Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 86

1.

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants.

Vizcardo R, Rafiqul Islam SM, Maeda T, Tamaoki N, Good ML, Klemen ND, Bosch-Marce M, Jia L, Kruhlak MJ, Restifo NP.

J Vis Exp. 2019 Aug 9;(150). doi: 10.3791/58672.

PMID:
31449236
2.

KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.

Sharma NR, Majerciak V, Kruhlak MJ, Yu L, Kang JG, Yang A, Gu S, Fritzler MJ, Zheng ZM.

Nucleic Acids Res. 2019 Sep 26;47(17):9368-9385. doi: 10.1093/nar/gkz683.

3.

E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.

Kadakia T, Tai X, Kruhlak M, Wisniewski J, Hwang IY, Roy S, Guinter TI, Alag A, Kehrl JH, Zhuang Y, Singer A.

J Exp Med. 2019 Aug 5;216(8):1749-1761. doi: 10.1084/jem.20182285. Epub 2019 Jun 14.

PMID:
31201207
4.

T cell stemness and dysfunction in tumors are triggered by a common mechanism.

Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP.

Science. 2019 Mar 29;363(6434). pii: eaau0135. doi: 10.1126/science.aau0135.

PMID:
30923193
5.

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB.

Mol Cell. 2019 Mar 21;73(6):1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006. Epub 2019 Feb 7.

PMID:
30745086
6.

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A.

Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28.

PMID:
30704900
7.

TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib.

Dadashian EL, McAuley EM, Liu D, Shaffer AL 3rd, Young RM, Iyer JR, Kruhlak MJ, Staudt LM, Wiestner A, Herman SEM.

Cancer Res. 2019 Jan 15;79(2):360-371. doi: 10.1158/0008-5472.CAN-18-0781. Epub 2018 Nov 29.

PMID:
30498085
8.

Author Correction: T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation.

Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V.

Nat Immunol. 2018 Aug;19(8):898. doi: 10.1038/s41590-018-0139-6.

PMID:
29959442
9.

A multiprotein supercomplex controlling oncogenic signalling in lymphoma.

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.

Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20.

10.

Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development.

Brown ZJ, Fu Q, Ma C, Kruhlak M, Zhang H, Luo J, Heinrich B, Yu SJ, Zhang Q, Wilson A, Shi ZD, Swenson R, Greten TF.

Cell Death Dis. 2018 May 23;9(6):620. doi: 10.1038/s41419-018-0687-6.

11.

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.

Vizcardo R, Klemen ND, Islam SMR, Gurusamy D, Tamaoki N, Yamada D, Koseki H, Kidder BL, Yu Z, Jia L, Henning AN, Good ML, Bosch-Marce M, Maeda T, Liu C, Abdullaev Z, Pack S, Palmer DC, Stroncek DF, Ito F, Flomerfelt FA, Kruhlak MJ, Restifo NP.

Cell Rep. 2018 Mar 20;22(12):3175-3190. doi: 10.1016/j.celrep.2018.02.087.

12.

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.

Klebanoff CA, Crompton JG, Leonardi AJ, Yamamoto TN, Chandran SS, Eil RL, Sukumar M, Vodnala SK, Hu J, Ji Y, Clever D, Black MA, Gurusamy D, Kruhlak MJ, Jin P, Stroncek DF, Gattinoni L, Feldman SA, Restifo NP.

JCI Insight. 2017 Dec 7;2(23). pii: 95103. doi: 10.1172/jci.insight.95103.

13.

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.

Sharma NR, Majerciak V, Kruhlak MJ, Zheng ZM.

PLoS Pathog. 2017 Oct 30;13(10):e1006677. doi: 10.1371/journal.ppat.1006677. eCollection 2017 Oct.

14.

NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells.

House CD, Jordan E, Hernandez L, Ozaki M, James JM, Kim M, Kruhlak MJ, Batchelor E, Elloumi F, Cam MC, Annunziata CM.

Cancer Res. 2017 Dec 15;77(24):6927-6940. doi: 10.1158/0008-5472.CAN-17-0366. Epub 2017 Oct 26.

15.

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis.

Murgai M, Ju W, Eason M, Kline J, Beury DW, Kaczanowska S, Miettinen MM, Kruhlak M, Lei H, Shern JF, Cherepanova OA, Owens GK, Kaplan RN.

Nat Med. 2017 Oct;23(10):1176-1190. doi: 10.1038/nm.4400. Epub 2017 Sep 18.

16.

BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1).

Pongas G, Kim MK, Min DJ, House CD, Jordan E, Caplen N, Chakka S, Ohiri J, Kruhlak MJ, Annunziata CM.

Oncotarget. 2017 May 3;8(31):51402-51415. doi: 10.18632/oncotarget.17572. eCollection 2017 Aug 1.

17.

T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation.

Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V.

Nat Immunol. 2017 Oct;18(10):1117-1127. doi: 10.1038/ni.3816. Epub 2017 Aug 14. Erratum in: Nat Immunol. 2018 Aug;19(8):898.

18.

Cell Type- and Tissue Context-dependent Nuclear Distribution of Human Ago2.

Sharma NR, Wang X, Majerciak V, Ajiro M, Kruhlak M, Meyers C, Zheng ZM.

J Biol Chem. 2016 Jan 29;291(5):2302-9. doi: 10.1074/jbc.C115.695049. Epub 2015 Dec 23.

19.

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation.

Strickfaden H, McDonald D, Kruhlak MJ, Haince JF, Th'ng JP, Rouleau M, Ishibashi T, Corry GN, Ausio J, Underhill DA, Poirier GG, Hendzel MJ.

J Biol Chem. 2016 Jan 22;291(4):1789-802. doi: 10.1074/jbc.M115.694992. Epub 2015 Nov 11.

20.

Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice.

Bhattacharya P, Dey R, Dagur PK, Kruhlak M, Ismail N, Debrabant A, Joshi AB, Akue A, Kukuruga M, Takeda K, Selvapandiyan A, McCoy JP Jr, Nakhasi HL.

Infect Immun. 2015 Oct;83(10):3800-15. doi: 10.1128/IAI.00184-15. Epub 2015 Jul 13.

21.

Expression of the SNARE protein SNAP-23 is essential for cell survival.

Kaul S, Mittal SK, Feigenbaum L, Kruhlak MJ, Roche PA.

PLoS One. 2015 Feb 23;10(2):e0118311. doi: 10.1371/journal.pone.0118311. eCollection 2015.

22.

Activation of DNA damage response signaling by condensed chromatin.

Burgess RC, Burman B, Kruhlak MJ, Misteli T.

Cell Rep. 2014 Dec 11;9(5):1703-1717. doi: 10.1016/j.celrep.2014.10.060. Epub 2014 Nov 20.

23.

Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage.

Eggert T, Medina-Echeverz J, Kapanadze T, Kruhlak MJ, Korangy F, Greten TF.

PLoS One. 2014 Nov 17;9(11):e112717. doi: 10.1371/journal.pone.0112717. eCollection 2014.

24.

A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.

Khurana S, Kruhlak MJ, Kim J, Tran AD, Liu J, Nyswaner K, Shi L, Jailwala P, Sung MH, Hakim O, Oberdoerffer P.

Cell Rep. 2014 Aug 21;8(4):1049-62. doi: 10.1016/j.celrep.2014.07.024. Epub 2014 Aug 14.

25.

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A.

J Exp Med. 2014 Jun 2;211(6):1027-36. doi: 10.1084/jem.20131939. Epub 2014 May 19.

26.

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD.

Mol Cell. 2014 May 8;54(3):378-91. doi: 10.1016/j.molcel.2014.03.007. Epub 2014 Apr 3.

27.
28.

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.

Yang Y, Schmitz R, Mitala J, Whiting A, Xiao W, Ceribelli M, Wright GW, Zhao H, Yang Y, Xu W, Rosenwald A, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Wiestner A, Kruhlak MJ, Iwai K, Bernal F, Staudt LM.

Cancer Discov. 2014 Apr;4(4):480-93. doi: 10.1158/2159-8290.CD-13-0915. Epub 2014 Feb 3.

29.

Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.

J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13.

30.

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12. doi: 10.1073/pnas.1314859111. Epub 2013 Dec 9.

31.

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.

Cell. 2013 Jun 6;153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30.

32.

Control of autophagic cell death by caspase-10 in multiple myeloma.

Lamy L, Ngo VN, Emre NC, Shaffer AL 3rd, Yang Y, Tian E, Nair V, Kruhlak MJ, Zingone A, Landgren O, Staudt LM.

Cancer Cell. 2013 Apr 15;23(4):435-49. doi: 10.1016/j.ccr.2013.02.017. Epub 2013 Mar 28.

33.

Correlative fluorescence and EFTEM imaging of the organized components of the mammalian nucleus.

Kruhlak MJ.

Methods Mol Biol. 2013;950:397-416. doi: 10.1007/978-1-62703-137-0_22.

PMID:
23086887
34.

Introduction: nanoimaging techniques in biology.

Sousa AA, Kruhlak MJ.

Methods Mol Biol. 2013;950:1-10. doi: 10.1007/978-1-62703-137-0_1. Review.

PMID:
23086866
35.

Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.

Massimelli MJ, Majerciak V, Kruhlak M, Zheng ZM.

J Virol. 2013 Jan;87(1):243-56. doi: 10.1128/JVI.01693-12. Epub 2012 Oct 17.

36.

Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.

Müller JR, Waldmann TA, Kruhlak MJ, Dubois S.

J Biol Chem. 2012 Nov 23;287(48):40328-38. doi: 10.1074/jbc.M112.378612. Epub 2012 Oct 16.

37.

Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles.

Sousa AA, Morgan JT, Brown PH, Adams A, Jayasekara MP, Zhang G, Ackerson CJ, Kruhlak MJ, Leapman RD.

Small. 2012 Jul 23;8(14):2277-86. doi: 10.1002/smll.201200071. Epub 2012 Apr 20.

38.

Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis.

Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T.

Circ Res. 2012 Apr 27;110(9):1202-10. doi: 10.1161/CIRCRESAHA.111.256370. Epub 2012 Mar 27.

39.

Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker.

Ben-Aissa K, Patino-Lopez G, Belkina NV, Maniti O, Rosales T, Hao JJ, Kruhlak MJ, Knutson JR, Picart C, Shaw S.

J Biol Chem. 2012 May 11;287(20):16311-23. doi: 10.1074/jbc.M111.304881. Epub 2012 Mar 20.

40.

Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.

Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A.

Blood. 2012 May 31;119(22):5155-63. doi: 10.1182/blood-2011-11-388918. Epub 2012 Mar 7.

41.

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.

Liu Y, Belkina NV, Park C, Nambiar R, Loughhead SM, Patino-Lopez G, Ben-Aissa K, Hao JJ, Kruhlak MJ, Qi H, von Andrian UH, Kehrl JH, Tyska MJ, Shaw S.

Blood. 2012 Jan 12;119(2):445-53. doi: 10.1182/blood-2011-07-368860. Epub 2011 Nov 21.

42.

Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis.

Lonsdorf AS, Krämer BF, Fahrleitner M, Schönberger T, Gnerlich S, Ring S, Gehring S, Schneider SW, Kruhlak MJ, Meuth SG, Nieswandt B, Gawaz M, Enk AH, Langer HF.

J Biol Chem. 2012 Jan 13;287(3):2168-78. doi: 10.1074/jbc.M111.269811. Epub 2011 Nov 18.

43.

Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.

Kang JG, Majerciak V, Uldrick TS, Wang X, Kruhlak M, Yarchoan R, Zheng ZM.

J Pathol. 2011 Nov;225(3):378-89. doi: 10.1002/path.2962. Epub 2011 Aug 24.

44.

Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression.

Kang JG, Pripuzova N, Majerciak V, Kruhlak M, Le SY, Zheng ZM.

J Virol. 2011 Mar;85(6):2620-30. doi: 10.1128/JVI.02144-10. Epub 2011 Jan 5.

45.

Cooperative epigenetic modulation by cancer amplicon genes.

Rui L, Emre NC, Kruhlak MJ, Chung HJ, Steidl C, Slack G, Wright GW, Lenz G, Ngo VN, Shaffer AL, Xu W, Zhao H, Yang Y, Lamy L, Davis RE, Xiao W, Powell J, Maloney D, Thomas CJ, Möller P, Rosenwald A, Ott G, Muller-Hermelink HK, Savage K, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Weisenburger DD, Chan WC, Gascoyne RD, Levens D, Staudt LM.

Cancer Cell. 2010 Dec 14;18(6):590-605. doi: 10.1016/j.ccr.2010.11.013.

46.

Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.

Majerciak V, Uranishi H, Kruhlak M, Pilkington GR, Massimelli MJ, Bear J, Pavlakis GN, Felber BK, Zheng ZM.

J Virol. 2011 Feb;85(4):1528-40. doi: 10.1128/JVI.01709-10. Epub 2010 Nov 24.

47.

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.

Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T.

Blood. 2010 Nov 25;116(22):4395-403. doi: 10.1182/blood-2010-01-261503. Epub 2010 Jul 12.

48.

Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions.

Nakata H, Kruhlak M, Kamata W, Ogata-Aoki H, Li J, Maeda K, Ghosh AK, Mitsuya H.

Antivir Ther. 2010;15(3):321-31. doi: 10.3851/IMP1529.

49.

Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents.

Katragkou A, Kruhlak MJ, Simitsopoulou M, Chatzimoschou A, Taparkou A, Cotten CJ, Paliogianni F, Diza-Mataftsi E, Tsantali C, Walsh TJ, Roilides E.

J Infect Dis. 2010 Jun 15;201(12):1941-9. doi: 10.1086/652783.

50.

Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.

Majerciak V, Kruhlak M, Dagur PK, McCoy JP Jr, Zheng ZM.

J Biol Chem. 2010 Apr 9;285(15):11297-307. doi: 10.1074/jbc.M109.068221. Epub 2010 Feb 16.

Supplemental Content

Loading ...
Support Center