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Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium.

Cagnet S, Ataca D, Sflomos G, Aouad P, Schuepbach-Mallepell S, Hugues H, Krust A, Ayyanan A, Scabia V, Brisken C.

Nat Commun. 2018 Nov 9;9(1):4723. doi: 10.1038/s41467-018-07175-0.


SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice.

Börjesson AE, Farman HH, Movérare-Skrtic S, Engdahl C, Antal MC, Koskela A, Tuukkanen J, Carlsten H, Krust A, Chambon P, Sjögren K, Lagerquist MK, Windahl SH, Ohlsson C.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E912-8. doi: 10.1152/ajpendo.00488.2015. Epub 2016 Apr 5.


The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis.

Engdahl C, Börjesson AE, Forsman HF, Andersson A, Stubelius A, Krust A, Chambon P, Islander U, Ohlsson C, Carlsten H, Lagerquist MK.

Arthritis Res Ther. 2014 Jul 15;16(4):R150. doi: 10.1186/ar4612.


Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair.

Campbell L, Emmerson E, Williams H, Saville CR, Krust A, Chambon P, Mace KA, Hardman MJ.

J Invest Dermatol. 2014 Sep;134(9):2447-2457. doi: 10.1038/jid.2014.175. Epub 2014 Apr 9.


Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E283-90. doi: 10.1073/pnas.1322057111. Epub 2013 Dec 26.


Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable.

Handgraaf S, Riant E, Fabre A, Waget A, Burcelin R, Lière P, Krust A, Chambon P, Arnal JF, Gourdy P.

Diabetes. 2013 Dec;62(12):4098-108. doi: 10.2337/db13-0282. Epub 2013 Jul 31.


Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.

Seillet C, Rouquié N, Foulon E, Douin-Echinard V, Krust A, Chambon P, Arnal JF, Guéry JC, Laffont S.

J Immunol. 2013 Jun 1;190(11):5459-70. doi: 10.4049/jimmunol.1203312. Epub 2013 Apr 26.


The role of activation functions 1 and 2 of estrogen receptor-α for the effects of estradiol and selective estrogen receptor modulators in male mice.

Börjesson AE, Farman HH, Engdahl C, Koskela A, Sjögren K, Kindblom JM, Stubelius A, Islander U, Carlsten H, Antal MC, Krust A, Chambon P, Tuukkanen J, Lagerquist MK, Windahl SH, Ohlsson C.

J Bone Miner Res. 2013 May;28(5):1117-26. doi: 10.1002/jbmr.1842. Erratum in: J Bone Miner Res. 2013 Nov;28(11):2432.


Estrogen dependent activation function of ERβ is essential for the sexual behavior of mouse females.

Antal MC, Petit-Demoulière B, Meziane H, Chambon P, Krust A.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19822-7. doi: 10.1073/pnas.1217668109. Epub 2012 Nov 12.


Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.

Windahl SH, Saxon L, Börjesson AE, Lagerquist MK, Frenkel B, Henning P, Lerner UH, Galea GL, Meakin LB, Engdahl C, Sjögren K, Antal MC, Krust A, Chambon P, Lanyon LE, Price JS, Ohlsson C.

J Bone Miner Res. 2013 Feb;28(2):291-301. doi: 10.1002/jbmr.1754.


Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance.

Zhu L, Brown WC, Cai Q, Krust A, Chambon P, McGuinness OP, Stafford JM.

Diabetes. 2013 Feb;62(2):424-34. doi: 10.2337/db11-1718. Epub 2012 Sep 10.


Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk.

Emmerson E, Campbell L, Davies FC, Ross NL, Ashcroft GS, Krust A, Chambon P, Hardman MJ.

J Invest Dermatol. 2012 Dec;132(12):2838-48. doi: 10.1038/jid.2012.228. Epub 2012 Jul 19.


Stromal estrogen receptor-α promotes tumor growth by normalizing an increased angiogenesis.

Péqueux C, Raymond-Letron I, Blacher S, Boudou F, Adlanmerini M, Fouque MJ, Rochaix P, Noël A, Foidart JM, Krust A, Chambon P, Brouchet L, Arnal JF, Lenfant F.

Cancer Res. 2012 Jun 15;72(12):3010-9. doi: 10.1158/0008-5472.CAN-11-3768. Epub 2012 Apr 20.


The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice.

Börjesson AE, Windahl SH, Karimian E, Eriksson EE, Lagerquist MK, Engdahl C, Antal MC, Krust A, Chambon P, Sävendahl L, Ohlsson C.

Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1381-9. doi: 10.1152/ajpendo.00646.2011. Epub 2012 Mar 13.


Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.

Illing A, Liu P, Ostermay S, Schilling A, de Haan G, Krust A, Amling M, Chambon P, Schinke T, Tuckermann JP.

Haematologica. 2012 Aug;97(8):1131-5. doi: 10.3324/haematol.2011.052456. Epub 2012 Feb 27.


Estrogen receptor-α expression in neuronal cells affects bone mass.

Ohlsson C, Engdahl C, Börjesson AE, Windahl SH, Studer E, Westberg L, Eriksson E, Koskela A, Tuukkanen J, Krust A, Chambon P, Carlsten H, Lagerquist MK.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):983-8. doi: 10.1073/pnas.1111436109. Epub 2012 Jan 3.


Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.

Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13311-6. doi: 10.1073/pnas.1105632108. Epub 2011 Jul 25.


Identification of estradiol/ERα-regulated genes in the mouse pituitary.

Kim HJ, Gieske MC, Trudgen KL, Hudgins-Spivey S, Kim BG, Krust A, Chambon P, Jeong JW, Blalock E, Ko C.

J Endocrinol. 2011 Sep;210(3):309-21. doi: 10.1530/JOE-11-0098. Epub 2011 Jun 23.


From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause.

Arnal JF, Lenfant F, Flouriot G, Tremollières F, Laurell H, Fontaine C, Krust A, Chambon P, Gourdy P.

Br J Pharmacol. 2012 Jan;165(1):57-66. doi: 10.1111/j.1476-5381.2011.01538.x. Review.


Genistein impairs early testosterone production in fetal mouse testis via estrogen receptor alpha.

Lehraiki A, Chamaillard C, Krust A, Habert R, Levacher C.

Toxicol In Vitro. 2011 Dec;25(8):1542-7. doi: 10.1016/j.tiv.2011.05.017. Epub 2011 May 23.


Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.

Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6288-93. doi: 10.1073/pnas.1100454108. Epub 2011 Mar 28.


Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1.

Della Torre S, Rando G, Meda C, Stell A, Chambon P, Krust A, Ibarra C, Magni P, Ciana P, Maggi A.

Cell Metab. 2011 Feb 2;13(2):205-14. doi: 10.1016/j.cmet.2011.01.002.


Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice.

Park CJ, Zhao Z, Glidewell-Kenney C, Lazic M, Chambon P, Krust A, Weiss J, Clegg DJ, Dunaif A, Jameson JL, Levine JE.

J Clin Invest. 2011 Feb;121(2):604-12. doi: 10.1172/JCI41702. Epub 2011 Jan 18.


Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications.

Yadav VK, Oury F, Tanaka KF, Thomas T, Wang Y, Cremers S, Hen R, Krust A, Chambon P, Karsenty G.

J Exp Med. 2011 Jan 17;208(1):41-52. doi: 10.1084/jem.20101940. Epub 2010 Dec 27. Erratum in: J Exp Med. 2011 Feb 14;208(2):413. Tanaka, Kenji [corrected to Tanaka, Kenji F].


Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities.

Campbell L, Emmerson E, Davies F, Gilliver SC, Krust A, Chambon P, Ashcroft GS, Hardman MJ.

J Exp Med. 2010 Aug 30;207(9):1825-33. doi: 10.1084/jem.20100500. Epub 2010 Aug 23.


The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth.

Börjesson AE, Lagerquist MK, Liu C, Shao R, Windahl SH, Karlsson C, Sjögren K, Movérare-Skrtic S, Antal MC, Krust A, Mohan S, Chambon P, Sävendahl L, Ohlsson C.

J Bone Miner Res. 2010 Dec;25(12):2690-700. doi: 10.1002/jbmr.156. Epub 2010 Jun 18. Erratum in: J Bone Miner Res. 2011 Feb;26(2):439.


17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

Calippe B, Douin-Echinard V, Delpy L, Laffargue M, Lélu K, Krust A, Pipy B, Bayard F, Arnal JF, Guéry JC, Gourdy P.

J Immunol. 2010 Jul 15;185(2):1169-76. doi: 10.4049/jimmunol.0902383. Epub 2010 Jun 16.


Estrogen receptor-alpha as a drug target candidate for preventing lung inflammation.

Vegeto E, Cuzzocrea S, Crisafulli C, Mazzon E, Sala A, Krust A, Maggi A.

Endocrinology. 2010 Jan;151(1):174-84. doi: 10.1210/en.2009-0876. Epub 2009 Dec 1.


Estrogen Receptor-α as a Drug Target Candidate for Preventing Lung Inflammation.

Vegeto E, Cuzzocrea S, Crisafulli C, Mazzon E, Sala A, Krust A, Maggi A.

Endocr Rev. 2009 Dec 1;30(7):930. doi: 10.1210/edrv.30.7.9991. No abstract available.


Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism.

Lehraiki A, Racine C, Krust A, Habert R, Levacher C.

Toxicol Sci. 2009 Oct;111(2):372-82. doi: 10.1093/toxsci/kfp153. Epub 2009 Jul 10.


Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely.

Lee S, Kang DW, Hudgins-Spivey S, Krust A, Lee EY, Koo Y, Cheon Y, Gye MC, Chambon P, Ko C.

Endocrinology. 2009 Aug;150(8):3855-62. doi: 10.1210/en.2008-1774. Epub 2009 May 7.


The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.

Billon-Galés A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2053-8. doi: 10.1073/pnas.0808742106. Epub 2009 Feb 2.


Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network.

Toutain CE, Brouchet L, Raymond-Letron I, Vicendo P, Bergès H, Favre J, Fouque MJ, Krust A, Schmitt AM, Chambon P, Gourdy P, Arnal JF, Lenfant F.

Circ Res. 2009 Jan 30;104(2):245-54, 12p following 254. doi: 10.1161/CIRCRESAHA.108.182410. Epub 2008 Dec 4.


Distinct roles of estrogen receptor-alpha and beta in the modulation of vascular inducible nitric-oxide synthase in diabetes.

Cignarella A, Bolego C, Pelosi V, Meda C, Krust A, Pinna C, Gaion RM, Vegeto E, Maggi A.

J Pharmacol Exp Ther. 2009 Jan;328(1):174-82. doi: 10.1124/jpet.108.143511. Epub 2008 Oct 2.


Functional alterations of the nigrostriatal dopamine system in estrogen receptor-alpha knockout (ERKO) mice.

Küppers E, Krust A, Chambon P, Beyer C.

Psychoneuroendocrinology. 2008 Jul;33(6):832-8. doi: 10.1016/j.psyneuen.2008.03.007. Epub 2008 May 8.


Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes.

Ullrich ND, Krust A, Collins P, MacLeod KT.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2421-7. doi: 10.1152/ajpheart.01225.2007. Epub 2008 Apr 25.


Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin.

Hirosawa M, Minata M, Harada KH, Hitomi T, Krust A, Koizumi A.

Biochem Biophys Res Commun. 2008 Jun 27;371(2):320-3. doi: 10.1016/j.bbrc.2008.04.073. Epub 2008 Apr 24.


Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production.

Douin-Echinard V, Laffont S, Seillet C, Delpy L, Krust A, Chambon P, Gourdy P, Arnal JF, Guéry JC.

J Immunol. 2008 Mar 15;180(6):3661-9. Erratum in: J Immunol. 2008 May 15;180(10):7047.


Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant.

Antal MC, Krust A, Chambon P, Mark M.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2433-8. doi: 10.1073/pnas.0712029105. Epub 2008 Feb 11.


Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary.

Kim HJ, Gieske MC, Hudgins S, Kim BG, Krust A, Chambon P, Ko C.

J Endocrinol. 2007 Dec;195(3):393-405.


Pituitary gonadotroph estrogen receptor-alpha is necessary for fertility in females.

Gieske MC, Kim HJ, Legan SJ, Koo Y, Krust A, Chambon P, Ko C.

Endocrinology. 2008 Jan;149(1):20-7. Epub 2007 Oct 18.


Estradiol improves cerebellar memory formation by activating estrogen receptor beta.

Andreescu CE, Milojkovic BA, Haasdijk ED, Kramer P, De Jong FH, Krust A, De Zeeuw CI, De Jeu MT.

J Neurosci. 2007 Oct 3;27(40):10832-9.


Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.

Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S.

Cell. 2007 Sep 7;130(5):811-23.


Effects of loss of classical estrogen response element signaling on bone in male mice.

Syed FA, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S.

Endocrinology. 2007 Apr;148(4):1902-10. Epub 2007 Jan 4.


A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis.

Qiu J, Bosch MA, Tobias SC, Krust A, Graham SM, Murphy SJ, Korach KS, Chambon P, Scanlan TS, Rønnekleiv OK, Kelly MJ.

J Neurosci. 2006 May 24;26(21):5649-55.


The estrogen-responsive adrenomedullin and receptor-modifying protein 3 gene identified by DNA microarray analysis are directly regulated by estrogen receptor.

Watanabe H, Takahashi E, Kobayashi M, Goto M, Krust A, Chambon P, Iguchi T.

J Mol Endocrinol. 2006 Feb;36(1):81-9.


Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland.

Mallepell S, Krust A, Chambon P, Brisken C.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2196-201. Epub 2006 Feb 1.


Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways.

Syed FA, Mödder UI, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S.

J Bone Miner Res. 2005 Nov;20(11):1992-2001. Epub 2005 Jul 18.


Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction.

Korte T, Fuchs M, Arkudas A, Geertz S, Meyer R, Gardiwal A, Klein G, Niehaus M, Krust A, Chambon P, Drexler H, Fink K, Grohé C.

Circulation. 2005 May 10;111(18):2282-90. Epub 2005 May 2.


Estrogen receptor-alpha is associated with the plasma membrane of astrocytes and coupled to the MAP/Src-kinase pathway.

Pawlak J, Karolczak M, Krust A, Chambon P, Beyer C.

Glia. 2005 May;50(3):270-5.


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