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Screening Human Embryos for Polygenic Traits Has Limited Utility.

Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S.

Cell. 2019 Nov 27;179(6):1424-1435.e8. doi: 10.1016/j.cell.2019.10.033. Epub 2019 Nov 21.


Rare variants contribute disproportionately to quantitative trait variation in yeast.

Bloom JS, Boocock J, Treusch S, Sadhu MJ, Day L, Oates-Barker H, Kruglyak L.

Elife. 2019 Oct 24;8. pii: e49212. doi: 10.7554/eLife.49212.


Analysis of the genetic basis of height in large Jewish nuclear families.

Zeevi D, Bloom JS, Sadhu MJ, Ben Yehuda A, Zangen D, Levy-Lahad E, Kruglyak L.

PLoS Genet. 2019 Jul 8;15(7):e1008082. doi: 10.1371/journal.pgen.1008082. eCollection 2019 Jul.


Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk.

Burga A, Ben-David E, Lemus Vergara T, Boocock J, Kruglyak L.

Nat Commun. 2019 Jun 18;10(1):2680. doi: 10.1038/s41467-019-10636-9.


How Low Can You Go?

Sadhu MJ, Kruglyak L.

CRISPR J. 2018 Oct;1:312-313. doi: 10.1089/crispr.2018.0042. No abstract available.


The Genetic Basis of Mutation Rate Variation in Yeast.

Gou L, Bloom JS, Kruglyak L.

Genetics. 2019 Feb;211(2):731-740. doi: 10.1534/genetics.118.301609. Epub 2018 Nov 30.


Genetics of trans-regulatory variation in gene expression.

Albert FW, Bloom JS, Siegel J, Day L, Kruglyak L.

Elife. 2018 Jul 17;7. pii: e35471. doi: 10.7554/eLife.35471.


Highly parallel genome variant engineering with CRISPR-Cas9.

Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L.

Nat Genet. 2018 Apr;50(4):510-514. doi: 10.1038/s41588-018-0087-y. Epub 2018 Apr 9.


Genetic variation in adaptability and pleiotropy in budding yeast.

Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM.

Elife. 2017 Aug 17;6. pii: e27167. doi: 10.7554/eLife.27167.


The genetic basis of natural variation in a phoretic behavior.

Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J.

Nat Commun. 2017 Aug 17;8(1):273. doi: 10.1038/s41467-017-00386-x.


A genetic signature of the evolution of loss of flight in the Galapagos cormorant.

Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L.

Science. 2017 Jun 2;356(6341). pii: eaal3345. doi: 10.1126/science.aal3345.


A maternal-effect selfish genetic element in Caenorhabditis elegans.

Ben-David E, Burga A, Kruglyak L.

Science. 2017 Jun 9;356(6342):1051-1055. doi: 10.1126/science.aan0621. Epub 2017 May 11.


Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast.

Forsberg SK, Bloom JS, Sadhu MJ, Kruglyak L, Carlborg Ö.

Nat Genet. 2017 Apr;49(4):497-503. doi: 10.1038/ng.3800. Epub 2017 Feb 27.


The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.

Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC.

Genetics. 2016 Sep;204(1):371-83. doi: 10.1534/genetics.116.191148. Epub 2016 Jul 22.


Complex Traits and Simple Systems: An Interview with Leonid Kruglyak.

Kruglyak L.

Genetics. 2016 Jul;203(3):1023-5. doi: 10.1534/genetics.116.191866.


CRISPR-directed mitotic recombination enables genetic mapping without crosses.

Sadhu MJ, Bloom JS, Day L, Kruglyak L.

Science. 2016 May 27;352(6289):1113-6. doi: 10.1126/science.aaf5124. Epub 2016 May 5.


2015 Curt Stern Award.

Kruglyak L.

Am J Hum Genet. 2016 Mar 3;98(3):428-430. doi: 10.1016/j.ajhg.2016.01.002. No abstract available.


Genetic interactions contribute less than additive effects to quantitative trait variation in yeast.

Bloom JS, Kotenko I, Sadhu MJ, Treusch S, Albert FW, Kruglyak L.

Nat Commun. 2015 Nov 5;6:8712. doi: 10.1038/ncomms9712.


Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans.

Ghosh R, Bloom JS, Mohammadi A, Schumer ME, Andolfatto P, Ryu W, Kruglyak L.

Genetics. 2015 Aug;200(4):1327-39. doi: 10.1534/genetics.115.178491. Epub 2015 Jun 19.


Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856.

Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJ, Brenchley R, Van't Hof A, Bevers RP, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, Andersen EC, Moerman DG, Hillier LW, Kammenga JE, Waterston RH.

Genetics. 2015 Jul;200(3):975-89. doi: 10.1534/genetics.115.175950. Epub 2015 May 19.


Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis.

Thomas CG, Wang W, Jovelin R, Ghosh R, Lomasko T, Trinh Q, Kruglyak L, Stein LD, Cutter AD.

Genome Res. 2015 May;25(5):667-78. doi: 10.1101/gr.187237.114. Epub 2015 Mar 17.


A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains.

Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, Kruglyak L.

G3 (Bethesda). 2015 Mar 13;5(5):911-20. doi: 10.1534/g3.115.017178.


The role of regulatory variation in complex traits and disease.

Albert FW, Kruglyak L.

Nat Rev Genet. 2015 Apr;16(4):197-212. doi: 10.1038/nrg3891. Epub 2015 Feb 24. Review.


A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite.

Balla KM, Andersen EC, Kruglyak L, Troemel ER.

PLoS Pathog. 2015 Feb 13;11(2):e1004583. doi: 10.1371/journal.ppat.1004583. eCollection 2015 Feb.


Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae.

Treusch S, Albert FW, Bloom JS, Kotenko IE, Kruglyak L.

PLoS Genet. 2015 Jan 8;11(1):e1004913. doi: 10.1371/journal.pgen.1004913. eCollection 2015 Jan.


Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent.

Wang X, Kruglyak L.

PLoS Genet. 2014 Dec 18;10(12):e1004894. doi: 10.1371/journal.pgen.1004894. eCollection 2014 Dec.


Genetic influences on translation in yeast.

Albert FW, Muzzey D, Weissman JS, Kruglyak L.

PLoS Genet. 2014 Oct 23;10(10):e1004692. doi: 10.1371/journal.pgen.1004692. eCollection 2014 Oct.


Genetic influences on brain gene expression in rats selected for tameness and aggression.

Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW.

Genetics. 2014 Nov;198(3):1277-90. doi: 10.1534/genetics.114.168948. Epub 2014 Sep 3.


Genetic basis of metabolome variation in yeast.

Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L.

PLoS Genet. 2014 Mar 6;10(3):e1004142. doi: 10.1371/journal.pgen.1004142. eCollection 2014 Mar.


A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology.

Andersen EC, Bloom JS, Gerke JP, Kruglyak L.

PLoS Genet. 2014 Feb 27;10(2):e1004156. doi: 10.1371/journal.pgen.1004156. eCollection 2014 Feb. Erratum in: PLoS Genet. 2014 Mar;10(3):e1004316.


Genetics of single-cell protein abundance variation in large yeast populations.

Albert FW, Treusch S, Shockley AH, Bloom JS, Kruglyak L.

Nature. 2014 Feb 27;506(7489):494-7. doi: 10.1038/nature12904. Epub 2014 Jan 8.


Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case.

Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess DC.

G3 (Bethesda). 2013 Apr 9;3(4):733-740. doi: 10.1534/g3.113.005884.


A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A.

PLoS Genet. 2013;9(3):e1003329. doi: 10.1371/journal.pgen.1003329. Epub 2013 Mar 7.


Finding the sources of missing heritability in a yeast cross.

Bloom JS, Ehrenreich IM, Loo WT, Lite TL, Kruglyak L.

Nature. 2013 Feb 14;494(7436):234-7. doi: 10.1038/nature11867. Epub 2013 Feb 3.


Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans.

Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI.

PLoS Genet. 2012;8(12):e1003157. doi: 10.1371/journal.pgen.1003157. Epub 2012 Dec 20.


Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans.

Ghosh R, Mohammadi A, Kruglyak L, Ryu WS.

BMC Biol. 2012 Oct 31;10:85. doi: 10.1186/1741-7007-10-85.


More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans.

Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC.

Genetics. 2012 Dec;192(4):1533-42. doi: 10.1534/genetics.112.142877. Epub 2012 Oct 19.


Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS.

Khan Z, Bloom JS, Amini S, Singh M, Perlman DH, Caudy AA, Kruglyak L.

Mol Syst Biol. 2012;8:602. doi: 10.1038/msb.2012.34.


Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells.

Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ.

Science. 2012 Jul 27;337(6093):470-3. doi: 10.1126/science.1219861. Epub 2012 Jul 8.


Genetic architecture of highly complex chemical resistance traits across four yeast strains.

Ehrenreich IM, Bloom J, Torabi N, Wang X, Jia Y, Kruglyak L.

PLoS Genet. 2012;8(3):e1002570. doi: 10.1371/journal.pgen.1002570. Epub 2012 Mar 15.


Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast.

Torabi N, Kruglyak L.

PLoS Genet. 2012;8(3):e1002546. doi: 10.1371/journal.pgen.1002546. Epub 2012 Mar 1.


Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.

Ghosh R, Andersen EC, Shapiro JA, Gerke JP, Kruglyak L.

Science. 2012 Feb 3;335(6068):574-8. doi: 10.1126/science.1214318.


Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity.

Andersen EC, Gerke JP, Shapiro JA, Crissman JR, Ghosh R, Bloom JS, Félix MA, Kruglyak L.

Nat Genet. 2012 Jan 29;44(3):285-90. doi: 10.1038/ng.1050.


Accurate proteome-wide protein quantification from high-resolution 15N mass spectra.

Khan Z, Amini S, Bloom JS, Ruse C, Caudy AA, Kruglyak L, Singh M, Perlman DH, Tavazoie S.

Genome Biol. 2011 Dec 19;12(12):R122. doi: 10.1186/gb-2011-12-12-r122.


Genetic variation shapes protein networks mainly through non-transcriptional mechanisms.

Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A.

PLoS Biol. 2011 Sep;9(9):e1001144. doi: 10.1371/journal.pbio.1001144. Epub 2011 Sep 6.


Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.

Kwan EX, Foss E, Kruglyak L, Bedalov A.

PLoS Genet. 2011 Aug;7(8):e1002250. doi: 10.1371/journal.pgen.1002250. Epub 2011 Aug 25.


Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae.

Torabi N, Kruglyak L.

PLoS Genet. 2011 Jul;7(7):e1002211. doi: 10.1371/journal.pgen.1002211. Epub 2011 Jul 28.


A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans.

Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L.

PLoS Biol. 2011 Jul;9(7):e1001115. doi: 10.1371/journal.pbio.1001115. Epub 2011 Jul 26.


Catecholamine receptor polymorphisms affect decision-making in C. elegans.

Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, Bargmann CI.

Nature. 2011 Apr 21;472(7343):313-8. doi: 10.1038/nature09821. Epub 2011 Mar 16.


Selection at linked sites shapes heritable phenotypic variation in C. elegans.

Rockman MV, Skrovanek SS, Kruglyak L.

Science. 2010 Oct 15;330(6002):372-6. doi: 10.1126/science.1194208.

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