ.

Eukaryot Cell. 2012 Jun;11(6):708-17. doi: 10.1128/EC.00044-12. Epub 2012 Apr 27. Review.


A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis.

Bharucha N, Chabrier-Rosello Y, Xu T, Johnson C, Sobczynski S, Song Q, Dobry CJ, Eckwahl MJ, Anderson CP, Benjamin AJ, Kumar A, Krysan DJ.

PLoS Genet. 2011 Apr;7(4):e1002058. doi: 10.1371/journal.pgen.1002058.


A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms.

DiDone L, Oga D, Krysan DJ.

Yeast. 2011 Aug;28(8):561-8. doi: 10.1002/yea.1860. Epub 2011 Jun 15.


Age and symptoms affect the prevalence of group A beta-hemolytic streptococcus in pharyngeal cultures of school-age children.

Kainth MK, Krysan DJ.

J Pediatr. 2011 Mar;158(3):515-6. doi: 10.1016/j.jpeds.2011.01.013. No abstract available.


Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.

Baxter BK, DiDone L, Ogu D, Schor S, Krysan DJ.

ACS Chem Biol. 2011 May 20;6(5):502-10. doi: 10.1021/cb100399x. Epub 2011 Feb 22.


A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis.

DiDone L, Scrimale T, Baxter BK, Krysan DJ.

Nat Protoc. 2010 Jun;5(6):1107-14. doi: 10.1038/nprot.2010.47. Epub 2010 May 27.


Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization.

Dolan K, Montgomery S, Buchheit B, Didone L, Wellington M, Krysan DJ.

Antimicrob Agents Chemother. 2009 Aug;53(8):3337-46. doi: 10.1128/AAC.01564-08. Epub 2009 Jun 1.


Live Candida albicans suppresses production of reactive oxygen species in phagocytes.

Wellington M, Dolan K, Krysan DJ.

Infect Immun. 2009 Jan;77(1):405-13. doi: 10.1128/IAI.00860-08. Epub 2008 Nov 3.


The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae.

Scrimale T, Didone L, de Mesy Bentley KL, Krysan DJ.

Mol Biol Cell. 2009 Jan;20(1):164-75. doi: 10.1091/mbc.E08-08-0809. Epub 2008 Oct 29.


A high-throughput screening assay for small molecules that disrupt yeast cell integrity.

Krysan DJ, Didone L.

J Biomol Screen. 2008 Aug;13(7):657-64. doi: 10.1177/1087057108320713. Epub 2008 Jul 14.


Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast.

Vadaie N, Dionne H, Akajagbor DS, Nickerson SR, Krysan DJ, Cullen PJ.

J Cell Biol. 2008 Jun 30;181(7):1073-81. doi: 10.1083/jcb.200704079.


Unconventional genomic architecture in the budding yeast saccharomyces cerevisiae masks the nested antisense gene NAG1.

Ma J, Dobry CJ, Krysan DJ, Kumar A.

Eukaryot Cell. 2008 Aug;7(8):1289-98. doi: 10.1128/EC.00053-08. Epub 2008 Feb 29.


Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.

Krysan DJ, Ting EL, Abeijon C, Kroos L, Fuller RS.

Eukaryot Cell. 2005 Aug;4(8):1364-74.


Effectiveness over time of varicella vaccine.

Krysan DJ.

J Pediatr. 2004 Sep;145(3):416-7. No abstract available.


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