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Items: 1 to 50 of 62

1.

Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.

Krupenko SA, Krupenko NI.

Chem Biol Interact. 2019 Apr 1;302:149-155. doi: 10.1016/j.cbi.2019.02.013. Epub 2019 Feb 20. Review.

PMID:
30794800
2.

Metabolic Phenotype of Wild-Type and As3mt-Knockout C57BL/6J Mice Exposed to Inorganic Arsenic: The Role of Dietary Fat and Folate Intake.

Huang MC, Douillet C, Dover EN, Zhang C, Beck R, Tejan-Sie A, Krupenko SA, St├Żblo M.

Environ Health Perspect. 2018 Dec;126(12):127003. doi: 10.1289/EHP3951.

3.

ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer.

Krupenko SA, Krupenko NI.

Adv Exp Med Biol. 2018;1032:127-143. doi: 10.1007/978-3-319-98788-0_10. Review.

PMID:
30362096
4.

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response.

Fekry B, Jeffries KA, Esmaeilniakooshkghazi A, Szulc ZM, Knagge KJ, Kirchner DR, Horita DA, Krupenko SA, Krupenko NI.

Nat Commun. 2018 Oct 8;9(1):4149. doi: 10.1038/s41467-018-06650-y.

5.

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.

Khan QA, Pediaditakis P, Malakhau Y, Esmaeilniakooshkghazi A, Ashkavand Z, Sereda V, Krupenko NI, Krupenko SA.

PLoS One. 2018 Jul 6;13(7):e0199699. doi: 10.1371/journal.pone.0199699. eCollection 2018.

6.

Modeling of interactions between functional domains of ALDH1L1.

Horita DA, Krupenko SA.

Chem Biol Interact. 2017 Oct 1;276:23-30. doi: 10.1016/j.cbi.2017.04.011. Epub 2017 Apr 14.

7.

Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype.

Ashkavand Z, O'Flanagan C, Hennig M, Du X, Hursting SD, Krupenko SA.

Mol Cancer Res. 2017 Feb;15(2):189-200. doi: 10.1158/1541-7786.MCR-16-0317.

8.

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress.

Fekry B, Jeffries KA, Esmaeilniakooshkghazi A, Ogretmen B, Krupenko SA, Krupenko NI.

J Biol Chem. 2016 Aug 5;291(32):16586-96. doi: 10.1074/jbc.M116.716902. Epub 2016 Jun 14.

9.

Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.

Fekry B, Esmaeilniakooshkghazi A, Krupenko SA, Krupenko NI.

PLoS One. 2016 Jan 19;11(1):e0146618. doi: 10.1371/journal.pone.0146618. eCollection 2016.

10.

Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.

Krupenko NI, Holmes RS, Tsybovsky Y, Krupenko SA.

Chem Biol Interact. 2015 Jun 5;234:12-7. doi: 10.1016/j.cbi.2014.12.022. Epub 2014 Dec 27.

11.

Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.

Oleinik NV, Helke KL, Kistner-Griffin E, Krupenko NI, Krupenko SA.

J Biol Chem. 2014 Sep 19;289(38):26383-94. doi: 10.1074/jbc.M114.569657. Epub 2014 Aug 1.

12.

JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1.

Prakasam A, Ghose S, Oleinik NV, Bethard JR, Peterson YK, Krupenko NI, Krupenko SA.

Cell Death Dis. 2014 Jul 31;5:e1358. doi: 10.1038/cddis.2014.316.

13.

A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization.

DebRoy S, Kramarenko II, Ghose S, Oleinik NV, Krupenko SA, Krupenko NI.

PLoS One. 2013 Jul 30;8(7):e70062. doi: 10.1371/journal.pone.0070062. Print 2013.

14.

Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.

Hoeferlin LA, Fekry B, Ogretmen B, Krupenko SA, Krupenko NI.

J Biol Chem. 2013 May 3;288(18):12880-90. doi: 10.1074/jbc.M113.461798. Epub 2013 Mar 21.

15.

The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1.

Tsybovsky Y, Malakhau Y, Strickland KC, Krupenko SA.

Chem Biol Interact. 2013 Feb 25;202(1-3):62-9. doi: 10.1016/j.cbi.2012.12.015. Epub 2013 Jan 5.

16.

Molecular mechanisms underlying the potentially adverse effects of folate.

Strickland KC, Krupenko NI, Krupenko SA.

Clin Chem Lab Med. 2013 Mar 1;51(3):607-16. doi: 10.1515/cclm-2012-0561. Review.

17.

Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress.

Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA.

Genes Cancer. 2011 Sep;2(9):889-99. doi: 10.1177/1947601911432495.

18.

Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers.

Oleinik NV, Krupenko NI, Krupenko SA.

Genes Cancer. 2011 Feb;2(2):130-9. doi: 10.1177/1947601911405841.

19.

Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.

Carrasco MP, Enyedy EA, Krupenko NI, Krupenko SA, Nuti E, Tuccinardi T, Santamaria S, Rossello A, Martinelli A, Santos MA.

Med Chem. 2011 Jul;7(4):265-74.

PMID:
21568878
20.

Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme.

Tsybovsky Y, Krupenko SA.

J Biol Chem. 2011 Jul 1;286(26):23357-67. doi: 10.1074/jbc.M111.221069. Epub 2011 May 3.

21.

Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.

Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA.

Chem Biol Interact. 2011 May 30;191(1-3):129-36. doi: 10.1016/j.cbi.2011.01.008. Epub 2011 Jan 14.

22.

Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.

Strickland KC, Holmes RS, Oleinik NV, Krupenko NI, Krupenko SA.

Chem Biol Interact. 2011 May 30;191(1-3):122-8. doi: 10.1016/j.cbi.2010.12.025. Epub 2011 Jan 6.

23.

ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A.

Oleinik NV, Krupenko NI, Krupenko SA.

Oncogene. 2010 Nov 25;29(47):6233-44. doi: 10.1038/onc.2010.356. Epub 2010 Aug 23.

24.

Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.

Marques SM, Enyedy EA, Supuran CT, Krupenko NI, Krupenko SA, Santos MA.

Bioorg Med Chem. 2010 Jul 15;18(14):5081-9. doi: 10.1016/j.bmc.2010.05.072. Epub 2010 Jun 2.

PMID:
20580561
25.

ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.

Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA.

J Biol Chem. 2010 Jul 23;285(30):23056-63. doi: 10.1074/jbc.M110.128843. Epub 2010 May 24.

26.

Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.

Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA.

J Biol Chem. 2010 Jan 15;285(3):1627-33. doi: 10.1074/jbc.M109.080556. Epub 2009 Nov 20.

27.

10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status.

Ghose S, Oleinik NV, Krupenko NI, Krupenko SA.

Mol Cancer Res. 2009 Jan;7(1):99-107. doi: 10.1158/1541-7786.MCR-08-0309.

28.

FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism.

Krupenko SA.

Chem Biol Interact. 2009 Mar 16;178(1-3):84-93. doi: 10.1016/j.cbi.2008.09.007. Epub 2008 Sep 19. Review.

29.

Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.

Celtikci B, Leclerc D, Lawrance AK, Deng L, Friedman HC, Krupenko NI, Krupenko SA, Melnyk S, James SJ, Peterson AC, Rozen R.

Pharmacogenet Genomics. 2008 Jul;18(7):577-89. doi: 10.1097/FPC.0b013e32830058aa.

PMID:
18551038
30.

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.

Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA.

J Neurosci. 2008 Jan 2;28(1):264-78. doi: 10.1523/JNEUROSCI.4178-07.2008.

31.

10-formyltetrahydrofolate dehydrogenase requires a 4'-phosphopantetheine prosthetic group for catalysis.

Donato H, Krupenko NI, Tsybovsky Y, Krupenko SA.

J Biol Chem. 2007 Nov 23;282(47):34159-66. Epub 2007 Sep 20.

32.

Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway.

Oleinik NV, Krupenko NI, Krupenko SA.

Oncogene. 2007 Nov 8;26(51):7222-30. Epub 2007 May 21.

PMID:
17525747
33.

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.

Elmore CL, Wu X, Leclerc D, Watson ED, Bottiglieri T, Krupenko NI, Krupenko SA, Cross JC, Rozen R, Gravel RA, Matthews RG.

Mol Genet Metab. 2007 May;91(1):85-97. Epub 2007 Mar 21.

34.

Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.

Tsybovsky Y, Donato H, Krupenko NI, Davies C, Krupenko SA.

Biochemistry. 2007 Mar 20;46(11):2917-29. Epub 2007 Feb 16.

PMID:
17302434
35.

Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs.

Santos MA, Enyedy EA, Nuti E, Rossello A, Krupenko NI, Krupenko SA.

Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. Epub 2006 Nov 14.

PMID:
17127067
36.

Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation.

Oleinik NV, Krupenko NI, Reuland SN, Krupenko SA.

Biochem Pharmacol. 2006 Jul 14;72(2):256-66. Epub 2006 Apr 25.

PMID:
16712799
37.

Modular organization of FDH: Exploring the basis of hydrolase catalysis.

Reuland SN, Vlasov AP, Krupenko SA.

Protein Sci. 2006 May;15(5):1076-84. Epub 2006 Apr 5.

38.

The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.

Chattopadhyay S, Zhao R, Krupenko SA, Krupenko N, Goldman ID.

Mol Cancer Ther. 2006 Feb;5(2):438-49.

39.

Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression.

Oleinik NV, Krupenko NI, Priest DG, Krupenko SA.

Biochem J. 2005 Nov 1;391(Pt 3):503-11.

40.
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43.

Crystallization and preliminary X-ray diffraction analysis of recombinant hydrolase domain of 10-formyltetrahydrofolate dehydrogenase.

Chumanevich AA, Davies C, Krupenko SA.

Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1841-2. Epub 2002 Sep 28.

PMID:
12351832
45.
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50.

Baculovirus expression and purification of rat 10-formyltetrahydrofolate dehydrogenase.

Krupenko SA, Horstman DA, Wagner C, Cook RJ.

Protein Expr Purif. 1995 Aug;6(4):457-64.

PMID:
8527931

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