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Items: 1 to 50 of 58

1.

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB.

Mol Cell. 2019 Mar 21;73(6):1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006. Epub 2019 Feb 7.

PMID:
30745086
2.

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A.

Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28.

PMID:
30704900
3.

TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib.

Dadashian EL, McAuley EM, Liu D, Shaffer AL 3rd, Young RM, Iyer JR, Kruhlak MJ, Staudt LM, Wiestner A, Herman SEM.

Cancer Res. 2019 Jan 15;79(2):360-371. doi: 10.1158/0008-5472.CAN-18-0781. Epub 2018 Nov 29.

PMID:
30498085
4.

Author Correction: T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation.

Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V.

Nat Immunol. 2018 Aug;19(8):898. doi: 10.1038/s41590-018-0139-6.

PMID:
29959442
5.

A multiprotein supercomplex controlling oncogenic signalling in lymphoma.

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.

Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20.

6.

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.

Vizcardo R, Klemen ND, Islam SMR, Gurusamy D, Tamaoki N, Yamada D, Koseki H, Kidder BL, Yu Z, Jia L, Henning AN, Good ML, Bosch-Marce M, Maeda T, Liu C, Abdullaev Z, Pack S, Palmer DC, Stroncek DF, Ito F, Flomerfelt FA, Kruhlak MJ, Restifo NP.

Cell Rep. 2018 Mar 20;22(12):3175-3190. doi: 10.1016/j.celrep.2018.02.087.

7.

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.

Klebanoff CA, Crompton JG, Leonardi AJ, Yamamoto TN, Chandran SS, Eil RL, Sukumar M, Vodnala SK, Hu J, Ji Y, Clever D, Black MA, Gurusamy D, Kruhlak MJ, Jin P, Stroncek DF, Gattinoni L, Feldman SA, Restifo NP.

JCI Insight. 2017 Dec 7;2(23). pii: 95103. doi: 10.1172/jci.insight.95103.

8.

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.

Sharma NR, Majerciak V, Kruhlak MJ, Zheng ZM.

PLoS Pathog. 2017 Oct 30;13(10):e1006677. doi: 10.1371/journal.ppat.1006677. eCollection 2017 Oct.

9.

NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells.

House CD, Jordan E, Hernandez L, Ozaki M, James JM, Kim M, Kruhlak MJ, Batchelor E, Elloumi F, Cam MC, Annunziata CM.

Cancer Res. 2017 Dec 15;77(24):6927-6940. doi: 10.1158/0008-5472.CAN-17-0366. Epub 2017 Oct 26.

10.

BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1).

Pongas G, Kim MK, Min DJ, House CD, Jordan E, Caplen N, Chakka S, Ohiri J, Kruhlak MJ, Annunziata CM.

Oncotarget. 2017 May 3;8(31):51402-51415. doi: 10.18632/oncotarget.17572. eCollection 2017 Aug 1.

11.

T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation.

Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V.

Nat Immunol. 2017 Oct;18(10):1117-1127. doi: 10.1038/ni.3816. Epub 2017 Aug 14. Erratum in: Nat Immunol. 2018 Aug;19(8):898.

12.

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation.

Strickfaden H, McDonald D, Kruhlak MJ, Haince JF, Th'ng JP, Rouleau M, Ishibashi T, Corry GN, Ausio J, Underhill DA, Poirier GG, Hendzel MJ.

J Biol Chem. 2016 Jan 22;291(4):1789-802. doi: 10.1074/jbc.M115.694992. Epub 2015 Nov 11.

13.

Expression of the SNARE protein SNAP-23 is essential for cell survival.

Kaul S, Mittal SK, Feigenbaum L, Kruhlak MJ, Roche PA.

PLoS One. 2015 Feb 23;10(2):e0118311. doi: 10.1371/journal.pone.0118311. eCollection 2015.

14.

Activation of DNA damage response signaling by condensed chromatin.

Burgess RC, Burman B, Kruhlak MJ, Misteli T.

Cell Rep. 2014 Dec 11;9(5):1703-1717. doi: 10.1016/j.celrep.2014.10.060. Epub 2014 Nov 20.

15.

Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage.

Eggert T, Medina-Echeverz J, Kapanadze T, Kruhlak MJ, Korangy F, Greten TF.

PLoS One. 2014 Nov 17;9(11):e112717. doi: 10.1371/journal.pone.0112717. eCollection 2014.

16.

A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.

Khurana S, Kruhlak MJ, Kim J, Tran AD, Liu J, Nyswaner K, Shi L, Jailwala P, Sung MH, Hakim O, Oberdoerffer P.

Cell Rep. 2014 Aug 21;8(4):1049-62. doi: 10.1016/j.celrep.2014.07.024. Epub 2014 Aug 14.

17.

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A.

J Exp Med. 2014 Jun 2;211(6):1027-36. doi: 10.1084/jem.20131939. Epub 2014 May 19.

18.
19.

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.

Yang Y, Schmitz R, Mitala J, Whiting A, Xiao W, Ceribelli M, Wright GW, Zhao H, Yang Y, Xu W, Rosenwald A, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Wiestner A, Kruhlak MJ, Iwai K, Bernal F, Staudt LM.

Cancer Discov. 2014 Apr;4(4):480-93. doi: 10.1158/2159-8290.CD-13-0915. Epub 2014 Feb 3.

20.

Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.

J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13.

21.

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.

Cell. 2013 Jun 6;153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30.

22.

Control of autophagic cell death by caspase-10 in multiple myeloma.

Lamy L, Ngo VN, Emre NC, Shaffer AL 3rd, Yang Y, Tian E, Nair V, Kruhlak MJ, Zingone A, Landgren O, Staudt LM.

Cancer Cell. 2013 Apr 15;23(4):435-49. doi: 10.1016/j.ccr.2013.02.017. Epub 2013 Mar 28.

23.

Correlative fluorescence and EFTEM imaging of the organized components of the mammalian nucleus.

Kruhlak MJ.

Methods Mol Biol. 2013;950:397-416. doi: 10.1007/978-1-62703-137-0_22.

PMID:
23086887
24.

Introduction: nanoimaging techniques in biology.

Sousa AA, Kruhlak MJ.

Methods Mol Biol. 2013;950:1-10. doi: 10.1007/978-1-62703-137-0_1. Review.

PMID:
23086866
25.

Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.

Müller JR, Waldmann TA, Kruhlak MJ, Dubois S.

J Biol Chem. 2012 Nov 23;287(48):40328-38. doi: 10.1074/jbc.M112.378612. Epub 2012 Oct 16.

26.

Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles.

Sousa AA, Morgan JT, Brown PH, Adams A, Jayasekara MP, Zhang G, Ackerson CJ, Kruhlak MJ, Leapman RD.

Small. 2012 Jul 23;8(14):2277-86. doi: 10.1002/smll.201200071. Epub 2012 Apr 20.

27.

Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis.

Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T.

Circ Res. 2012 Apr 27;110(9):1202-10. doi: 10.1161/CIRCRESAHA.111.256370. Epub 2012 Mar 27.

28.

Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker.

Ben-Aissa K, Patino-Lopez G, Belkina NV, Maniti O, Rosales T, Hao JJ, Kruhlak MJ, Knutson JR, Picart C, Shaw S.

J Biol Chem. 2012 May 11;287(20):16311-23. doi: 10.1074/jbc.M111.304881. Epub 2012 Mar 20.

29.

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.

Liu Y, Belkina NV, Park C, Nambiar R, Loughhead SM, Patino-Lopez G, Ben-Aissa K, Hao JJ, Kruhlak MJ, Qi H, von Andrian UH, Kehrl JH, Tyska MJ, Shaw S.

Blood. 2012 Jan 12;119(2):445-53. doi: 10.1182/blood-2011-07-368860. Epub 2011 Nov 21.

30.

Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis.

Lonsdorf AS, Krämer BF, Fahrleitner M, Schönberger T, Gnerlich S, Ring S, Gehring S, Schneider SW, Kruhlak MJ, Meuth SG, Nieswandt B, Gawaz M, Enk AH, Langer HF.

J Biol Chem. 2012 Jan 13;287(3):2168-78. doi: 10.1074/jbc.M111.269811. Epub 2011 Nov 18.

31.

Cooperative epigenetic modulation by cancer amplicon genes.

Rui L, Emre NC, Kruhlak MJ, Chung HJ, Steidl C, Slack G, Wright GW, Lenz G, Ngo VN, Shaffer AL, Xu W, Zhao H, Yang Y, Lamy L, Davis RE, Xiao W, Powell J, Maloney D, Thomas CJ, Möller P, Rosenwald A, Ott G, Muller-Hermelink HK, Savage K, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Weisenburger DD, Chan WC, Gascoyne RD, Levens D, Staudt LM.

Cancer Cell. 2010 Dec 14;18(6):590-605. doi: 10.1016/j.ccr.2010.11.013.

32.

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.

Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T.

Blood. 2010 Nov 25;116(22):4395-403. doi: 10.1182/blood-2010-01-261503. Epub 2010 Jul 12.

33.

Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents.

Katragkou A, Kruhlak MJ, Simitsopoulou M, Chatzimoschou A, Taparkou A, Cotten CJ, Paliogianni F, Diza-Mataftsi E, Tsantali C, Walsh TJ, Roilides E.

J Infect Dis. 2010 Jun 15;201(12):1941-9. doi: 10.1086/652783.

34.

Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH).

Patino-Lopez G, Aravind L, Dong X, Kruhlak MJ, Ostap EM, Shaw S.

J Biol Chem. 2010 Mar 19;285(12):8675-86. doi: 10.1074/jbc.M109.086959. Epub 2010 Jan 12.

35.

Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.

Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A.

Cell Cycle. 2009 Aug;8(15):2408-12. Epub 2009 Aug 21.

36.

Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy.

Kruhlak MJ, Celeste A, Nussenzweig A.

Methods Mol Biol. 2009;523:125-40. doi: 10.1007/978-1-59745-190-1_9.

PMID:
19381917
37.

53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.

Nature. 2008 Nov 27;456(7221):529-33. doi: 10.1038/nature07476. Epub 2008 Oct 19.

38.

Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.

Patino-Lopez G, Dong X, Ben-Aissa K, Bernot KM, Itoh T, Fukuda M, Kruhlak MJ, Samelson LE, Shaw S.

J Biol Chem. 2008 Jun 27;283(26):18323-30. doi: 10.1074/jbc.M800056200. Epub 2008 Apr 30.

39.

Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity.

Liu Y, Kruhlak MJ, Hao JJ, Shaw S.

J Leukoc Biol. 2007 Sep;82(3):742-51. Epub 2007 Jun 15.

40.

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis.

Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A.

J Exp Med. 2007 May 14;204(5):1003-11. Epub 2007 May 3.

41.

Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy.

Hope WW, Kruhlak MJ, Lyman CA, Petraitiene R, Petraitis V, Francesconi A, Kasai M, Mickiene D, Sein T, Peter J, Kelaher AM, Hughes JE, Cotton MP, Cotten CJ, Bacher J, Tripathi S, Bermudez L, Maugel TK, Zerfas PM, Wingard JR, Drusano GL, Walsh TJ.

J Infect Dis. 2007 Feb 1;195(3):455-66. Epub 2006 Dec 21.

PMID:
17205486
42.

Spatio-temporal dynamics of chromatin containing DNA breaks.

Kruhlak MJ, Celeste A, Nussenzweig A.

Cell Cycle. 2006 Sep;5(17):1910-2. Epub 2006 Sep 1.

PMID:
16929171
43.

Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.

Herbeuval JP, Nilsson J, Boasso A, Hardy AW, Kruhlak MJ, Anderson SA, Dolan MJ, Dy M, Andersson J, Shearer GM.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7000-5. Epub 2006 Apr 21.

44.

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.

Kruhlak MJ, Celeste A, Dellaire G, Fernandez-Capetillo O, Müller WG, McNally JG, Bazett-Jones DP, Nussenzweig A.

J Cell Biol. 2006 Mar 13;172(6):823-34. Epub 2006 Mar 6.

45.

Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells.

Sarkar K, Kruhlak MJ, Erlandsen SL, Shaw S.

Immunology. 2005 Dec;116(4):513-24.

46.

Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes.

Nijhara R, van Hennik PB, Gignac ML, Kruhlak MJ, Hordijk PL, Delon J, Shaw S.

J Immunol. 2004 Oct 15;173(8):4985-93.

47.

TLR9 is localized in the endoplasmic reticulum prior to stimulation.

Leifer CA, Kennedy MN, Mazzoni A, Lee C, Kruhlak MJ, Segal DM.

J Immunol. 2004 Jul 15;173(2):1179-83.

48.

Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly.

Puri N, Kruhlak MJ, Whiteheart SW, Roche PA.

J Immunol. 2003 Nov 15;171(10):5345-52.

49.

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A.

Nat Cell Biol. 2003 Jul;5(7):675-9.

PMID:
12792649
50.

Same serial section correlative light and energy-filtered transmission electron microscopy.

Ren Y, Kruhlak MJ, Bazett-Jones DP.

J Histochem Cytochem. 2003 May;51(5):605-12.

PMID:
12704208

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