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Items: 1 to 50 of 56

1.

A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery.

Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG.

PLoS Genet. 2018 Oct 18;14(10):e1007726. doi: 10.1371/journal.pgen.1007726. [Epub ahead of print]

2.

Structural basis for σ1 receptor ligand recognition.

Schmidt HR, Betz RM, Dror RO, Kruse AC.

Nat Struct Mol Biol. 2018 Oct;25(10):981-987. doi: 10.1038/s41594-018-0137-2. Epub 2018 Oct 5.

PMID:
30291362
3.

Structural Basis of Smoothened Activation in Hedgehog Signaling.

Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A.

Cell. 2018 Sep 20;175(1):295-297. doi: 10.1016/j.cell.2018.09.003. No abstract available.

PMID:
30241610
4.

In Vivo Evidence for ATPase-Dependent DNA Translocation by the Bacillus subtilis SMC Condensin Complex.

Wang X, Hughes AC, Brandão HB, Walker B, Lierz C, Cochran JC, Oakley MG, Kruse AC, Rudner DZ.

Mol Cell. 2018 Sep 6;71(5):841-847.e5. doi: 10.1016/j.molcel.2018.07.006. Epub 2018 Aug 9.

PMID:
30100265
5.

Loss of specificity variants of WzxC suggest that substrate recognition is coupled with transporter opening in MOP-family flippases.

Sham LT, Zheng S, Yakhnina AA, Kruse AC, Bernhardt TG.

Mol Microbiol. 2018 Sep;109(5):633-641. doi: 10.1111/mmi.14002. Epub 2018 Sep 15.

PMID:
29907971
6.

Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.

Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6709-6714. doi: 10.1073/pnas.1802192115. Epub 2018 Jun 11.

PMID:
29891673
7.

Structural Basis of Smoothened Activation in Hedgehog Signaling.

Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A.

Cell. 2018 Jul 12;174(2):312-324.e16. doi: 10.1016/j.cell.2018.04.029. Epub 2018 May 24. Erratum in: Cell. 2018 Sep 20;175(1):295-297.

PMID:
29804838
8.

Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.

Linkens K, Schmidt HR, Sahn JJ, Kruse AC, Martin SF.

Eur J Med Chem. 2018 May 10;151:557-567. doi: 10.1016/j.ejmech.2018.02.024. Epub 2018 Mar 29.

PMID:
29656199
9.

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis.

Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC.

Nature. 2018 Apr 5;556(7699):118-121. doi: 10.1038/nature25985. Epub 2018 Mar 28.

10.

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3834-3839. doi: 10.1073/pnas.1722336115. Epub 2018 Mar 26.

11.

Structural Basis for G Protein-Coupled Receptor Signaling.

Erlandson SC, McMahon C, Kruse AC.

Annu Rev Biophys. 2018 Mar 2. doi: 10.1146/annurev-biophys-070317-032931. [Epub ahead of print]

PMID:
29498889
12.

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.

Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428. doi: 10.1073/pnas.1718037115. Epub 2018 Feb 16.

13.

Yeast surface display platform for rapid discovery of conformationally selective nanobodies.

McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC.

Nat Struct Mol Biol. 2018 Mar;25(3):289-296. doi: 10.1038/s41594-018-0028-6. Epub 2018 Feb 12.

14.

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC.

Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7.

PMID:
29224781
15.

Structural Basis for G Protein-Coupled Receptor Activation.

Manglik A, Kruse AC.

Biochemistry. 2017 Oct 24;56(42):5628-5634. doi: 10.1021/acs.biochem.7b00747. Epub 2017 Oct 10. Review.

PMID:
28967738
16.

A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis.

Ramírez-Guadiana FH, Meeske AJ, Rodrigues CDA, Barajas-Ornelas RDC, Kruse AC, Rudner DZ.

PLoS Genet. 2017 Sep 25;13(9):e1007015. doi: 10.1371/journal.pgen.1007015. eCollection 2017 Sep.

17.

Identification of the gene that codes for the σ2 receptor.

Alon A, Schmidt HR, Wood MD, Sahn JJ, Martin SF, Kruse AC.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7160-7165. doi: 10.1073/pnas.1705154114. Epub 2017 May 30.

18.

Reevaluation of fenpropimorph as a σ receptor ligand: Structure-affinity relationship studies at human σ1 receptors.

Sguazzini E, Schmidt HR, Iyer KA, Kruse AC, Dukat M.

Bioorg Med Chem Lett. 2017 Jul 1;27(13):2912-2919. doi: 10.1016/j.bmcl.2017.04.088. Epub 2017 Apr 29.

PMID:
28495085
19.

Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling.

Paek J, Kalocsay M, Staus DP, Wingler L, Pascolutti R, Paulo JA, Gygi SP, Kruse AC.

Cell. 2017 Apr 6;169(2):338-349.e11. doi: 10.1016/j.cell.2017.03.028.

20.

Structural Perspectives on Sigma-1 Receptor Function.

Alon A, Schmidt H, Zheng S, Kruse AC.

Adv Exp Med Biol. 2017;964:5-13. doi: 10.1007/978-3-319-50174-1_2. Review.

PMID:
28315261
21.

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.

Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, Blacklow SC.

Cell. 2016 Nov 3;167(4):1041-1051.e11. doi: 10.1016/j.cell.2016.09.056. Epub 2016 Oct 27.

22.

Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.

Pascolutti R, Sun X, Kao J, Maute RL, Ring AM, Bowman GR, Kruse AC.

Structure. 2016 Oct 4;24(10):1719-1728. doi: 10.1016/j.str.2016.06.026. Epub 2016 Sep 8.

23.

SEDS proteins are a widespread family of bacterial cell wall polymerases.

Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ.

Nature. 2016 Sep 29;537(7622):634-638. doi: 10.1038/nature19331. Epub 2016 Aug 15.

24.

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ.

Nature. 2016 Jul 21;535(7612):448-52. Epub 2016 Jul 13.

25.

Crystal structure of the human σ1 receptor.

Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC.

Nature. 2016 Apr 28;532(7600):527-30. doi: 10.1038/nature17391. Epub 2016 Apr 4.

26.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

27.

High-density grids for efficient data collection from multiple crystals.

Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):2-11. doi: 10.1107/S2059798315020847. Epub 2016 Jan 1.

28.

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.

Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6506-14. doi: 10.1073/pnas.1519623112. Epub 2015 Nov 10.

29.

Non-classical amine recognition evolved in a large clade of olfactory receptors.

Li Q, Tachie-Baffour Y, Liu Z, Baldwin MW, Kruse AC, Liberles SD.

Elife. 2015 Oct 31;4:e10441. doi: 10.7554/eLife.10441.

30.

Goniometer-based femtosecond crystallography with X-ray free electron lasers.

Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17122-7. doi: 10.1073/pnas.1418733111. Epub 2014 Oct 31.

31.

Covalent agonists for studying G protein-coupled receptor activation.

Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10744-8. doi: 10.1073/pnas.1410415111. Epub 2014 Jul 8.

32.

Muscarinic acetylcholine receptors: novel opportunities for drug development.

Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J.

Nat Rev Drug Discov. 2014 Jul;13(7):549-60. doi: 10.1038/nrd4295. Epub 2014 Jun 6. Review.

33.

Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development.

Kruse AC, Hu J, Kobilka BK, Wess J.

Curr Opin Pharmacol. 2014 Jun;16:24-30. doi: 10.1016/j.coph.2014.02.006. Epub 2014 Mar 21. Review.

34.

Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK.

Nature. 2013 Dec 5;504(7478):101-6. doi: 10.1038/nature12735. Epub 2013 Nov 20.

35.

Applications of molecular replacement to G protein-coupled receptors.

Kruse AC, Manglik A, Kobilka BK, Weis WI.

Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2287-92. doi: 10.1107/S090744491301322X. Epub 2013 Oct 18.

36.

Novel tripod amphiphiles for membrane protein analysis.

Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH.

Chemistry. 2013 Nov 11;19(46):15645-51. doi: 10.1002/chem.201301423. Epub 2013 Oct 2.

37.

Novel insights into M3 muscarinic acetylcholine receptor physiology and structure.

Kruse AC, Li J, Hu J, Kobilka BK, Wess J.

J Mol Neurosci. 2014 Jul;53(3):316-23. doi: 10.1007/s12031-013-0127-0. Epub 2013 Sep 26. Review.

38.

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.

Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK.

Nature. 2013 Oct 24;502(7472):575-579. doi: 10.1038/nature12572. Epub 2013 Sep 22.

39.

Muscarinic receptors as model targets and antitargets for structure-based ligand discovery.

Kruse AC, Weiss DR, Rossi M, Hu J, Hu K, Eitel K, Gmeiner P, Wess J, Kobilka BK, Shoichet BK.

Mol Pharmacol. 2013 Oct;84(4):528-40. doi: 10.1124/mol.113.087551. Epub 2013 Jul 25.

40.

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.

Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ.

Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21.

41.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH.

Chem Commun (Camb). 2013 Mar 21;49(23):2287-9. doi: 10.1039/c2cc36844g. Erratum in: Chem Commun (Camb). 2013 Dec 28;49(100):11821-2.

42.

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.

Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH.

Chemistry. 2012 Jul 27;18(31):9485-90. doi: 10.1002/chem.201200069. Epub 2012 Jun 22. No abstract available. Erratum in: Chemistry. 2013 Apr 15;19(16):4964.

43.

Structure of the δ-opioid receptor bound to naltrindole.

Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK.

Nature. 2012 May 16;485(7398):400-4. doi: 10.1038/nature11111.

44.

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.

Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S.

Nature. 2012 Mar 21;485(7398):321-6. doi: 10.1038/nature10954.

45.

Structure and dynamics of the M3 muscarinic acetylcholine receptor.

Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK.

Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867.

46.

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

Haga K, Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T.

Nature. 2012 Jan 25;482(7386):547-51. doi: 10.1038/nature10753.

47.

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.

Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC.

Immunity. 2011 Nov 23;35(5):681-93. doi: 10.1016/j.immuni.2011.09.013.

48.

Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK.

Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361.

49.

Structure of a mutant β toxin from Staphylococcus aureus reveals domain swapping and conformational flexibility.

Kruse AC, Huseby MJ, Shi K, Digre J, Ohlendorf DH, Earhart CA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):438-41. doi: 10.1107/S1744309111005239. Epub 2011 Mar 24.

50.

Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).

Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM.

J Immunol. 2011 May 15;186(10):5823-32. doi: 10.4049/jimmunol.1100197. Epub 2011 Apr 13.

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