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Items: 1 to 50 of 108

1.

Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation.

Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11585-11590. doi: 10.1073/pnas.1804556115. Epub 2018 Oct 22.

PMID:
30348790
2.

Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.

Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR.

Mucosal Immunol. 2018 Oct 18. doi: 10.1038/s41385-018-0096-2. [Epub ahead of print]

PMID:
30337651
3.

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.

Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF.

Nat Med. 2018 Aug;24(8):1178-1191. doi: 10.1038/s41591-018-0085-8. Epub 2018 Jun 25.

PMID:
29942093
4.

Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4+ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin.

Bąbała N, Bovens A, de Vries E, Iglesias-Guimarais V, Ahrends T, Krummel MF, Borst J, Bins AD.

Cancer Immunol Res. 2018 Jul;6(7):835-847. doi: 10.1158/2326-6066.CIR-17-0408. Epub 2018 May 15.

PMID:
29764836
5.

Understanding the tumor immune microenvironment (TIME) for effective therapy.

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF.

Nat Med. 2018 May;24(5):541-550. doi: 10.1038/s41591-018-0014-x. Epub 2018 Apr 23. Review.

6.

Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.

Hung LY, Oniskey TK, Sen D, Krummel MF, Vaughan AE, Cohen NA, Herbert DR.

Am J Pathol. 2018 May;188(5):1161-1170. doi: 10.1016/j.ajpath.2018.01.020. Epub 2018 Feb 16.

PMID:
29458008
7.

TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.

de Mingo Pulido Á, Gardner A, Hiebler S, Soliman H, Rugo HS, Krummel MF, Coussens LM, Ruffell B.

Cancer Cell. 2018 Jan 8;33(1):60-74.e6. doi: 10.1016/j.ccell.2017.11.019.

PMID:
29316433
8.

Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy.

Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI.

JCI Insight. 2017 Jul 20;2(14). pii: 93433. doi: 10.1172/jci.insight.93433. [Epub ahead of print]

9.

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P.

Sci Immunol. 2017 Apr 28;2(10). pii: eaam8929. doi: 10.1126/sciimmunol.aam8929.

10.

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF.

Science. 2017 May 12;356(6338). pii: eaal3118. doi: 10.1126/science.aal3118.

PMID:
28495700
11.

Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.

Tumeh PC, Hellmann MD, Hamid O, Tsai KK, Loo KL, Gubens MA, Rosenblum M, Harview CL, Taube JM, Handley N, Khurana N, Nosrati A, Krummel MF, Tucker A, Sosa EV, Sanchez PJ, Banayan N, Osorio JC, Nguyen-Kim DL, Chang J, Shintaku IP, Boasberg PD, Taylor EJ, Munster PN, Algazi AP, Chmielowski B, Dummer R, Grogan TR, Elashoff D, Hwang J, Goldinger SM, Garon EB, Pierce RH, Daud A.

Cancer Immunol Res. 2017 May;5(5):417-424. doi: 10.1158/2326-6066.CIR-16-0325. Epub 2017 Apr 14.

12.

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.

Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR.

Nature. 2017 Apr 6;544(7648):105-109. doi: 10.1038/nature21706. Epub 2017 Mar 22.

13.

Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer.

Wong PT, Roberts EW, Tang S, Mukherjee J, Cannon J, Nip AJ, Corbin K, Krummel MF, Choi SK.

ACS Chem Biol. 2017 Apr 21;12(4):1001-1010. doi: 10.1021/acschembio.6b00999. Epub 2017 Feb 17.

14.
15.

CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG.

J Exp Med. 2016 Oct 17;213(11):2293-2314. Epub 2016 Oct 10.

16.

CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity.

Loyher PL, Rochefort J, Baudesson de Chanville C, Hamon P, Lescaille G, Bertolus C, Guillot-Delost M, Krummel MF, Lemoine FM, Combadière C, Boissonnas A.

Cancer Res. 2016 Nov 15;76(22):6483-6494. doi: 10.1158/0008-5472.CAN-16-0984. Epub 2016 Sep 28.

17.

Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung.

Sen D, Jones SM, Oswald EM, Pinkard H, Corbin K, Krummel MF.

PLoS One. 2016 Oct 18;11(10):e0165064. doi: 10.1371/journal.pone.0165064. eCollection 2016.

18.

iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation.

Thanabalasuriar A, Neupane AS, Wang J, Krummel MF, Kubes P.

Cell Rep. 2016 Sep 20;16(12):3260-3272. doi: 10.1016/j.celrep.2016.07.052.

19.

Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.

Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach IV, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum MD.

J Clin Invest. 2016 Sep 1;126(9):3447-52. doi: 10.1172/JCI87324. Epub 2016 Aug 15.

20.

Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.

Roberts EW, Broz ML, Binnewies M, Headley MB, Nelson AE, Wolf DM, Kaisho T, Bogunovic D, Bhardwaj N, Krummel MF.

Cancer Cell. 2016 Aug 8;30(2):324-336. doi: 10.1016/j.ccell.2016.06.003. Epub 2016 Jul 14.

21.

Visualization of immediate immune responses to pioneer metastatic cells in the lung.

Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF.

Nature. 2016 Mar 24;531(7595):513-7. doi: 10.1038/nature16985. Epub 2016 Mar 16.

22.

Spatiotemporal Rank Filtering Improves Image Quality Compared to Frame Averaging in 2-Photon Laser Scanning Microscopy.

Pinkard H, Corbin K, Krummel MF.

PLoS One. 2016 Mar 3;11(3):e0150430. doi: 10.1371/journal.pone.0150430. eCollection 2016.

23.

T cell migration, search strategies and mechanisms.

Krummel MF, Bartumeus F, Gérard A.

Nat Rev Immunol. 2016 Mar;16(3):193-201. doi: 10.1038/nri.2015.16. Epub 2016 Feb 8. Review.

24.

A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.

Mujal AM, Gilden JK, Gérard A, Kinoshita M, Krummel MF.

Nat Immunol. 2016 Mar;17(3):315-22. doi: 10.1038/ni.3330. Epub 2015 Dec 21.

25.

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z.

Dev Cell. 2015 Sep 14;34(5):493-504. doi: 10.1016/j.devcel.2015.07.015. Epub 2015 Aug 27.

26.

TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL.

J Immunol. 2015 Aug 1;195(3):1182-90. doi: 10.4049/jimmunol.1500348. Epub 2015 Jun 24.

27.

The emerging understanding of myeloid cells as partners and targets in tumor rejection.

Broz ML, Krummel MF.

Cancer Immunol Res. 2015 Apr;3(4):313-9. doi: 10.1158/2326-6066.CIR-15-0041. Review.

28.

Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.

Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF.

PLoS One. 2015 Mar 19;10(3):e0118513. doi: 10.1371/journal.pone.0118513. eCollection 2015.

29.

A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease.

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL.

J Immunol. 2015 Apr 15;194(8):3962-9. doi: 10.4049/jimmunol.1403043. Epub 2015 Mar 18.

30.

Antigen recognition in the islets changes with progression of autoimmune islet infiltration.

Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS.

J Immunol. 2015 Jan 15;194(2):522-30. doi: 10.4049/jimmunol.1400626. Epub 2014 Dec 10.

31.

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF.

Cancer Cell. 2014 Dec 8;26(6):938. doi: 10.1016/j.ccell.2014.11.010. Epub 2014 Dec 8. No abstract available.

32.

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF.

Cancer Cell. 2014 Nov 10;26(5):638-52. doi: 10.1016/j.ccell.2014.09.007. Epub 2014 Oct 16.

33.

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.

Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR.

Blood. 2014 Oct 23;124(17):2625-34. doi: 10.1182/blood-2014-03-562876. Epub 2014 Aug 20.

34.

Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.

Gérard A, Patino-Lopez G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, Totah FJ, Tyska MJ, Shaw S, Krummel MF.

Cell. 2014 Jul 31;158(3):492-505. doi: 10.1016/j.cell.2014.05.044.

35.

Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice.

Li M, Wetzel-Strong SE, Hua X, Tilley SL, Oswald E, Krummel MF, Caron KM.

PLoS One. 2014 Jul 10;9(7):e102356. doi: 10.1371/journal.pone.0102356. eCollection 2014.

36.

The spatiotemporal cellular dynamics of lung immunity.

Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF.

Trends Immunol. 2014 Aug;35(8):379-86. doi: 10.1016/j.it.2014.05.005. Epub 2014 Jun 26. Review.

37.

Assessing and benchmarking multiphoton microscopes for biologists.

Corbin K, Pinkard H, Peck S, Beemiller P, Krummel MF.

Methods Cell Biol. 2014;123:135-51. doi: 10.1016/B978-0-12-420138-5.00008-2.

38.

An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function.

Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9223-8. doi: 10.1073/pnas.1322193111. Epub 2014 Jun 10.

39.

Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA.

Krummel MF, Friedman RS, Jacobelli J.

Curr Opin Cell Biol. 2014 Oct;30:9-16. doi: 10.1016/j.ceb.2014.05.003. Epub 2014 Jun 3. Review.

40.

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.

Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD.

J Exp Med. 2014 Jun 30;211(7):1281-8. doi: 10.1084/jem.20132336. Epub 2014 Jun 2.

41.

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.

Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM.

Immunity. 2014 Mar 20;40(3):414-24. doi: 10.1016/j.immuni.2014.02.003. Epub 2014 Mar 13.

42.

Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm.

Beemiller P, Krummel MF.

Immunol Rev. 2013 Nov;256(1):148-59. doi: 10.1111/imr.12120. Review.

43.

Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy.

Pinkard H, Stuurman N, Corbin K, Vale R, Krummel MF.

Nat Methods. 2016 Sep 29;13(10):807-809. doi: 10.1038/nmeth.3991. No abstract available.

44.

Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.

Jacobelli J, Estin Matthews M, Chen S, Krummel MF.

PLoS One. 2013 Sep 19;8(9):e75151. doi: 10.1371/journal.pone.0075151. eCollection 2013.

45.

Type 2 innate lymphoid cells control eosinophil homeostasis.

Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM.

Nature. 2013 Oct 10;502(7470):245-8. doi: 10.1038/nature12526. Epub 2013 Sep 15.

46.

Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.

Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF.

Nat Immunol. 2013 Apr;14(4):356-63. doi: 10.1038/ni.2547. Epub 2013 Mar 10.

47.

Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.

Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM.

Immunity. 2013 Jan 24;38(1):166-75. doi: 10.1016/j.immuni.2012.09.022. Epub 2013 Jan 3.

48.

Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses.

Gérard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF.

Immunol Rev. 2013 Jan;251(1):80-96. doi: 10.1111/imr.12021. Review.

49.

Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells.

Zhang Y, Chen YC, Krummel MF, Rosen SD.

J Immunol. 2012 Oct 15;189(8):3914-24. doi: 10.4049/jimmunol.1201604. Epub 2012 Sep 7.

50.

Integration of the movement of signaling microclusters with cellular motility in immunological synapses.

Beemiller P, Jacobelli J, Krummel MF.

Nat Immunol. 2012 Jul 1;13(8):787-95. doi: 10.1038/ni.2364.

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