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Items: 33

1.

Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation.

Ding X, Krutzik PO, Ghaffari AA, Zhaozhi Y, Miranda D Jr, Cheng G, Ho CM, Nolan GP, Sanchez DJ.

Antiviral Res. 2019 Sep 9;171:104598. doi: 10.1016/j.antiviral.2019.104598. [Epub ahead of print]

PMID:
31513822
2.

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy.

Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC.

Cell Rep. 2019 Jul 16;28(3):819-831.e4. doi: 10.1016/j.celrep.2019.06.049.

3.

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC.

Elife. 2017 May 12;6. pii: e22882. doi: 10.7554/eLife.22882.

4.

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.

Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, Majeti R, Constantinescu SN, Piehler J, Garcia KC.

Cell. 2015 Mar 12;160(6):1196-208. doi: 10.1016/j.cell.2015.02.011. Epub 2015 Feb 26.

5.

COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication.

Kinoshita SM, Krutzik PO, Nolan GP.

PLoS One. 2012;7(7):e41725. doi: 10.1371/journal.pone.0041725. Epub 2012 Jul 24.

6.

Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators.

Bodenmiller B, Zunder ER, Finck R, Chen TJ, Savig ES, Bruggner RV, Simonds EF, Bendall SC, Sachs K, Krutzik PO, Nolan GP.

Nat Biotechnol. 2012 Sep;30(9):858-67.

7.

Single-cell phospho-protein analysis by flow cytometry.

Schulz KR, Danna EA, Krutzik PO, Nolan GP.

Curr Protoc Immunol. 2012 Feb;Chapter 8:Unit 8.17.1-20. doi: 10.1002/0471142735.im0817s96.

PMID:
22314834
8.

Structural linkage between ligand discrimination and receptor activation by type I interferons.

Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC.

Cell. 2011 Aug 19;146(4):621-32. doi: 10.1016/j.cell.2011.06.048.

9.

Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.

Bendall SC, Simonds EF, Qiu P, Amir el-AD, Krutzik PO, Finck R, Bruggner RV, Melamed R, Trejo A, Ornatsky OI, Balderas RS, Plevritis SK, Sachs K, Pe'er D, Tanner SD, Nolan GP.

Science. 2011 May 6;332(6030):687-96. doi: 10.1126/science.1198704.

10.

Fluorescent cell barcoding for multiplex flow cytometry.

Krutzik PO, Clutter MR, Trejo A, Nolan GP.

Curr Protoc Cytom. 2011 Jan;Chapter 6:Unit 6.31. doi: 10.1002/0471142956.cy0631s55. Review.

11.

Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples.

Krutzik PO, Trejo A, Schulz KR, Nolan GP.

Methods Mol Biol. 2011;699:179-202. doi: 10.1007/978-1-61737-950-5_9.

PMID:
21116984
12.

Tyramide signal amplification for analysis of kinase activity by intracellular flow cytometry.

Clutter MR, Heffner GC, Krutzik PO, Sachen KL, Nolan GP.

Cytometry A. 2010 Nov;77(11):1020-31. doi: 10.1002/cyto.a.20970.

13.

Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses.

O'Gorman WE, Sampath P, Simonds EF, Sikorski R, O'Malley M, Krutzik PO, Chen H, Panchanathan V, Chaudhri G, Karupiah G, Lewis DB, Thorne SH, Nolan GP.

Cell Host Microbe. 2010 Aug 19;8(2):174-85. doi: 10.1016/j.chom.2010.07.008.

14.

Web-based analysis and publication of flow cytometry experiments.

Kotecha N, Krutzik PO, Irish JM.

Curr Protoc Cytom. 2010 Jul;Chapter 10:Unit10.17. doi: 10.1002/0471142956.cy1017s53.

15.

Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus.

Hale MB, Krutzik PO, Samra SS, Crane JM, Nolan GP.

PLoS One. 2009 Aug 25;4(8):e6756. doi: 10.1371/journal.pone.0006756.

16.

The initial phase of an immune response functions to activate regulatory T cells.

O'Gorman WE, Dooms H, Thorne SH, Kuswanto WF, Simonds EF, Krutzik PO, Nolan GP, Abbas AK.

J Immunol. 2009 Jul 1;183(1):332-9. doi: 10.4049/jimmunol.0900691.

17.

WebFlow: a software package for high-throughput analysis of flow cytometry data.

Hammer MM, Kotecha N, Irish JM, Nolan GP, Krutzik PO.

Assay Drug Dev Technol. 2009 Feb;7(1):44-55. doi: 10.1089/adt.2008.174.

18.

Single-cell phospho-protein analysis by flow cytometry.

Schulz KR, Danna EA, Krutzik PO, Nolan GP.

Curr Protoc Immunol. 2007 Aug;Chapter 8:Unit 8.17. doi: 10.1002/0471142735.im0817s78.

PMID:
18432997
19.

High-content single-cell drug screening with phosphospecific flow cytometry.

Krutzik PO, Crane JM, Clutter MR, Nolan GP.

Nat Chem Biol. 2008 Feb;4(2):132-42. Epub 2007 Dec 23.

PMID:
18157122
20.
21.

Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence.

Wehrman TS, von Degenfeld G, Krutzik PO, Nolan GP, Blau HM.

Nat Methods. 2006 Apr;3(4):295-301.

PMID:
16554835
22.

Phospho-specific flow cytometry in drug discovery.

Clutter MR, Krutzik PO, Nolan GP.

Drug Discov Today Technol. 2005 Autumn;2(3):295-302. doi: 10.1016/j.ddtec.2005.08.010.

PMID:
24981951
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26.

Single cell profiling of potentiated phospho-protein networks in cancer cells.

Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud Ø, Gjertsen BT, Nolan GP.

Cell. 2004 Jul 23;118(2):217-28.

27.

Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications.

Krutzik PO, Irish JM, Nolan GP, Perez OD.

Clin Immunol. 2004 Mar;110(3):206-21. Review.

PMID:
15047199
28.

Flow cytometric analysis of kinase signaling cascades.

Perez OD, Krutzik PO, Nolan GP.

Methods Mol Biol. 2004;263:67-94.

PMID:
14976361
29.
30.

Synthesis of DNA-binding polyamides. Robust solid-phase methods for coupling heterocyclic aromatic amino acids.

Krutzik PO, Chamberlin AR.

Methods Mol Biol. 2002;201:77-92. No abstract available.

PMID:
12357940
31.

Rapid solid-phase synthesis of DNA-binding pyrrole-imidazole polyamides.

Krutzik PO, Chamberlin AR.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2129-32.

PMID:
12127520
32.

5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity.

Phillips D, Sonnenberg J, Arai AC, Vaswani R, Krutzik PO, Kleisli T, Kessler M, Granger R, Lynch G, Richard Chamberlin A.

Bioorg Med Chem. 2002 May;10(5):1229-48.

PMID:
11886787
33.

Increasing rates of reaction: microwave-assisted organic synthesis for combinatorial chemistry.

Lew A, Krutzik PO, Hart ME, Chamberlin AR.

J Comb Chem. 2002 Mar-Apr;4(2):95-105. Review. No abstract available.

PMID:
11886281

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