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Editorial: For The Future of Alkaliphiles: 50th Anniversary Year Since the Rediscovery of Alkaliphiles by Dr. Koki Horikoshi.

Ito M, Krulwich TA.

Front Microbiol. 2019 Sep 3;10:2017. doi: 10.3389/fmicb.2019.02017. eCollection 2019. No abstract available.


Mutational loss of carotenoids in alkaliphilic Bacillus pseudofirmus OF4 results in sensitivity to oxidative stress and growth at high pH.

Hicks DB, Jereen A, Fackelmayer OJ, LaFountain AM, Frank HA, Krulwich TA.

Microbiology. 2019 Sep;165(9):1001-1012. doi: 10.1099/mic.0.000828.


A Hydrophobic Small Protein, BpOF4_01690, Is Critical for Alkaliphily of Alkaliphilic Bacillus pseudofirmus OF4.

Takahashi T, Krulwich TA, Ito M.

Front Microbiol. 2018 Aug 28;9:1994. doi: 10.3389/fmicb.2018.01994. eCollection 2018.


The Lysine 299 Residue Endows the Multisubunit Mrp1 Antiporter with Dominant Roles in Na+ Resistance and pH Homeostasis in Corynebacterium glutamicum.

Xu N, Zheng Y, Wang X, Krulwich TA, Ma Y, Liu J.

Appl Environ Microbiol. 2018 May 1;84(10). pii: e00110-18. doi: 10.1128/AEM.00110-18. Print 2018 May 15.


Roles of Staphylococcus aureus Mnh1 and Mnh2 Antiporters in Salt Tolerance, Alkali Tolerance, and Pathogenesis.

Vaish M, Price-Whelan A, Reyes-Robles T, Liu J, Jereen A, Christie S, Alonzo F 3rd, Benson MA, Torres VJ, Krulwich TA.

J Bacteriol. 2018 Feb 7;200(5). pii: e00611-17. doi: 10.1128/JB.00611-17. Print 2018 Mar 1.


Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea.

Ito M, Morino M, Krulwich TA.

Front Microbiol. 2017 Nov 23;8:2325. doi: 10.3389/fmicb.2017.02325. eCollection 2017. Review.


Differences in the phenotypic effects of mutations in homologous MrpA and MrpD subunits of the multi-subunit Mrp-type Na+/H+ antiporter.

Morino M, Ogoda S, Krulwich TA, Ito M.

Extremophiles. 2017 Jan;21(1):51-64. doi: 10.1007/s00792-016-0877-z. Epub 2016 Oct 5.


Alkaliphilic Bacteria with Impact on Industrial Applications, Concepts of Early Life Forms, and Bioenergetics of ATP Synthesis.

Preiss L, Hicks DB, Suzuki S, Meier T, Krulwich TA.

Front Bioeng Biotechnol. 2015 Jun 3;3:75. doi: 10.3389/fbioe.2015.00075. eCollection 2015. Review.


Draft Genome Sequence of Bacillus alcalophilus AV1934, a Classic Alkaliphile Isolated from Human Feces in 1934.

Attie O, Jayaprakash A, Shah H, Paulsen IT, Morino M, Takahashi Y, Narumi I, Sachidanandam R, Satoh K, Ito M, Krulwich TA.

Genome Announc. 2014 Nov 13;2(6). pii: e01175-14. doi: 10.1128/genomeA.01175-14.


Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus.

DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE.

Elife. 2014 Nov 11;3. doi: 10.7554/eLife.04387.


The c-ring ion binding site of the ATP synthase from Bacillus pseudofirmus OF4 is adapted to alkaliphilic lifestyle.

Preiss L, Langer JD, Hicks DB, Liu J, Yildiz O, Krulwich TA, Meier T.

Mol Microbiol. 2014 Jun;92(5):973-84. doi: 10.1111/mmi.12605. Epub 2014 Apr 24.


Cardiolipin is dispensable for oxidative phosphorylation and non-fermentative growth of alkaliphilic Bacillus pseudofirmus OF4.

Liu J, Ryabichko S, Bogdanov M, Fackelmayer OJ, Dowhan W, Krulwich TA.

J Biol Chem. 2014 Jan 31;289(5):2960-71. doi: 10.1074/jbc.M113.536193. Epub 2013 Dec 13.


Purification and functional reconstitution of a seven-subunit mrp-type na+/h+ antiporter.

Morino M, Suzuki T, Ito M, Krulwich TA.

J Bacteriol. 2014 Jan;196(1):28-35. doi: 10.1128/JB.01029-13. Epub 2013 Oct 18.


Transcriptional profiling of Staphylococcus aureus during growth in 2 M NaCl leads to clarification of physiological roles for Kdp and Ktr K+ uptake systems.

Price-Whelan A, Poon CK, Benson MA, Eidem TT, Roux CM, Boyd JM, Dunman PM, Torres VJ, Krulwich TA.

MBio. 2013 Aug 20;4(4). pii: e00407-13. doi: 10.1128/mBio.00407-13.


The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4.

Preiss L, Klyszejko AL, Hicks DB, Liu J, Fackelmayer OJ, Yildiz Ö, Krulwich TA, Meier T.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7874-9. doi: 10.1073/pnas.1303333110. Epub 2013 Apr 23.


Roles of AtpI and two YidC-type proteins from alkaliphilic Bacillus pseudofirmus OF4 in ATP synthase assembly and nonfermentative growth.

Liu J, Hicks DB, Krulwich TA.

J Bacteriol. 2013 Jan;195(2):220-30. doi: 10.1128/JB.01493-12. Epub 2012 Nov 2.


Role of institutional climate in fostering diversity in biomedical research workforce: a case study.

Butts GC, Hurd Y, Palermo AG, Delbrune D, Saran S, Zony C, Krulwich TA.

Mt Sinai J Med. 2012 Jul-Aug;79(4):498-511. doi: 10.1002/msj.21323.


Developing talent to increase diversity in biomedical sciences workforce.

Krulwich TA, Saran S, McGee R Jr.

Mt Sinai J Med. 2012 Jul-Aug;79(4):497. doi: 10.1002/msj.21330. No abstract available.


Diversity in the biomedical research workforce: developing talent.

McGee R Jr, Saran S, Krulwich TA.

Mt Sinai J Med. 2012 May-Jun;79(3):397-411. doi: 10.1002/msj.21310. Review.


Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4.

Janto B, Ahmed A, Ito M, Liu J, Hicks DB, Pagni S, Fackelmayer OJ, Smith TA, Earl J, Elbourne LD, Hassan K, Paulsen IT, Kolstø AB, Tourasse NJ, Ehrlich GD, Boissy R, Ivey DM, Li G, Xue Y, Ma Y, Hu FZ, Krulwich TA.

Environ Microbiol. 2011 Dec;13(12):3289-309. doi: 10.1111/j.1462-2920.2011.02591.x. Epub 2011 Sep 27.


Mutations in a helix-1 motif of the ATP synthase c-subunit of Bacillus pseudofirmus OF4 cause functional deficits and changes in the c-ring stability and mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

Liu J, Fackelmayer OJ, Hicks DB, Preiss L, Meier T, Sobie EA, Krulwich TA.

Biochemistry. 2011 Jun 21;50(24):5497-506. doi: 10.1021/bi2005009. Epub 2011 May 23.


Molecular aspects of bacterial pH sensing and homeostasis.

Krulwich TA, Sachs G, Padan E.

Nat Rev Microbiol. 2011 May;9(5):330-43. doi: 10.1038/nrmicro2549. Epub 2011 Apr 5. Review.


ATP synthases: cellular nanomotors characterized by LILBID mass spectrometry.

Hoffmann J, Sokolova L, Preiss L, Hicks DB, Krulwich TA, Morgner N, Wittig I, Schägger H, Meier T, Brutschy B.

Phys Chem Chem Phys. 2010 Nov 7;12(41):13375-82. doi: 10.1039/c0cp00733a. Epub 2010 Aug 27.


The ATP synthase a-subunit of extreme alkaliphiles is a distinct variant: mutations in the critical alkaliphile-specific residue Lys-180 and other residues that support alkaliphile oxidative phosphorylation.

Fujisawa M, Fackelmayer OJ, Liu J, Krulwich TA, Hicks DB.

J Biol Chem. 2010 Oct 15;285(42):32105-15. doi: 10.1074/jbc.M110.165084. Epub 2010 Aug 17.


A new type of proton coordination in an F(1)F(o)-ATP synthase rotor ring.

Preiss L, Yildiz O, Hicks DB, Krulwich TA, Meier T.

PLoS Biol. 2010 Aug 3;8(8):e1000443. doi: 10.1371/journal.pbio.1000443.


Training in systems pharmacology: predoctoral program in pharmacology and systems biology at Mount Sinai School of Medicine.

Sobie EA, Jenkins SL, Iyengar R, Krulwich TA.

Clin Pharmacol Ther. 2010 Jul;88(1):19-22. doi: 10.1038/clpt.2010.41.


F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations.

Hicks DB, Liu J, Fujisawa M, Krulwich TA.

Biochim Biophys Acta. 2010 Aug;1797(8):1362-77. doi: 10.1016/j.bbabio.2010.02.028. Epub 2010 Mar 1. Review.


Motility and chemotaxis in alkaliphilic Bacillus species.

Fujinami S, Terahara N, Krulwich TA, Ito M.

Future Microbiol. 2009 Nov;4(9):1137-49. doi: 10.2217/fmb.09.76. Review.


Cation/proton antiporter complements of bacteria: why so large and diverse?

Krulwich TA, Hicks DB, Ito M.

Mol Microbiol. 2009 Oct;74(2):257-60. doi: 10.1111/j.1365-2958.2009.06842.x. Epub 2009 Aug 11.


Cytoplasmic pH measurement and homeostasis in bacteria and archaea.

Slonczewski JL, Fujisawa M, Dopson M, Krulwich TA.

Adv Microb Physiol. 2009;55:1-79, 317. doi: 10.1016/S0065-2911(09)05501-5. Review.


Characterization of the Functionally Critical AXAXAXA and PXXEXXP Motifs of the ATP Synthase c-Subunit from an Alkaliphilic Bacillus.

Liu J, Fujisawa M, Hicks DB, Krulwich TA.

J Biol Chem. 2009 Mar 27;284(13):8714-25. doi: 10.1074/jbc.M808738200. Epub 2009 Jan 28.


Mutations alter the sodium versus proton use of a Bacillus clausii flagellar motor and confer dual ion use on Bacillus subtilis motors.

Terahara N, Krulwich TA, Ito M.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14359-64. doi: 10.1073/pnas.0802106105. Epub 2008 Sep 16.


Single gene deletions of mrpA to mrpG and mrpE point mutations affect activity of the Mrp Na+/H+ antiporter of alkaliphilic Bacillus and formation of hetero-oligomeric Mrp complexes.

Morino M, Natsui S, Swartz TH, Krulwich TA, Ito M.

J Bacteriol. 2008 Jun;190(12):4162-72. doi: 10.1128/JB.00294-08. Epub 2008 Apr 11.


Purification of two putative type II NADH dehydrogenases with different substrate specificities from alkaliphilic Bacillus pseudofirmus OF4.

Liu J, Krulwich TA, Hicks DB.

Biochim Biophys Acta. 2008 May;1777(5):453-61. doi: 10.1016/j.bbabio.2008.02.004. Epub 2008 Mar 5.


The Vibrio cholerae Mrp system: cation/proton antiport properties and enhancement of bile salt resistance in a heterologous host.

Dzioba-Winogrodzki J, Winogrodzki O, Krulwich TA, Boin MA, Häse CC, Dibrov P.

J Mol Microbiol Biotechnol. 2009;16(3-4):176-86. doi: 10.1159/000119547. Epub 2008 Mar 3.


The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4.

Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M.

Microbiology. 2007 Dec;153(Pt 12):4027-38.


Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity.

Fujisawa M, Ito M, Krulwich TA.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13289-94. Epub 2007 Aug 6.


Adaptive gene expression in Bacillus subtilis strains deleted for tetL.

Wei Y, Deikus G, Powers B, Shelden V, Krulwich TA, Bechhofer DH.

J Bacteriol. 2006 Oct;188(20):7090-100.


Alkaline pH homeostasis in bacteria: new insights.

Padan E, Bibi E, Ito M, Krulwich TA.

Biochim Biophys Acta. 2005 Nov 30;1717(2):67-88. Epub 2005 Sep 26. Review.


The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment.

Liu J, Xue Y, Wang Q, Wei Y, Swartz TH, Hicks DB, Ito M, Ma Y, Krulwich TA.

J Bacteriol. 2005 Nov;187(22):7589-95.


The Mrp system: a giant among monovalent cation/proton antiporters?

Swartz TH, Ikewada S, Ishikawa O, Ito M, Krulwich TA.

Extremophiles. 2005 Oct;9(5):345-54. Epub 2005 Jun 25. Review.


Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study.

Krulwich TA, Lewinson O, Padan E, Bibi E.

Nat Rev Microbiol. 2005 Jul;3(7):566-72. Review.


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