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Items: 14

1.

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.

Kluth O, Stadion M, Gottmann P, Aga H, Jähnert M, Scherneck S, Vogel H, Krus U, Seelig A, Ling C, Gerdes J, Schürmann A.

Cell Rep. 2019 Mar 12;26(11):3027-3036.e3. doi: 10.1016/j.celrep.2019.02.056.

2.

Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation.

King BC, Kulak K, Krus U, Rosberg R, Golec E, Wozniak K, Gomez MF, Zhang E, O'Connell DJ, Renström E, Blom AM.

Cell Metab. 2019 Jan 8;29(1):202-210.e6. doi: 10.1016/j.cmet.2018.09.009. Epub 2018 Oct 4.

PMID:
30293775
3.

Genetic determinants of circulating GIP and GLP-1 concentrations.

Almgren P, Lindqvist A, Krus U, Hakaste L, Ottosson-Laakso E, Asplund O, Sonestedt E, Prasad RB, Laurila E, Orho-Melander M, Melander O, Tuomi T, Holst JJ, Nilsson PM, Wierup N, Groop L, Ahlqvist E.

JCI Insight. 2017 Nov 2;2(21). pii: 93306. doi: 10.1172/jci.insight.93306.

4.

Glucose-Induced Changes in Gene Expression in Human Pancreatic Islets: Causes or Consequences of Chronic Hyperglycemia.

Ottosson-Laakso E, Krus U, Storm P, Prasad RB, Oskolkov N, Ahlqvist E, Fadista J, Hansson O, Groop L, Vikman P.

Diabetes. 2017 Dec;66(12):3013-3028. doi: 10.2337/db17-0311. Epub 2017 Sep 7.

5.

C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity.

Sjölander J, Byman E, Kulak K, Nilsson SC, Zhang E, Krus U, Westermark GT, Storm P, King BC, Renström E, Blom AM.

J Biol Chem. 2016 Oct 7;291(41):21644-21655. Epub 2016 Aug 26.

6.

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

Bennet H, Balhuizen A, Medina A, Dekker Nitert M, Ottosson Laakso E, Essén S, Spégel P, Storm P, Krus U, Wierup N, Fex M.

Peptides. 2015 Sep;71:113-20. doi: 10.1016/j.peptides.2015.07.008. Epub 2015 Jul 20.

PMID:
26206285
7.

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.

Fadista J, Vikman P, Laakso EO, Mollet IG, Esguerra JL, Taneera J, Storm P, Osmark P, Ladenvall C, Prasad RB, Hansson KB, Finotello F, Uvebrant K, Ofori JK, Di Camillo B, Krus U, Cilio CM, Hansson O, Eliasson L, Rosengren AH, Renström E, Wollheim CB, Groop L.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13924-9. doi: 10.1073/pnas.1402665111. Epub 2014 Sep 8.

8.

The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events.

Krus U, King BC, Nagaraj V, Gandasi NR, Sjölander J, Buda P, Garcia-Vaz E, Gomez MF, Ottosson-Laakso E, Storm P, Fex M, Vikman P, Zhang E, Barg S, Blom AM, Renström E.

Cell Metab. 2014 May 6;19(5):883-90. doi: 10.1016/j.cmet.2014.03.001. Epub 2014 Apr 10.

9.

Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans.

Jonsson A, Ladenvall C, Ahluwalia TS, Kravic J, Krus U, Taneera J, Isomaa B, Tuomi T, Renström E, Groop L, Lyssenko V.

Diabetes. 2013 Aug;62(8):2978-83. doi: 10.2337/db12-1627. Epub 2013 Apr 4.

10.

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.

Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH.

Cell Metab. 2012 Nov 7;16(5):625-33. doi: 10.1016/j.cmet.2012.10.009.

11.

A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.

Taneera J, Lang S, Sharma A, Fadista J, Zhou Y, Ahlqvist E, Jonsson A, Lyssenko V, Vikman P, Hansson O, Parikh H, Korsgren O, Soni A, Krus U, Zhang E, Jing XJ, Esguerra JL, Wollheim CB, Salehi A, Rosengren A, Renström E, Groop L.

Cell Metab. 2012 Jul 3;16(1):122-34. doi: 10.1016/j.cmet.2012.06.006.

12.

Abnormal peripheral chemokine profile in Huntington's disease.

Wild E, Magnusson A, Lahiri N, Krus U, Orth M, Tabrizi SJ, Björkqvist M.

PLoS Curr. 2011 Apr 13;3:RRN1231. doi: 10.1371/currents.RRN1231.

13.

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.

Krus U, Kotova O, Spégel P, Hallgard E, Sharoyko VV, Vedin A, Moritz T, Sugden MC, Koeck T, Mulder H.

Biochem J. 2010 Jul 1;429(1):205-13. doi: 10.1042/BJ20100142.

PMID:
20415663
14.

[An information system for analyzing the need for examining certain aspects of radiologic contamination caused by the Czernobyl catastrophe].

Michalewicz M, Kłopotek M, Krupiński L, Kruś U, Wierzchoń S, Matuszewski A.

Endokrynol Pol. 1991;42(2):181-8. Polish.

PMID:
1364471

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