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Items: 39

1.

A modified gas-trapping method for high-throughput metabolic experiments in Drosophila melanogaster.

Francis D, Krycer JR, Cooney GJ, James DE.

Biotechniques. 2019 Sep;67(3):123-125. doi: 10.2144/btn-2019-0062. Epub 2019 Aug 6.

2.

Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism.

Nagarajan SR, Paul-Heng M, Krycer JR, Fazakerley DJ, Sharland AF, Hoy AJ.

Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E578-E589. doi: 10.1152/ajpendo.00365.2018. Epub 2019 Jan 29.

PMID:
30694691
3.

Muscle and adipose tissue insulin resistance: malady without mechanism?

Fazakerley DJ, Krycer JR, Kearney AL, Hocking SL, James DE.

J Lipid Res. 2018 Jul 27. pii: jlr.R087510. doi: 10.1194/jlr.R087510. [Epub ahead of print]

4.

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways.

van Geldermalsen M, Quek LE, Turner N, Freidman N, Pang A, Guan YF, Krycer JR, Ryan R, Wang Q, Holst J.

BMC Cancer. 2018 Jun 26;18(1):689. doi: 10.1186/s12885-018-4599-8.

5.

Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1).

Duan X, Krycer JR, Cooke KC, Yang G, James DE, Fazakerley DJ.

Biochemistry. 2018 Jul 3;57(26):3606-3615. doi: 10.1021/acs.biochem.8b00361. Epub 2018 Jun 7.

PMID:
29787242
6.

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.

Fazakerley DJ, Minard AY, Krycer JR, Thomas KC, Stöckli J, Harney DJ, Burchfield JG, Maghzal GJ, Caldwell ST, Hartley RC, Stocker R, Murphy MP, James DE.

J Biol Chem. 2018 May 11;293(19):7315-7328. doi: 10.1074/jbc.RA117.001254. Epub 2018 Mar 29.

7.

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.

Burchfield JG, Kebede MA, Meoli CC, Stöckli J, Whitworth PT, Wright AL, Hoffman NJ, Minard AY, Ma X, Krycer JR, Nelson ME, Tan SX, Yau B, Thomas KC, Wee NKY, Khor EC, Enriquez RF, Vissel B, Biden TJ, Baldock PA, Hoehn KL, Cantley J, Cooney GJ, James DE, Fazakerley DJ.

J Biol Chem. 2018 Apr 13;293(15):5731-5745. doi: 10.1074/jbc.RA117.000808. Epub 2018 Feb 13.

8.

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake.

Small L, Brandon AE, Quek LE, Krycer JR, James DE, Turner N, Cooney GJ.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E258-E266. doi: 10.1152/ajpendo.00386.2017. Epub 2018 Feb 6.

9.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Fazakerley DJ, Chaudhuri R, Yang P, Maghzal GJ, Thomas KC, Krycer JR, Humphrey SJ, Parker BL, Fisher-Wellman KH, Meoli CC, Hoffman NJ, Diskin C, Burchfield JG, Cowley MJ, Kaplan W, Modrusan Z, Kolumam G, Yang JY, Chen DL, Samocha-Bonet D, Greenfield JR, Hoehn KL, Stocker R, James DE.

Elife. 2018 Feb 6;7. pii: e32111. doi: 10.7554/eLife.32111.

10.

A gas trapping method for high-throughput metabolic experiments.

Krycer JR, Diskin C, Nelson ME, Zeng XY, Fazakerley DJ, James DE.

Biotechniques. 2018 Jan 1;64(1):27-29. doi: 10.2144/000114629.

11.

The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes.

Chaudhuri R, Krycer JR, Fazakerley DJ, Fisher-Wellman KH, Su Z, Hoehn KL, Yang JYH, Kuncic Z, Vafaee F, James DE.

Sci Rep. 2018 Jan 29;8(1):1774. doi: 10.1038/s41598-018-20104-x.

12.

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.

Krycer JR, Yugi K, Hirayama A, Fazakerley DJ, Quek LE, Scalzo R, Ohno S, Hodson MP, Ikeda S, Shoji F, Suzuki K, Domanova W, Parker BL, Nelson ME, Humphrey SJ, Turner N, Hoehn KL, Cooney GJ, Soga T, Kuroda S, James DE.

Cell Rep. 2017 Dec 19;21(12):3536-3547. doi: 10.1016/j.celrep.2017.11.085.

13.

Correction: Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

Domanova W, Krycer JR, Chaudhuri R, Yang P, Vafaee F, Fazakerley DJ, Humphrey SJ, James DE, Kuncic Z.

PLoS One. 2017 Sep 28;12(9):e0185871. doi: 10.1371/journal.pone.0185871. eCollection 2017.

14.

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2017 Aug 30;8:16125. doi: 10.1038/ncomms16125.

15.

An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction.

Norris DM, Yang P, Krycer JR, Fazakerley DJ, James DE, Burchfield JG.

J Cell Sci. 2017 Aug 15;130(16):2757-2766. doi: 10.1242/jcs.205369. Epub 2017 Jun 29.

16.

Bicarbonate alters cellular responses in respiration assays.

Krycer JR, Fisher-Wellman KH, Fazakerley DJ, Muoio DM, James DE.

Biochem Biophys Res Commun. 2017 Aug 5;489(4):399-403. doi: 10.1016/j.bbrc.2017.05.151. Epub 2017 May 27.

17.

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.

Krycer JR, Fazakerley DJ, Cater RJ, C Thomas K, Naghiloo S, Burchfield JG, Humphrey SJ, Vandenberg RJ, Ryan RM, James DE.

FEBS Lett. 2017 Jan;591(2):322-330. doi: 10.1002/1873-3468.12549. Epub 2017 Jan 13.

18.

ORTI: An Open-Access Repository of Transcriptional Interactions for Interrogating Mammalian Gene Expression Data.

Vafaee F, Krycer JR, Ma X, Burykin T, James DE, Kuncic Z.

PLoS One. 2016 Oct 10;11(10):e0164535. doi: 10.1371/journal.pone.0164535. eCollection 2016.

19.

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework.

Solon-Biet SM, Cogger VC, Pulpitel T, Heblinski M, Wahl D, McMahon AC, Warren A, Durrant-Whyte J, Walters KA, Krycer JR, Ponton F, Gokarn R, Wali JA, Ruohonen K, Conigrave AD, James DE, Raubenheimer D, Morrison CD, Le Couteur DG, Simpson SJ.

Cell Metab. 2016 Oct 11;24(4):555-565. doi: 10.1016/j.cmet.2016.09.001. Epub 2016 Sep 29.

20.

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2016 Sep 27;7:12862. doi: 10.1038/ncomms12862. Erratum in: Nat Commun. 2017 Aug 30;8:16125.

21.

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3.

Kleinert M, Parker BL, Chaudhuri R, Fazakerley DJ, Serup A, Thomas KC, Krycer JR, Sylow L, Fritzen AM, Hoffman NJ, Jeppesen J, Schjerling P, Ruegg MA, Kiens B, James DE, Richter EA.

Mol Metab. 2016 Jun 22;5(8):646-655. doi: 10.1016/j.molmet.2016.06.007. eCollection 2016 Aug.

22.

Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

Domanova W, Krycer J, Chaudhuri R, Yang P, Vafaee F, Fazakerley D, Humphrey S, James D, Kuncic Z.

PLoS One. 2016 Jun 23;11(6):e0157763. doi: 10.1371/journal.pone.0157763. eCollection 2016. Erratum in: PLoS One. 2017 Sep 28;12 (9):e0185871.

23.

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway.

Trefely S, Khoo PS, Krycer JR, Chaudhuri R, Fazakerley DJ, Parker BL, Sultani G, Lee J, Stephan JP, Torres E, Jung K, Kuijl C, James DE, Junutula JR, Stöckli J.

J Biol Chem. 2015 Oct 23;290(43):25834-46. doi: 10.1074/jbc.M115.658815. Epub 2015 Sep 4.

24.

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes.

Fazakerley DJ, Naghiloo S, Chaudhuri R, Koumanov F, Burchfield JG, Thomas KC, Krycer JR, Prior MJ, Parker BL, Murrow BA, Stöckli J, Meoli CC, Holman GD, James DE.

J Biol Chem. 2015 Sep 25;290(39):23528-42. doi: 10.1074/jbc.M115.657361. Epub 2015 Aug 3.

25.

SnapShot: Insulin/IGF1 Signaling.

Ma DK, Stolte C, Krycer JR, James DE, O'Donoghue SI.

Cell. 2015 May 7;161(4):948-948.e1. doi: 10.1016/j.cell.2015.04.041. Erratum in: Cell. 2015 Jul 30;162(3):689.

26.

A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systems.

Wong MK, Krycer JR, Burchfield JG, James DE, Kuncic Z.

FEBS Open Bio. 2015 Mar 9;5:226-39. doi: 10.1016/j.fob.2015.03.002. eCollection 2015.

27.

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.

Kleinert M, Sylow L, Fazakerley DJ, Krycer JR, Thomas KC, Oxbøll AJ, Jordy AB, Jensen TE, Yang G, Schjerling P, Kiens B, James DE, Ruegg MA, Richter EA.

Mol Metab. 2014 Jun 27;3(6):630-41. doi: 10.1016/j.molmet.2014.06.004. eCollection 2014 Sep.

28.

The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.

Fletcher R, Gribben C, Ma X, Burchfield JG, Thomas KC, Krycer JR, James DE, Fazakerley DJ.

PLoS One. 2014 Apr 21;9(4):e95598. doi: 10.1371/journal.pone.0095598. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e116042. Ma, Xuiquan [corrected to Ma, Xiuquan]. PLoS One. 2014;9(7):e103797.

29.

A practical comparison of ligation-independent cloning techniques.

Stevenson J, Krycer JR, Phan L, Brown AJ.

PLoS One. 2013 Dec 23;8(12):e83888. doi: 10.1371/journal.pone.0083888. eCollection 2013.

30.

Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells.

Prabhu AV, Krycer JR, Brown AJ.

FEBS Lett. 2013 Apr 2;587(7):983-8. doi: 10.1016/j.febslet.2013.02.040. Epub 2013 Feb 27.

31.

Cholesterol accumulation in prostate cancer: a classic observation from a modern perspective.

Krycer JR, Brown AJ.

Biochim Biophys Acta. 2013 Apr;1835(2):219-29. doi: 10.1016/j.bbcan.2013.01.002. Epub 2013 Jan 26. Review.

PMID:
23357067
32.

Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis?

Krycer JR, Brown AJ.

PLoS One. 2013;8(1):e54007. doi: 10.1371/journal.pone.0054007. Epub 2013 Jan 8.

33.

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.

Krycer JR, Phan L, Brown AJ.

Biochem J. 2012 Sep 1;446(2):191-201. doi: 10.1042/BJ20120545.

PMID:
22657538
34.

Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis.

Krycer JR, Brown AJ.

J Biol Chem. 2011 Jun 10;286(23):20637-47. doi: 10.1074/jbc.M111.227082. Epub 2011 Apr 13.

35.

The Akt-SREBP nexus: cell signaling meets lipid metabolism.

Krycer JR, Sharpe LJ, Luu W, Brown AJ.

Trends Endocrinol Metab. 2010 May;21(5):268-76. doi: 10.1016/j.tem.2010.01.001. Epub 2010 Feb 1. Review.

PMID:
20117946
36.

Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3.

Krycer JR, Kristiana I, Brown AJ.

PLoS One. 2009 Dec 30;4(12):e8496. doi: 10.1371/journal.pone.0008496.

37.

Putative fat fighter hits the middle man.

Krycer JR, Brown AJ.

Chem Biol. 2009 Aug 28;16(8):798-800. doi: 10.1016/j.chembiol.2009.08.003.

38.

High throughput protein-protein interaction data: clues for the architecture of protein complexes.

Krycer JR, Pang CN, Wilkins MR.

Proteome Sci. 2008 Nov 26;6:32. doi: 10.1186/1477-5956-6-32.

39.

Are protein complexes made of cores, modules and attachments?

Pang CN, Krycer JR, Lek A, Wilkins MR.

Proteomics. 2008 Feb;8(3):425-34. doi: 10.1002/pmic.200700801.

PMID:
18175372

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