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Items: 32


CRISPR/Cas12a Mediated Genome Editing To Introduce Amino Acid Substitutions into the Mechanosensitive Channel MscCG of Corynebacterium glutamicum.

Krumbach K, Sonntag CK, Eggeling L, Marienhagen J.

ACS Synth Biol. 2019 Dec 20;8(12):2726-2734. doi: 10.1021/acssynbio.9b00361. Epub 2019 Dec 11.


AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core.

Alderwick LJ, Birch HL, Krumbach K, Bott M, Eggeling L, Besra GS.

Cell Surf. 2018 Mar;1:2-14. doi: 10.1016/j.tcsw.2017.10.001.


The myo-inositol/proton symporter IolT1 contributes to d-xylose uptake in Corynebacterium glutamicum.

Brüsseler C, Radek A, Tenhaef N, Krumbach K, Noack S, Marienhagen J.

Bioresour Technol. 2018 Feb;249:953-961. doi: 10.1016/j.biortech.2017.10.098. Epub 2017 Nov 1.


Mutations in MurE, the essential UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase of Corynebacterium glutamicum: effect on L-lysine formation and analysis of systemic consequences.

Hochheim J, Kranz A, Krumbach K, Sokolowsky S, Eggeling L, Noack S, Bocola M, Bott M, Marienhagen J.

Biotechnol Lett. 2017 Feb;39(2):283-288. doi: 10.1007/s10529-016-2243-8. Epub 2016 Oct 25.


Formation of xylitol and xylitol-5-phosphate and its impact on growth of d-xylose-utilizing Corynebacterium glutamicum strains.

Radek A, Müller MF, Gätgens J, Eggeling L, Krumbach K, Marienhagen J, Noack S.

J Biotechnol. 2016 Aug 10;231:160-166. doi: 10.1016/j.jbiotec.2016.06.009. Epub 2016 Jun 11.


Identification of the phd gene cluster responsible for phenylpropanoid utilization in Corynebacterium glutamicum.

Kallscheuer N, Vogt M, Kappelmann J, Krumbach K, Noack S, Bott M, Marienhagen J.

Appl Microbiol Biotechnol. 2016 Feb;100(4):1871-81. doi: 10.1007/s00253-015-7165-1. Epub 2015 Nov 26.


Anaerobic growth of Corynebacterium glutamicum via mixed-acid fermentation.

Michel A, Koch-Koerfges A, Krumbach K, Brocker M, Bott M.

Appl Environ Microbiol. 2015 Nov;81(21):7496-508. doi: 10.1128/AEM.02413-15. Epub 2015 Aug 14.


Acyl-CoA sensing by FasR to adjust fatty acid synthesis in Corynebacterium glutamicum.

Irzik K, van Ooyen J, Gätgens J, Krumbach K, Bott M, Eggeling L.

J Biotechnol. 2014 Dec 20;192 Pt A:96-101.


Engineering of Corynebacterium glutamicum for minimized carbon loss during utilization of D-xylose containing substrates.

Radek A, Krumbach K, Gätgens J, Wendisch VF, Wiechert W, Bott M, Noack S, Marienhagen J.

J Biotechnol. 2014 Dec 20;192 Pt A:156-60. doi: 10.1016/j.jbiotec.2014.09.026. Epub 2014 Oct 7.


The contest for precursors: channelling L-isoleucine synthesis in Corynebacterium glutamicum without byproduct formation.

Vogt M, Krumbach K, Bang WG, van Ooyen J, Noack S, Klein B, Bott M, Eggeling L.

Appl Microbiol Biotechnol. 2015 Jan;99(2):791-800. doi: 10.1007/s00253-014-6109-5. Epub 2014 Oct 10.


Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis.

Grover S, Alderwick LJ, Mishra AK, Krumbach K, Marienhagen J, Eggeling L, Bhatt A, Besra GS.

J Biol Chem. 2014 Feb 28;289(9):6177-87. doi: 10.1074/jbc.M113.522623. Epub 2014 Jan 20.


Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation.

Mishra AK, Alves JE, Krumbach K, Nigou J, Castro AG, Geurtsen J, Eggeling L, Saraiva M, Besra GS.

J Biol Chem. 2012 Dec 28;287(53):44173-83. doi: 10.1074/jbc.M112.402396. Epub 2012 Nov 9.


A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level.

Binder S, Schendzielorz G, Stäbler N, Krumbach K, Hoffmann K, Bott M, Eggeling L.

Genome Biol. 2012 May 28;13(5):R40. doi: 10.1186/gb-2012-13-5-r40.


Deletion of manC in Corynebacterium glutamicum results in a phospho-myo-inositol mannoside- and lipoglycan-deficient mutant.

Mishra AK, Krumbach K, Rittmann D, Batt SM, Lee OY, De S, Frunzke J, Besra GS, Eggeling L.

Microbiology. 2012 Jul;158(Pt 7):1908-1917. doi: 10.1099/mic.0.057653-0. Epub 2012 Apr 26.


MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria.

Varela C, Rittmann D, Singh A, Krumbach K, Bhatt K, Eggeling L, Besra GS, Bhatt A.

Chem Biol. 2012 Apr 20;19(4):498-506. doi: 10.1016/j.chembiol.2012.03.006.


The cytotoxic early protein 77 of mycobacteriophage L5 interacts with MSMEG_3532, an L-serine dehydratase of Mycobacterium smegmatis.

Rybniker J, Krumbach K, van Gumpel E, Plum G, Eggeling L, Hartmann P.

J Basic Microbiol. 2011 Oct;51(5):515-22. doi: 10.1002/jobm.201000446. Epub 2011 Jun 9.


Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching.

Mishra AK, Krumbach K, Rittmann D, Appelmelk B, Pathak V, Pathak AK, Nigou J, Geurtsen J, Eggeling L, Besra GS.

Mol Microbiol. 2011 Jun;80(5):1241-59. doi: 10.1111/j.1365-2958.2011.07640.x. Epub 2011 Apr 4.


Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.

Batt SM, Jabeen T, Mishra AK, Veerapen N, Krumbach K, Eggeling L, Besra GS, Fütterer K.

J Biol Chem. 2010 Nov 26;285(48):37741-52. doi: 10.1074/jbc.M110.165407. Epub 2010 Sep 15.


Identification of a terminal rhamnopyranosyltransferase (RptA) involved in Corynebacterium glutamicum cell wall biosynthesis.

Birch HL, Alderwick LJ, Rittmann D, Krumbach K, Etterich H, Grzegorzewicz A, McNeil MR, Eggeling L, Besra GS.

J Bacteriol. 2009 Aug;191(15):4879-87. doi: 10.1128/JB.00296-09. Epub 2009 May 29.


Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase.

Birch HL, Alderwick LJ, Bhatt A, Rittmann D, Krumbach K, Singh A, Bai Y, Lowary TL, Eggeling L, Besra GS.

Mol Microbiol. 2008 Sep;69(5):1191-206. doi: 10.1111/j.1365-2958.2008.06354.x. Epub 2008 Jul 4.


Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant.

Tatituri RV, Alderwick LJ, Mishra AK, Nigou J, Gilleron M, Krumbach K, Hitchen P, Giordano A, Morris HR, Dell A, Eggeling L, Besra GS.

Microbiology. 2007 Aug;153(Pt 8):2621-9.


The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis.

Gande R, Dover LG, Krumbach K, Besra GS, Sahm H, Oikawa T, Eggeling L.

J Bacteriol. 2007 Jul;189(14):5257-64. Epub 2007 May 4.


Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.

Tatituri RV, Illarionov PA, Dover LG, Nigou J, Gilleron M, Hitchen P, Krumbach K, Morris HR, Spencer N, Dell A, Eggeling L, Besra GS.

J Biol Chem. 2007 Feb 16;282(7):4561-72. Epub 2006 Dec 19.


Characterization of myo-inositol utilization by Corynebacterium glutamicum: the stimulon, identification of transporters, and influence on L-lysine formation.

Krings E, Krumbach K, Bathe B, Kelle R, Wendisch VF, Sahm H, Eggeling L.

J Bacteriol. 2006 Dec;188(23):8054-61. Epub 2006 Sep 22.


Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

Gande R, Gibson KJ, Brown AK, Krumbach K, Dover LG, Sahm H, Shioyama S, Oikawa T, Besra GS, Eggeling L.

J Biol Chem. 2004 Oct 22;279(43):44847-57. Epub 2004 Aug 11.


Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, and the generation of lipoglycan-less mutants in Corynebacterium glutamicum.

Gibson KJ, Eggeling L, Maughan WN, Krumbach K, Gurcha SS, Nigou J, Puzo G, Sahm H, Besra GS.

J Biol Chem. 2003 Oct 17;278(42):40842-50. Epub 2003 Aug 6.


Linking central metabolism with increased pathway flux: L-valine accumulation by Corynebacterium glutamicum.

Radmacher E, Vaitsikova A, Burger U, Krumbach K, Sahm H, Eggeling L.

Appl Environ Microbiol. 2002 May;68(5):2246-50.


Expression of genes of lipid synthesis and altered lipid composition modulates L-glutamate efflux of Corynebacterium glutamicum.

Nampoothiri KM, Hoischen C, Bathe B, Möckel B, Pfefferle W, Krumbach K, Sahm H, Eggeling L.

Appl Microbiol Biotechnol. 2002 Jan;58(1):89-96.


L-glutamate efflux with Corynebacterium glutamicum: why is penicillin treatment or Tween addition doing the same?

Eggeling L, Krumbach K, Sahm H.

J Mol Microbiol Biotechnol. 2001 Jan;3(1):67-8. No abstract available.


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