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Items: 1 to 50 of 146


A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus.

Chen G, Ma LC, Wang S, Woltz RL, Grasso EM, Montelione GT, Krug RM.

Nucleic Acids Res. 2020 Jan 10;48(1):304-315. doi: 10.1093/nar/gkz1094.


Framing natural assets for advancing sustainability research: translating different perspectives into actions.

Martinez-Harms MJ, Gelcich S, Krug RM, Maseyk FJF, Moersberger H, Rastogi A, Wambugu G, Krug CB, Spehn EM, Pascual U.

Sustain Sci. 2018;13(6):1519-1531. doi: 10.1007/s11625-018-0599-5. Epub 2018 Jul 17.


Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.

Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL.

Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5.


Influenza NS1 directly modulates Hedgehog signaling during infection.

Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zúñiga EI, Krug RM, Oldstone MB, Bier E.

PLoS Pathog. 2017 Aug 24;13(8):e1006588. doi: 10.1371/journal.ppat.1006588. eCollection 2017 Aug.


Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins.

Zhao C, Sridharan H, Chen R, Baker DP, Wang S, Krug RM.

Nat Commun. 2016 Sep 2;7:12754. doi: 10.1038/ncomms12754.


A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus.

Ma LC, Guan R, Hamilton K, Aramini JM, Mao L, Wang S, Krug RM, Montelione GT.

Structure. 2016 Sep 6;24(9):1562-72. doi: 10.1016/j.str.2016.07.001. Epub 2016 Aug 18.


Role of N Terminus-Truncated NS1 Proteins of Influenza A Virus in Inhibiting IRF3 Activation.

Kuo RL, Li LH, Lin SJ, Li ZH, Chen GW, Chang CK, Wang YR, Tam EH, Gong YN, Krug RM, Shih SR.

J Virol. 2016 Apr 14;90(9):4696-4705. doi: 10.1128/JVI.02843-15. Print 2016 May.


Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein.

Liu CH, Zhou L, Chen G, Krug RM.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14048-53. doi: 10.1073/pnas.1509745112. Epub 2015 Oct 26.


Functions of the influenza A virus NS1 protein in antiviral defense.

Krug RM.

Curr Opin Virol. 2015 Jun;12:1-6. doi: 10.1016/j.coviro.2015.01.007. Epub 2015 Jan 29. Review.


Influenza: An RNA-synthesizing machine.

Krug RM.

Nature. 2014 Dec 18;516(7531):338-9. doi: 10.1038/516338a. No abstract available.


Viral proteins that bind double-stranded RNA: countermeasures against host antiviral responses.

Krug RM.

J Interferon Cytokine Res. 2014 Jun;34(6):464-8. doi: 10.1089/jir.2014.0005. Review.


Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein.

Chen G, Liu CH, Zhou L, Krug RM.

Cell Host Microbe. 2014 Apr 9;15(4):484-93. doi: 10.1016/j.chom.2014.03.002.


(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.

Aramini JM, Hamilton K, Ma LC, Swapna GVT, Leonard PG, Ladbury JE, Krug RM, Montelione GT.

Structure. 2014 Apr 8;22(4):515-525. doi: 10.1016/j.str.2014.01.010. Epub 2014 Feb 27.


Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.

Barman S, You L, Chen R, Codrea V, Kago G, Edupuganti R, Robertus J, Krug RM, Anslyn EV.

Eur J Med Chem. 2014 Jan;71:81-90. doi: 10.1016/j.ejmech.2013.10.063. Epub 2013 Nov 7.


Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells.

Seo GJ, Kincaid RP, Phanaksri T, Burke JM, Pare JM, Cox JE, Hsiang TY, Krug RM, Sullivan CS.

Cell Host Microbe. 2013 Oct 16;14(4):435-45. doi: 10.1016/j.chom.2013.09.002. Epub 2013 Sep 26.


Interferon-induced ISG15 pathway: an ongoing virus-host battle.

Zhao C, Collins MN, Hsiang TY, Krug RM.

Trends Microbiol. 2013 Apr;21(4):181-6. doi: 10.1016/j.tim.2013.01.005. Epub 2013 Feb 14. Review.


Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza A virus ribonucleoprotein.

Ye Q, Guu TS, Mata DA, Kuo RL, Smith B, Krug RM, Tao YJ.

mBio. 2012 Dec 26;4(1):e00467-12. doi: 10.1128/mBio.00467-12.


LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.

Malur M, Gale M Jr, Krug RM.

J Virol. 2012 Oct;86(19):10733-8. doi: 10.1128/JVI.00510-12. Epub 2012 Jul 25.


Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses.

Hsiang TY, Zhou L, Krug RM.

J Virol. 2012 Oct;86(19):10370-6. doi: 10.1128/JVI.00732-12. Epub 2012 Jul 11.


Sequence in the influenza A virus nucleoprotein required for viral polymerase binding and RNA synthesis.

Marklund JK, Ye Q, Dong J, Tao YJ, Krug RM.

J Virol. 2012 Jul;86(13):7292-7. doi: 10.1128/JVI.00014-12. Epub 2012 Apr 24.


Assemble, replicate, remodel and evade.

Sundquist WI, Krug RM.

Curr Opin Virol. 2012 Apr;2(2):111-4. doi: 10.1016/j.coviro.2012.02.008. Epub 2012 Mar 10. No abstract available.


Identification of influenza virus inhibitors targeting NS1A utilizing fluorescence polarization-based high-throughput assay.

Cho EJ, Xia S, Ma LC, Robertus J, Krug RM, Anslyn EV, Montelione GT, Ellington AD.

J Biomol Screen. 2012 Apr;17(4):448-59. doi: 10.1177/1087057111431488. Epub 2012 Jan 5.


Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.

Guan R, Ma LC, Leonard PG, Amer BR, Sridharan H, Zhao C, Krug RM, Montelione GT.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13468-73. doi: 10.1073/pnas.1107032108. Epub 2011 Aug 1.


Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions.

Aramini JM, Ma LC, Zhou L, Schauder CM, Hamilton K, Amer BR, Mack TR, Lee HW, Ciccosanti CT, Zhao L, Xiao R, Krug RM, Montelione GT.

J Biol Chem. 2011 Jul 22;286(29):26050-60. doi: 10.1074/jbc.M111.248765. Epub 2011 May 26.


The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins.

Spesock A, Malur M, Hossain MJ, Chen LM, Njaa BL, Davis CT, Lipatov AS, York IA, Krug RM, Donis RO.

J Virol. 2011 Jul;85(14):7048-58. doi: 10.1128/JVI.00417-11. Epub 2011 May 18.


Backbone and Ile-δ1, Leu, Val methyl 1H, 13C and 15N NMR chemical shift assignments for human interferon-stimulated gene 15 protein.

Yin C, Aramini JM, Ma LC, Cort JR, Swapna GV, Krug RM, Montelione GT.

Biomol NMR Assign. 2011 Oct;5(2):215-9. doi: 10.1007/s12104-011-9303-8. Epub 2011 May 5.


Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.

You L, Cho EJ, Leavitt J, Ma LC, Montelione GT, Anslyn EV, Krug RM, Ellington A, Robertus JD.

Bioorg Med Chem Lett. 2011 May 15;21(10):3007-11. doi: 10.1016/j.bmcl.2011.03.042. Epub 2011 Mar 17.


Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region.

Schauder C, Ma LC, Krug RM, Montelione GT, Guan R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1567-71. doi: 10.1107/S1744309110041333. Epub 2010 Nov 16.


Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription.

Kuo RL, Zhao C, Malur M, Krug RM.

Virology. 2010 Dec 20;408(2):146-58. doi: 10.1016/j.virol.2010.09.012. Epub 2010 Oct 8.


The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble.

Liu H, Golebiewski L, Dow EC, Krug RM, Javier RT, Rice AP.

J Virol. 2010 Nov;84(21):11164-74. doi: 10.1128/JVI.01278-10. Epub 2010 Aug 11.


Structures of influenza A proteins and insights into antiviral drug targets.

Das K, Aramini JM, Ma LC, Krug RM, Arnold E.

Nat Struct Mol Biol. 2010 May;17(5):530-8. doi: 10.1038/nsmb.1779. Epub 2010 Apr 11. Review.


ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.

Zhao C, Hsiang TY, Kuo RL, Krug RM.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2253-8. doi: 10.1073/pnas.0909144107. Epub 2010 Jan 19.


Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins.

Sridharan H, Zhao C, Krug RM.

J Biol Chem. 2010 Mar 12;285(11):7852-6. doi: 10.1074/jbc.C109.095703. Epub 2010 Jan 21.


Emerging antiviral targets for influenza A virus.

Krug RM, Aramini JM.

Trends Pharmacol Sci. 2009 Jun;30(6):269-77. doi: 10.1016/ Epub 2009 May 8. Review.


Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells.

Hsiang TY, Zhao C, Krug RM.

J Virol. 2009 Jun;83(12):5971-7. doi: 10.1128/JVI.01667-08. Epub 2009 Apr 8.


Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells.

Kuo RL, Krug RM.

J Virol. 2009 Feb;83(4):1611-6. doi: 10.1128/JVI.01491-08. Epub 2008 Dec 3.


Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication.

Newcomb LL, Kuo RL, Ye Q, Jiang Y, Tao YJ, Krug RM.

J Virol. 2009 Jan;83(1):29-36. doi: 10.1128/JVI.02293-07. Epub 2008 Oct 22.


Structural basis for suppression of a host antiviral response by influenza A virus.

Das K, Ma LC, Xiao R, Radvansky B, Aramini J, Zhao L, Marklund J, Kuo RL, Twu KY, Arnold E, Krug RM, Montelione GT.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13093-8. doi: 10.1073/pnas.0805213105. Epub 2008 Aug 25.


The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells.

Twu KY, Kuo RL, Marklund J, Krug RM.

J Virol. 2007 Aug;81(15):8112-21. Epub 2007 May 23.


Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses.

Yin C, Khan JA, Swapna GV, Ertekin A, Krug RM, Tong L, Montelione GT.

J Biol Chem. 2007 Jul 13;282(28):20584-92. Epub 2007 May 1.


Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.

Melén K, Kinnunen L, Fagerlund R, Ikonen N, Twu KY, Krug RM, Julkunen I.

J Virol. 2007 Jun;81(11):5995-6006. Epub 2007 Mar 21.


The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA.

Ye Q, Krug RM, Tao YJ.

Nature. 2006 Dec 21;444(7122):1078-82. Epub 2006 Dec 6.


Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.

Sirén J, Imaizumi T, Sarkar D, Pietilä T, Noah DL, Lin R, Hiscott J, Krug RM, Fisher PB, Julkunen I, Matikainen S.

Microbes Infect. 2006 Jul;8(8):2013-20. Epub 2006 May 22.


The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.

Twu KY, Noah DL, Rao P, Kuo RL, Krug RM.

J Virol. 2006 Apr;80(8):3957-65.


Virology. Clues to the virulence of H5N1 viruses in humans.

Krug RM.

Science. 2006 Mar 17;311(5767):1562-3. No abstract available.


Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.

Dastur A, Beaudenon S, Kelley M, Krug RM, Huibregtse JM.

J Biol Chem. 2006 Feb 17;281(7):4334-8. Epub 2005 Dec 28.

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